diff --git a/scripts/cmake/z_vcpkg_fixup_rpath_macho.cmake b/scripts/cmake/z_vcpkg_fixup_rpath_macho.cmake
index d8be25bd9c65b3..57eba48016b5f9 100644
--- a/scripts/cmake/z_vcpkg_fixup_rpath_macho.cmake
+++ b/scripts/cmake/z_vcpkg_fixup_rpath_macho.cmake
@@ -127,7 +127,9 @@ function(z_vcpkg_fixup_macho_rpath_in_dir)
                     continue()
                 endif()
 
-                string(REGEX REPLACE "${macho_file}:\n" "" get_id_ov "${get_id_ov}")
+                # Escape regex special characters
+                string(REGEX REPLACE "([][+.*()^])" "\\\\\\1" regex "${macho_file}")
+                string(REGEX REPLACE "${regex}:\n" "" get_id_ov "${get_id_ov}")
                 string(REGEX REPLACE "\n.*" "" get_id_ov "${get_id_ov}")
                 list(APPEND adjusted_shared_lib_old_ids "${get_id_ov}")
                 list(APPEND adjusted_shared_lib_new_ids "${macho_new_id}")
@@ -189,7 +191,8 @@ function(z_vcpkg_fixup_macho_rpath_in_dir)
             endif()
             foreach(i RANGE ${last_adjusted_index})
                 list(GET adjusted_shared_lib_old_ids ${i} adjusted_old_id)
-                if(NOT get_deps_ov MATCHES "[ \t]${adjusted_old_id} ")
+                string(REGEX REPLACE "([][+.*()^])" "\\\\\\1" regex "${adjusted_old_id}")
+                if(NOT get_deps_ov MATCHES "[ \t]${regex} ")
                     continue()
                 endif()
                 list(GET adjusted_shared_lib_new_ids ${i} adjusted_new_id)