diff --git a/crates/uv/src/commands/project/init.rs b/crates/uv/src/commands/project/init.rs
index 794bafc759fa5..654d95519873d 100644
--- a/crates/uv/src/commands/project/init.rs
+++ b/crates/uv/src/commands/project/init.rs
@@ -989,6 +989,9 @@ fn pyproject_build_system(package: &PackageName, build_backend: ProjectBuildBack
                 python-packages = ["{module_name}"]
                 python-source = "src"
 
+                [tool.uv]
+                cache-keys = [{{ file = "pyproject.toml" }}, {{ file = "src/**/*.rs" }}, {{ file = "Cargo.toml" }}, {{ file = "Cargo.lock" }}]
+
                 [build-system]
                 requires = ["maturin>=1.0,<2.0"]
                 build-backend = "maturin"
@@ -998,6 +1001,9 @@ fn pyproject_build_system(package: &PackageName, build_backend: ProjectBuildBack
                 minimum-version = "build-system.requires"
                 build-dir = "build/{wheel_tag}"
 
+                [tool.uv]
+                cache-keys = [{ file = "pyproject.toml" }, { file = "src/**/*.{h,c,hpp,cpp}" }, { file = "CMakeLists.txt" }]
+
                 [build-system]
                 requires = ["scikit-build-core>=0.10", "pybind11"]
                 build-backend = "scikit_build_core.build"
diff --git a/crates/uv/tests/it/init.rs b/crates/uv/tests/it/init.rs
index 3f374eada3ee6..c106978c14b6d 100644
--- a/crates/uv/tests/it/init.rs
+++ b/crates/uv/tests/it/init.rs
@@ -3279,6 +3279,9 @@ fn init_app_build_backend_maturin() -> Result<()> {
         python-packages = ["foo"]
         python-source = "src"
 
+        [tool.uv]
+        cache-keys = [{ file = "pyproject.toml" }, { file = "src/**/*.rs" }, { file = "Cargo.toml" }, { file = "Cargo.lock" }]
+
         [build-system]
         requires = ["maturin>=1.0,<2.0"]
         build-backend = "maturin"
@@ -3408,6 +3411,9 @@ fn init_app_build_backend_scikit() -> Result<()> {
         minimum-version = "build-system.requires"
         build-dir = "build/{wheel_tag}"
 
+        [tool.uv]
+        cache-keys = [{ file = "pyproject.toml" }, { file = "src/**/*.{h,c,hpp,cpp}" }, { file = "CMakeLists.txt" }]
+
         [build-system]
         requires = ["scikit-build-core>=0.10", "pybind11"]
         build-backend = "scikit_build_core.build"
@@ -3530,6 +3536,9 @@ fn init_lib_build_backend_maturin() -> Result<()> {
         python-packages = ["foo"]
         python-source = "src"
 
+        [tool.uv]
+        cache-keys = [{ file = "pyproject.toml" }, { file = "src/**/*.rs" }, { file = "Cargo.toml" }, { file = "Cargo.lock" }]
+
         [build-system]
         requires = ["maturin>=1.0,<2.0"]
         build-backend = "maturin"
@@ -3656,6 +3665,9 @@ fn init_lib_build_backend_scikit() -> Result<()> {
         minimum-version = "build-system.requires"
         build-dir = "build/{wheel_tag}"
 
+        [tool.uv]
+        cache-keys = [{ file = "pyproject.toml" }, { file = "src/**/*.{h,c,hpp,cpp}" }, { file = "CMakeLists.txt" }]
+
         [build-system]
         requires = ["scikit-build-core>=0.10", "pybind11"]
         build-backend = "scikit_build_core.build"