diff --git a/.github/workflows/ci-tests.yml b/.github/workflows/ci-tests.yml
index 4cdc3f5e94..2657e1e42a 100644
--- a/.github/workflows/ci-tests.yml
+++ b/.github/workflows/ci-tests.yml
@@ -3,7 +3,7 @@
 #   - https://github.com/actions/checkout
 #   - https://github.com/marketplace/actions/setup-miniconda
 
-name: ci-tests 
+name: ci-tests
 
 on:
   push:
diff --git a/.github/workflows/ci-wheels.yml b/.github/workflows/ci-wheels.yml
new file mode 100644
index 0000000000..265489883f
--- /dev/null
+++ b/.github/workflows/ci-wheels.yml
@@ -0,0 +1,166 @@
+# Reference:
+#   - https://github.com/actions/checkout
+#   - https://github.com/actions/download-artifact
+#   - https://github.com/actions/upload-artifact
+#   - https://github.com/pypa/build
+#   - https://github.com/pypa/gh-action-pypi-publish
+#   - https://test.pypi.org/help/#apitoken
+
+name: ci-wheels
+
+on:
+  pull_request:
+
+  push:
+    tags:
+      - "v*"
+    branches-ignore:
+      - "auto-update-lockfiles"
+      - "pre-commit-ci-update-config"
+      - "dependabot/*"
+
+concurrency:
+  group: ${{ github.workflow }}-${{ github.ref }}
+  cancel-in-progress: true
+
+jobs:
+  build:
+    name: "build sdist & wheel"
+    runs-on: ubuntu-latest
+    steps:
+    - uses: actions/checkout@v3
+      with:
+        fetch-depth: 0
+
+    - name: "building"
+      shell: bash
+      run: |
+        # require build with explicit --sdist and --wheel in order to
+        # get correct version associated with sdist and bdist artifacts
+        pipx run build --sdist --wheel
+
+    - uses: actions/upload-artifact@v3
+      with:
+        name: pypi-artifacts
+        path: ${{ github.workspace }}/dist/*
+
+  test-wheel:
+    needs: build
+    name: "test wheel (py${{ matrix.python-version }})"
+    runs-on: ubuntu-latest
+    defaults:
+      run:
+        shell: bash -l {0}
+    strategy:
+      fail-fast: false
+      matrix:
+        python-version: ["3.8", "3.9", "3.10"]
+        session: ["wheel"]
+    env:
+      ENV_NAME: "ci-wheels"
+    steps:
+    - uses: actions/checkout@v3
+      with:
+        fetch-depth: 0
+
+    - uses: actions/download-artifact@v3
+      with:
+        name: pypi-artifacts
+        path: ${{ github.workspace }}/dist
+
+    - name: "environment configure"
+      env:
+        # Maximum cache period (in weeks) before forcing a cache refresh.
+          CACHE_WEEKS: 2
+      run: |
+        echo "CACHE_PERIOD=$(date +%Y).$(expr $(date +%U) / ${CACHE_WEEKS})" >> ${GITHUB_ENV}
+        echo "LOCK_FILE=requirements/ci/nox.lock/py$(echo ${{ matrix.python-version }} | tr -d '.')-linux-64.lock" >> ${GITHUB_ENV}
+
+    - name: "conda package cache"
+      uses: ./.github/workflows/composite/conda-pkg-cache
+      with:
+        cache_build: 0
+        cache_period: ${{ env.CACHE_PERIOD }}
+        env_name: ${{ env.ENV_NAME }}
+
+    - name: "conda install"
