diff --git a/crates/uv-install-wheel/src/wheel.rs b/crates/uv-install-wheel/src/wheel.rs
index afe8ba05d5b..68a19ff641e 100644
--- a/crates/uv-install-wheel/src/wheel.rs
+++ b/crates/uv-install-wheel/src/wheel.rs
@@ -161,6 +161,8 @@ fn get_script_executable(python_executable: &Path, is_gui: bool) -> PathBuf {
 }
 
 const RESERVED_SCRIPT_NAMES_ERROR: &[&str; 3] = &["python", "pythonw", "python3"];
+const RESERVED_VERSIONED_SCRIPT_NAME_PREFIX_ERROR: &str = "python3.";
+const RESERVED_FREE_THREADED_SCRIPT_NAME_PREFIXES_ERROR: &[&str; 2] = &["python3.", "pythonw3."];
 const RESERVED_SCRIPT_NAMES_WARN: &[&str; 2] = &["activate", "activate_this.py"];
 
 /// A form of [`Script`] guaranteed by [`ValidatedScript::try_from_script`] to be constrained to
@@ -193,25 +195,32 @@ impl<'script> ValidatedScript<'script> {
             );
         }
 
-        if RESERVED_SCRIPT_NAMES_ERROR.contains(&name.as_str())
-            || name
-                .strip_prefix("python3.")
-                .is_some_and(|suffix| suffix.parse::<u8>().is_ok())
+        // Reserve CPython launcher basenames emitted by `uv venv` across supported platforms.
+        // Apply the Windows launcher normalization before checking so wheel validity is portable.
+        // FIXME: What are the in-reality rules here for name normalization?
+        let normalized_name = name.strip_suffix(".py").unwrap_or(name.as_str());
+        if RESERVED_SCRIPT_NAMES_ERROR.contains(&normalized_name)
+            || normalized_name
+                .strip_prefix(RESERVED_VERSIONED_SCRIPT_NAME_PREFIX_ERROR)
+                .is_some_and(|minor| minor.parse::<u8>().is_ok())
+            || RESERVED_FREE_THREADED_SCRIPT_NAME_PREFIXES_ERROR
+                .iter()
+                .any(|prefix| {
+                    normalized_name
+                        .strip_prefix(prefix)
+                        .and_then(|minor| minor.strip_suffix('t'))
+                        .is_some_and(|minor| minor.parse::<u8>().is_ok())
+                })
         {
             return Err(Error::ReservedScriptName {
-                reserved: name,
+                reserved: normalized_name.to_string(),
                 declared: script.name.clone(),
             });
         }
 
         let path = if cfg!(windows) {
             // On Windows we actually build an `.exe` wrapper.
-            let name = name
-                // FIXME: What are the in-reality rules here for names?
-                .strip_suffix(".py")
-                .unwrap_or(&name)
-                .to_string()
-                + std::env::consts::EXE_SUFFIX;
+            let name = normalized_name.to_string() + std::env::consts::EXE_SUFFIX;
 
             layout.scheme.scripts.join(name)
         } else {
diff --git a/crates/uv/tests/it/pip_install.rs b/crates/uv/tests/it/pip_install.rs
index c381c74cc23..fc4127442e5 100644
--- a/crates/uv/tests/it/pip_install.rs
+++ b/crates/uv/tests/it/pip_install.rs
@@ -13419,6 +13419,93 @@ fn reject_normalized_reserved_gui_wheel_entrypoint_name() -> Result<()> {
     Ok(())
 }
 
+#[test]
+fn reject_free_threaded_python_wheel_entrypoint_name() -> Result<()> {
+    let context = uv_test::test_context!("3.12");
+    let repacked_wheel =
+        repacked_wheel_with_entrypoint(&context, "console_scripts", "python3.13t")?;
+
+    uv_snapshot!(context.filters(), context.pip_install().arg(&repacked_wheel), @"
+    success: false
+    exit_code: 2
+    ----- stdout -----
+
+    ----- stderr -----
+    Resolved 1 package in [TIME]
+    Prepared 1 package in [TIME]
+    error: Failed to install: foo-0.1.0-py3-none-any.whl (foo==0.1.0 (from file://[TEMP_DIR]/foo-0.1.0-py3-none-any.whl))
+      Caused by: Scripts must not use the reserved name `python3.13t`, got: `python3.13t`
+    "
+    );
+
+    Ok(())
+}
+
+#[test]
+fn reject_windowed_free_threaded_python_wheel_entrypoint_name() -> Result<()> {
+    let context = uv_test::test_context!("3.12");
+    let repacked_wheel =
+        repacked_wheel_with_entrypoint(&context, "console_scripts", "pythonw3.13t")?;
+
+    uv_snapshot!(context.filters(), context.pip_install().arg(&repacked_wheel), @"
+    success: false
+    exit_code: 2
+    ----- stdout -----
+
+    ----- stderr -----
+    Resolved 1 package in [TIME]
+    Prepared 1 package in [TIME]
+    error: Failed to install: foo-0.1.0-py3-none-any.whl (foo==0.1.0 (from file://[TEMP_DIR]/foo-0.1.0-py3-none-any.whl))
+      Caused by: Scripts must not use the reserved name `pythonw3.13t`, got: `pythonw3.13t`
+    "
+    );
+
+    Ok(())
+}
+
+#[test]
+fn reject_windows_rewritten_python_wheel_entrypoint_name() -> Result<()> {
+    let context = uv_test::test_context!("3.12");
+    let repacked_wheel = repacked_wheel_with_entrypoint(&context, "console_scripts", "python.py")?;
+
+    uv_snapshot!(context.filters(), context.pip_install().arg(&repacked_wheel), @"
+    success: false
+    exit_code: 2
+    ----- stdout -----
+
+    ----- stderr -----
+    Resolved 1 package in [TIME]
+    Prepared 1 package in [TIME]
+    error: Failed to install: foo-0.1.0-py3-none-any.whl (foo==0.1.0 (from file://[TEMP_DIR]/foo-0.1.0-py3-none-any.whl))
+      Caused by: Scripts must not use the reserved name `python`, got: `python.py`
+    "
+    );
+
+    Ok(())
+}
+
+#[test]
+fn reject_windows_rewritten_free_threaded_python_wheel_entrypoint_name() -> Result<()> {
+    let context = uv_test::test_context!("3.12");
+    let repacked_wheel =
+        repacked_wheel_with_entrypoint(&context, "console_scripts", "pythonw3.13t.py")?;
+
+    uv_snapshot!(context.filters(), context.pip_install().arg(&repacked_wheel), @"
+    success: false
+    exit_code: 2
+    ----- stdout -----
+
+    ----- stderr -----
+    Resolved 1 package in [TIME]
+    Prepared 1 package in [TIME]
+    error: Failed to install: foo-0.1.0-py3-none-any.whl (foo==0.1.0 (from file://[TEMP_DIR]/foo-0.1.0-py3-none-any.whl))
+      Caused by: Scripts must not use the reserved name `pythonw3.13t`, got: `pythonw3.13t.py`
+    "
+    );
+
+    Ok(())
+}
+
 #[test]
 fn warn_normalized_activation_wheel_entrypoint_name() -> Result<()> {
     let context = uv_test::test_context!("3.12");