diff --git a/crates/bevy_ecs/src/lib.rs b/crates/bevy_ecs/src/lib.rs
index 46f1a8dc4281c..02780adff3318 100644
--- a/crates/bevy_ecs/src/lib.rs
+++ b/crates/bevy_ecs/src/lib.rs
@@ -1267,6 +1267,15 @@ mod tests {
         assert_eq!(*world.non_send_resource_mut::<i64>(), 456);
     }
 
+    #[test]
+    fn non_send_resource_points_to_distinct_data() {
+        let mut world = World::default();
+        world.insert_resource(A(123));
+        world.insert_non_send_resource(A(456));
+        assert_eq!(*world.resource::<A>(), A(123));
+        assert_eq!(*world.non_send_resource::<A>(), A(456));
+    }
+
     #[test]
     #[should_panic]
     fn non_send_resource_panic() {
@@ -1406,31 +1415,18 @@ mod tests {
         assert_eq!(world.resource::<A>().0, 1);
     }
 
-    #[test]
-    fn non_send_resource_scope() {
-        let mut world = World::default();
-        world.insert_non_send_resource(NonSendA::default());
-        world.resource_scope(|world: &mut World, mut value: Mut<NonSendA>| {
-            value.0 += 1;
-            assert!(!world.contains_resource::<NonSendA>());
-        });
-        assert_eq!(world.non_send_resource::<NonSendA>().0, 1);
-    }
-
     #[test]
     #[should_panic(
-        expected = "attempted to access NonSend resource bevy_ecs::tests::NonSendA off of the main thread"
+        expected = "Attempted to access or drop non-send resource bevy_ecs::tests::NonSendA from thread"
     )]
-    fn non_send_resource_scope_from_different_thread() {
+    fn non_send_resource_drop_from_different_thread() {
         let mut world = World::default();
         world.insert_non_send_resource(NonSendA::default());
 
         let thread = std::thread::spawn(move || {
-            // Accessing the non-send resource on a different thread
+            // Dropping the non-send resource on a different thread
             // Should result in a panic
-            world.resource_scope(|_: &mut World, mut value: Mut<NonSendA>| {
-                value.0 += 1;
-            });
+            drop(world);
         });
 
         if let Err(err) = thread.join() {
@@ -1438,6 +1434,13 @@ mod tests {
         }
     }
 
+    #[test]
+    fn non_send_resource_drop_from_same_thread() {
+        let mut world = World::default();
+        world.insert_non_send_resource(NonSendA::default());
+        drop(world);
+    }
+
     #[test]
     fn insert_overwrite_drop() {
         let (dropck1, dropped1) = DropCk::new_pair();
diff --git a/crates/bevy_ecs/src/schedule/ambiguity_detection.rs b/crates/bevy_ecs/src/schedule/ambiguity_detection.rs
index 558754c9dfcd5..5e1269309154d 100644
--- a/crates/bevy_ecs/src/schedule/ambiguity_detection.rs
+++ b/crates/bevy_ecs/src/schedule/ambiguity_detection.rs
@@ -335,6 +335,7 @@ mod tests {
     fn read_only() {
         let mut world = World::new();
         world.insert_resource(R);
+        world.insert_non_send_resource(R);
         world.spawn(A);
         world.init_resource::<Events<E>>();
 
@@ -394,6 +395,7 @@ mod tests {
     fn nonsend() {
         let mut world = World::new();
         world.insert_resource(R);
+        world.insert_non_send_resource(R);
 
         let mut test_stage = SystemStage::parallel();
         test_stage
@@ -497,6 +499,7 @@ mod tests {
     fn ignore_all_ambiguities() {
         let mut world = World::new();
         world.insert_resource(R);
+        world.insert_non_send_resource(R);
 
         let mut test_stage = SystemStage::parallel();
         test_stage
@@ -513,6 +516,7 @@ mod tests {
     fn ambiguous_with_label() {
         let mut world = World::new();
         world.insert_resource(R);
+        world.insert_non_send_resource(R);
 
         #[derive(SystemLabel)]
         struct IgnoreMe;
diff --git a/crates/bevy_ecs/src/storage/mod.rs b/crates/bevy_ecs/src/storage/mod.rs
index 6e848a042b492..b2fab3fdcb590 100644
--- a/crates/bevy_ecs/src/storage/mod.rs
+++ b/crates/bevy_ecs/src/storage/mod.rs
@@ -14,5 +14,6 @@ pub use table::*;
 pub struct Storages {
     pub sparse_sets: SparseSets,
     pub tables: Tables,
-    pub resources: Resources,
+    pub resources: Resources<true>,
+    pub non_send_resources: Resources<false>,
 }
diff --git a/crates/bevy_ecs/src/storage/resource.rs b/crates/bevy_ecs/src/storage/resource.rs
index 01fa742e06362..40f5554591337 100644
--- a/crates/bevy_ecs/src/storage/resource.rs
+++ b/crates/bevy_ecs/src/storage/resource.rs
@@ -2,19 +2,61 @@ use crate::archetype::ArchetypeComponentId;
 use crate::component::{ComponentId, ComponentTicks, Components, TickCells};
 use crate::storage::{Column, SparseSet, TableRow};
 use bevy_ptr::{OwningPtr, Ptr, UnsafeCellDeref};
+use std::{mem::ManuallyDrop, thread::ThreadId};
 