+      uses: conda-incubator/setup-miniconda@v2
+      with:
+        miniforge-version: latest
+        channels: conda-forge,defaults
+        activate-environment: ${{ env.ENV_NAME }}
+        auto-update-conda: false
+        use-only-tar-bz2: true
+
+    - name: "conda environment cache"
+      uses: ./.github/workflows/composite/conda-env-cache
+      with:
+        cache_build: 0
+        cache_period: ${{ env.CACHE_PERIOD }}
+        env_name: ${{ env.ENV_NAME }}
+        install_packages: "nox pip"
+
+    - name: "nox cache"
+      uses: ./.github/workflows/composite/nox-cache
+      with:
+        cache_build: 0
+        env_name: ${{ env.ENV_NAME }}
+        lock_file: ${{ env.LOCK_FILE }}
+
+    - name: "nox install and test wheel"
+      env:
+        PY_VER: ${{ matrix.python-version }}
+      run: |
+        nox --session ${{ matrix.session }} -- --verbose
+
+  show-artifacts:
+    needs: build
+    name: "show artifacts"
+    runs-on: ubuntu-latest
+    steps:
+    - uses: actions/download-artifact@v3
+      with:
+        name: pypi-artifacts
+        path: ${{ github.workspace }}/dist
+
+    - shell: bash
+      run: |
+        ls -l ${{ github.workspace }}/dist
+
+  publish-artifacts-test-pypi:
+    needs: test-wheel
+    name: "publish to test.pypi"
+    runs-on: ubuntu-latest
+    # upload to Test PyPI for every commit on main branch
+    if: github.event_name == 'push' && github.event.ref == 'refs/heads/main'
+    steps:
+    - uses: actions/download-artifact@v3
+      with:
+        name: pypi-artifacts
+        path: ${{ github.workspace }}/dist
+
+    - uses: pypa/gh-action-pypi-publish@release/v1
+      with:
+        user: __token__
+        password: ${{ secrets.TEST_PYPI_API_TOKEN }}
+        repository_url: https://test.pypi.org/legacy/
+        skip_existing: true
+        print_hash: true
+
+  publish-artifacts-pypi:
+    needs: test-wheel
+    name: "publish to pypi"
+    runs-on: ubuntu-latest
+    # upload to PyPI for every tag starting with 'v'
+    if: github.event_name == 'push' && startsWith(github.event.ref, 'refs/tags/v')
+    steps:
+    - uses: actions/download-artifact@v3
+      with:
+        name: pypi-artifacts
+        path: ${{ github.workspace }}/dist
+
+    - uses: pypa/gh-action-pypi-publish@release/v1
+      with:
+        user: __token__
+        password: ${{ secrets.PYPI_API_TOKEN }}
+        print_hash: true
\ No newline at end of file
diff --git a/.readthedocs.yml b/.readthedocs.yml
index 8ec8ab145c..58d5b26769 100644
--- a/.readthedocs.yml
+++ b/.readthedocs.yml
@@ -6,6 +6,9 @@ build:
     python: mambaforge-4.10
   jobs:
     post_checkout:
+      # The SciTools/iris repository is shallow i.e., has a .git/shallow,
+      # therefore complete the repository with a full history in order
+      # to allow setuptools-scm to correctly auto-discover the version.
       - git fetch --unshallow
       - git fetch --all
 
