diff --git a/packages/ui/CHANGELOG.md b/packages/ui/CHANGELOG.md
index 5e69b99bd89b64..cb5ecac82d3427 100644
--- a/packages/ui/CHANGELOG.md
+++ b/packages/ui/CHANGELOG.md
@@ -32,6 +32,7 @@
 -   `Autocomplete.Input`, `Combobox.Input`: Omit the `type` prop, since the combobox role is only valid on `input type="text"` ([#80636](https://github.com/WordPress/gutenberg/pull/80636)).
 -   `Card`: Use the normal neutral surface stroke for the default border. ([#81746](https://github.com/WordPress/gutenberg/pull/81746))
 -   `Calendar`, `RangeCalendar`: Preserve day focus when a controlled month change removes the focused day. ([#81635](https://github.com/WordPress/gutenberg/pull/81635))
+-   `Button`: Fix the loading spinner being off-center in RTL ([#81901](https://github.com/WordPress/gutenberg/pull/81901)).
 
 ### Documentation
 
diff --git a/packages/ui/src/button/style.module.css b/packages/ui/src/button/style.module.css
index 9cffd960c174e3..fe9ac4c5260291 100644
--- a/packages/ui/src/button/style.module.css
+++ b/packages/ui/src/button/style.module.css
@@ -115,7 +115,8 @@
 				content: "";
 				position: absolute;
 				top: 50%;
-				inset-inline-start: 50%;
+				/* stylelint-disable-next-line plugin/use-logical-properties-and-values -- Physical centering technique used with transform: translate(-50%, -50%) */
+				left: 50%;
 				transform: translate(-50%, -50%);
 
 				display: block;