 /// The type-erased backing storage and metadata for a single resource within a [`World`].
 ///
+/// If `SEND` is false, values of this type will panic if dropped from a different thread.
+///
 /// [`World`]: crate::world::World
-pub struct ResourceData {
-    column: Column,
+pub struct ResourceData<const SEND: bool> {
+    column: ManuallyDrop<Column>,
+    type_name: String,
     id: ArchetypeComponentId,
+    origin_thread_id: Option<ThreadId>,
+}
+
+impl<const SEND: bool> Drop for ResourceData<SEND> {
+    fn drop(&mut self) {
+        if self.is_present() {
+            // If this thread is already panicking, panicking again will cause
+            // the entire process to abort. In this case we choose to avoid
+            // dropping or checking this altogether and just leak the column.
+            if std::thread::panicking() {
+                return;
+            }
+            self.validate_access();
+        }
+        // SAFETY: Drop is only called once upon dropping the ResourceData
+        // and is inaccessible after this as the parent ResourceData has
+        // been dropped. The validate_access call above will check that the
+        // data is dropped on the thread it was inserted from.
+        unsafe {
+            ManuallyDrop::drop(&mut self.column);
+        }
+    }
 }
 
-impl ResourceData {
+impl<const SEND: bool> ResourceData<SEND> {
     /// The only row in the underlying column.
     const ROW: TableRow = TableRow::new(0);
 
+    #[inline]
+    fn validate_access(&self) {
+        if SEND {
+            return;
+        }
+        if self.origin_thread_id != Some(std::thread::current().id()) {
+            // Panic in tests, as testing for aborting is nearly impossible
+            panic!(
+                "Attempted to access or drop non-send resource {} from thread {:?} on a thread {:?}. This is not allowed. Aborting.",
+                self.type_name,
+                self.origin_thread_id,
+                std::thread::current().id()
+            );
+        }
+    }
+
     /// Returns true if the resource is populated.
     #[inline]
     pub fn is_present(&self) -> bool {
@@ -28,9 +70,16 @@ impl ResourceData {
     }
 
     /// Gets a read-only pointer to the underlying resource, if available.
+    ///
+    /// # Panics
+    /// If `SEND` is false, this will panic if a value is present and is not accessed from the
+    /// original thread it was inserted from.
     #[inline]
     pub fn get_data(&self) -> Option<Ptr<'_>> {
-        self.column.get_data(Self::ROW)
+        self.column.get_data(Self::ROW).map(|res| {
+            self.validate_access();
+            res
+        })
     }
 
     /// Gets a read-only reference to the change ticks of the underlying resource, if available.
@@ -39,26 +88,35 @@ impl ResourceData {
         self.column.get_ticks(Self::ROW)
     }
 
+    /// # Panics
+    /// If `SEND` is false, this will panic if a value is present and is not accessed from the
+    /// original thread it was inserted in.
     #[inline]
     pub(crate) fn get_with_ticks(&self) -> Option<(Ptr<'_>, TickCells<'_>)> {
-        self.column.get(Self::ROW)
+        self.column.get(Self::ROW).map(|res| {
+            self.validate_access();
+            res
+        })
     }
 
     /// Inserts a value into the resource. If a value is already present
     /// it will be replaced.
     ///
-    /// # Safety
-    /// `value` must be valid for the underlying type for the resource.
-    ///
-    /// The underlying type must be [`Send`] or be inserted from the main thread.
-    /// This can be validated with [`World::validate_non_send_access_untyped`].
+    /// # Panics
+    /// If `SEND` is false, this will panic if a value is present and is not replaced from
+    /// the original thread it was inserted in.
     ///
-    /// [`World::validate_non_send_access_untyped`]: crate::world::World::validate_non_send_access_untyped
+    /// # Safety
+    /// - `value` must be valid for the underlying type for the resource.
     #[inline]
     pub(crate) unsafe fn insert(&mut self, value: OwningPtr<'_>, change_tick: u32) {
         if self.is_present() {
+            self.validate_access();
             self.column.replace(Self::ROW, value, change_tick);
         } else {
+            if !SEND {
+                self.origin_thread_id = Some(std::thread::current().id());
+            }
             self.column.push(value, ComponentTicks::new(change_tick));
         }
     }
@@ -66,13 +124,12 @@ impl ResourceData {
     /// Inserts a value into the resource with a pre-existing change tick. If a
     /// value is already present it will be replaced.
     ///
-    /// # Safety
-    /// `value` must be valid for the underlying type for the resource.
-    ///
-    /// The underlying type must be [`Send`] or be inserted from the main thread.
-    /// This can be validated with [`World::validate_non_send_access_untyped`].
+    /// # Panics
+    /// If `SEND` is false, this will panic if a value is present and is not replaced from
+    /// the original thread it was inserted in.
     ///
-    /// [`World::validate_non_send_access_untyped`]: crate::world::World::validate_non_send_access_untyped
+    /// # Safety
+    /// - `value` must be valid for the underlying type for the resource.
     #[inline]
     pub(crate) unsafe fn insert_with_ticks(
         &mut self,
@@ -80,6 +137,7 @@ impl ResourceData {
         change_ticks: ComponentTicks,
     ) {
         if self.is_present() {
+            self.validate_access();
             self.column.replace_untracked(Self::ROW, value);
             *self.column.get_added_ticks_unchecked(Self::ROW).deref_mut() = change_ticks.added;
             *self
@@ -87,35 +145,41 @@ impl ResourceData {
                 .get_changed_ticks_unchecked(Self::ROW)
                 .deref_mut() = change_ticks.changed;
         } else {
+            if !SEND {
+                self.origin_thread_id = Some(std::thread::current().id());
+            }
             self.column.push(value, change_ticks);
         }
     }
 
