diff --git a/src/FrameAnnotations.cpp b/src/FrameAnnotations.cpp
index 2bda0a1acf..14fafd6e98 100644
--- a/src/FrameAnnotations.cpp
+++ b/src/FrameAnnotations.cpp
@@ -1,6 +1,7 @@
 #include "FrameAnnotations.h"
 
 #include "State.h"
+#include "Util.h"
 
 #pragma comment(lib, "dxguid.lib")
 
@@ -34,7 +35,8 @@ namespace FrameAnnotations
 				if (globals::game::currentPixelShader && *globals::game::currentPixelShader) {
 					descriptor = (*globals::game::currentPixelShader)->id;
 				}
-				std::string diskPath = std::format("Data/ShaderCache/{}/{:X}.pso", shader->fxpFilename, descriptor);
+				const std::string definesSuffix = Util::GetShaderDefinesSuffix(globals::state->shaderDefinesString);
+				std::string diskPath = std::format("Data/ShaderCache/{}/{:X}{}.pso", shader->fxpFilename, descriptor, definesSuffix);
 				const std::string passName = std::format("[{}:{:X}] ({:X}) <{}> {} -> {}", magic_enum::enum_name(ShaderType), descriptor, pass->passEnum,
 					pass->accumulationHint, pass->geometry->name.c_str(), diskPath);
 				globals::state->BeginPerfEvent(passName);
diff --git a/src/ShaderCache.cpp b/src/ShaderCache.cpp
index 16128e531e..efe5ef7c11 100644
--- a/src/ShaderCache.cpp
+++ b/src/ShaderCache.cpp
@@ -1,6 +1,7 @@
 #include "ShaderCache.h"
 #include "Globals.h"
 #include "ShaderFileWatcher.h"
+#include "Util.h"
 
 #include <d3dcompiler.h>
 
@@ -1300,13 +1301,17 @@ namespace SIE
 
 		std::wstring GetDiskPath(const std::string_view& name, uint32_t descriptor, ShaderClass shaderClass)
 		{
+			const auto suffixNarrow = Util::GetShaderDefinesSuffix(globals::state->shaderDefinesString);
+			const std::wstring suffix(suffixNarrow.begin(), suffixNarrow.end());
+
+			const auto wname = std::wstring(name.begin(), name.end());
 			switch (shaderClass) {
 			case ShaderClass::Pixel:
-				return std::format(L"Data/ShaderCache/{}/{:X}.pso", std::wstring(name.begin(), name.end()), descriptor);
+				return std::format(L"Data/ShaderCache/{}/{:X}{}.pso", wname, descriptor, suffix);
 			case ShaderClass::Vertex:
-				return std::format(L"Data/ShaderCache/{}/{:X}.vso", std::wstring(name.begin(), name.end()), descriptor);
+				return std::format(L"Data/ShaderCache/{}/{:X}{}.vso", wname, descriptor, suffix);
 			case ShaderClass::Compute:
-				return std::format(L"Data/ShaderCache/{}/{:X}.cso", std::wstring(name.begin(), name.end()), descriptor);
+				return std::format(L"Data/ShaderCache/{}/{:X}{}.cso", wname, descriptor, suffix);
 			}
 			return {};
 		}
diff --git a/src/Utils/Format.cpp b/src/Utils/Format.cpp
index 2b0d88905b..5ec1ebea34 100644
--- a/src/Utils/Format.cpp
+++ b/src/Utils/Format.cpp
@@ -264,4 +264,16 @@ namespace Util
 											   return std::tolower(static_cast<unsigned char>(ca)) == std::tolower(static_cast<unsigned char>(cb));
 										   });
 	}
+
+	std::string GetShaderDefinesSuffix(const std::string& definesStr)
+	{
+		if (definesStr.empty())
+			return {};
+		uint32_t h = 2166136261u;  // FNV-1a 32-bit offset basis
+		for (unsigned char c : definesStr) {
+			h ^= c;
+			h *= 16777619u;  // FNV prime
+		}
+		return std::format("_{:08X}", h);
+	}
 }  // namespace Util
diff --git a/src/Utils/Format.h b/src/Utils/Format.h
index dcee025bce..476b9b1847 100644
--- a/src/Utils/Format.h
+++ b/src/Utils/Format.h
@@ -120,4 +120,14 @@ namespace Util
 
 	/** Case-insensitive equality for two strings. */
 	bool IEquals(std::string_view a, std::string_view b);
+
+	/**
+	 * Returns the defines-based shader cache filename suffix for the given shader
+	 * defines string, or an empty string when definesStr is empty.  The suffix
+	 * has the form "_{:08X}" where the hex value is a 32-bit FNV-1a hash of the string.
+	 *
+	 * This matches the suffix logic used by SIE::SShaderCache::GetDiskPath so
+	 * that any code building a cache path by hand stays in sync.
+	 */
+	std::string GetShaderDefinesSuffix(const std::string& definesStr);
 }  // namespace Util
\ No newline at end of file