diff --git a/.changeset/prevent-whitespace-saving.md b/.changeset/prevent-whitespace-saving.md
new file mode 100644
index 0000000000000..8dabee58dbd17
--- /dev/null
+++ b/.changeset/prevent-whitespace-saving.md
@@ -0,0 +1,5 @@
+---
+"@rocket.chat/meteor": patch
+---
+
+Prevent saving whitespace-only changes in nickname and bio and other fields in profile section
diff --git a/apps/meteor/client/views/account/profile/AccountProfileForm.tsx b/apps/meteor/client/views/account/profile/AccountProfileForm.tsx
index 74eef8f84754b..69537e886c4ad 100644
--- a/apps/meteor/client/views/account/profile/AccountProfileForm.tsx
+++ b/apps/meteor/client/views/account/profile/AccountProfileForm.tsx
@@ -35,7 +35,7 @@ import { getUserEmailAddress } from '../../../../lib/getUserEmailAddress';
 import UserStatusMenu from '../../../components/UserStatusMenu';
 import UserAvatarEditor from '../../../components/avatar/UserAvatarEditor';
 import { useUpdateAvatar } from '../../../hooks/useUpdateAvatar';
-import { USER_STATUS_TEXT_MAX_LENGTH, BIO_TEXT_MAX_LENGTH } from '../../../lib/constants';
+import { USER_STATUS_TEXT_MAX_LENGTH } from '../../../lib/constants';
 
 const AccountProfileForm = (props: AllHTMLAttributes<HTMLFormElement>): ReactElement => {
 	const t = useTranslation();
@@ -110,16 +110,23 @@ const AccountProfileForm = (props: AllHTMLAttributes<HTMLFormElement>): ReactEle
 	const updateAvatar = useUpdateAvatar(avatar, user?._id || '');
 
 	const handleSave = async ({ email, name, username, statusType, statusText, nickname, bio, customFields }: AccountProfileFormValues) => {
+		const trimmedName = name.trim();
+		const trimmedUsername = username.trim();
+		const trimmedEmail = email.trim();
+		const trimmedStatusText = statusText?.trim() ?? '';
+		const trimmedNickname = nickname?.trim() ?? '';
+		const trimmedBio = bio?.trim() ?? '';
+
 		try {
 			await updateOwnBasicInfo({
 				data: {
-					name,
-					...(user ? getUserEmailAddress(user) !== email && { email } : {}),
-					username,
-					statusText,
+					name: trimmedName,
+					...(user ? getUserEmailAddress(user) !== trimmedEmail && { email: trimmedEmail } : {}),
+					username: trimmedUsername,
+					statusText: trimmedStatusText,
 					statusType,
-					nickname,
-					bio,
+					nickname: trimmedNickname,
+					bio: trimmedBio,
 				},
 				customFields,
 			});
@@ -129,7 +136,16 @@ const AccountProfileForm = (props: AllHTMLAttributes<HTMLFormElement>): ReactEle
 		} catch (error) {
 			dispatchToastMessage({ type: 'error', message: error });
 		} finally {
-			reset({ email, name, username, statusType, statusText, nickname, bio, customFields });
+			reset({
+				email: trimmedEmail,
+				name: trimmedName,
+				username: trimmedUsername,
+				statusType,
+				statusText: trimmedStatusText,
+				nickname: trimmedNickname,
+				bio: trimmedBio,
+				customFields,
+			});
 		}
 	};
 