     /// Removes a value from the resource, if present.
     ///
-    /// # Safety
-    /// The underlying type must be [`Send`] or be removed from the main thread.
-    /// This can be validated with [`World::validate_non_send_access_untyped`].
-    ///
-    /// The removed value must be used or dropped.
-    ///
-    /// [`World::validate_non_send_access_untyped`]: crate::world::World::validate_non_send_access_untyped
+    /// # Panics
+    /// If `SEND` is false, this will panic if a value is present and is not removed from the
+    /// original thread it was inserted from.
     #[inline]
     #[must_use = "The returned pointer to the removed component should be used or dropped"]
-    pub(crate) unsafe fn remove(&mut self) -> Option<(OwningPtr<'_>, ComponentTicks)> {
-        self.column.swap_remove_and_forget(Self::ROW)
+    pub(crate) fn remove(&mut self) -> Option<(OwningPtr<'_>, ComponentTicks)> {
+        if SEND {
+            self.column.swap_remove_and_forget(Self::ROW)
+        } else {
+            self.is_present()
+                .then(|| self.validate_access())
+                .and_then(|_| self.column.swap_remove_and_forget(Self::ROW))
+        }
     }
 
     /// Removes a value from the resource, if present, and drops it.
     ///
-    /// # Safety
-    /// The underlying type must be [`Send`] or be removed from the main thread.
-    /// This can be validated with [`World::validate_non_send_access_untyped`].
-    ///
-    /// [`World::validate_non_send_access_untyped`]: crate::world::World::validate_non_send_access_untyped
+    /// # Panics
+    /// If `SEND` is false, this will panic if a value is present and is not
+    /// accessed from the original thread it was inserted in.
     #[inline]
-    pub(crate) unsafe fn remove_and_drop(&mut self) {
-        self.column.clear();
+    pub(crate) fn remove_and_drop(&mut self) {
+        if self.is_present() {
+            self.validate_access();
+            self.column.clear();
+        }
     }
 }
 
@@ -124,11 +188,11 @@ impl ResourceData {
 /// [`Resource`]: crate::system::Resource
 /// [`World`]: crate::world::World
 #[derive(Default)]
-pub struct Resources {
-    resources: SparseSet<ComponentId, ResourceData>,
+pub struct Resources<const SEND: bool> {
+    resources: SparseSet<ComponentId, ResourceData<SEND>>,
 }
 
-impl Resources {
+impl<const SEND: bool> Resources<SEND> {
     /// The total number of resources stored in the [`World`]
     ///
     /// [`World`]: crate::world::World
@@ -138,7 +202,7 @@ impl Resources {
     }
 
     /// Iterate over all resources that have been initialized, i.e. given a [`ComponentId`]
-    pub fn iter(&self) -> impl Iterator<Item = (ComponentId, &ResourceData)> {
+    pub fn iter(&self) -> impl Iterator<Item = (ComponentId, &ResourceData<SEND>)> {
         self.resources.iter().map(|(id, data)| (*id, data))
     }
 
@@ -153,13 +217,13 @@ impl Resources {
 
     /// Gets read-only access to a resource, if it exists.
     #[inline]
-    pub fn get(&self, component_id: ComponentId) -> Option<&ResourceData> {
+    pub fn get(&self, component_id: ComponentId) -> Option<&ResourceData<SEND>> {
         self.resources.get(component_id)
     }
 
     /// Gets mutable access to a resource, if it exists.
     #[inline]
-    pub(crate) fn get_mut(&mut self, component_id: ComponentId) -> Option<&mut ResourceData> {
+    pub(crate) fn get_mut(&mut self, component_id: ComponentId) -> Option<&mut ResourceData<SEND>> {
         self.resources.get_mut(component_id)
     }
 
@@ -167,17 +231,23 @@ impl Resources {
     ///
     /// # Panics
     /// Will panic if `component_id` is not valid for the provided `components`
+    /// If `SEND` is false, this will panic if `component_id`'s `ComponentInfo` is not registered as being `Send` + `Sync`.
     pub(crate) fn initialize_with(
         &mut self,
         component_id: ComponentId,
         components: &Components,
         f: impl FnOnce() -> ArchetypeComponentId,
-    ) -> &mut ResourceData {
+    ) -> &mut ResourceData<SEND> {
         self.resources.get_or_insert_with(component_id, || {
             let component_info = components.get_info(component_id).unwrap();
+            if SEND {
+                assert!(component_info.is_send_and_sync());
+            }
             ResourceData {
-                column: Column::with_capacity(component_info, 1),
+                column: ManuallyDrop::new(Column::with_capacity(component_info, 1)),
+                type_name: String::from(component_info.name()),
                 id: f(),
+                origin_thread_id: None,
             }
         })
     }
diff --git a/crates/bevy_ecs/src/system/system_param.rs b/crates/bevy_ecs/src/system/system_param.rs
index 814ac6316e441..11605b6bfbcd6 100644
--- a/crates/bevy_ecs/src/system/system_param.rs
+++ b/crates/bevy_ecs/src/system/system_param.rs
@@ -1038,7 +1038,7 @@ unsafe impl<'a, T: 'static> SystemParam for NonSend<'a, T> {
             .add_unfiltered_read(component_id);
 
