diff --git a/.github/workflows/ci-tests.yml b/.github/workflows/ci-tests.yml
index 9277451efd..4cdc3f5e94 100644
--- a/.github/workflows/ci-tests.yml
+++ b/.github/workflows/ci-tests.yml
@@ -35,9 +35,12 @@ jobs:
       fail-fast: false
       matrix:
         os: ["ubuntu-latest"]
-        python-version: ["3.9"]
+        python-version: ["3.10"]
         session: ["tests", "doctest", "gallery", "linkcheck"]
         include:
+          - os: "ubuntu-latest"
+            python-version: "3.9"
+            session: "tests"
           - os: "ubuntu-latest"
             python-version: "3.8"
             session: "tests"
diff --git a/.github/workflows/refresh-lockfiles.yml b/.github/workflows/refresh-lockfiles.yml
index e817131c5e..72b330c815 100644
--- a/.github/workflows/refresh-lockfiles.yml
+++ b/.github/workflows/refresh-lockfiles.yml
@@ -33,7 +33,7 @@ jobs:
     steps:
       - uses: actions/checkout@v3
       - id: get_py
-        run: echo "::set-output name=matrix::$(ls -1 requirements/ci/py??.yml | xargs -n1 basename | sed 's/....$//' | jq -cnR '[inputs]')"
+        run: echo "::set-output name=matrix::$(ls -1 requirements/ci/py*.yml | xargs -n1 basename | sed 's/....$//' | jq -cnR '[inputs]')"
 
   gen_lockfiles:
     # this is a matrix job: it splits to create new lockfiles for each
diff --git a/lib/iris/coords.py b/lib/iris/coords.py
index d176a0bb20..48fabfaf64 100644
--- a/lib/iris/coords.py
+++ b/lib/iris/coords.py
@@ -1345,7 +1345,24 @@ def __add__(self, mod):
         return Cell(point, bound)
 
     def __hash__(self):
-        return super().__hash__()
+        # Required for >py39 and >np1.22.x due to changes in Cell behaviour for
+        # point=np.nan, as calling super().__hash__() returns a different
+        # hash and thus does not trigger the following call to Cell.__eq__
+        # to determine equality.
+        # Note that, no explicit Cell bound nan check is performed here.
+        # That is delegated to Cell.__eq__ instead. It's imperative we keep
+        # Cell.__hash__ light-weight to minimise performance degradation.
+        # Reference:
+        #   - https://bugs.python.org/issue43475
+        #   - https://github.com/numpy/numpy/issues/18833
+        #   - https://github.com/numpy/numpy/pull/18908
+        #   - https://github.com/numpy/numpy/issues/21210
+
+        try:
+            point = "nan" if np.isnan(self.point) else self.point
+        except TypeError:
+            point = self.point
+        return hash((point,))
 
     def __eq__(self, other):
         """
diff --git a/requirements/ci/iris.yml b/requirements/ci/iris.yml
index 26a7748cce..1e473d36d5 120000
--- a/requirements/ci/iris.yml
+++ b/requirements/ci/iris.yml
@@ -1 +1 @@
-py39.yml
\ No newline at end of file
+py310.yml
\ No newline at end of file
diff --git a/requirements/ci/nox.lock/py310-linux-64.lock b/requirements/ci/nox.lock/py310-linux-64.lock
new file mode 100644
index 0000000000..1b1c973e15
--- /dev/null
+++ b/requirements/ci/nox.lock/py310-linux-64.lock
@@ -0,0 +1,254 @@
+# Generated by conda-lock.