@@ -283,13 +299,7 @@ const AccountProfileForm = (props: AllHTMLAttributes<HTMLFormElement>): ReactEle
 				<Field>
 					<FieldLabel htmlFor={nicknameId}>{t('Nickname')}</FieldLabel>
 					<FieldRow>
-						<Controller
-							control={control}
-							name='nickname'
-							render={({ field }) => (
-								<TextInput {...field} id={nicknameId} flexGrow={1} addon={<Icon name='edit' size='x20' alignSelf='center' />} />
-							)}
-						/>
+						<Controller control={control} name='nickname' render={({ field }) => <TextInput {...field} id={nicknameId} flexGrow={1} />} />
 					</FieldRow>
 				</Field>
 				<Field>
@@ -298,7 +308,6 @@ const AccountProfileForm = (props: AllHTMLAttributes<HTMLFormElement>): ReactEle
 						<Controller
 							control={control}
 							name='bio'
-							rules={{ maxLength: { value: BIO_TEXT_MAX_LENGTH, message: t('Max_length_is', BIO_TEXT_MAX_LENGTH) } }}
 							render={({ field }) => (
 								<TextAreaInput
 									{...field}
@@ -307,7 +316,7 @@ const AccountProfileForm = (props: AllHTMLAttributes<HTMLFormElement>): ReactEle
 									rows={3}
 									flexGrow={1}
 									addon={<Icon name='edit' size='x20' alignSelf='center' />}
-									aria-invalid={errors.statusText ? 'true' : 'false'}
+									aria-invalid={errors.bio ? 'true' : 'false'}
 									aria-describedby={`${bioId}-error`}
 								/>
 							)}
diff --git a/apps/meteor/client/views/account/profile/AccountProfilePage.tsx b/apps/meteor/client/views/account/profile/AccountProfilePage.tsx
index eda29d780c3d9..24d0278f0d66f 100644
--- a/apps/meteor/client/views/account/profile/AccountProfilePage.tsx
+++ b/apps/meteor/client/views/account/profile/AccountProfilePage.tsx
@@ -13,8 +13,8 @@ import {
 	useLayout,
 } from '@rocket.chat/ui-contexts';
 import type { ReactElement } from 'react';
-import { useId, useState, useCallback } from 'react';
-import { FormProvider, useForm } from 'react-hook-form';
+import { useId, useState, useCallback, useMemo } from 'react';
+import { FormProvider, useForm, useWatch } from 'react-hook-form';
 
 import AccountProfileForm from './AccountProfileForm';
 import ActionConfirmModal from './ActionConfirmModal';
@@ -44,9 +44,33 @@ const AccountProfilePage = (): ReactElement => {
 
 	const {
 		reset,
+		control,
 		formState: { isDirty, isSubmitting },
 	} = methods;
 
+	const watchedValues = useWatch({ control });
+	const defaultValues = useMemo(() => getProfileInitialValues(user), [user]);
+
+	const isTrulyDirty = useMemo(() => {
+		if (!isDirty || !watchedValues) return false;
+
+		const stringFields = ['name', 'username', 'statusText', 'nickname', 'bio', 'email'] as const;
+
+		for (const field of stringFields) {
+			const currentValue = (watchedValues[field] ?? '').toString().trim();
+			const defaultValue = (defaultValues[field] ?? '').toString().trim();
+			if (currentValue !== defaultValue) {
+				return true;
+			}
+		}
+
+		if (watchedValues.avatar !== defaultValues.avatar) return true;
+		if (watchedValues.statusType !== defaultValues.statusType) return true;
+		if (JSON.stringify(watchedValues.customFields) !== JSON.stringify(defaultValues.customFields)) return true;
+
+		return false;
+	}, [isDirty, watchedValues, defaultValues]);
+
 	const logoutOtherClients = useEndpoint('POST', '/v1/users.logoutOtherClients');
 	const deleteOwnAccount = useEndpoint('POST', '/v1/users.deleteOwnAccount');
 
@@ -134,12 +158,12 @@ const AccountProfilePage = (): ReactElement => {
 					</Box>
 				</Box>
 			</PageScrollableContentWithShadow>
-			<PageFooter isDirty={isDirty}>
+			<PageFooter isDirty={isTrulyDirty}>
 				<ButtonGroup>
-					<Button disabled={!isDirty} onClick={() => reset(getProfileInitialValues(user))}>
+					<Button disabled={!isTrulyDirty} onClick={() => reset(getProfileInitialValues(user))}>
 						{t('Cancel')}
 					</Button>
-					<Button form={profileFormId} primary disabled={!isDirty || loggingOut} loading={isSubmitting} type='submit'>
+					<Button form={profileFormId} primary disabled={!isTrulyDirty || loggingOut} loading={isSubmitting} type='submit'>
 						{t('Save_changes')}
 					</Button>
 				</ButtonGroup>