diff --git a/packages/ui/CHANGELOG.md b/packages/ui/CHANGELOG.md
index 23b1569bc7f826..000d74032c09b6 100644
--- a/packages/ui/CHANGELOG.md
+++ b/packages/ui/CHANGELOG.md
@@ -9,6 +9,7 @@
 
 ### Code Quality
 
+-   `Button`: Reference the medium font-weight design token instead of a literal value. No visual change ([#79278](https://github.com/WordPress/gutenberg/pull/79278)).
 -   Move `@types/react` from `dependencies` to an optional peer dependency so consumers' React type version is used ([#79095](https://github.com/WordPress/gutenberg/pull/79095)).
 -   `Button` and `AlertDialog`: Reference the tone-specific `brand`/`error` disabled color tokens for disabled states instead of the `neutral` ones, to match each element's tone. Disabled `Select`/`Autocomplete`/`Combobox` list items also adopt the `brand` disabled background token. No visual change ([#79124](https://github.com/WordPress/gutenberg/pull/79124)).
 
diff --git a/packages/ui/src/button/style.module.css b/packages/ui/src/button/style.module.css
index 4b750d8c815fad..9030ac8fb2ec88 100644
--- a/packages/ui/src/button/style.module.css
+++ b/packages/ui/src/button/style.module.css
@@ -10,7 +10,7 @@
 
 		.button {
 			/* Internal variables */
-			--wp-ui-button-font-weight: 499;
+			--wp-ui-button-font-weight: var(--wpds-typography-font-weight-medium);
 
 			--wp-ui-button-background-color: var(--wpds-color-background-interactive-brand-strong);
 			--wp-ui-button-background-color-active: var(--wpds-color-background-interactive-brand-strong-active);