diff --git a/crates/ruff_linter/resources/test/fixtures/refurb/FURB180.py b/crates/ruff_linter/resources/test/fixtures/refurb/FURB180.py
index 33576061fc23a7..84e309c1d554fc 100644
--- a/crates/ruff_linter/resources/test/fixtures/refurb/FURB180.py
+++ b/crates/ruff_linter/resources/test/fixtures/refurb/FURB180.py
@@ -56,3 +56,11 @@ def foo(self): pass
 class A7(B0, abc.ABC, B1):
     @abstractmethod
     def foo(self): pass
+
+# Issue 22631 reproduction
+class C(
+    other_kwarg=1,
+    # comment
+    metaclass=abc.ABCMeta,
+):
+    pass
\ No newline at end of file
diff --git a/crates/ruff_linter/src/rules/refurb/rules/metaclass_abcmeta.rs b/crates/ruff_linter/src/rules/refurb/rules/metaclass_abcmeta.rs
index 7e5a432968334e..17152b0b66599e 100644
--- a/crates/ruff_linter/src/rules/refurb/rules/metaclass_abcmeta.rs
+++ b/crates/ruff_linter/src/rules/refurb/rules/metaclass_abcmeta.rs
@@ -39,9 +39,11 @@ use crate::{AlwaysFixableViolation, Edit, Fix};
 /// ```
 ///
 /// ## Fix safety
-/// The rule's fix is unsafe if the class has base classes. This is because the base classes might
-/// be validating the class's other base classes (e.g., `typing.Protocol` does this) or otherwise
-/// alter runtime behavior if more base classes are added.
+/// The rule's fix is unsafe if the class has base classes, or if the fix would result in the
+/// deletion of comments.
+///
+/// If the class has base classes, inheriting from `abc.ABC` might alter the runtime behavior if
+/// those base classes validate the class's other base classes (e.g., `typing.Protocol`).
 ///
 /// ## References
 /// - [Python documentation: `abc.ABC`](https://docs.python.org/3/library/abc.html#abc.ABC)
@@ -82,11 +84,25 @@ pub(crate) fn metaclass_abcmeta(checker: &Checker, class_def: &StmtClassDef) {
         return;
     }
 
-    let applicability = if class_def.bases().is_empty() {
+    let mut applicability = if class_def.bases().is_empty() {
         Applicability::Safe
     } else {
         Applicability::Unsafe
     };
+
+    // If the fix involves a range deletion or replacement that contains a comment, the fix is
+    // unsafe.
+    if applicability == Applicability::Safe {
+        let range = if position > 0 {
+            TextRange::new(class_def.keywords()[position - 1].end(), keyword.end())
+        } else {
+            keyword.range()
+        };
+        if checker.comment_ranges().intersects(range) {
+            applicability = Applicability::Unsafe;
+        }
+    }
+
     let mut diagnostic = checker.report_diagnostic(MetaClassABCMeta, keyword.range);
 
     diagnostic.try_set_fix(|| {
diff --git a/crates/ruff_linter/src/rules/refurb/snapshots/ruff_linter__rules__refurb__tests__FURB180_FURB180.py.snap b/crates/ruff_linter/src/rules/refurb/snapshots/ruff_linter__rules__refurb__tests__FURB180_FURB180.py.snap
index be994f1cc5d438..444068ac397f0c 100644
--- a/crates/ruff_linter/src/rules/refurb/snapshots/ruff_linter__rules__refurb__tests__FURB180_FURB180.py.snap
+++ b/crates/ruff_linter/src/rules/refurb/snapshots/ruff_linter__rules__refurb__tests__FURB180_FURB180.py.snap
@@ -75,3 +75,25 @@ help: Replace with `abc.ABC`
 33 | 
 34 | 
 note: This is an unsafe fix and may change runtime behavior
+
+FURB180 [*] Use of `metaclass=abc.ABCMeta` to define abstract base class
+  --> FURB180.py:64:5
+   |
+62 |     other_kwarg=1,
+63 |     # comment
+64 |     metaclass=abc.ABCMeta,
+   |     ^^^^^^^^^^^^^^^^^^^^^
+65 | ):
+66 |     pass
+   |
+help: Replace with `abc.ABC`
+59 | 
+60 | # Issue 22631 reproduction
+61 | class C(
+   -     other_kwarg=1,
+   -     # comment
+   -     metaclass=abc.ABCMeta,
+62 +     abc.ABC, other_kwarg=1,
+63 | ):
+64 |     pass
+note: This is an unsafe fix and may change runtime behavior