diff --git a/crates/uv/src/commands/project/mod.rs b/crates/uv/src/commands/project/mod.rs
index 1244bf44f0f..e1869388ebb 100644
--- a/crates/uv/src/commands/project/mod.rs
+++ b/crates/uv/src/commands/project/mod.rs
@@ -717,7 +717,7 @@ impl ScriptInterpreter {
                         .path
                         .file_stem()
                         .and_then(|name| name.to_str())
-                        .and_then(|name| cache_name(name, None))
+                        .and_then(|name| cache_name(name, Some(100)))
                     {
                         format!("{file_name}-{digest}")
                     } else {
diff --git a/crates/uv/tests/it/run.rs b/crates/uv/tests/it/run.rs
index 0a944fc8a15..a642bb47cd2 100644
--- a/crates/uv/tests/it/run.rs
+++ b/crates/uv/tests/it/run.rs
@@ -510,6 +510,44 @@ fn run_pep723_script() -> Result<()> {
     Ok(())
 }
 
+/// A PEP 723 script with a long file name should still succeed at creating a script environment on
+/// Windows.
+#[test]
+fn run_pep723_script_long_filename() -> Result<()> {
+    let context = uv_test::test_context!("3.12");
+
+    // The cache environment entry path, which is derived from the script's name, would exceed many
+    // common path component length limits if it was not truncated first.
+    let script_name = format!("{}.py", "a".repeat(240));
+    let test_script = context.temp_dir.child(&script_name);
+    test_script.write_str(indoc! { r#"
+        # /// script
+        # requires-python = ">=3.11"
+        # dependencies = [
+        #   "iniconfig",
+        # ]
+        # ///
+
+        print("Hello, world!")
+       "#
+    })?;
+
+    uv_snapshot!(context.filters(), context.run().arg(&script_name), @"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+    Hello, world!
+
+    ----- stderr -----
+    Resolved 1 package in [TIME]
+    Prepared 1 package in [TIME]
+    Installed 1 package in [TIME]
+     + iniconfig==2.0.0
+    ");
+
+    Ok(())
+}
+
 #[test]
 fn run_pep723_script_requires_python() -> Result<()> {
     let context = uv_test::test_context_with_versions!(&["3.11", "3.12"]);