         let archetype_component_id = world
-            .get_resource_archetype_component_id(component_id)
+            .get_non_send_archetype_component_id(component_id)
             .unwrap();
         system_meta
             .archetype_component_access
@@ -1054,9 +1054,8 @@ unsafe impl<'a, T: 'static> SystemParam for NonSend<'a, T> {
         world: &'w World,
         change_tick: u32,
     ) -> Self::Item<'w, 's> {
-        world.validate_non_send_access::<T>();
         let (ptr, ticks) = world
-            .get_resource_with_ticks(component_id)
+            .get_non_send_with_ticks(component_id)
             .unwrap_or_else(|| {
                 panic!(
                     "Non-send resource requested by {} does not exist: {}",
@@ -1090,9 +1089,8 @@ unsafe impl<T: 'static> SystemParam for Option<NonSend<'_, T>> {
         world: &'w World,
         change_tick: u32,
     ) -> Self::Item<'w, 's> {
-        world.validate_non_send_access::<T>();
         world
-            .get_resource_with_ticks(component_id)
+            .get_non_send_with_ticks(component_id)
             .map(|(ptr, ticks)| NonSend {
                 value: ptr.deref(),
                 ticks: ticks.read(),
@@ -1130,7 +1128,7 @@ unsafe impl<'a, T: 'static> SystemParam for NonSendMut<'a, T> {
             .add_unfiltered_write(component_id);
 
         let archetype_component_id = world
-            .get_resource_archetype_component_id(component_id)
+            .get_non_send_archetype_component_id(component_id)
             .unwrap();
         system_meta
             .archetype_component_access
@@ -1146,9 +1144,8 @@ unsafe impl<'a, T: 'static> SystemParam for NonSendMut<'a, T> {
         world: &'w World,
         change_tick: u32,
     ) -> Self::Item<'w, 's> {
-        world.validate_non_send_access::<T>();
         let (ptr, ticks) = world
-            .get_resource_with_ticks(component_id)
+            .get_non_send_with_ticks(component_id)
             .unwrap_or_else(|| {
                 panic!(
                     "Non-send resource requested by {} does not exist: {}",
@@ -1179,9 +1176,8 @@ unsafe impl<'a, T: 'static> SystemParam for Option<NonSendMut<'a, T>> {
         world: &'w World,
         change_tick: u32,
     ) -> Self::Item<'w, 's> {
-        world.validate_non_send_access::<T>();
         world
-            .get_resource_with_ticks(component_id)
+            .get_non_send_with_ticks(component_id)
             .map(|(ptr, ticks)| NonSendMut {
                 value: ptr.assert_unique().deref_mut(),
                 ticks: Ticks::from_tick_cells(ticks, system_meta.last_change_tick, change_tick),
diff --git a/crates/bevy_ecs/src/world/mod.rs b/crates/bevy_ecs/src/world/mod.rs
index e4569f6be5220..3146f2a97f60c 100644
--- a/crates/bevy_ecs/src/world/mod.rs
+++ b/crates/bevy_ecs/src/world/mod.rs
@@ -16,6 +16,7 @@ use crate::{
     },
     entity::{AllocAtWithoutReplacement, Entities, Entity, EntityLocation},
     event::{Event, Events},
+    ptr::UnsafeCellDeref,
     query::{QueryState, ReadOnlyWorldQuery, WorldQuery},
     storage::{ResourceData, SparseSet, Storages},
     system::Resource,
@@ -60,7 +61,6 @@ pub struct World {
     pub(crate) removed_components: SparseSet<ComponentId, Vec<Entity>>,
     /// Access cache used by [WorldCell].
     pub(crate) archetype_component_access: ArchetypeComponentAccess,
-    main_thread_validator: MainThreadValidator,
     pub(crate) change_tick: AtomicU32,
     pub(crate) last_change_tick: u32,
 }
@@ -76,7 +76,6 @@ impl Default for World {
             bundles: Default::default(),
             removed_components: Default::default(),
             archetype_component_access: Default::default(),
-            main_thread_validator: Default::default(),
             // Default value is `1`, and `last_change_tick`s default to `0`, such that changes
             // are detected on first system runs and for direct world queries.
             change_tick: AtomicU32::new(1),
@@ -803,7 +802,7 @@ impl World {
     /// Panics if called from a thread other than the main thread.
     #[inline]
     pub fn init_non_send_resource<R: 'static + FromWorld>(&mut self) {
-        if !self.contains_resource::<R>() {
+        if !self.contains_non_send::<R>() {
             let resource = R::from_world(self);
             self.insert_non_send_resource(resource);
         }
@@ -816,16 +815,15 @@ impl World {
     /// Systems with `NonSend` resources are always scheduled on the main thread.
     ///
     /// # Panics
-    ///
-    /// Panics if called from a thread other than the main thread.
+    /// If a value is already present, this function will panic if called
+    /// from a different thread than where the original value was inserted from.
     #[inline]
     pub fn insert_non_send_resource<R: 'static>(&mut self, value: R) {
-        self.validate_non_send_access::<R>();
         let component_id = self.components.init_non_send::<R>();
         OwningPtr::make(value, |ptr| {
             // SAFETY: component_id was just initialized and corresponds to resource of type R
             unsafe {
-                self.insert_resource_by_id(component_id, ptr);
+                self.insert_non_send_by_id(component_id, ptr);
             }
         });
     }
@@ -833,37 +831,51 @@ impl World {
     /// Removes the resource of a given type and returns it, if it exists. Otherwise returns [None].
     #[inline]
     pub fn remove_resource<R: Resource>(&mut self) -> Option<R> {
-        // SAFETY: R is Send + Sync
-        unsafe { self.remove_resource_unchecked() }
+        let component_id = self.components.get_resource_id(TypeId::of::<R>())?;
+        let (ptr, _) = self.storages.resources.get_mut(component_id)?.remove()?;
+        // SAFETY: `component_id` was gotten via looking up the `R` type
+        unsafe { Some(ptr.read::<R>()) }
     }
 