+# platform: linux-64
+# input_hash: 6e4ca9b4ac3d61e97093bdf528ea99b9569aafeab377acd24324cf6d63069a97
+@EXPLICIT
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+https://conda.anaconda.org/conda-forge/linux-64/pango-1.50.7-hbd2fdc8_0.tar.bz2#1cff4bab8ed133d59b7c22fe7bf09263
+https://conda.anaconda.org/conda-forge/noarch/pyopenssl-22.0.0-pyhd8ed1ab_0.tar.bz2#1d7e241dfaf5475e893d4b824bb71b44
+https://conda.anaconda.org/conda-forge/linux-64/pyqt5-sip-12.9.0-py310hd8f1fbe_1.tar.bz2#21ae1ac216cfc85e24dc7c09570ddf31
+https://conda.anaconda.org/conda-forge/noarch/pytest-forked-1.4.0-pyhd8ed1ab_0.tar.bz2#95286e05a617de9ebfe3246cecbfb72f
+https://conda.anaconda.org/conda-forge/linux-64/qt-main-5.15.4-ha5833f6_2.tar.bz2#dd3aa6715b9e9efaf842febf18ce4261
+https://conda.anaconda.org/conda-forge/linux-64/cartopy-0.20.2-py310hb408dcc_6.tar.bz2#69abe28e5da19c0bc7efc798ecd86a27
+https://conda.anaconda.org/conda-forge/linux-64/esmpy-8.2.0-mpi_mpich_py310hd9c82d4_101.tar.bz2#0333d51ee594be40f50b157ac6f27b5a
+https://conda.anaconda.org/conda-forge/linux-64/gtk2-2.24.33-h90689f9_2.tar.bz2#957a0255ab58aaf394a91725d73ab422
+https://conda.anaconda.org/conda-forge/linux-64/librsvg-2.54.3-h7abd40a_0.tar.bz2#02b82b1dc4e876242900dcaff109e697
+https://conda.anaconda.org/conda-forge/noarch/nc-time-axis-1.4.1-pyhd8ed1ab_0.tar.bz2#281b58948bf60a2582de9e548bcc5369
+https://conda.anaconda.org/conda-forge/linux-64/pre-commit-2.19.0-py310hff52083_0.tar.bz2#bcf63938923fd8c16c684a4e7157b062
+https://conda.anaconda.org/conda-forge/linux-64/pyqt-5.15.4-py310h29803b5_1.tar.bz2#d34f0b4c9ad5705d0ffe501d5d8aa26f
+https://conda.anaconda.org/conda-forge/noarch/pytest-xdist-2.5.0-pyhd8ed1ab_0.tar.bz2#1fdd1f3baccf0deb647385c677a1a48e
+https://conda.anaconda.org/conda-forge/noarch/urllib3-1.26.9-pyhd8ed1ab_0.tar.bz2#0ea179ee251aa7100807c35bc0252693
+https://conda.anaconda.org/conda-forge/linux-64/graphviz-4.0.0-h5abf519_0.tar.bz2#970a4e3632a3c2f27f1860600f2f5fb5
+https://conda.anaconda.org/conda-forge/linux-64/matplotlib-3.5.2-py310hff52083_0.tar.bz2#0b90a9f77544f943264d47677d63ac9e
+https://conda.anaconda.org/conda-forge/noarch/requests-2.28.0-pyhd8ed1ab_1.tar.bz2#5db4d14905f98da161e2153b1c9d2bce
+https://conda.anaconda.org/conda-forge/noarch/sphinx-4.5.0-pyh6c4a22f_0.tar.bz2#46b38d88c4270ff9ba78a89c83c66345
+https://conda.anaconda.org/conda-forge/noarch/pydata-sphinx-theme-0.8.1-pyhd8ed1ab_0.tar.bz2#7d8390ec71225ea9841b276552fdffba
+https://conda.anaconda.org/conda-forge/noarch/sphinx-copybutton-0.5.0-pyhd8ed1ab_0.tar.bz2#4c969cdd5191306c269490f7ff236d9c
+https://conda.anaconda.org/conda-forge/noarch/sphinx-gallery-0.10.1-pyhd8ed1ab_0.tar.bz2#4918585fe5e5341740f7e63c61743efb
+https://conda.anaconda.org/conda-forge/noarch/sphinx-panels-0.6.0-pyhd8ed1ab_0.tar.bz2#6eec6480601f5d15babf9c3b3987f34a
