diff --git a/packages/react/src/components/Tooltip/next/DefinitionTooltip.js b/packages/react/src/components/Tooltip/next/DefinitionTooltip.js
new file mode 100644
index 000000000000..49bea88f49ae
--- /dev/null
+++ b/packages/react/src/components/Tooltip/next/DefinitionTooltip.js
@@ -0,0 +1,70 @@
+/**
+ * Copyright IBM Corp. 2016, 2018
+ *
+ * This source code is licensed under the Apache-2.0 license found in the
+ * LICENSE file in the root directory of this source tree.
+ */
+
+import PropTypes from 'prop-types';
+import React, { useState } from 'react';
+import { Popover, PopoverContent } from '../../Popover';
+import { match, keys } from '../../../internal/keyboard';
+import { usePrefix } from '../../../internal/usePrefix';
+import { useId } from '../../../internal/useId';
+
+function DefinitionTooltip({ children, definition, ...rest }) {
+  const [isOpen, setOpen] = useState(false);
+  const prefix = usePrefix();
+  const id = useId();
+
+  function handleKeyDown(event) {
+    if (isOpen && match(event, keys.Escape)) {
+      event.stopPropagation();
+      setOpen(false);
+    }
+  }
+
+  return (
+    <Popover
+      align="bottom-left"
+      dropShadow={false}
+      highContrast
+      onMouseLeave={() => {
+        setOpen(false);
+      }}
+      open={isOpen}>
+      <button
+        className={`${prefix}--definition-term`}
+        {...rest}
+        aria-controls={id}
+        aria-expanded={isOpen}
+        onBlur={() => {
+          setOpen(false);
+        }}
+        onClick={() => {
+          setOpen(!isOpen);
+        }}
+        onKeyDown={handleKeyDown}
+        type="button">
+        {children}
+      </button>
+      <PopoverContent className={`${prefix}--definition-tooltip`} id={id}>
+        {definition}
+      </PopoverContent>
+    </Popover>
+  );
+}
+
+DefinitionTooltip.propTypes = {
+  /**
+   * Provide the content being defined
+   */
+  children: PropTypes.node,
+
+  /**
+   * Provide the content being defined
+   */
+  definition: PropTypes.string.isRequired,
+};
+
+export { DefinitionTooltip };
diff --git a/packages/react/src/components/Tooltip/next/Tooltip.stories.js b/packages/react/src/components/Tooltip/next/Tooltip.stories.js
index ff23db16a297..e0abfcda687d 100644
--- a/packages/react/src/components/Tooltip/next/Tooltip.stories.js
+++ b/packages/react/src/components/Tooltip/next/Tooltip.stories.js
@@ -10,6 +10,7 @@ import './story.scss';
 import { Checkbox16 } from '@carbon/icons-react';
 import React from 'react';
 import { Tooltip } from '../next';
+import { DefinitionTooltip } from './DefinitionTooltip.js';
 
 export default {
   title: 'Experimental/unstable_Tooltip',
@@ -68,6 +69,22 @@ export const Duration = () => {
   );
 };
 
