diff --git a/clients/client-route-53/src/commands/AssociateVPCWithHostedZoneCommand.ts b/clients/client-route-53/src/commands/AssociateVPCWithHostedZoneCommand.ts
index efa596e4c477..3df9b38ca7d9 100644
--- a/clients/client-route-53/src/commands/AssociateVPCWithHostedZoneCommand.ts
+++ b/clients/client-route-53/src/commands/AssociateVPCWithHostedZoneCommand.ts
@@ -72,7 +72,7 @@ export interface AssociateVPCWithHostedZoneCommandOutput extends AssociateVPCWit
  * const input = { // AssociateVPCWithHostedZoneRequest
  *   HostedZoneId: "STRING_VALUE", // required
  *   VPC: { // VPC
- *     VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1",
+ *     VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5",
  *     VPCId: "STRING_VALUE",
  *   },
  *   Comment: "STRING_VALUE",
diff --git a/clients/client-route-53/src/commands/ChangeResourceRecordSetsCommand.ts b/clients/client-route-53/src/commands/ChangeResourceRecordSetsCommand.ts
index 64da9844f3e0..82fd333b6e57 100644
--- a/clients/client-route-53/src/commands/ChangeResourceRecordSetsCommand.ts
+++ b/clients/client-route-53/src/commands/ChangeResourceRecordSetsCommand.ts
@@ -137,7 +137,7 @@ export interface ChangeResourceRecordSetsCommandOutput extends ChangeResourceRec
  *           Type: "SOA" || "A" || "TXT" || "NS" || "CNAME" || "MX" || "NAPTR" || "PTR" || "SRV" || "SPF" || "AAAA" || "CAA" || "DS", // required
  *           SetIdentifier: "STRING_VALUE",
  *           Weight: Number("long"),
- *           Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-north-1" || "cn-northwest-1" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1",
+ *           Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-north-1" || "cn-northwest-1" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5",
  *           GeoLocation: { // GeoLocation
  *             ContinentCode: "STRING_VALUE",
  *             CountryCode: "STRING_VALUE",
diff --git a/clients/client-route-53/src/commands/CreateHealthCheckCommand.ts b/clients/client-route-53/src/commands/CreateHealthCheckCommand.ts
index df3e58c525ec..931c296bbbb2 100644
--- a/clients/client-route-53/src/commands/CreateHealthCheckCommand.ts
+++ b/clients/client-route-53/src/commands/CreateHealthCheckCommand.ts
@@ -92,7 +92,7 @@ export interface CreateHealthCheckCommandOutput extends CreateHealthCheckRespons
  *       "us-east-1" || "us-west-1" || "us-west-2" || "eu-west-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-northeast-1" || "sa-east-1",
  *     ],
  *     AlarmIdentifier: { // AlarmIdentifier
- *       Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-central-1" || "eu-central-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-northwest-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "ap-southeast-4" || "il-central-1" || "ca-west-1", // required
+ *       Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-central-1" || "eu-central-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-northwest-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5", // required
  *       Name: "STRING_VALUE", // required
  *     },
  *     InsufficientDataHealthStatus: "Healthy" || "Unhealthy" || "LastKnownStatus",
@@ -130,7 +130,7 @@ export interface CreateHealthCheckCommandOutput extends CreateHealthCheckRespons
  * //         "us-east-1" || "us-west-1" || "us-west-2" || "eu-west-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-northeast-1" || "sa-east-1",
  * //       ],
  * //       AlarmIdentifier: { // AlarmIdentifier
- * //         Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-central-1" || "eu-central-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-northwest-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "ap-southeast-4" || "il-central-1" || "ca-west-1", // required
+ * //         Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-central-1" || "eu-central-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-northwest-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5", // required
  * //         Name: "STRING_VALUE", // required
  * //       },
  * //       InsufficientDataHealthStatus: "Healthy" || "Unhealthy" || "LastKnownStatus",
diff --git a/clients/client-route-53/src/commands/CreateHostedZoneCommand.ts b/clients/client-route-53/src/commands/CreateHostedZoneCommand.ts
index d6a8b2cf97f7..1e8898cf62fa 100644
--- a/clients/client-route-53/src/commands/CreateHostedZoneCommand.ts
+++ b/clients/client-route-53/src/commands/CreateHostedZoneCommand.ts
@@ -101,7 +101,7 @@ export interface CreateHostedZoneCommandOutput extends CreateHostedZoneResponse,
