diff --git a/crates/uv-cli/src/lib.rs b/crates/uv-cli/src/lib.rs
index 6befc34b95950..fa601a813c84c 100644
--- a/crates/uv-cli/src/lib.rs
+++ b/crates/uv-cli/src/lib.rs
@@ -1432,7 +1432,7 @@ pub struct PipCompileArgs {
     /// Include optional dependencies from the specified extra name; may be provided more than once.
     ///
     /// Only applies to `pyproject.toml`, `setup.py`, and `setup.cfg` sources.
-    #[arg(long, conflicts_with = "all_extras", value_parser = extra_name_with_clap_error)]
+    #[arg(long, value_delimiter = ',', conflicts_with = "all_extras", value_parser = extra_name_with_clap_error)]
     pub extra: Option<Vec<ExtraName>>,
 
     /// Include all optional dependencies.
@@ -1789,7 +1789,7 @@ pub struct PipSyncArgs {
     /// Include optional dependencies from the specified extra name; may be provided more than once.
     ///
     /// Only applies to `pylock.toml`, `pyproject.toml`, `setup.py`, and `setup.cfg` sources.
-    #[arg(long, conflicts_with = "all_extras", value_parser = extra_name_with_clap_error)]
+    #[arg(long, value_delimiter = ',', conflicts_with = "all_extras", value_parser = extra_name_with_clap_error)]
     pub extra: Option<Vec<ExtraName>>,
 
     /// Include all optional dependencies.
@@ -2158,7 +2158,7 @@ pub struct PipInstallArgs {
     /// Include optional dependencies from the specified extra name; may be provided more than once.
     ///
     /// Only applies to `pylock.toml`, `pyproject.toml`, `setup.py`, and `setup.cfg` sources.
-    #[arg(long, conflicts_with = "all_extras", value_parser = extra_name_with_clap_error)]
+    #[arg(long, value_delimiter = ',', conflicts_with = "all_extras", value_parser = extra_name_with_clap_error)]
     pub extra: Option<Vec<ExtraName>>,
 
     /// Include all optional dependencies.
@@ -3459,6 +3459,7 @@ pub struct RunArgs {
         long,
         conflicts_with = "all_extras",
         conflicts_with = "only_group",
+        value_delimiter = ',',
         value_parser = extra_name_with_clap_error,
         value_hint = ValueHint::Other,
     )]
@@ -3786,6 +3787,7 @@ pub struct SyncArgs {
         long,
         conflicts_with = "all_extras",
         conflicts_with = "only_group",
+        value_delimiter = ',',
         value_parser = extra_name_with_clap_error,
         value_hint = ValueHint::Other,
     )]
@@ -4793,7 +4795,7 @@ pub struct ExportArgs {
     /// Include optional dependencies from the specified extra name.
     ///
     /// May be provided more than once.
-    #[arg(long, conflicts_with = "all_extras", conflicts_with = "only_group", value_parser = extra_name_with_clap_error)]
+    #[arg(long, value_delimiter = ',', conflicts_with = "all_extras", conflicts_with = "only_group", value_parser = extra_name_with_clap_error)]
     pub extra: Option<Vec<ExtraName>>,
 
     /// Include all optional dependencies.
diff --git a/crates/uv/tests/it/sync.rs b/crates/uv/tests/it/sync.rs
index cdcdeb3628acf..25638b81217b6 100644
--- a/crates/uv/tests/it/sync.rs
+++ b/crates/uv/tests/it/sync.rs
@@ -9296,6 +9296,45 @@ fn sync_all_extras() -> Result<()> {
     Ok(())
 }
 
+#[test]
+fn sync_extra_comma_separated() -> Result<()> {
+    let context = TestContext::new("3.12");
+
+    let pyproject_toml = context.temp_dir.child("pyproject.toml");
+    pyproject_toml.write_str(
+        r#"
+        [project]
+        name = "project"
+        version = "0.1.0"
+        requires-python = ">=3.12"
+        dependencies = []
+
+        [project.optional-dependencies]
+        types = ["typing-extensions>=4"]
+        async = ["anyio>3"]
+        "#,
+    )?;
+
+    context.lock().assert().success();
+
+    uv_snapshot!(context.filters(), context.sync().arg("--extra").arg("types,async"), @r#"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+
+    ----- stderr -----
+    Resolved 5 packages in [TIME]
+    Prepared 4 packages in [TIME]
+    Installed 4 packages in [TIME]
+     + anyio==4.3.0
+     + idna==3.6
+     + sniffio==1.3.1
+     + typing-extensions==4.10.0
+    "#);
+
+    Ok(())
+}
+
 /// Sync all members in a workspace with dynamic extras.
 #[test]
 fn sync_all_extras_dynamic() -> Result<()> {