diff --git a/requirements/ci/nox.lock/py38-linux-64.lock b/requirements/ci/nox.lock/py38-linux-64.lock
index 39a203a241..e563cf9695 100644
--- a/requirements/ci/nox.lock/py38-linux-64.lock
+++ b/requirements/ci/nox.lock/py38-linux-64.lock
@@ -97,7 +97,7 @@ https://conda.anaconda.org/conda-forge/linux-64/libpng-1.6.37-h21135ba_2.tar.bz2
 https://conda.anaconda.org/conda-forge/linux-64/libssh2-1.10.0-ha56f1ee_2.tar.bz2#6ab4eaa11ff01801cffca0a27489dc04
 https://conda.anaconda.org/conda-forge/linux-64/libtiff-4.4.0-hc85c160_1.tar.bz2#151f9fae3ab50f039c8735e47770aa2d
 https://conda.anaconda.org/conda-forge/linux-64/libxml2-2.9.14-h22db469_0.tar.bz2#7d623237b73d93dd856b5dd0f5fedd6b
-https://conda.anaconda.org/conda-forge/linux-64/libzip-1.8.0-h4de3113_1.tar.bz2#175a746a43d42c053b91aa765fbc197d
+https://conda.anaconda.org/conda-forge/linux-64/libzip-1.9.2-hc869a4a_0.tar.bz2#2d9e11c1183391882e95fec81d0d71c8
 https://conda.anaconda.org/conda-forge/linux-64/mysql-libs-8.0.29-h28c427c_1.tar.bz2#36dbdbf505b131c7e79a3857f3537185
 https://conda.anaconda.org/conda-forge/linux-64/sqlite-3.39.0-h4ff8645_0.tar.bz2#ead30581ba8cfd52d69632868b844d4a
 https://conda.anaconda.org/conda-forge/linux-64/xcb-util-0.4.0-h166bdaf_0.tar.bz2#384e7fcb3cd162ba3e4aed4b687df566
@@ -206,7 +206,7 @@ https://conda.anaconda.org/conda-forge/linux-64/cryptography-37.0.2-py38h2b5fc30
 https://conda.anaconda.org/conda-forge/noarch/dask-core-2022.6.1-pyhd8ed1ab_0.tar.bz2#69655c7e78034d4293130f5a5ecf7421
 https://conda.anaconda.org/conda-forge/linux-64/fonttools-4.33.3-py38h0a891b7_0.tar.bz2#fd11badf5b3f7d738cc983cb2c75946e
 https://conda.anaconda.org/conda-forge/linux-64/gst-plugins-base-1.20.3-hf6a322e_0.tar.bz2#6ea2ce6265c3207876ef2369b7479f08
-https://conda.anaconda.org/conda-forge/linux-64/harfbuzz-4.3.0-hf9f4e7c_0.tar.bz2#2a9c6660562d7e3fdeda0f0159e1046d
+https://conda.anaconda.org/conda-forge/linux-64/harfbuzz-4.4.0-hf9f4e7c_0.tar.bz2#dbb42a46de29a600e71952dfdabfba7e
 https://conda.anaconda.org/conda-forge/noarch/jinja2-3.1.2-pyhd8ed1ab_1.tar.bz2#c8490ed5c70966d232fdd389d0dbed37
 https://conda.anaconda.org/conda-forge/linux-64/mo_pack-0.2.0-py38h71d37f0_1007.tar.bz2#c8d3d8f137f8af7b1daca318131223b1
 https://conda.anaconda.org/conda-forge/linux-64/netcdf-fortran-4.5.4-mpi_mpich_h1364a43_0.tar.bz2#b6ba4f487ef9fd5d353ff277df06d133
diff --git a/requirements/ci/nox.lock/py39-linux-64.lock b/requirements/ci/nox.lock/py39-linux-64.lock
index a32ca66ce5..6b8194e37f 100644
--- a/requirements/ci/nox.lock/py39-linux-64.lock
+++ b/requirements/ci/nox.lock/py39-linux-64.lock
@@ -98,7 +98,7 @@ https://conda.anaconda.org/conda-forge/linux-64/libpng-1.6.37-h21135ba_2.tar.bz2
 https://conda.anaconda.org/conda-forge/linux-64/libssh2-1.10.0-ha56f1ee_2.tar.bz2#6ab4eaa11ff01801cffca0a27489dc04
