diff --git a/crates/ruff_linter/resources/test/fixtures/refurb/FURB180.py b/crates/ruff_linter/resources/test/fixtures/refurb/FURB180.py
index 33576061fc23a7..5a4902ebc724a6 100644
--- a/crates/ruff_linter/resources/test/fixtures/refurb/FURB180.py
+++ b/crates/ruff_linter/resources/test/fixtures/refurb/FURB180.py
@@ -32,6 +32,15 @@ class A3(B0, before_metaclass=1, metaclass=abc.ABCMeta):
     pass
 
 
+# Fix should be unsafe when a comment would be deleted
+class A4_comment(
+    other_kwarg=1,
+    # comment
+    metaclass=abc.ABCMeta,
+):
+    pass
+
+
 # OK
 
 class Meta(type):
diff --git a/crates/ruff_linter/src/rules/refurb/rules/metaclass_abcmeta.rs b/crates/ruff_linter/src/rules/refurb/rules/metaclass_abcmeta.rs
index 7e5a432968334e..a01bb3f302763d 100644
--- a/crates/ruff_linter/src/rules/refurb/rules/metaclass_abcmeta.rs
+++ b/crates/ruff_linter/src/rules/refurb/rules/metaclass_abcmeta.rs
@@ -43,6 +43,8 @@ use crate::{AlwaysFixableViolation, Edit, Fix};
 /// be validating the class's other base classes (e.g., `typing.Protocol` does this) or otherwise
 /// alter runtime behavior if more base classes are added.
 ///
+/// The fix is also marked unsafe if it would delete comments.
+///
 /// ## References
 /// - [Python documentation: `abc.ABC`](https://docs.python.org/3/library/abc.html#abc.ABC)
 /// - [Python documentation: `abc.ABCMeta`](https://docs.python.org/3/library/abc.html#abc.ABCMeta)
@@ -82,11 +84,6 @@ pub(crate) fn metaclass_abcmeta(checker: &Checker, class_def: &StmtClassDef) {
         return;
     }
 
-    let applicability = if class_def.bases().is_empty() {
-        Applicability::Safe
-    } else {
-        Applicability::Unsafe
-    };
     let mut diagnostic = checker.report_diagnostic(MetaClassABCMeta, keyword.range);
 
     diagnostic.try_set_fix(|| {
@@ -98,12 +95,20 @@ pub(crate) fn metaclass_abcmeta(checker: &Checker, class_def: &StmtClassDef) {
         Ok(if position > 0 {
             // When the `abc.ABCMeta` is not the first keyword, put `abc.ABC` before the first
             // keyword.
+            let deletion_range = TextRange::new(
+                class_def.keywords()[position - 1].end(),
+                keyword.end(),
+            );
+            // The fix is unsafe if the class has base classes or if comments would be deleted.
+            let applicability =
+                if class_def.bases().is_empty() && !checker.comment_ranges().intersects(deletion_range) {
+                    Applicability::Safe
+                } else {
+                    Applicability::Unsafe
+                };
             Fix::applicable_edits(
                 // Delete from the previous argument, to the end of the `metaclass` argument.
-                Edit::range_deletion(TextRange::new(
-                    class_def.keywords()[position - 1].end(),
-                    keyword.end(),
-                )),
+                Edit::range_deletion(deletion_range),
                 // Insert `abc.ABC` before the first keyword.
                 [
                     Edit::insertion(format!("{binding}, "), class_def.keywords()[0].start()),
@@ -112,6 +117,11 @@ pub(crate) fn metaclass_abcmeta(checker: &Checker, class_def: &StmtClassDef) {
                 applicability,
             )
         } else {
+            let applicability = if class_def.bases().is_empty() {
+                Applicability::Safe
+            } else {
+                Applicability::Unsafe
+            };
             Fix::applicable_edits(
                 Edit::range_replacement(binding, keyword.range),
                 [import_edit],
diff --git a/crates/ruff_linter/src/rules/refurb/snapshots/ruff_linter__rules__refurb__tests__FURB180_FURB180.py.snap b/crates/ruff_linter/src/rules/refurb/snapshots/ruff_linter__rules__refurb__tests__FURB180_FURB180.py.snap
index be994f1cc5d438..7e4c40cc835747 100644
--- a/crates/ruff_linter/src/rules/refurb/snapshots/ruff_linter__rules__refurb__tests__FURB180_FURB180.py.snap
+++ b/crates/ruff_linter/src/rules/refurb/snapshots/ruff_linter__rules__refurb__tests__FURB180_FURB180.py.snap
@@ -75,3 +75,26 @@ help: Replace with `abc.ABC`
 33 | 
 34 | 
 note: This is an unsafe fix and may change runtime behavior
+
+FURB180 [*] Use of `metaclass=abc.ABCMeta` to define abstract base class
+  --> FURB180.py:39:5
+   |
+37 |     other_kwarg=1,
+38 |     # comment
+39 |     metaclass=abc.ABCMeta,
+   |     ^^^^^^^^^^^^^^^^^^^^^
+40 | ):
+41 |     pass
+   |
+help: Replace with `abc.ABC`
+34 | 
+35 | # Fix should be unsafe when a comment would be deleted
+36 | class A4_comment(
+   -     other_kwarg=1,
+   -     # comment
+   -     metaclass=abc.ABCMeta,
+37 +     abc.ABC, other_kwarg=1,
+38 | ):
+39 |     pass
+40 | 
+note: This is an unsafe fix and may change runtime behavior