diff --git a/scripts/fuzz_opt.py b/scripts/fuzz_opt.py
index 54c24be86a7..1b0ce447329 100755
--- a/scripts/fuzz_opt.py
+++ b/scripts/fuzz_opt.py
@@ -767,8 +767,10 @@ def can_compare_to_others(self):
                     D8(),
                     D8Liftoff(),
                     D8TurboFan(),
-                    Wasm2C(),
-                    Wasm2C2Wasm()]
+                    # TODO: Enable Wasm2C & Wasm2C2Wasm after #4723 issue resolved
+                    # Wasm2C(),
+                    # Wasm2C2Wasm()
+                    ]
 
     def handle_pair(self, input, before_wasm, after_wasm, opts):
         before = self.run_vms(before_wasm)