diff --git a/.github/workflows/CI.yml b/.github/workflows/CI.yml
index b7ac7bb..34ad699 100644
--- a/.github/workflows/CI.yml
+++ b/.github/workflows/CI.yml
@@ -23,7 +23,7 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        target: [x86_64]
+        target: [x86_64, aarch64, ppc64le]
     steps:
       - uses: actions/checkout@v3
       - uses: actions/setup-python@v4
diff --git a/rust/Cargo.toml b/rust/Cargo.toml
index 7893489..c7ed765 100644
--- a/rust/Cargo.toml
+++ b/rust/Cargo.toml
@@ -12,4 +12,4 @@ crate-type = ["cdylib"]
 bgzip = { git = "https://github.com/informationsea/bgzip-rs/", rev = "4492b5d6abb3e191c2eb007f148b704b654d528e", default-features = false, features = ["rust_backend", "rayon", "log"] }
 itertools = "0.12.1"
 pyo3 = { version = "0.20.2", features = ["abi3-py38", "extension-module"] }
-rust-htslib = { version = "0.44.1", default-features = false, features = ["libdeflate"] }
+rust-htslib = { version = "0.45.0", default-features = false, features = ["libdeflate"] }