diff --git a/MANIFEST.in b/MANIFEST.in
index 81d7165199..ad28df9c7c 100644
--- a/MANIFEST.in
+++ b/MANIFEST.in
@@ -1,15 +1,13 @@
 # Top-level files
 include CHANGES COPYING COPYING.LESSER
+prune .github
+exclude .gitignore
 
-# Files from setup.py package_data that are not automatically added to source distributions
-recursive-include lib/iris/tests/results *.cml *.cdl *.txt *.xml *.json
-recursive-include lib/iris/etc *
-include lib/iris/tests/stock/file_headers/*
-
+# Files required for conda package management
 recursive-include requirements *
 
-# File required to build docs
-recursive-include docs Makefile *.js *.png *.py *.rst
+# Files required to build docs
+recursive-include docs *
 prune docs/src/_build
 prune docs/src/generated
 prune docs/gallery_tests
@@ -18,7 +16,5 @@ prune docs/gallery_tests
 include tools/generate_std_names.py
 include etc/cf-standard-name-table.xml
 
-global-exclude *.pyc
-global-exclude __pycache__
-global-exclude iris_image_test_output
-exclude lib/iris/_version.py
\ No newline at end of file
+global-exclude *.py[cod]
+global-exclude __pycache__
\ No newline at end of file
diff --git a/docs/src/conf.py b/docs/src/conf.py
index 4f1eae7403..6b11e83a8c 100644
--- a/docs/src/conf.py
+++ b/docs/src/conf.py
@@ -89,7 +89,9 @@ def autolog(message):
 version = get_version("scitools-iris")
 if version.endswith("+dirty"):
     version = version[: -len("+dirty")]
+release = version
 autolog(f"Iris Version = {version}")
+autolog(f"Iris Release = {release}")
 
 # -- General configuration ---------------------------------------------------
 
diff --git a/docs/src/developers_guide/release.rst b/docs/src/developers_guide/release.rst
index 182ab482b3..25a426e20b 100644
--- a/docs/src/developers_guide/release.rst
+++ b/docs/src/developers_guide/release.rst
@@ -123,6 +123,14 @@ conda package on the `conda-forge Anaconda channel`_.
 Update PyPI
 -----------
 
+.. note::
+
+  As part of our Continuous-Integration (CI), the building and publishing of
+  PyPI artifacts is now automated by a dedicated GitHub Action.
+  
+  The following instructions **no longer** require to be performed manually,
+  but remain part of the documentation for reference purposes only.
+
 Update the `scitools-iris`_ project on PyPI with the latest Iris release.
 
 To do this perform the following steps.
diff --git a/docs/src/whatsnew/latest.rst b/docs/src/whatsnew/latest.rst
index 761833ba15..7ff731d4cb 100644
--- a/docs/src/whatsnew/latest.rst
+++ b/docs/src/whatsnew/latest.rst
@@ -254,6 +254,9 @@ This document explains the changes made to Iris for this release
 #. `@bjlittle`_ and `@trexfeathers`_ (reviewer) adopted `setuptools-scm`_ for
    automated ``iris`` package versioning. (:pull:`4841`)
 
+#. `@bjlittle`_ and `@trexfeathers`_ (reviewer) added building, testing and
+   publishing of ``iris`` PyPI ``sdist`` and binary ``wheels`` as part of
+   our GitHub Continuous-Integration. (:pull`4849`)
 
 .. comment
     Whatsnew author names (@github name) in alphabetical order. Note that,
diff --git a/noxfile.py b/noxfile.py
index 2b1df8fb00..8aabf862fb 100755
--- a/noxfile.py
+++ b/noxfile.py
@@ -271,6 +271,36 @@ def linkcheck(session: nox.sessions.Session):
     )
 
 
+@nox.session(python=PY_VER, venv_backend="conda")
+def wheel(session: nox.sessions.Session):
+    """
+    Perform iris local wheel install and import test.
+
+    Parameters
+    ----------
+    session: object
+        A `nox.sessions.Session` object.
+
+    """
+    prepare_venv(session)
+    session.cd("dist")
+    fname = list(Path(".").glob("scitools_iris-*.whl"))
+    if len(fname) == 0:
+        raise ValueError("Cannot find wheel to install.")
+    if len(fname) > 1:
+        emsg = (
+            f"Expected to find 1 wheel to install, found {len(fname)} instead."
+        )
+        raise ValueError(emsg)
+    session.install(fname[0].name)
+    session.run(
+        "python",
+        "-c",
+        "import iris; print(f'{iris.__version__=}')",
+        external=True,
+    )
+
+
 @nox.session
 @nox.parametrize(
     "run_type",
diff --git a/setup.cfg b/setup.cfg
index 66e865572e..a60d107835 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -54,7 +54,7 @@ install_requires =
     numpy>=1.19
     scipy
     xxhash
-packages = find:
+packages = find_namespace:
 package_dir =
     =lib
 python_requires =