  * const input = { // CreateHostedZoneRequest
  *   Name: "STRING_VALUE", // required
  *   VPC: { // VPC
- *     VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1",
+ *     VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5",
  *     VPCId: "STRING_VALUE",
  *   },
  *   CallerReference: "STRING_VALUE", // required
@@ -142,7 +142,7 @@ export interface CreateHostedZoneCommandOutput extends CreateHostedZoneResponse,
  * //     ],
  * //   },
  * //   VPC: { // VPC
- * //     VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1",
+ * //     VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5",
  * //     VPCId: "STRING_VALUE",
  * //   },
  * //   Location: "STRING_VALUE", // required
diff --git a/clients/client-route-53/src/commands/CreateVPCAssociationAuthorizationCommand.ts b/clients/client-route-53/src/commands/CreateVPCAssociationAuthorizationCommand.ts
index 93513f064ccd..f2d40db6e2bd 100644
--- a/clients/client-route-53/src/commands/CreateVPCAssociationAuthorizationCommand.ts
+++ b/clients/client-route-53/src/commands/CreateVPCAssociationAuthorizationCommand.ts
@@ -57,7 +57,7 @@ export interface CreateVPCAssociationAuthorizationCommandOutput
  * const input = { // CreateVPCAssociationAuthorizationRequest
  *   HostedZoneId: "STRING_VALUE", // required
  *   VPC: { // VPC
- *     VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1",
+ *     VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5",
  *     VPCId: "STRING_VALUE",
  *   },
  * };
@@ -66,7 +66,7 @@ export interface CreateVPCAssociationAuthorizationCommandOutput
  * // { // CreateVPCAssociationAuthorizationResponse
  * //   HostedZoneId: "STRING_VALUE", // required
  * //   VPC: { // VPC
- * //     VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1",
+ * //     VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5",
  * //     VPCId: "STRING_VALUE",
  * //   },
  * // };
diff --git a/clients/client-route-53/src/commands/DeleteVPCAssociationAuthorizationCommand.ts b/clients/client-route-53/src/commands/DeleteVPCAssociationAuthorizationCommand.ts
index 121b9d31e818..f8b550686ba7 100644
--- a/clients/client-route-53/src/commands/DeleteVPCAssociationAuthorizationCommand.ts
+++ b/clients/client-route-53/src/commands/DeleteVPCAssociationAuthorizationCommand.ts
@@ -58,7 +58,7 @@ export interface DeleteVPCAssociationAuthorizationCommandOutput
  * const input = { // DeleteVPCAssociationAuthorizationRequest
  *   HostedZoneId: "STRING_VALUE", // required
  *   VPC: { // VPC
- *     VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1",
+ *     VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5",
  *     VPCId: "STRING_VALUE",
  *   },
  * };
diff --git a/clients/client-route-53/src/commands/DisassociateVPCFromHostedZoneCommand.ts b/clients/client-route-53/src/commands/DisassociateVPCFromHostedZoneCommand.ts
index 11160b9df73f..0d3a43ce3dd4 100644
--- a/clients/client-route-53/src/commands/DisassociateVPCFromHostedZoneCommand.ts
+++ b/clients/client-route-53/src/commands/DisassociateVPCFromHostedZoneCommand.ts
@@ -92,7 +92,7 @@ export interface DisassociateVPCFromHostedZoneCommandOutput
  * const input = { // DisassociateVPCFromHostedZoneRequest
  *   HostedZoneId: "STRING_VALUE", // required
  *   VPC: { // VPC
- *     VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1",
+ *     VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5",
  *     VPCId: "STRING_VALUE",
  *   },
  *   Comment: "STRING_VALUE",
diff --git a/clients/client-route-53/src/commands/GetHealthCheckCommand.ts b/clients/client-route-53/src/commands/GetHealthCheckCommand.ts
index d74d6ed39446..23b0fbc4265a 100644
--- a/clients/client-route-53/src/commands/GetHealthCheckCommand.ts
+++ b/clients/client-route-53/src/commands/GetHealthCheckCommand.ts
@@ -69,7 +69,7 @@ export interface GetHealthCheckCommandOutput extends GetHealthCheckResponse, __M
  * //         "us-east-1" || "us-west-1" || "us-west-2" || "eu-west-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-northeast-1" || "sa-east-1",
  * //       ],
  * //       AlarmIdentifier: { // AlarmIdentifier
- * //         Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-central-1" || "eu-central-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-northwest-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "ap-southeast-4" || "il-central-1" || "ca-west-1", // required
