-
Notifications
You must be signed in to change notification settings - Fork 0
/
Copy pathresearch.html
381 lines (333 loc) · 23.2 KB
/
research.html
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
<!DOCTYPE html>
<html>
<head>
<!-- Standard Meta -->
<meta charset="utf-8" />
<meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1" />
<meta name="viewport" content="width=device-width, initial-scale=1.0, maximum-scale=1.0">
<!-- Site Properties -->
<title>MS Genetics</title>
<link rel="icon" href="favicon.ico?v=2" type="image/x-icon" />
<!-- Semantic UI -->
<link rel="stylesheet" type="text/css" href="semantic/components/reset.css">
<link rel="stylesheet" type="text/css" href="semantic/components/site.css">
<link rel="stylesheet" type="text/css" href="semantic/components/container.css">
<link rel="stylesheet" type="text/css" href="semantic/components/grid.css">
<link rel="stylesheet" type="text/css" href="semantic/components/header.css">
<link rel="stylesheet" type="text/css" href="semantic/components/image.css">
<link rel="stylesheet" type="text/css" href="semantic/components/menu.css">
<link rel="stylesheet" type="text/css" href="semantic/components/divider.css">
<link rel="stylesheet" type="text/css" href="semantic/components/dropdown.css">
<link rel="stylesheet" type="text/css" href="semantic/components/segment.css">
<link rel="stylesheet" type="text/css" href="semantic/components/button.css">
<link rel="stylesheet" type="text/css" href="semantic/components/list.css">
<link rel="stylesheet" type="text/css" href="semantic/components/icon.css">
<link rel="stylesheet" type="text/css" href="semantic/components/sidebar.css">
<link rel="stylesheet" type="text/css" href="semantic/components/transition.css">
<link rel="stylesheet" type="text/css" href="semantic/components/popup.css">
<link rel="stylesheet" type="text/css" href="semantic/components/modal.css">
<link rel="stylesheet" type="text/css" href="semantic/components/dimmer.css">
<link rel="stylesheet" type="text/css" href="css/custom.css">
<script src="https://ajax.googleapis.com/ajax/libs/jquery/1.12.0/jquery.min.js"></script>
<script src="semantic/components/visibility.js"></script>
<script src="semantic/components/sidebar.js"></script>
<script src="semantic/components/transition.js"></script>
<script src="semantic/components/popup.js"></script>
<script src="semantic/components/modal.js"></script>
<script src="semantic/components/dimmer.js"></script>
<!-- Custom -->
<script src="js/custom.js"></script>
<script src="js/research.js"></script>
<!-- google analytics -->
<script>
(function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){
(i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o),
m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m)
})(window,document,'script','//www.google-analytics.com/analytics.js','ga');
ga('create', 'UA-72792729-1', 'auto');
ga('send', 'pageview');
</script>
</head>
<body>
<!-- Following Menu -->
<div class="ui huge top fixed hidden menu following">
<div class="ui container">
<a class="item tabbed about-tab" href="index.html">About</a>
<a class="active item tabbed research-tab" href="research.html">Research</a>
<a class="item tabbed participate-tab" href="participate.html">Participate</a>
<a class="item tabbed publications-tab" href="publications.html">Publications</a>
<!-- <a class="item tabbed newsletter-tab">Newsletter</a>
<a class="item tabbed links-tab">Links</a> -->
<a class="item tabbed resources-tab" href="resources.html">Scientist Resources</a>
<a class="item tabbed our-lab-tab" href="our_lab.html">Our Lab</a>
</div>
</div>
<!-- Sidebar Menu -->
<div class="ui vertical inverted sidebar menu">
<a class="item tabbed about-tab" href="index.html">About</a>
<a class="active item tabbed research-tab" href="research.html">Research</a>
<a class="item tabbed participate-tab" href="participate.html">Participate</a>
<a class="item tabbed publications-tab" href="publications.html">Publications</a>
<!-- <a class="item tabbed newsletter-tab">Newsletter</a>
<a class="item tabbed links-tab">Links</a> -->
<a class="item tabbed resources-tab" href="resources.html">Scientist Resources</a>