+    /// Removes a `!Send` resource from the world and returns it, if present.
+    ///
+    /// `NonSend` resources cannot be sent across threads,
+    /// and do not need the `Send + Sync` bounds.
+    /// Systems with `NonSend` resources are always scheduled on the main thread.
+    ///
+    /// Returns `None` if a value was not previously present.
+    ///
+    /// # Panics
+    /// If a value is present, this function will panic if called from a different
+    /// thread than where the value was inserted from.
     #[inline]
     pub fn remove_non_send_resource<R: 'static>(&mut self) -> Option<R> {
-        self.validate_non_send_access::<R>();
-        // SAFETY: we are on main thread
-        unsafe { self.remove_resource_unchecked() }
+        let component_id = self.components.get_resource_id(TypeId::of::<R>())?;
+        let (ptr, _) = self
+            .storages
+            .non_send_resources
+            .get_mut(component_id)?
+            .remove()?;
+        // SAFETY: `component_id` was gotten via looking up the `R` type
+        unsafe { Some(ptr.read::<R>()) }
     }
 
+    /// Returns `true` if a resource of type `R` exists. Otherwise returns `false`.
     #[inline]
-    /// # Safety
-    /// Only remove `NonSend` resources from the main thread
-    /// as they cannot be sent across threads
-    #[allow(unused_unsafe)]
-    pub unsafe fn remove_resource_unchecked<R: 'static>(&mut self) -> Option<R> {
-        let component_id = self.components.get_resource_id(TypeId::of::<R>())?;
-        // SAFETY: the resource is of type R and the value is returned back to the caller.
-        unsafe {
-            let (ptr, _) = self.storages.resources.get_mut(component_id)?.remove()?;
-            Some(ptr.read::<R>())
-        }
+    pub fn contains_resource<R: Resource>(&self) -> bool {
+        self.components
+            .get_resource_id(TypeId::of::<R>())
+            .and_then(|component_id| self.storages.resources.get(component_id))
+            .map(|info| info.is_present())
+            .unwrap_or(false)
     }
 
     /// Returns `true` if a resource of type `R` exists. Otherwise returns `false`.
     #[inline]
-    pub fn contains_resource<R: 'static>(&self) -> bool {
+    pub fn contains_non_send<R: 'static>(&self) -> bool {
         self.components
             .get_resource_id(TypeId::of::<R>())
-            .and_then(|component_id| self.storages.resources.get(component_id))
+            .and_then(|component_id| self.storages.non_send_resources.get(component_id))
             .map(|info| info.is_present())
             .unwrap_or(false)
     }
@@ -979,6 +991,8 @@ impl World {
     ///
     /// Panics if the resource does not exist.
     /// Use [`get_non_send_resource`](World::get_non_send_resource) instead if you want to handle this case.
+    ///
+    /// This function will panic if it isn't called from the same thread that the resource was inserted from.
     #[inline]
     #[track_caller]
     pub fn non_send_resource<R: 'static>(&self) -> &R {
@@ -999,6 +1013,8 @@ impl World {
     ///
     /// Panics if the resource does not exist.
     /// Use [`get_non_send_resource_mut`](World::get_non_send_resource_mut) instead if you want to handle this case.
+    ///
+    /// This function will panic if it isn't called from the same thread that the resource was inserted from.
     #[inline]
     #[track_caller]
     pub fn non_send_resource_mut<R: 'static>(&mut self) -> Mut<'_, R> {
@@ -1014,7 +1030,10 @@ impl World {
     }
 
     /// Gets a reference to the non-send resource of the given type, if it exists.
-    /// Otherwise returns [None]
+    /// Otherwise returns [None].
+    ///
+    /// # Panics
+    /// This function will panic if it isn't called from the same thread that the resource was inserted from.
     #[inline]
     pub fn get_non_send_resource<R: 'static>(&self) -> Option<&R> {
         let component_id = self.components.get_resource_id(TypeId::of::<R>())?;
@@ -1024,6 +1043,9 @@ impl World {
 
     /// Gets a mutable reference to the non-send resource of the given type, if it exists.
     /// Otherwise returns [None]
+    ///
+    /// # Panics
+    /// This function will panic if it isn't called from the same thread that the resource was inserted from.
     #[inline]
     pub fn get_non_send_resource_mut<R: 'static>(&mut self) -> Option<Mut<'_, R>> {
         // SAFETY: unique world access
@@ -1033,6 +1055,9 @@ impl World {
     /// Gets a mutable reference to the non-send resource of the given type, if it exists.
     /// Otherwise returns [None]
     ///
+    /// # Panics
+    /// This function will panic if it isn't called from the same thread that the resource was inserted from.
+    ///
     /// # Safety
     /// This will allow aliased mutable access to the given non-send resource type. The caller must
     /// ensure that there is either only one mutable access or multiple immutable accesses at a time.
@@ -1051,6 +1076,21 @@ impl World {
         self.storages.resources.get(component_id)?.get_with_ticks()
     }
 
