diff --git a/packages/base-styles/_z-index.scss b/packages/base-styles/_z-index.scss
index 0a0bda32a054fa..0015d03d18c71f 100644
--- a/packages/base-styles/_z-index.scss
+++ b/packages/base-styles/_z-index.scss
@@ -142,6 +142,9 @@ $z-layers: (
 	".skip-to-selected-block": 100000,
 	".interface-interface-skeleton__actions": 100000,
 
+	// The focus styles of the region navigation containers should be above their content.
+	".is-focusing-regions {region} :focus::after": 1000000
+
 	// Show NUX tips above popovers, wp-admin menus, submenus, and sidebar:
 	".nux-dot-tip": 1000001,
 
diff --git a/packages/components/src/higher-order/navigate-regions/style.scss b/packages/components/src/higher-order/navigate-regions/style.scss
index 25495f4a8bd73f..6e66c854dd70ee 100644
--- a/packages/components/src/higher-order/navigate-regions/style.scss
+++ b/packages/components/src/higher-order/navigate-regions/style.scss
@@ -4,22 +4,17 @@
 }
 
 .is-focusing-regions {
-	[role="region"]:focus {
+	[role="region"]:focus::after {
+		position: absolute;
+		top: 0;
+		left: 0;
+		right: 0;
+		bottom: 0;
+		content: "";
+		pointer-events: none;
 		outline: 4px solid $components-color-accent;
 		outline-offset: -4px;
-
-		&::after {
-			position: absolute;
-			top: 0;
-			left: 0;
-			right: 0;
-			bottom: 0;
-			content: "";
-			pointer-events: none;
-			outline: 4px solid $components-color-accent;
-			outline-offset: -4px;
-			z-index: 9999999;
-		}
+		z-index: z-index(".is-focusing-regions {region} :focus::after");
 	}
 
 	// Fixes for edge cases.
@@ -33,31 +28,10 @@
 	// regardles of the CSS used on other components.
 
 	// Header top bar when Distraction free mode is on.
-	&.is-distraction-free .interface-interface-skeleton__header {
-		.edit-post-header {
-			outline: inherit;
-			outline-offset: inherit;
-		}
-	}
-
-	// Sidebar toggle button shown when navigating regions.
-	.interface-interface-skeleton__sidebar {
-		.edit-post-layout__toggle-sidebar-panel {
-			outline: inherit;
-			outline-offset: inherit;
-		}
-	}
-
-	// Publish sidebar toggle button shown when navigating regions.
-	.interface-interface-skeleton__actions {
-		.edit-post-layout__toggle-publish-panel {
-			outline: inherit;
-			outline-offset: inherit;
-		}
-	}
-
-	// Publish sidebar.
-	[role="region"].interface-interface-skeleton__actions:focus  .editor-post-publish-panel {
+	&.is-distraction-free .interface-interface-skeleton__header .edit-post-header,
+	.interface-interface-skeleton__sidebar .edit-post-layout__toggle-sidebar-panel,
+	.interface-interface-skeleton__actions .edit-post-layout__toggle-publish-panel,
+	.editor-post-publish-panel {
 		outline: 4px solid $components-color-accent;
 		outline-offset: -4px;
 	}