<a class="item tabbed our-lab-tab" href="our_lab.html">Our Lab</a>
</div>
<!-- Page Contents -->
<div class="pusher" style="background-color: #FEFFFA">
<div class='content research-tab-content'>
<div class="ui container masthead">
<div class="ui huge secondary pointing menu plain-menu pointing" style=" border: none">
<a class="toc item">
<i class="sidebar icon"></i>
</a>
<a class="item tabbed about-tab" href="index.html">About</a>
<a class="active item tabbed research-tab" href="research.html">Research</a>
<a class="item tabbed participate-tab" href="participate.html">Participate</a>
<a class="item tabbed publications-tab" href="publications.html">Publications</a>
<!-- <a class="item tabbed newsletter-tab">Newsletter</a> -->
<!-- <a class="item tabbed links-tab">Useful Links</a> -->
<a class="item tabbed resources-tab" href="resources.html">Scientist Resources</a>
<a class="item tabbed our-lab-tab" href="our_lab.html">Our Lab</a>
</div>
</div>
<div class="ui vertical stripe segment">
<div class="ui middle aligned stackable grid container centered">
<div class="ui grid">
<div class='sixteen wide column'>
<h1 class="ui header">Studies open for enrollment</h1>
</div>
<div class='sixteen wide column'>
<div class='ui blue segment'>
<br>
<br>
<div class="ui grid">
<div class="eight wide column">
<div class='ui list'>
<div class="item"><h4><a class='research-link case-control' href="#case-control">Case/Control Study</a></h4></div>
<div class="item"><h4><a class='research-link multi-case' href="#multi-case">Multi-Case Family Study</a></h4></div>
<div class="item"><a class='research-link quartet' href="#quartet"><h4>Quartet Study</h4></a></div>
<div class="item"><a class='research-link twins' href="#twins"><h4>Twins Study</h4></a></div>
</div>
</div>
<div class="eight wide column">
<div class='ui list'>
<div class="item"><h4><a class='research-link arhms' href="#arhms">ARHMS (Alliance for Research in Hispanic MS) Study</a></h4></div>
<div class="item"><h4><a class='research-link african' href="#african">African American Study</a></h4></div>
<div class="item"><a class='research-link pediatric' href="#pediatric"><h4>Pediatric Study</h4></a></div>
<div class="item"><a class='research-link microbiome' href="#microbiome"><h4>Microbiome Study</h4></a></div>
</div>
</div>
</div>
<br>
<br>
</div>
<br>
</div>
<div class='sixteen wide column'>
<p class='justify'>Multiple sclerosis is the most common cause of non-traumatic neurological disability in young adults, affecting approximately 2.3 million people worldwide and more than 400,000 individuals in the US.</p>
<p class='justify'> In the last two decades MS related research has become one of the most productive areas of clinical neuroscience and has delivered remarkable progress on multiple fronts, including the identification of multiple DNA variants determining inherited risk, the deconstruction of the immunology underlying focal inflammatory demyelination, the unprecedented resolution of central nervous system imaging, and most notably, the development of an extensive repertoire of therapeutic agents capable of suppressing the relapsing aspects of disease.</p>
<p class='justify'>Due primarily to highly coordinated international efforts, the genetic underpinnings responsible for MS susceptibility have now been substantially clarified. There are, however, significant questions that remain to be answered to maximize the value of genetic research in MS, including the role of genetics in determining the clinical trajectory of the disease or the favorable response to treatment.</p>
<p class='justify'>To address these questions we build recent extraordinary developments in understanding the human genome, but more important, we relay on the cooperation of thousands of altruistic individuals who donate their blood to these experiments. The demonstration of even a modest functional effect of a known gene or group of genes on the course of MS has great potential to elucidate fundamental disease mechanisms that drive neurodegeneration and yield novel prognostic and therapeutic opportunities for progressive MS, the major unmet need in the field.