+    // Shorthand helper function for getting the data and change ticks for a resource.
+    ///
+    /// # Panics
+    /// This function will panic if it isn't called from the same thread that the resource was inserted from.
+    #[inline]
+    pub(crate) fn get_non_send_with_ticks(
+        &self,
+        component_id: ComponentId,
+    ) -> Option<(Ptr<'_>, TickCells<'_>)> {
+        self.storages
+            .non_send_resources
+            .get(component_id)?
+            .get_with_ticks()
+    }
+
     // Shorthand helper function for getting the [`ArchetypeComponentId`] for a resource.
     #[inline]
     pub(crate) fn get_resource_archetype_component_id(
@@ -1061,6 +1101,16 @@ impl World {
         Some(resource.id())
     }
 
+    // Shorthand helper function for getting the [`ArchetypeComponentId`] for a resource.
+    #[inline]
+    pub(crate) fn get_non_send_archetype_component_id(
+        &self,
+        component_id: ComponentId,
+    ) -> Option<ArchetypeComponentId> {
+        let resource = self.storages.non_send_resources.get(component_id)?;
+        Some(resource.id())
+    }
+
     /// For a given batch of ([Entity], [Bundle]) pairs, either spawns each [Entity] with the given
     /// bundle (if the entity does not exist), or inserts the [Bundle] (if the entity already exists).
     /// This is faster than doing equivalent operations one-by-one.
@@ -1207,13 +1257,7 @@ impl World {
     /// });
     /// assert_eq!(world.get_resource::<A>().unwrap().0, 2);
     /// ```
-    pub fn resource_scope<
-        R: 'static, /* The resource doesn't need to be Send nor Sync. */
-        U,
-    >(
-        &mut self,
-        f: impl FnOnce(&mut World, Mut<R>) -> U,
-    ) -> U {
+    pub fn resource_scope<R: Resource, U>(&mut self, f: impl FnOnce(&mut World, Mut<R>) -> U) -> U {
         let last_change_tick = self.last_change_tick();
         let change_tick = self.change_tick();
 
@@ -1222,17 +1266,11 @@ impl World {
             .get_resource_id(TypeId::of::<R>())
             .unwrap_or_else(|| panic!("resource does not exist: {}", std::any::type_name::<R>()));
         // If the resource isn't send and sync, validate that we are on the main thread, so that we can access it.
-        let component_info = self.components().get_info(component_id).unwrap();
-        if !component_info.is_send_and_sync() {
-            self.validate_non_send_access::<R>();
-        }
-
         let (ptr, mut ticks) = self
             .storages
             .resources
             .get_mut(component_id)
-            // SAFETY: The type R is Send and Sync or we've already validated that we're on the main thread.
-            .and_then(|info| unsafe { info.remove() })
+            .and_then(|info| info.remove())
             .unwrap_or_else(|| panic!("resource does not exist: {}", std::any::type_name::<R>()));
         // Read the value onto the stack to avoid potential mut aliasing.
         // SAFETY: pointer is of type R
@@ -1331,8 +1369,13 @@ impl World {
         &self,
         component_id: ComponentId,
     ) -> Option<&R> {
-        self.validate_non_send_access::<R>();
-        self.get_resource_with_id(component_id)
+        Some(
+            self.storages
+                .non_send_resources
+                .get(component_id)?
+                .get_data()?
+                .deref::<R>(),
+        )
     }
 
     /// # Safety
@@ -1343,8 +1386,20 @@ impl World {
         &self,
         component_id: ComponentId,
     ) -> Option<Mut<'_, R>> {
-        self.validate_non_send_access::<R>();
-        self.get_resource_unchecked_mut_with_id(component_id)
+        let (ptr, ticks) = self
+            .storages
+            .non_send_resources
+            .get(component_id)?
+            .get_with_ticks()?;
+        Some(Mut {
+            value: ptr.assert_unique().deref_mut(),
+            ticks: Ticks {
+                added: ticks.added.deref_mut(),
+                changed: ticks.changed.deref_mut(),
+                last_change_tick: self.last_change_tick(),
+                change_tick: self.read_change_tick(),
+            },
+        })
     }
 
     /// Inserts a new resource with the given `value`. Will replace the value if it already existed.
@@ -1353,8 +1408,7 @@ impl World {
     /// use this in cases where the actual types are not known at compile time.**
     ///
     /// # Safety
-    /// The value referenced by `value` must be valid for the given [`ComponentId`] of this world
-    /// `component_id` must exist in this [`World`]
+    /// The value referenced by `value` must be valid for the given [`ComponentId`] of this world.
     #[inline]
     pub unsafe fn insert_resource_by_id(
         &mut self,
@@ -1363,18 +1417,43 @@ impl World {
     ) {
         let change_tick = self.change_tick();
 
-        // SAFETY: component_id is valid, ensured by caller
+        // SAFETY: value is valid for component_id, ensured by caller
         self.initialize_resource_internal(component_id)
             .insert(value, change_tick);
     }
 
+    /// Inserts a new `!Send` resource with the given `value`. Will replace the value if it already
+    /// existed.
+    ///
+    /// **You should prefer to use the typed API [`World::insert_non_send_resource`] where possible and only
+    /// use this in cases where the actual types are not known at compile time.**
+    ///
+    /// # Panics
+    /// If a value is already present, this function will panic if not called from the same
+    /// thread that the original value was inserted from.
+    ///
     /// # Safety
-    /// `component_id` must be valid for this world
+    /// The value referenced by `value` must be valid for the given [`ComponentId`] of this world.
     #[inline]
-    unsafe fn initialize_resource_internal(
+    pub unsafe fn insert_non_send_by_id(
         &mut self,
         component_id: ComponentId,
-    ) -> &mut ResourceData {
+        value: OwningPtr<'_>,
+    ) {
+        let change_tick = self.change_tick();
+
+        // SAFETY: value is valid for component_id, ensured by caller
+        self.initialize_non_send_internal(component_id)
+            .insert(value, change_tick);
+    }
+
+    /// # Panics
+    /// Panics if `component_id` is not registered as a `Send` component type in this `World`
+    #[inline]
+    fn initialize_resource_internal(
+        &mut self,
+        component_id: ComponentId,
+    ) -> &mut ResourceData<true> {
         let archetype_component_count = &mut self.archetypes.archetype_component_count;
         self.storages
             .resources
@@ -1385,36 +1464,35 @@ impl World {
             })
     }
 
