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gocam-betacat.yaml
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gocam-betacat.yaml
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input_id: /Users/cjm/repos/ontogpt/tests/input/cases/gocam-betacat.txt
input_text: "Title: \u03B2-Catenin Is Required for the cGAS/STING Signaling Pathway\
\ but Antagonized by the Herpes Simplex Virus 1 US3 Protein\nText:\nThe cGAS/STING-mediated\
\ DNA-sensing signaling pathway is crucial\nfor interferon (IFN) production and\
\ host antiviral\nresponses. Herpes simplex virus I (HSV-1) is a DNA virus that\
\ has\nevolved multiple strategies to evade host immune responses. Here,\nwe demonstrate\
\ that the highly conserved \u03B2-catenin protein in the\nWnt signaling pathway\
\ is an important factor to enhance the\ntranscription of type I interferon (IFN-I)\
\ in the cGAS/STING\nsignaling pathway, and the production of IFN-I mediated by\n\
\u03B2-catenin was antagonized by HSV-1 US3 protein via its kinase\nactivity. Infection\
\ by US3-deficienct HSV-1 and its kinase-dead\nvariants failed to downregulate IFN-I\
\ and IFN-stimulated\ngene (ISG) production induced by \u03B2-catenin. Consistent\
\ with this,\nabsence of \u03B2-catenin enhanced the replication of US3-deficienct\n\
HSV-1, but not wild-type HSV-1. The underlying mechanism was the\ninteraction of\
\ US3 with \u03B2-catenin and its hyperphosphorylation of\n\u03B2-catenin at Thr556\
\ to block its nuclear translocation. For the\nfirst time, HSV-1 US3 has been shown\
\ to inhibit IFN-I production\nthrough hyperphosphorylation of \u03B2-catenin and\
\ to subvert host\nantiviral innate immunity.IMPORTANCE Although increasing evidence\n\
has demonstrated that HSV-1 subverts host immune responses and\nestablishes lifelong\
\ latent infection, the molecular mechanisms\nby which HSV-1 interrupts antiviral\
\ innate immunity, especially\nthe cGAS/STING-mediated cellular DNA-sensing signaling\
\ pathway,\nhave not been fully explored. Here, we show that \u03B2-catenin\npromotes\
\ cGAS/STING-mediated activation of the IFN pathway, which\nis important for cellular\
\ innate immune responses and intrinsic\nresistance to DNA virus infection. The\
\ protein kinase US3\nantagonizes the production of IFN by targeting \u03B2-catenin\
\ via its\nkinase activity. The findings in this study reveal a novel\nmechanism\
\ for HSV-1 to evade host antiviral immunity and add new\nknowledge to help in understanding\
\ the interaction between the\nhost and HSV-1 infection.\n\nKeywords: HSV-1; US3;\
\ type I IFN; \u03B2-catenin."
raw_completion_output: "genes: cGAS; STING; \u03B2-catenin; US3; IFN; ISG; Thr556\n\
organisms: Homo sapiens; Herpes simplex virus I\ngene_organisms: cGAS/Homo sapiens;\
\ STING/Homo sapiens; \u03B2-catenin/Homo sapiens; US3/Herpes simplex virus I; IFN/Homo\
\ sapiens; ISG/Homo sapiens; Thr556/Homo sapiens\nactivities: transcription; replication;\
\ production; nuclear translocation\ngene_functions: cGAS/activate type I IFN; STING/activate\
\ type I IFN; \u03B2-catenin/enhance transcription of type I IFN; US3/antagonize\
\ production of IFN; IFN/produce type I IFN; ISG/produce type I IFN; Thr556/block\
\ nuclear translocation\ncellular_processes: DNA-sensing; interferon production;\
\ host antiviral responses; Wnt signaling; hyperphosphorylation\npathways: cGAS/STING\
\ signaling; Wnt signaling\ngene_gene_interactions: US3/\u03B2-catenin\ngene_localizations:\
\ cGAS/--; STING/--; \u03B2-catenin/nuclear; US3/--; IFN/--; ISG/--; Thr556/--"
prompt: 'Split the following piece of text into fields in the following format:
gene: <the value for gene>
location: <the value for location>
Text:
Thr556/--
===
'
extracted_object:
genes:
- HGNC:21367
- HGNC:27962
- HGNC:2514
- AUTO:US3
- HGNC:5417
- AUTO:ISG
- AUTO:Thr556
organisms:
- NCBITaxon:9606
- NCBITaxon:10298
gene_organisms:
- gene: HGNC:21367
organism: NCBITaxon:9606