</p>
</div>
</div>
</div>
</div>
<div class="ui vertical stripe segment">
<div class='ui grid centered'>
<div class='twelve wide column'>
<h3 id='case-control'>Case/Control Study</h3>
</div>
<div class='twelve wide column'>
<p>It is important to study the genetic differences that exist between individuals with and without MS. In this study, we take advantage of the discovery of many hundreds of thousands of genetic markers scattered across the genome. The markers are of little or no functional consequence themselves, but do provide reliable and stable taggers to which we can return for additional analysis. If a gene of interest lies close to one of these signposts, we can compare that gene in MS patients and non-MS controls.</p>
<p> <a href="#" class='show-enrollment-case'>Show Enrollment Criteria</a></p>
<div class="ui modal case-control">
<div class="contents">
<div class='sixteen wide column right aligned'>
<a href="#" class='color-initial'><i class="remove icon large"></i></a>
</div>
<div class='ui grid centered'>
<div class="twelve wide column">
<h1 class='center color-red'> Case/Control Study </h1>
<h2> Enrollment Criteria </h2>
<p> Participation in this study will require a one-time donation of a blood sample from the individual with MS and, if available, a control. The control cannot be a family member but can be a spouse or friend. Preferably the control will be of the same ethnicity and approximately the same age as the individual with MS. This is a nationwide study; participation does not require that you live near San Francisco, CA.</p>
<p><strong>PLEASE NOTE: To be eligible, controls must not have MS or a family history of any autoimmune disease</strong></p>
<h4>To participate or request additional information, please complete our brief <a href="https://redcap.ucsf.edu/surveys/?s=849FYFLPA7" target="_blank">intake survey.</a></h4>
<p>OR you may contact us directly:</p>
<p>Toll Free Phone: 1-866-MS-Genes or (1-866-674-3637) </p>
<p>Email: <a href="mailto:[email protected]">[email protected]</a></p>
</div>
</div>
</div>
</div>
</div>
<div class='twelve wide column'>
<h3 id='multi-case'>Multi-Case Family Study</h3>
</div>
<div class='twelve wide column'>
<p>This study is for families in which multiple, living family members have been diagnosed with MS. Studies show that the risk of developing MS is about 1 in 750 to 1 in 1000 in the population. The risk of a sibling of a person with MS is 20 to 40 fold higher. The study of families with multiple-affected individuals allows us to identify genes, or clusters of genes, that two or more MS affected siblings have inherited in common. Families with an affected parent and an affected child are of particular interest.</p>
<p> <a href="#" class='show-enrollment-multi'>Show Enrollment Criteria</a></p>
<div class="ui modal case-multi">
<div class="contents">
<div class='sixteen wide column right aligned'>
<a href="#" class='color-initial'><i class="remove icon large"></i></a>
</div>
<div class='ui grid centered'>
<div class="twelve wide column">
<h1 class='center color-red'>Multi-Case Family Study</h1>
<h2> Enrollment Criteria </h2>
<p>We are asking for the donation of a blood sample from all affected siblings, unaffected siblings, and both parents. If not all of the individuals requested are able to participate, enrollment is still possible and will be discussed by phone.</p>
<h4>To participate or request additional information, please complete our brief <a href="https://redcap.ucsf.edu/surveys/?s=849FYFLPA7" target="_blanK">intake survey.</a></h4>
<p>OR you may contact us directly:</p>
<p>Toll Free Phone: 1-866-MS-Genes or (1-866-674-3637) </p>
<p>Email: <a href="mailto:[email protected]">[email protected]</a></p>
</div>
</div>
</div>
</div>
</div>
<div class='twelve wide column'>
<h3 id="quartet">Quartet Study</h3>
</div>
<div class='twelve wide column'>
<p>This study focuses on families with one parent with MS, one parent without MS, and an affected child. Our goal is to identify and characterize heritability patterns of genetic variants linked to risk from the affected and unaffected parent to the affected child.</p>
<p> <a href="#" class='show-enrollment-quartet'>Show Enrollment Criteria</a></p>
<div class="ui modal case-quartet">
<div class="contents">
<div class='sixteen wide column right aligned'>