+export const Definition = () => {
+  const definition =
+    'Uniform Resource Locator; the address of a resource (such as a document or website) on the Internet.';
+  return (
+    <div>
+      <p>
+        Custom domains direct requests for your apps in this Cloud Foundry
+        organization to a{' '}
+        <DefinitionTooltip definition={definition}>URL</DefinitionTooltip> that
+        you own. A custom domain can be a shared domain, a shared subdomain, or
+        a shared domain and host.
+      </p>
+    </div>
+  );
+};
+
 const PlaygroundStory = (props) => {
   const {
     align,
diff --git a/packages/react/src/components/Tooltip/next/__tests__/DefinitionTooltip-test.js b/packages/react/src/components/Tooltip/next/__tests__/DefinitionTooltip-test.js
new file mode 100644
index 000000000000..d2eeaa9c7a49
--- /dev/null
+++ b/packages/react/src/components/Tooltip/next/__tests__/DefinitionTooltip-test.js
@@ -0,0 +1,50 @@
+/**
+ * Copyright IBM Corp. 2016, 2018
+ *
+ * This source code is licensed under the Apache-2.0 license found in the
+ * LICENSE file in the root directory of this source tree.
+ */
+
+import { render, screen } from '@testing-library/react';
+import userEvent from '@testing-library/user-event';
+import React from 'react';
+import { DefinitionTooltip } from '../../next/DefinitionTooltip';
+
+describe('DefintiionTooltip', () => {
+  it('should support a custom className with the `className` prop', () => {
+    const definition = 'Uniform Resource Locator';
+    render(
+      <DefinitionTooltip definition={definition} className="tooltip-class">
+        URL
+      </DefinitionTooltip>
+    );
+    expect(screen.getByText('URL')).toHaveClass('tooltip-class');
+  });
+
+  it('should apply additional props to the outermost element', () => {
+    const definition = 'Uniform Resource Locator';
+    render(
+      <DefinitionTooltip
+        data-testid="test"
+        definition={definition}
+        className="tooltip-class">
+        URL
+      </DefinitionTooltip>
+    );
+    expect(screen.getByText('URL')).toHaveAttribute('data-testid', 'test');
+  });
+
+  it('should display onClick a defintion provided via prop', () => {
+    const definition = 'Uniform Resource Locator';
+    render(
+      <DefinitionTooltip
+        data-testid="test"
+        definition={definition}
+        className="tooltip-class">
+        URL
+      </DefinitionTooltip>
+    );
+    userEvent.click(screen.getByText('URL'));
+    expect(screen.getByText(definition)).toHaveTextContent(definition);
+  });
+});
diff --git a/packages/styles/scss/components/tooltip/_index.scss b/packages/styles/scss/components/tooltip/_index.scss
index a8d2eef640b9..3f06a3a645f8 100644
--- a/packages/styles/scss/components/tooltip/_index.scss
+++ b/packages/styles/scss/components/tooltip/_index.scss
@@ -10,3 +10,4 @@
 
 @include tooltip.tooltip;
 @include tooltip.icon-tooltip;
+@include tooltip.definition-tooltip;
diff --git a/packages/styles/scss/components/tooltip/_tooltip.scss b/packages/styles/scss/components/tooltip/_tooltip.scss
index 1b9154810811..2986026106cd 100644
--- a/packages/styles/scss/components/tooltip/_tooltip.scss
+++ b/packages/styles/scss/components/tooltip/_tooltip.scss
@@ -11,6 +11,8 @@
 @use '../../type';
 @use '../../utilities/custom-property';
 @use '../../utilities/convert';
+@use '../../utilities/button-reset';
+@use '../../utilities/focus-outline';
 
 $tooltip-padding-block: custom-property.get-var(
   'tooltip-padding-block',
@@ -37,6 +39,34 @@ $tooltip-padding-inline: custom-property.get-var(
   }
 }
 
+@mixin definition-tooltip {
+  .#{$prefix}--definition-term {
+    @include button-reset.reset;
+
+    border-bottom: 1px dotted theme.$border-strong;
+    border-radius: 0;
+
+    color: theme.$text-primary;
+  }
+
+  .#{$prefix}--definition-term:focus {
+    @include focus-outline.focus-outline;
+
+    border-bottom-color: theme.$border-interactive;
+  }
+
+  .#{$prefix}--definition-term:hover {
+    border-bottom-color: theme.$border-interactive;
+  }
+
+  .#{$prefix}--definition-tooltip {
+    @include type.type-style('body-long-01');
+
+    max-width: convert.rem(176px);
+    padding: convert.rem(8px) convert.rem(16px);
+  }
+}
+
 @mixin icon-tooltip {
   .#{$prefix}--icon-tooltip {
     @include custom-property.declaration(