+ * //         Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-central-1" || "eu-central-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-northwest-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5", // required
  * //         Name: "STRING_VALUE", // required
  * //       },
  * //       InsufficientDataHealthStatus: "Healthy" || "Unhealthy" || "LastKnownStatus",
diff --git a/clients/client-route-53/src/commands/GetHostedZoneCommand.ts b/clients/client-route-53/src/commands/GetHostedZoneCommand.ts
index a1f54b532450..92e1a8a448da 100644
--- a/clients/client-route-53/src/commands/GetHostedZoneCommand.ts
+++ b/clients/client-route-53/src/commands/GetHostedZoneCommand.ts
@@ -66,7 +66,7 @@ export interface GetHostedZoneCommandOutput extends GetHostedZoneResponse, __Met
  * //   },
  * //   VPCs: [ // VPCs
  * //     { // VPC
- * //       VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1",
+ * //       VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5",
  * //       VPCId: "STRING_VALUE",
  * //     },
  * //   ],
diff --git a/clients/client-route-53/src/commands/ListHealthChecksCommand.ts b/clients/client-route-53/src/commands/ListHealthChecksCommand.ts
index 50730cdea270..5b47924f763f 100644
--- a/clients/client-route-53/src/commands/ListHealthChecksCommand.ts
+++ b/clients/client-route-53/src/commands/ListHealthChecksCommand.ts
@@ -71,7 +71,7 @@ export interface ListHealthChecksCommandOutput extends ListHealthChecksResponse,
  * //           "us-east-1" || "us-west-1" || "us-west-2" || "eu-west-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-northeast-1" || "sa-east-1",
  * //         ],
  * //         AlarmIdentifier: { // AlarmIdentifier
- * //           Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-central-1" || "eu-central-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-northwest-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "ap-southeast-4" || "il-central-1" || "ca-west-1", // required
+ * //           Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-central-1" || "eu-central-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-northwest-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5", // required
  * //           Name: "STRING_VALUE", // required
  * //         },
  * //         InsufficientDataHealthStatus: "Healthy" || "Unhealthy" || "LastKnownStatus",
diff --git a/clients/client-route-53/src/commands/ListHostedZonesByVPCCommand.ts b/clients/client-route-53/src/commands/ListHostedZonesByVPCCommand.ts
index 7e1ead5eb4bc..a1455b838575 100644
--- a/clients/client-route-53/src/commands/ListHostedZonesByVPCCommand.ts
+++ b/clients/client-route-53/src/commands/ListHostedZonesByVPCCommand.ts
@@ -76,7 +76,7 @@ export interface ListHostedZonesByVPCCommandOutput extends ListHostedZonesByVPCR
  * const client = new Route53Client(config);
  * const input = { // ListHostedZonesByVPCRequest
  *   VPCId: "STRING_VALUE", // required
- *   VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1", // required
+ *   VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5", // required
  *   MaxItems: Number("int"),
  *   NextToken: "STRING_VALUE",
  * };
diff --git a/clients/client-route-53/src/commands/ListResourceRecordSetsCommand.ts b/clients/client-route-53/src/commands/ListResourceRecordSetsCommand.ts
index dca45ae79772..8a3ac1f8fc09 100644
--- a/clients/client-route-53/src/commands/ListResourceRecordSetsCommand.ts
+++ b/clients/client-route-53/src/commands/ListResourceRecordSetsCommand.ts
@@ -122,7 +122,7 @@ export interface ListResourceRecordSetsCommandOutput extends ListResourceRecordS
  * //       Type: "SOA" || "A" || "TXT" || "NS" || "CNAME" || "MX" || "NAPTR" || "PTR" || "SRV" || "SPF" || "AAAA" || "CAA" || "DS", // required
  * //       SetIdentifier: "STRING_VALUE",
  * //       Weight: Number("long"),
- * //       Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-north-1" || "cn-northwest-1" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1",
+ * //       Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-north-1" || "cn-northwest-1" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5",
  * //       GeoLocation: { // GeoLocation
  * //         ContinentCode: "STRING_VALUE",
  * //         CountryCode: "STRING_VALUE",
diff --git a/clients/client-route-53/src/commands/ListVPCAssociationAuthorizationsCommand.ts b/clients/client-route-53/src/commands/ListVPCAssociationAuthorizationsCommand.ts
index ebaba095b19f..01202cf3414b 100644
--- a/clients/client-route-53/src/commands/ListVPCAssociationAuthorizationsCommand.ts
+++ b/clients/client-route-53/src/commands/ListVPCAssociationAuthorizationsCommand.ts