<a href="#" class='color-initial'><i class="remove icon large"></i></a>
</div>
<div class='ui grid centered'>
<div class="twelve wide column">
<h1 class='center color-red'>Quartet Study</h1>
<h2> Enrollment Criteria </h2>
<p>We are asking for the donation of a blood sample from the affected and unaffected parents, affected and unaffected siblings. If not all of the individuals requested are able to participate, enrollment is still possible and will be discussed by phone.</p>
<h4>To participate or request additional information, please complete our brief <a href="https://redcap.ucsf.edu/surveys/?s=849FYFLPA7" target="_blanK">intake survey.</a></h4>
<p>OR you may contact us directly:</p>
<p>Toll Free Phone: 1-866-MS-Genes or (1-866-674-3637) </p>
<p>Email: <a href="mailto:[email protected]">[email protected]</a></p>
</div>
</div>
</div>
</div>
</div>
<div class='twelve wide column'>
<h3 id="arhms">ARHMS (Alliance for Research in Hispanic MS) Study</h3>
</div>
<div class='twelve wide column'>
<p>Despite MS now being increasingly diagnosed among the Hispanics and Latinos, few comprehensive studies exist. The ARHMS study is a newly formed consortium intended to bring scientists across multiple leading MS Centers with an interest in understanding the factors that drive MS risk and progression in the diverse US Hispanic population.</p>
<p> <a href="#" class='show-enrollment-arhms'>Show Enrollment Criteria</a></p>
<div class="ui modal case-arhms">
<div class="contents">
<div class='sixteen wide column right aligned'>
<a href="#" class='color-initial'><i class="remove icon large"></i></a>
</div>
<div class='ui grid centered'>
<div class="twelve wide column">
<h1 class='center color-red'>ARHMS (Alliance for Research in Hispanic MS) Study</h1>
<h2> Enrollment Criteria </h2>
<p> For individuals self-identify as Hispanic, we are asking for the donation of a blood sample from the individual with MS and non-MS controls.</p>
<h4>To participate or request additional information, please complete our brief <a href="https://redcap.ucsf.edu/surveys/?s=849FYFLPA7" target="_blanK">intake survey.</a></h4>
<p>OR you may contact us directly:</p>
<p>Toll Free Phone: 1-866-MS-Genes or (1-866-674-3637) </p>
<p>Email: <a href="mailto:[email protected]">[email protected]</a></p>
</div>
</div>
</div>
</div>
</div>
<div class='twelve wide column'>
<h3 id="african">African American Study</h3>
</div>
<div class='twelve wide column'>
<p>Multiple Sclerosis is a recognized disorder of African Americans, but the problem of MS in this community has not been adequately addressed since members of this group are thought to develop the disease less frequently than European Americans. Knowledge of ancestry is important in research studying diseases that behave differently in different ethnic groups. In fact, the study of populations with unique clinical, demographic, and/or historic characteristics has been shown to be extraordinarily informative in deciphering the genetics of cancer and other complex diseases, including MS.</p>
<p> <a href="#" class='show-enrollment-african'>Show Enrollment Criteria</a></p>
<div class="ui modal case-african">
<div class="contents">
<div class='sixteen wide column right aligned'>
<a href="#" class='color-initial'><i class="remove icon large"></i></a>
</div>
<div class='ui grid centered'>
<div class="twelve wide column">
<h1 class='center color-red'> African American Study</h1>
<h2> Enrollment Criteria </h2>
<p> For individuals who are African American, we are asking for the donation of a blood sample from the individual with MS and non-MS controls. It is not required, but the participation of certain family members is preferred as well.</p>
<h4>To participate or request additional information, please complete our brief <a href="https://redcap.ucsf.edu/surveys/?s=849FYFLPA7" target="_blanK">intake survey.</a></h4>
<p>OR you may contact us directly:</p>
<p>Toll Free Phone: 1-866-MS-Genes or (1-866-674-3637) </p>
<p>Email: <a href="mailto:[email protected]">[email protected]</a></p>
</div>
</div>
</div>
</div>
</div>
<div class='twelve wide column'>
<h3 id="twins">Twins Study</h3>
</div>
<div class='twelve wide column'>
<p>Monozygotic (identical) twins share 100% of their genetic identity. That is, their genes are identical and in the exact same order/combination, yet they only have a 30% disease concordance. Twin studies provide important clues about the role of non-genomic and environmental factors involved in MS. </p>