+    /// # Panics
+    /// panics if `component_id` is not registered in this world
+    #[inline]
+    fn initialize_non_send_internal(
+        &mut self,
+        component_id: ComponentId,
+    ) -> &mut ResourceData<false> {
+        let archetype_component_count = &mut self.archetypes.archetype_component_count;
+        self.storages
+            .non_send_resources
+            .initialize_with(component_id, &self.components, || {
+                let id = ArchetypeComponentId::new(*archetype_component_count);
+                *archetype_component_count += 1;
+                id
+            })
+    }
+
     pub(crate) fn initialize_resource<R: Resource>(&mut self) -> ComponentId {
         let component_id = self.components.init_resource::<R>();
-        // SAFETY: resource initialized above
-        unsafe { self.initialize_resource_internal(component_id) };
+        self.initialize_resource_internal(component_id);
         component_id
     }
 
     pub(crate) fn initialize_non_send_resource<R: 'static>(&mut self) -> ComponentId {
         let component_id = self.components.init_non_send::<R>();
-        // SAFETY: resource initialized above
-        unsafe { self.initialize_resource_internal(component_id) };
+        self.initialize_non_send_internal(component_id);
         component_id
     }
 
-    pub(crate) fn validate_non_send_access<T: 'static>(&self) {
-        assert!(
-            self.main_thread_validator.is_main_thread(),
-            "attempted to access NonSend resource {} off of the main thread",
-            std::any::type_name::<T>(),
-        );
-    }
-
-    pub(crate) fn validate_non_send_access_untyped(&self, name: &str) {
-        assert!(
-            self.main_thread_validator.is_main_thread(),
-            "attempted to access NonSend resource {} off of the main thread",
-            name
-        );
-    }
-
     /// Empties queued entities and adds them to the empty [Archetype](crate::archetype::Archetype).
     /// This should be called before doing operations that might operate on queued entities,
     /// such as inserting a [Component].
@@ -1464,9 +1542,16 @@ impl World {
         // Iterate over all component change ticks, clamping their age to max age
         // PERF: parallelize
         let change_tick = self.change_tick();
-        self.storages.tables.check_change_ticks(change_tick);
-        self.storages.sparse_sets.check_change_ticks(change_tick);
-        self.storages.resources.check_change_ticks(change_tick);
+        let Storages {
+            ref mut tables,
+            ref mut sparse_sets,
+            ref mut resources,
+            ref mut non_send_resources,
+        } = self.storages;
+        tables.check_change_ticks(change_tick);
+        sparse_sets.check_change_ticks(change_tick);
+        resources.check_change_ticks(change_tick);
+        non_send_resources.check_change_ticks(change_tick);
     }
 
     pub fn clear_entities(&mut self) {
@@ -1486,10 +1571,6 @@ impl World {
     /// use this in cases where the actual types are not known at compile time.**
     #[inline]
     pub fn get_resource_by_id(&self, component_id: ComponentId) -> Option<Ptr<'_>> {
-        let info = self.components.get_info(component_id)?;
-        if !info.is_send_and_sync() {
-            self.validate_non_send_access_untyped(info.name());
-        }
         self.storages.resources.get(component_id)?.get_data()
     }
 
@@ -1501,13 +1582,7 @@ impl World {
     /// use this in cases where the actual types are not known at compile time.**
     #[inline]
     pub fn get_resource_mut_by_id(&mut self, component_id: ComponentId) -> Option<MutUntyped<'_>> {
-        let info = self.components.get_info(component_id)?;
-        if !info.is_send_and_sync() {
-            self.validate_non_send_access_untyped(info.name());
-        }
-
         let change_tick = self.change_tick();
-
         let (ptr, ticks) = self.get_resource_with_ticks(component_id)?;
 
         // SAFETY: This function has exclusive access to the world so nothing aliases `ticks`.
@@ -1522,22 +1597,73 @@ impl World {
         })
     }
 
