diff --git a/packages/react/src/components/ComboBox/ComboBox.js b/packages/react/src/components/ComboBox/ComboBox.js
index 47e3076d78af..3d943772e4a6 100644
--- a/packages/react/src/components/ComboBox/ComboBox.js
+++ b/packages/react/src/components/ComboBox/ComboBox.js
@@ -267,7 +267,7 @@ const ComboBox = (props) => {
               event.stopPropagation();
             }
 
-            if (match(event, keys.Enter)) {
+            if (match(event, keys.Enter) && !inputValue) {
               toggleMenu();
             }
           },