- gene: HGNC:27962
organism: NCBITaxon:9606
- gene: HGNC:2514
organism: NCBITaxon:9606
- gene: AUTO:US3
organism: NCBITaxon:10298
- gene: HGNC:5417
organism: NCBITaxon:9606
- gene: AUTO:ISG
organism: NCBITaxon:9606
- gene: AUTO:Thr556
organism: NCBITaxon:9606
activities:
- GO:0006351
- AUTO:replication
- AUTO:production
- AUTO:nuclear%20translocation
gene_functions:
- gene: HGNC:21367
molecular_activity: AUTO:activate%20type%20I%20IFN
- gene: HGNC:27962
molecular_activity: AUTO:activate%20type%20I%20IFN
- gene: HGNC:2514
molecular_activity: AUTO:enhance%20transcription%20of%20type%20I%20IFN
- gene: AUTO:US3
molecular_activity: AUTO:antagonize%20production%20of%20IFN
- gene: HGNC:5417
molecular_activity: AUTO:produce%20type%20I%20IFN
- gene: AUTO:ISG
molecular_activity: AUTO:produce%20type%20I%20IFN
- gene: AUTO:Thr556
molecular_activity: AUTO:block%20nuclear%20translocation
cellular_processes:
- AUTO:DNA-sensing
- GO:0001816
- AUTO:host%20antiviral%20responses
- AUTO:Wnt%20signaling
- GO:0048151
pathways:
- AUTO:cGAS/STING%20signaling
- AUTO:Wnt%20signaling
gene_gene_interactions:
- gene1: AUTO:US3
gene2: HGNC:2514
gene_localizations:
- gene: HGNC:21367
location: AUTO:--
- gene: HGNC:27962
location: AUTO:--
- gene: HGNC:2514
location: AUTO:nuclear
- gene: AUTO:US3
location: AUTO:--
- gene: HGNC:5417
location: AUTO:--
- gene: AUTO:ISG
location: AUTO:--
- gene: AUTO:Thr556
location: AUTO:--
named_entities:
- id: HGNC:16289
label: TRIM31
- id: HGNC:16400
label: NLRP3
- id: HGNC:5992
label: "IL-1\u03B2"
- id: HGNC:6121
label: LPS
- id: MESH:D006801
label: Homo sapiens
- id: NCBITaxon:10090
label: Mus musculus
- id: MESH:D006801
label: Homo sapiens
- id: MESH:D006801
label: Homo sapiens
- id: MESH:D006801
label: Homo sapiens
- id: MESH:D006801
label: Homo sapiens
- id: GO:0005488
label: binding
- id: GO:0005488
label: binding
- id: GO:0046903
label: secretion
- id: HGNC:16400
label: NLRP3
- id: HGNC:6121
label: LPS
- id: GO:0005737
label: cytoplasm
- id: HGNC:16400
label: NLRP3
- id: GO:0005739
label: mitochondrion
- id: HGNC:5992
label: Il1b
- id: HGNC:5993
label: Il1r1
- id: HGNC:16400
label: NLRP3
- id: HGNC:1499
label: caspase-1
- id: NCBITaxon:10090
label: Mus Musculus
- id: HGNC:5992
label: Il1b
- id: NCBITaxon:10090
label: Mus Musculus
- id: HGNC:5993
label: Il1r1
- id: NCBITaxon:10090
label: Mus Musculus
- id: HGNC:16400
label: NLRP3
- id: NCBITaxon:10090
label: Mus Musculus
- id: HGNC:1499
label: caspase-1
- id: NCBITaxon:10090
label: Mus Musculus
- id: NCBITaxon:10090
label: Mus Musculus
- id: HGNC:5992
label: Il1b
- id: HGNC:5993
label: Il1r1
- id: HGNC:16400
label: NLRP3
- id: HGNC:1499
label: caspase-1
- id: HGNC:5992
label: Il1b
- id: HGNC:5993
label: Il1r1
- id: HGNC:16400
label: NLRP3
- id: HGNC:1499
label: caspase-1
- id: HGNC:5992
label: Il1b
- id: HGNC:5993
label: Il1r1
- id: HGNC:16400
label: NLRP3
- id: HGNC:1499
label: caspase-1
- id: HGNC:21367
label: cGAS
- id: HGNC:27962
label: STING
- id: HGNC:2514
label: "\u03B2-catenin"
- id: HGNC:5417
label: IFN
- id: MESH:D006801
label: Homo sapiens
- id: MESH:D018259
label: Herpes simplex virus I
- id: HGNC:21367
label: cGAS
- id: MESH:D006801
label: Homo sapiens
- id: HGNC:27962
label: STING
- id: MESH:D006801
label: Homo sapiens
- id: HGNC:2514
label: "\u03B2-catenin"
- id: MESH:D006801
label: Homo sapiens
- id: MESH:D018259
label: Herpes simplex virus I
- id: HGNC:5417
label: IFN
- id: MESH:D006801
label: Homo sapiens
- id: MESH:D006801
label: Homo sapiens
- id: MESH:D006801
label: Homo sapiens
- id: GO:0006351
label: transcription
- id: HGNC:21367
label: cGAS
- id: HGNC:27962
label: STING
- id: HGNC:2514
label: "\u03B2-catenin"
- id: HGNC:5417
label: IFN
- id: GO:0001816
label: interferon production
- id: GO:0048151
label: hyperphosphorylation
- id: HGNC:2514
label: "\u03B2-catenin"
- id: HGNC:21367
label: cGAS
- id: HGNC:27962
label: STING
- id: HGNC:2514
label: "\u03B2-catenin"
- id: HGNC:5417
label: IFN