+    /// Gets a `!Send` resource to the resource with the id [`ComponentId`] if it exists.
+    /// The returned pointer must not be used to modify the resource, and must not be
+    /// dereferenced after the immutable borrow of the [`World`] ends.
+    ///
+    /// **You should prefer to use the typed API [`World::get_resource`] where possible and only
+    /// use this in cases where the actual types are not known at compile time.**
+    ///
+    /// # Panics
+    /// This function will panic if it isn't called from the same thread that the resource was inserted from.
+    #[inline]
+    pub fn get_non_send_by_id(&self, component_id: ComponentId) -> Option<Ptr<'_>> {
+        self.storages
+            .non_send_resources
+            .get(component_id)?
+            .get_data()
+    }
+
+    /// Gets a `!Send` resource to the resource with the id [`ComponentId`] if it exists.
+    /// The returned pointer may be used to modify the resource, as long as the mutable borrow
+    /// of the [`World`] is still valid.
+    ///
+    /// **You should prefer to use the typed API [`World::get_resource_mut`] where possible and only
+    /// use this in cases where the actual types are not known at compile time.**
+    ///
+    /// # Panics
+    /// This function will panic if it isn't called from the same thread that the resource was inserted from.
+    #[inline]
+    pub fn get_non_send_mut_by_id(&mut self, component_id: ComponentId) -> Option<MutUntyped<'_>> {
+        let change_tick = self.change_tick();
+        let (ptr, ticks) = self.get_non_send_with_ticks(component_id)?;
+
+        // SAFETY: This function has exclusive access to the world so nothing aliases `ticks`.
+        // - index is in-bounds because the column is initialized and non-empty
+        // - no other reference to the ticks of the same row can exist at the same time
+        let ticks = unsafe { Ticks::from_tick_cells(ticks, self.last_change_tick(), change_tick) };
+
+        Some(MutUntyped {
+            // SAFETY: This function has exclusive access to the world so nothing aliases `ptr`.
+            value: unsafe { ptr.assert_unique() },
+            ticks,
+        })
+    }
+
     /// Removes the resource of a given type, if it exists. Otherwise returns [None].
     ///
     /// **You should prefer to use the typed API [`World::remove_resource`] where possible and only
     /// use this in cases where the actual types are not known at compile time.**
     pub fn remove_resource_by_id(&mut self, component_id: ComponentId) -> Option<()> {
-        let info = self.components.get_info(component_id)?;
-        if !info.is_send_and_sync() {
-            self.validate_non_send_access_untyped(info.name());
-        }
-        // SAFETY: The underlying type is Send and Sync or we've already validated we're on the main thread
-        unsafe {
-            self.storages
-                .resources
-                .get_mut(component_id)?
-                .remove_and_drop();
-        }
+        self.storages
+            .resources
+            .get_mut(component_id)?
+            .remove_and_drop();
+        Some(())
+    }
+
+    /// Removes the resource of a given type, if it exists. Otherwise returns [None].
+    ///
+    /// **You should prefer to use the typed API [`World::remove_resource`] where possible and only
+    /// use this in cases where the actual types are not known at compile time.**
+    ///
+    /// # Panics
+    /// This function will panic if it isn't called from the same thread that the resource was inserted from.
+    pub fn remove_non_send_by_id(&mut self, component_id: ComponentId) -> Option<()> {
+        self.storages
+            .non_send_resources
+            .get_mut(component_id)?
+            .remove_and_drop();
         Some(())
     }
 
@@ -1546,6 +1672,9 @@ impl World {
     ///
     /// **You should prefer to use the typed API [`World::get_mut`] where possible and only
     /// use this in cases where the actual types are not known at compile time.**
+    ///
+    /// # Panics
+    /// This function will panic if it isn't called from the same thread that the resource was inserted from.
     #[inline]
     pub fn get_by_id(&self, entity: Entity, component_id: ComponentId) -> Option<Ptr<'_>> {
         let info = self.components().get_info(component_id)?;
@@ -1622,24 +1751,6 @@ impl<T: Default> FromWorld for T {
     }
 }
 
-struct MainThreadValidator {
-    main_thread: std::thread::ThreadId,
-}
-
-impl MainThreadValidator {
-    fn is_main_thread(&self) -> bool {
-        self.main_thread == std::thread::current().id()
-    }
-}
-
-impl Default for MainThreadValidator {
-    fn default() -> Self {
-        Self {
-            main_thread: std::thread::current().id(),
-        }
-    }
-}
-
 #[cfg(test)]
 mod tests {
     use super::World;
diff --git a/crates/bevy_ecs/src/world/world_cell.rs b/crates/bevy_ecs/src/world/world_cell.rs
index 5f0fb5aaa5a74..8e6699e076694 100644
--- a/crates/bevy_ecs/src/world/world_cell.rs
+++ b/crates/bevy_ecs/src/world/world_cell.rs
@@ -256,7 +256,7 @@ impl<'w> WorldCell<'w> {
         let component_id = self.world.components.get_resource_id(TypeId::of::<T>())?;
         let archetype_component_id = self
             .world
-            .get_resource_archetype_component_id(component_id)?;
+            .get_non_send_archetype_component_id(component_id)?;
         WorldBorrow::try_new(
             // SAFETY: ComponentId matches TypeId
             || unsafe { self.world.get_non_send_with_id(component_id) },
@@ -289,7 +289,7 @@ impl<'w> WorldCell<'w> {
         let component_id = self.world.components.get_resource_id(TypeId::of::<T>())?;
         let archetype_component_id = self
             .world
-            .get_resource_archetype_component_id(component_id)?;
+            .get_non_send_archetype_component_id(component_id)?;
         WorldBorrowMut::try_new(
             // SAFETY: ComponentId matches TypeId and access is checked by WorldBorrowMut
             || unsafe { self.world.get_non_send_unchecked_mut_with_id(component_id) },
diff --git a/crates/bevy_render/src/view/window.rs b/crates/bevy_render/src/view/window.rs
index 8e6f82c66c911..c5b0499b08534 100644
--- a/crates/bevy_render/src/view/window.rs
+++ b/crates/bevy_render/src/view/window.rs
@@ -29,7 +29,7 @@ impl Plugin for WindowRenderPlugin {
             render_app
                 .init_resource::<ExtractedWindows>()
                 .init_resource::<WindowSurfaces>()
-                .init_resource::<NonSendMarker>()
+                .init_non_send_resource::<NonSendMarker>()
                 .add_system_to_stage(RenderStage::Extract, extract_windows)
                 .add_system_to_stage(
                     RenderStage::Prepare,