 https://conda.anaconda.org/conda-forge/linux-64/libtiff-4.4.0-hc85c160_1.tar.bz2#151f9fae3ab50f039c8735e47770aa2d
 https://conda.anaconda.org/conda-forge/linux-64/libxml2-2.9.14-h22db469_0.tar.bz2#7d623237b73d93dd856b5dd0f5fedd6b
-https://conda.anaconda.org/conda-forge/linux-64/libzip-1.8.0-h4de3113_1.tar.bz2#175a746a43d42c053b91aa765fbc197d
+https://conda.anaconda.org/conda-forge/linux-64/libzip-1.9.2-hc869a4a_0.tar.bz2#2d9e11c1183391882e95fec81d0d71c8
 https://conda.anaconda.org/conda-forge/linux-64/mysql-libs-8.0.29-h28c427c_1.tar.bz2#36dbdbf505b131c7e79a3857f3537185
 https://conda.anaconda.org/conda-forge/linux-64/sqlite-3.39.0-h4ff8645_0.tar.bz2#ead30581ba8cfd52d69632868b844d4a
 https://conda.anaconda.org/conda-forge/linux-64/xcb-util-0.4.0-h166bdaf_0.tar.bz2#384e7fcb3cd162ba3e4aed4b687df566
@@ -207,7 +207,7 @@ https://conda.anaconda.org/conda-forge/linux-64/cryptography-37.0.2-py39hd97740a
 https://conda.anaconda.org/conda-forge/noarch/dask-core-2022.6.1-pyhd8ed1ab_0.tar.bz2#69655c7e78034d4293130f5a5ecf7421
 https://conda.anaconda.org/conda-forge/linux-64/fonttools-4.33.3-py39hb9d737c_0.tar.bz2#43f3c538bbcf6ed0da225891e11bf0a8
 https://conda.anaconda.org/conda-forge/linux-64/gst-plugins-base-1.20.3-hf6a322e_0.tar.bz2#6ea2ce6265c3207876ef2369b7479f08
-https://conda.anaconda.org/conda-forge/linux-64/harfbuzz-4.3.0-hf9f4e7c_0.tar.bz2#2a9c6660562d7e3fdeda0f0159e1046d
+https://conda.anaconda.org/conda-forge/linux-64/harfbuzz-4.4.0-hf9f4e7c_0.tar.bz2#dbb42a46de29a600e71952dfdabfba7e
 https://conda.anaconda.org/conda-forge/noarch/jinja2-3.1.2-pyhd8ed1ab_1.tar.bz2#c8490ed5c70966d232fdd389d0dbed37
 https://conda.anaconda.org/conda-forge/linux-64/mo_pack-0.2.0-py39hd257fcd_1007.tar.bz2#e7527bcf8da0dad996aaefd046c17480
 https://conda.anaconda.org/conda-forge/linux-64/netcdf-fortran-4.5.4-mpi_mpich_h1364a43_0.tar.bz2#b6ba4f487ef9fd5d353ff277df06d133
diff --git a/requirements/ci/py310.yml b/requirements/ci/py310.yml
new file mode 100644
index 0000000000..02deb5525f
--- /dev/null
+++ b/requirements/ci/py310.yml
@@ -0,0 +1,49 @@
+name: iris-dev
+
+channels:
+  - conda-forge
+
+dependencies:
+  - python =3.10
+
+# Setup dependencies.
+  - setuptools >=40.8.0
+
+# Core dependencies.
+  - cartopy >=0.20
+  - cf-units >=3
+  - cftime >=1.5
+  - dask-core >=2
+  - matplotlib
+  - netcdf4
+  - numpy >=1.19
+  - python-xxhash
+  - pyproj
+  - scipy
+
+# Optional dependencies.
+  - esmpy >=7.0
+  - graphviz
+  - iris-sample-data >=2.4.0
+  - mo_pack
+  - nc-time-axis >=1.4
+  - pandas
+  - pip
+  - python-stratify
+
+# Test dependencies.
+  - filelock
+  - imagehash >=4.0
+  - pre-commit
+  - psutil
+  - pytest
+  - pytest-xdist
+  - requests
+
+# Documentation dependencies.
+  - sphinx
+  - sphinxcontrib-napoleon
+  - sphinx-copybutton
+  - sphinx-gallery
+  - sphinx-panels
+  - pydata-sphinx-theme = 0.8.1