<p> <a href="#" class='show-enrollment-twins'>Show Enrollment Criteria</a></p>
<div class="ui modal case-twins">
<div class="contents">
<div class='sixteen wide column right aligned'>
<a href="#" class='color-initial'><i class="remove icon large"></i></a>
</div>
<div class='ui grid centered'>
<div class="twelve wide column">
<h1 class='center color-red'>Twins Study</h1>
<h2> Enrollment Criteria </h2>
<p> For individuals who are monozygotic (identical) twins where at least one has MS, we are asking for blood donations from affected and unaffected twins as well as an unaffected sibling. If no unaffected sibling is available, an unaffected 1st cousin will be asked to participate instead.</p>
<h4>To participate or request additional information, please complete our brief <a href="https://redcap.ucsf.edu/surveys/?s=849FYFLPA7" target="_blanK">intake survey.</a></h4>
<p>OR you may contact us directly:</p>
<p>Toll Free Phone: 1-866-MS-Genes or (1-866-674-3637) </p>
<p>Email: <a href="mailto:[email protected]">[email protected]</a></p>
</div>
</div>
</div>
</div>
</div>
<div class='twelve wide column'>
<h3 id="pediatric">Pediatric Study</h3>
</div>
<div class='twelve wide column'>
<p>Although the onset of multiple sclerosis usually occurs in young adulthood, approximately 5% of MS patients develop symptoms in childhood or adolescence. Currently, there is very limited literature concerning those who develop MS before 18 years of age. This means that the impact of the disease on neurologic function, cognition, academic achievement, and psychosocial adjustment in pediatric MS patients is relatively unknown. The primary goal of this investigation is to identify the underlying genetic causes of early onset MS. This study is in collaboration with the MS Pediatric Groups at UCSF and at the National Pediatric Center in Stony Brook, New York. Individuals interested in this study are referred to the UC San Francisco MS Pediatric Group.</p>
<p> <a href="http://www.ucsfchildrenshospital.org/clinics/multiple_sclerosis/index.html" target="_blank">For more information on how to participate, please visit the pediatric website.</a></p>
</div>
<div class='twelve wide column'>
<h3 id='microbiome'>Microbiome Study</h3>
</div>
<div class='twelve wide column'>
<p>The human body harbors more bacterial than human cells. Multiple families of these bacterial cells co-exist in a delicate equilibrium that is essential for maintaining a general state of well being. It has been recently shown that deviations from this equilibrium (caused by environmental effects, genetic causes or both) can result in disease. In this project we will study and compare the bacterial compositions present in the gut of MS patients at different stages of the disease and healthy individuals. These experiments will likely shed light on what are the beneficial and harmful microbial populations that associate with MS, and the possible mechanisms by which they can cause disease.</p>
<p> <a href="http://imsms.org/?page_id=227" target="_blank">For more information on how to participate, please visit the microbiome website.</a></p>
</div>
</div>
</div> <!-- end of research tab -->
</div> <!-- end of pusher -->
<div class="ui inverted vertical footer segment">
<div class="ui container">
<div class="ui stackable inverted divided equal height stackable grid">
<div class="three wide column">
<h4 class="ui inverted header">About</h4>
<div class="ui inverted link list">
<a href="mailto:[email protected]" class='item'>Contact Us</a>
</div>
</div>
<div class="seven wide column">
<h4 class="ui inverted header">Useful Links</h4>
<div class="ui inverted link list">
<a class='item' href="http://msgenes.ucsf.edu/">Multiple Sclerosis Genetics Research Laboratory</a>
<a class='item' href="http://neurology.ucsf.edu/">UCSF Department of Neurology</a>
<a class='item' href="http://multiplesclerosis.ucsf.edu/">UCSF Multiple Sclerosis Clinical Center</a>
<a class='item' href="http://www.nmss.org">National Multiple Sclerosis Society</a>
<a class='item' href="http://neurology.ucsf.edu/research/ms-bioscreen">MS Bioscreen</a>
</div>
</div>
<div class="six wide column right aligned">
<img src="images/logo.png" width="100px">
</div>
</div>
</div>
</div>
</body>
</html>