diff --git a/crates/uv/src/commands/project/mod.rs b/crates/uv/src/commands/project/mod.rs
index d3766df97a44b..ffb6c1ef08e86 100644
--- a/crates/uv/src/commands/project/mod.rs
+++ b/crates/uv/src/commands/project/mod.rs
@@ -1148,6 +1148,8 @@ pub(crate) fn centralized_environment_root(
     upgradeable: bool,
     cache: &Cache,
 ) -> PathBuf {
+    let workspace_path = fs_err::canonicalize(workspace.install_path())
+        .unwrap_or_else(|_| workspace.install_path().clone());
     let interpreter_key = interpreter.key();
     // Use the workspace path to isolate projects and the interpreter key to maximize intra-project
     // environment re-use while avoiding clashes with incompatible environments. Ignoring the patch
@@ -1158,12 +1160,12 @@ pub(crate) fn centralized_environment_root(
             .is_some_and(|link| link.exists())
     {
         (
-            cache_digest(&(workspace.install_path(), installation.minor_version_key())),
+            cache_digest(&(&workspace_path, installation.minor_version_key())),
             interpreter.python_minor_version(),
         )
     } else {
         (
-            cache_digest(&(workspace.install_path(), &interpreter_key)),
+            cache_digest(&(&workspace_path, &interpreter_key)),
             interpreter.python_version().clone(),
         )
     };
@@ -1173,8 +1175,7 @@ pub(crate) fn centralized_environment_root(
         .as_ref()
         .and_then(|project| cache_name(project.name.as_ref(), Some(100)))
         .or_else(|| {
-            workspace
-                .install_path()
+            workspace_path
                 .file_name()
                 .and_then(|name| name.to_str())
                 .and_then(|name| cache_name(name, Some(100)))
diff --git a/crates/uv/tests/sync/centralized_project_envs.rs b/crates/uv/tests/sync/centralized_project_envs.rs
index c2040f56e8053..94045f2c53cd6 100644
--- a/crates/uv/tests/sync/centralized_project_envs.rs
+++ b/crates/uv/tests/sync/centralized_project_envs.rs
@@ -270,6 +270,50 @@ fn sync_centralized_env_avoids_project_name_collisions() -> Result<()> {
     Ok(())
 }
 
+#[test]
+#[cfg(unix)]
+fn sync_centralized_env_reuses_symlinked_workspace() -> Result<()> {
+    let context = uv_test::test_context_with_versions!(&["3.12"]);
+    let project = context.temp_dir.child("project");
+    project.create_dir_all()?;
+    project.child("pyproject.toml").write_str(
+        r#"
+        [project]
+        name = "project"
+        version = "0.1.0"
+        requires-python = ">=3.12"
+        dependencies = []
+        "#,
+    )?;
+
+    let symlink = context.temp_dir.child("project-link");
+    uv_fs::create_symlink(project.path(), symlink.path())?;
+
+    context
+        .sync()
+        .arg("--preview-features")
+        .arg("centralized-project-envs")
+        .arg("--project")
+        .arg(project.path())
+        .assert()
+        .success();
+    let first = fs_err::read_link(project.child(".venv").path())?;
+
+    fs_err::remove_file(project.child(".venv").path())?;
+    context
+        .sync()
+        .arg("--preview-features")
+        .arg("centralized-project-envs")
+        .arg("--project")
+        .arg(symlink.path())
+        .assert()
+        .success();
+    let second = fs_err::read_link(project.child(".venv").path())?;
+
+    assert_eq!(first, second);
+    Ok(())
+}
+
 #[test]
 fn sync_centralized_env_respects_explicit_environments() -> Result<()> {
     let context = uv_test::test_context_with_versions!(&["3.12"]);