diff --git a/CHANGELOG.md b/CHANGELOG.md
index 0ca0b3f5c998..c96b1c3fb23b 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -52,6 +52,7 @@ Ref: https://keepachangelog.com/en/1.0.0/
 
 ### Bug Fixes
 
+* (runtime) [#17284](https://github.com/cosmos/cosmos-sdk/pull/17284) Properly allow to combine depinject-enabled modules and non-depinject-enabled modules in app v2.
 * (baseapp) [#17251](https://github.com/cosmos/cosmos-sdk/pull/17251) VerifyVoteExtensions and ExtendVote initialize their own contexts/states, allowing VerifyVoteExtensions being called without ExtendVote.
 * (x/auth) [#17209](https://github.com/cosmos/cosmos-sdk/pull/17209) Internal error on AccountInfo when account's public key is not set.
 * (baseapp) [#17159](https://github.com/cosmos/cosmos-sdk/pull/17159) Validators can propose blocks that exceed the gas limit.
diff --git a/docs/docs/building-apps/01-app-go-v2.md b/docs/docs/building-apps/01-app-go-v2.md
index 04754414826c..00b69247181e 100644
--- a/docs/docs/building-apps/01-app-go-v2.md
+++ b/docs/docs/building-apps/01-app-go-v2.md
@@ -118,6 +118,31 @@ More information on how work `depinject.Configs` and `depinject.Supply` can be f
 https://github.com/cosmos/cosmos-sdk/blob/v0.50.0-alpha.0/simapp/app_v2.go#L114-L146
 ```
 
+### Registering non app wiring modules
+
+It is possible to combine app wiring / depinject enabled modules with non app wiring modules.
+To do so, use the `app.RegisterModules` method to register the modules on your app, as well as `app.RegisterStores` for registering the extra stores needed.
+
+```go
+// ....
+app.App = appBuilder.Build(db, traceStore, baseAppOptions...)
+
+// register module manually
+app.RegisterStores(storetypes.NewKVStoreKey(example.ModuleName))
+app.ExampleKeeper = examplekeeper.NewKeeper(app.appCodec, app.AccountKeeper.AddressCodec(), runtime.NewKVStoreService(app.GetKey(example.ModuleName)), authtypes.NewModuleAddress(govtypes.ModuleName).String())
+exampleAppModule := examplemodule.NewAppModule(app.ExampleKeeper)
+if err := app.RegisterModules(&exampleAppModule); err != nil {
+	panic(err)
+}
+
+// ....
+```
+
+:::warning
+When using AutoCLI and combining app wiring and non app wiring modules. The AutoCLI options should be manually constructed instead of injected.
+Otherwise it will miss the non depinject modules and not register their CLI.
+:::
+
 ### Complete `app_v2.go`
 
 :::tip
diff --git a/runtime/app.go b/runtime/app.go
index e1ed0da78c09..620b058a1183 100644
--- a/runtime/app.go
+++ b/runtime/app.go
@@ -9,6 +9,7 @@ import (
 
 	runtimev1alpha1 "cosmossdk.io/api/cosmos/app/runtime/v1alpha1"
 	appv1alpha1 "cosmossdk.io/api/cosmos/app/v1alpha1"
+	"cosmossdk.io/core/appmodule"
 	"cosmossdk.io/log"
 	storetypes "cosmossdk.io/store/types"
 
@@ -75,7 +76,26 @@ func (a *App) RegisterModules(modules ...module.AppModule) error {
 		appModule.RegisterInterfaces(a.interfaceRegistry)
 		appModule.RegisterLegacyAminoCodec(a.amino)
 
+		if module, ok := appModule.(module.HasServices); ok {
+			module.RegisterServices(a.configurator)
+		} else if module, ok := appModule.(appmodule.HasServices); ok {
+			if err := module.RegisterServices(a.configurator); err != nil {
+				return err
+			}
+		}
 	}
+
+	return nil
+}
+
+// RegisterStores registers the provided store keys.
+// This method should only be used for registering extra stores
+// wiich is necessary for modules that not registered using the app config.
+// To be used in combination of RegisterModules.
+func (a *App) RegisterStores(keys ...storetypes.StoreKey) error {
+	a.storeKeys = append(a.storeKeys, keys...)
+	a.MountStores(keys...)
+
 	return nil
 }
 
diff --git a/runtime/module.go b/runtime/module.go
index b544167dc029..7b3a54fc7842 100644
--- a/runtime/module.go
+++ b/runtime/module.go
@@ -176,8 +176,7 @@ func ProvideInterfaceRegistry(addressCodec address.Codec, validatorAddressCodec
 		return nil, err
 	}
 
-	err = interfaceRegistry.SigningContext().Validate()
-	if err != nil {
+	if err := interfaceRegistry.SigningContext().Validate(); err != nil {
 		return nil, err
 	}
 
diff --git a/scripts/init-simapp.sh b/scripts/init-simapp.sh
index 5db89d2c5066..9225e9b12456 100755
--- a/scripts/init-simapp.sh
+++ b/scripts/init-simapp.sh
@@ -7,6 +7,7 @@ echo "using $SIMD_BIN"
 if [ -d "$($SIMD_BIN config home)" ]; then rm -r $($SIMD_BIN config home); fi
 $SIMD_BIN config set client chain-id demo
 $SIMD_BIN config set client keyring-backend test
+$SIMD_BIN config set app api.enable true
 $SIMD_BIN keys add alice
 $SIMD_BIN keys add bob
 $SIMD_BIN init test --chain-id demo