diff --git a/src/coreclr/jit/flowgraph.cpp b/src/coreclr/jit/flowgraph.cpp
index b319fa2be39418..47a8c243a2e9e6 100644
--- a/src/coreclr/jit/flowgraph.cpp
+++ b/src/coreclr/jit/flowgraph.cpp
@@ -1061,14 +1061,26 @@ GenTree* Compiler::fgOptimizeDelegateConstructor(GenTreeCall*            call,
                 else
                 {
                     assert(oper != GT_FTN_ADDR);
-                    CORINFO_CONST_LOOKUP genericLookup;
-                    info.compCompHnd->getReadyToRunHelper(&ldftnToken->m_token, &pLookup.lookupKind,
-                                                          CORINFO_HELP_READYTORUN_GENERIC_HANDLE, info.compMethodHnd,
-                                                          &genericLookup);
-                    GenTree* ctxTree = getRuntimeContextTree(pLookup.lookupKind.runtimeLookupKind);
-                    call             = gtNewHelperCallNode(CORINFO_HELP_READYTORUN_DELEGATE_CTOR, TYP_VOID, thisPointer,
-                                                           targetObjPointers, ctxTree);
-                    call->setEntryPoint(genericLookup);
+
+                    if (pLookup.lookupKind.runtimeLookupKind != CORINFO_LOOKUP_NOT_SUPPORTED)
+                    {
+                        CORINFO_CONST_LOOKUP genericLookup;
+                        info.compCompHnd->getReadyToRunHelper(&ldftnToken->m_token, &pLookup.lookupKind,
+                                                              CORINFO_HELP_READYTORUN_GENERIC_HANDLE,
+                                                              info.compMethodHnd, &genericLookup);
+                        GenTree* ctxTree = getRuntimeContextTree(pLookup.lookupKind.runtimeLookupKind);
+                        call = gtNewHelperCallNode(CORINFO_HELP_READYTORUN_DELEGATE_CTOR, TYP_VOID, thisPointer,
+                                                   targetObjPointers, ctxTree);
+                        call->setEntryPoint(genericLookup);
+                    }
+                    else
+                    {
+                        // Runtime does not support inlining of all shapes of runtime lookups
+                        // Inlining has to be aborted in such a case
+                        assert(compIsForInlining());
+                        compInlineResult->NoteFatal(InlineObservation::CALLSITE_GENERIC_DICTIONARY_LOOKUP);
+                        JITDUMP("not optimized, generic inlining restriction\n");
+                    }
                 }
             }
             else
diff --git a/src/coreclr/jit/importercalls.cpp b/src/coreclr/jit/importercalls.cpp
index c3ba433be4d3f2..89f33319c8120a 100644
--- a/src/coreclr/jit/importercalls.cpp
+++ b/src/coreclr/jit/importercalls.cpp
@@ -1005,6 +1005,10 @@ var_types Compiler::impImportCall(OPCODE                  opcode,
                 // New inliner morph it in impImportCall.
                 // This will allow us to inline the call to the delegate constructor.
                 call = fgOptimizeDelegateConstructor(call->AsCall(), &exactContextHnd, ldftnInfo);
+                if (compDonotInline())
+                {
+                    return TYP_UNDEF;
+                }
             }
 
             if (!bIntrinsicImported)
diff --git a/src/coreclr/tools/aot/ILCompiler.RyuJit/JitInterface/CorInfoImpl.RyuJit.cs b/src/coreclr/tools/aot/ILCompiler.RyuJit/JitInterface/CorInfoImpl.RyuJit.cs
index 2e4013c9081bb5..46e3b1af0e4628 100644
--- a/src/coreclr/tools/aot/ILCompiler.RyuJit/JitInterface/CorInfoImpl.RyuJit.cs
+++ b/src/coreclr/tools/aot/ILCompiler.RyuJit/JitInterface/CorInfoImpl.RyuJit.cs
@@ -436,10 +436,17 @@ private void getReadyToRunDelegateCtorHelper(ref CORINFO_RESOLVED_TOKEN pTargetM
             {
                 pLookup.lookupKind.needsRuntimeLookup = true;
 
-                MethodDesc contextMethod = HandleToObject(callerHandle);
-                pLookup.lookupKind.runtimeLookupKind = GetGenericRuntimeLookupKind(contextMethod);
-                pLookup.lookupKind.runtimeLookupFlags = (ushort)ReadyToRunHelperId.DelegateCtor;
-                pLookup.lookupKind.runtimeLookupArgs = (void*)ObjectToHandle(delegateInfo);
+                if (pTargetMethod.tokenContext != contextFromMethodBeingCompiled())
+                {
+                    pLookup.lookupKind.runtimeLookupKind = CORINFO_RUNTIME_LOOKUP_KIND.CORINFO_LOOKUP_NOT_SUPPORTED;
+                }
+                else
+                {
+                    MethodDesc contextMethod = HandleToObject(callerHandle);
+                    pLookup.lookupKind.runtimeLookupKind = GetGenericRuntimeLookupKind(contextMethod);
+                    pLookup.lookupKind.runtimeLookupFlags = (ushort)ReadyToRunHelperId.DelegateCtor;
+                    pLookup.lookupKind.runtimeLookupArgs = (void*)ObjectToHandle(delegateInfo);
+                }
             }
             else
             {
diff --git a/src/tests/nativeaot/SmokeTests/UnitTests/Generics.cs b/src/tests/nativeaot/SmokeTests/UnitTests/Generics.cs
index f362c08d424649..5df11edec24563 100644
--- a/src/tests/nativeaot/SmokeTests/UnitTests/Generics.cs
+++ b/src/tests/nativeaot/SmokeTests/UnitTests/Generics.cs
@@ -56,6 +56,7 @@ internal static int Run()
         TestRecursionInFields.Run();
         TestGvmLookupDependency.Run();
         Test99198Regression.Run();
+        Test102259Regression.Run();
         TestInvokeMemberCornerCaseInGenerics.Run();
         TestRefAny.Run();
         TestNullableCasting.Run();
@@ -3555,6 +3556,26 @@ public static void Run()
         }
     }
 
+    class Test102259Regression
+    {
+        class Gen<T>
+        {
+            static Func<T, object> _theval;
+
+            public static object TheFunc(object obj) => obj;
+
+            static Gen()
+            {
+                _theval = typeof(Gen<T>).GetMethod(nameof(TheFunc), BindingFlags.Public | BindingFlags.Static).CreateDelegate<Func<T, object>>().WithObjectTResult();
+            }
+        }
+
+        public static void Run()
+        {
+            new Gen<object>();
+        }
+    }
+
     class TestInvokeMemberCornerCaseInGenerics
     {
         class Generic<T>
@@ -3601,3 +3622,16 @@ public static void Run()
         }
     }
 }
+
+static class Ext
+{
+    public static Func<T, object> WithObjectTResult<T, TResult>(this Func<T, TResult> function)
+    {
+        return function.InvokeWithObjectTResult;
+    }
+
+    private static object InvokeWithObjectTResult<T, TResult>(this Func<T, TResult> func, T arg)
+    {
+        return func(arg);
+    }
+}