diff --git a/.azure-pipelines/azure-pipelines-linux.yml b/.azure-pipelines/azure-pipelines-linux.yml
index 875d996..218a344 100755
--- a/.azure-pipelines/azure-pipelines-linux.yml
+++ b/.azure-pipelines/azure-pipelines-linux.yml
@@ -8,8 +8,12 @@ jobs:
     vmImage: ubuntu-latest
   strategy:
     matrix:
-      linux_64_:
-        CONFIG: linux_64_
+      linux_64_build_variantpyqt:
+        CONFIG: linux_64_build_variantpyqt
+        UPLOAD_PACKAGES: 'True'
+        DOCKER_IMAGE: quay.io/condaforge/linux-anvil-cos7-x86_64
+      linux_64_build_variantpyside6:
+        CONFIG: linux_64_build_variantpyside6
         UPLOAD_PACKAGES: 'True'
         DOCKER_IMAGE: quay.io/condaforge/linux-anvil-cos7-x86_64
   timeoutInMinutes: 360
diff --git a/.azure-pipelines/azure-pipelines-osx.yml b/.azure-pipelines/azure-pipelines-osx.yml
index a8ca2b4..78cd06f 100755
--- a/.azure-pipelines/azure-pipelines-osx.yml
+++ b/.azure-pipelines/azure-pipelines-osx.yml
@@ -8,8 +8,11 @@ jobs:
     vmImage: macOS-12
   strategy:
     matrix:
-      osx_64_:
-        CONFIG: osx_64_
+      osx_64_build_variantpyqt:
+        CONFIG: osx_64_build_variantpyqt
+        UPLOAD_PACKAGES: 'True'
+      osx_64_build_variantpyside6:
+        CONFIG: osx_64_build_variantpyside6
         UPLOAD_PACKAGES: 'True'
   timeoutInMinutes: 360
   variables: {}
diff --git a/.ci_support/linux_64_.yaml b/.ci_support/linux_64_build_variantpyqt.yaml
similarity index 88%
rename from .ci_support/linux_64_.yaml
rename to .ci_support/linux_64_build_variantpyqt.yaml
index 4fec014..cbeb270 100644
--- a/.ci_support/linux_64_.yaml
+++ b/.ci_support/linux_64_build_variantpyqt.yaml
@@ -1,3 +1,5 @@
+build_variant:
+- pyqt
 cdt_name:
 - cos6
 channel_sources:
diff --git a/.ci_support/linux_64_build_variantpyside6.yaml b/.ci_support/linux_64_build_variantpyside6.yaml
new file mode 100644
index 0000000..b160327
--- /dev/null
+++ b/.ci_support/linux_64_build_variantpyside6.yaml
@@ -0,0 +1,12 @@
+build_variant:
+- pyside6
+cdt_name:
+- cos6
+channel_sources:
+- conda-forge
+channel_targets:
+- conda-forge main
+docker_image:
+- quay.io/condaforge/linux-anvil-cos7-x86_64
+target_platform:
+- linux-64
diff --git a/.ci_support/osx_64_.yaml b/.ci_support/osx_64_build_variantpyqt.yaml
similarity index 90%
rename from .ci_support/osx_64_.yaml
rename to .ci_support/osx_64_build_variantpyqt.yaml
index 322c73b..65e6909 100644
--- a/.ci_support/osx_64_.yaml
+++ b/.ci_support/osx_64_build_variantpyqt.yaml
@@ -2,6 +2,8 @@ MACOSX_DEPLOYMENT_TARGET:
 - '10.13'
 MACOSX_SDK_VERSION:
 - '10.13'
+build_variant:
+- pyqt
 channel_sources:
 - conda-forge
 channel_targets:
diff --git a/.ci_support/osx_64_build_variantpyside6.yaml b/.ci_support/osx_64_build_variantpyside6.yaml
new file mode 100644
index 0000000..f6086b5
--- /dev/null
+++ b/.ci_support/osx_64_build_variantpyside6.yaml
@@ -0,0 +1,14 @@
+MACOSX_DEPLOYMENT_TARGET:
+- '10.13'
+MACOSX_SDK_VERSION:
+- '10.13'
+build_variant:
+- pyside6
+channel_sources:
+- conda-forge
+channel_targets:
+- conda-forge main
+macos_machine:
+- x86_64-apple-darwin13.4.0
+target_platform:
+- osx-64
diff --git a/recipe/conda_build_config.yaml b/recipe/conda_build_config.yaml
new file mode 100644
index 0000000..4f1798a
--- /dev/null
+++ b/recipe/conda_build_config.yaml
@@ -0,0 +1,3 @@
+build_variant:
+  - "pyqt"
+  - "pyside6"
diff --git a/recipe/meta.yaml b/recipe/meta.yaml
index 3792cad..310c416 100644
--- a/recipe/meta.yaml
+++ b/recipe/meta.yaml
@@ -2,7 +2,14 @@
 {% set version = "1.7.1" %}
 {% set sha256 = "a87bbc998b792532d2c87add8b0f7bbf28a4d8cf5db1bdfb6d6e260791754498" %}
 {% set pymin = "3.9" %}
-{% set build = 0 %}
+{% set build = 1 %}
+
+# Adapted from https://github.com/conda-forge/vtk-feedstock/blob/main/recipe/meta.yaml
+# PySide6 is lower priority than PyQt5 for backward compat (e.g., with matplotlib,
+# mayavi, etc.) until the ecosystem updates
+{% set build = build + 100 %}  # [build_variant == "pyside6"]
+{% set build = build + 200 %}  # [build_variant == "pyqt"]
+{% set build_string = '{}_py{}h{}_{}'.format(build_variant, CONDA_PY, PKG_HASH, build) %}
 
 package:
   name: {{ name|lower }}
@@ -15,6 +22,7 @@ source:
 
 build:
   number: {{ build }}
+  string: {{ build_string }}
 
 outputs:
   - name: mne-base
@@ -83,7 +91,8 @@ outputs:
         - pyvistaqt >=0.4
         - statsmodels
         - numexpr
-        - pyqt
+        - pyqt  # [build_variant == "pyqt"]
+        - pyside6  # [build_variant == "pyside6"]
         - pillow
         - joblib
         - psutil