@@ -57,7 +57,7 @@ export interface ListVPCAssociationAuthorizationsCommandOutput
  * //   NextToken: "STRING_VALUE",
  * //   VPCs: [ // VPCs // required
  * //     { // VPC
- * //       VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1",
+ * //       VPCRegion: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "eu-central-1" || "eu-central-2" || "ap-east-1" || "me-south-1" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "me-central-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-south-1" || "ap-south-2" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "ca-central-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5",
  * //       VPCId: "STRING_VALUE",
  * //     },
  * //   ],
diff --git a/clients/client-route-53/src/commands/UpdateHealthCheckCommand.ts b/clients/client-route-53/src/commands/UpdateHealthCheckCommand.ts
index de388029980a..ef0c8e9e73b1 100644
--- a/clients/client-route-53/src/commands/UpdateHealthCheckCommand.ts
+++ b/clients/client-route-53/src/commands/UpdateHealthCheckCommand.ts
@@ -58,7 +58,7 @@ export interface UpdateHealthCheckCommandOutput extends UpdateHealthCheckRespons
  *     "us-east-1" || "us-west-1" || "us-west-2" || "eu-west-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-northeast-1" || "sa-east-1",
  *   ],
  *   AlarmIdentifier: { // AlarmIdentifier
- *     Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-central-1" || "eu-central-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-northwest-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "ap-southeast-4" || "il-central-1" || "ca-west-1", // required
+ *     Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-central-1" || "eu-central-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-northwest-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5", // required
  *     Name: "STRING_VALUE", // required
  *   },
  *   InsufficientDataHealthStatus: "Healthy" || "Unhealthy" || "LastKnownStatus",
@@ -97,7 +97,7 @@ export interface UpdateHealthCheckCommandOutput extends UpdateHealthCheckRespons
  * //         "us-east-1" || "us-west-1" || "us-west-2" || "eu-west-1" || "ap-southeast-1" || "ap-southeast-2" || "ap-northeast-1" || "sa-east-1",
  * //       ],
  * //       AlarmIdentifier: { // AlarmIdentifier
- * //         Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-central-1" || "eu-central-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-northwest-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "ap-southeast-4" || "il-central-1" || "ca-west-1", // required
+ * //         Region: "us-east-1" || "us-east-2" || "us-west-1" || "us-west-2" || "ca-central-1" || "eu-central-1" || "eu-central-2" || "eu-west-1" || "eu-west-2" || "eu-west-3" || "ap-east-1" || "me-south-1" || "me-central-1" || "ap-south-1" || "ap-south-2" || "ap-southeast-1" || "ap-southeast-2" || "ap-southeast-3" || "ap-northeast-1" || "ap-northeast-2" || "ap-northeast-3" || "eu-north-1" || "sa-east-1" || "cn-northwest-1" || "cn-north-1" || "af-south-1" || "eu-south-1" || "eu-south-2" || "us-gov-west-1" || "us-gov-east-1" || "us-iso-east-1" || "us-iso-west-1" || "us-isob-east-1" || "ap-southeast-4" || "il-central-1" || "ca-west-1" || "ap-southeast-5", // required
  * //         Name: "STRING_VALUE", // required
  * //       },
  * //       InsufficientDataHealthStatus: "Healthy" || "Unhealthy" || "LastKnownStatus",
diff --git a/clients/client-route-53/src/models/models_0.ts b/clients/client-route-53/src/models/models_0.ts
index 7f29b2a30a76..92676192d0ba 100644
--- a/clients/client-route-53/src/models/models_0.ts
+++ b/clients/client-route-53/src/models/models_0.ts
@@ -289,6 +289,7 @@ export const CloudWatchRegion = {
   ap_southeast_2: "ap-southeast-2",
   ap_southeast_3: "ap-southeast-3",
   ap_southeast_4: "ap-southeast-4",
+  ap_southeast_5: "ap-southeast-5",
   ca_central_1: "ca-central-1",
   ca_west_1: "ca-west-1",
   cn_north_1: "cn-north-1",
@@ -807,6 +808,7 @@ export const VPCRegion = {
   ap_southeast_2: "ap-southeast-2",
   ap_southeast_3: "ap-southeast-3",
   ap_southeast_4: "ap-southeast-4",
+  ap_southeast_5: "ap-southeast-5",
   ca_central_1: "ca-central-1",
   ca_west_1: "ca-west-1",
   cn_north_1: "cn-north-1",
@@ -1444,6 +1446,7 @@ export const ResourceRecordSetRegion = {
   ap_southeast_2: "ap-southeast-2",
   ap_southeast_3: "ap-southeast-3",
   ap_southeast_4: "ap-southeast-4",
+  ap_southeast_5: "ap-southeast-5",
   ca_central_1: "ca-central-1",
   ca_west_1: "ca-west-1",
   cn_north_1: "cn-north-1",