diff --git a/.changeset/fifty-tools-walk.md b/.changeset/fifty-tools-walk.md
new file mode 100644
index 0000000000000..a3339bc48c78d
--- /dev/null
+++ b/.changeset/fifty-tools-walk.md
@@ -0,0 +1,6 @@
+---
+"@rocket.chat/meteor": patch
+"@rocket.chat/rest-typings": patch
+---
+
+Add OpenAPI support for the Rocket.Chat e2e.setRoomKeyID endpoints by migrating to a modern chained route definition syntax and utilizing shared AJV schemas for validation to enhance API documentation and ensure type safety through response validation.
diff --git a/apps/meteor/app/api/server/v1/e2e.ts b/apps/meteor/app/api/server/v1/e2e.ts
index a8a5e9175d876..3686f2a7b9007 100644
--- a/apps/meteor/app/api/server/v1/e2e.ts
+++ b/apps/meteor/app/api/server/v1/e2e.ts
@@ -1,7 +1,9 @@
 import { Subscriptions, Users } from '@rocket.chat/models';
 import {
+	ajv,
+	validateUnauthorizedErrorResponse,
+	validateBadRequestErrorResponse,
 	ise2eGetUsersOfRoomWithoutKeyParamsGET,
-	ise2eSetRoomKeyIDParamsPOST,
 	ise2eSetUserPublicAndPrivateKeysParamsPOST,
 	ise2eUpdateGroupKeyParamsPOST,
 	isE2EProvideUsersGroupKeyProps,
@@ -20,12 +22,61 @@ import { setRoomKeyIDMethod } from '../../../e2e/server/methods/setRoomKeyID';
 import { setUserPublicAndPrivateKeysMethod } from '../../../e2e/server/methods/setUserPublicAndPrivateKeys';
 import { updateGroupKey } from '../../../e2e/server/methods/updateGroupKey';
 import { settings } from '../../../settings/server';
+import type { ExtractRoutesFromAPI } from '../ApiClass';
 import { API } from '../api';
 
 // After 10s the room lock will expire, meaning that if for some reason the process never completed
 // The next reset will be available 10s after
 const LockMap = new ExpiryMap<string, boolean>(10000);
 
+type E2eSetRoomKeyIdProps = {
+	rid: string;
+	keyID: string;
+};
+
+const E2eSetRoomKeyIdSchema = {
+	type: 'object',
+	properties: {
+		rid: {
+			type: 'string',
+		},
+		keyID: {
+			type: 'string',
+		},
+	},
+	required: ['rid', 'keyID'],
+	additionalProperties: false,
+};
+
+const isE2eSetRoomKeyIdProps = ajv.compile<E2eSetRoomKeyIdProps>(E2eSetRoomKeyIdSchema);
+
+const e2eEndpoints = API.v1.post(
+	'e2e.setRoomKeyID',
+	{
+		authRequired: true,
+		body: isE2eSetRoomKeyIdProps,
+		response: {
+			400: validateBadRequestErrorResponse,
+			401: validateUnauthorizedErrorResponse,
+			200: ajv.compile<void>({
+				type: 'object',
+				properties: {
+					success: { type: 'boolean', enum: [true] },
+				},
+				required: ['success'],
+			}),
+		},
+	},
+
+	async function action() {
+		const { rid, keyID } = this.bodyParams;
+
+		await setRoomKeyIDMethod(this.userId, rid, keyID);
+
+		return API.v1.success();
+	},
+);
+
 API.v1.addRoute(
 	'e2e.fetchMyKeys',
 	{
@@ -57,55 +108,6 @@ API.v1.addRoute(
 	},
 );
 
-/**
- * @openapi
- *  /api/v1/e2e.setRoomKeyID:
- *    post:
- *      description: Sets the end-to-end encryption key ID for a room
- *      security:
- *        - autenticated: {}
- *      requestBody:
- *        description: A tuple containing the room ID and the key ID
- *        content:
- *          application/json:
- *            schema:
- *              type: object
- *              properties:
- *                rid:
- *                  type: string
- *                keyID:
- *                  type: string
- *      responses:
- *        200:
- *          content:
- *            application/json:
- *              schema:
- *                $ref: '#/components/schemas/ApiSuccessV1'
- *        default:
- *          description: Unexpected error
- *          content:
- *            application/json:
- *              schema:
- *                $ref: '#/components/schemas/ApiFailureV1'
- */
-
-API.v1.addRoute(
-	'e2e.setRoomKeyID',
-	{
-		authRequired: true,
-		validateParams: ise2eSetRoomKeyIDParamsPOST,
-	},
-	{
-		async post() {
-			const { rid, keyID } = this.bodyParams;
-
-			await setRoomKeyIDMethod(this.userId, rid, keyID);
-
-			return API.v1.success();
-		},
-	},
-);
-
 /**
  * @openapi
  *  /api/v1/e2e.setUserPublicAndPrivateKeys:
@@ -323,3 +325,10 @@ API.v1.addRoute(
 		},
 	},
 );
+
+export type E2eEndpoints = ExtractRoutesFromAPI<typeof e2eEndpoints>;
+
+declare module '@rocket.chat/rest-typings' {
+	// eslint-disable-next-line @typescript-eslint/naming-convention, @typescript-eslint/no-empty-interface
+	interface Endpoints extends E2eEndpoints {}
+}
diff --git a/packages/rest-typings/src/index.ts b/packages/rest-typings/src/index.ts
index 6b669d9b9b189..4f11ad9baf02e 100644
--- a/packages/rest-typings/src/index.ts
+++ b/packages/rest-typings/src/index.ts
@@ -249,7 +249,6 @@ export * from './v1/autotranslate/AutotranslateGetSupportedLanguagesParamsGET';
 export * from './v1/autotranslate/AutotranslateSaveSettingsParamsPOST';
 export * from './v1/autotranslate/AutotranslateTranslateMessageParamsPOST';
 export * from './v1/e2e/e2eGetUsersOfRoomWithoutKeyParamsGET';
-export * from './v1/e2e/e2eSetRoomKeyIDParamsPOST';
 export * from './v1/e2e/e2eSetUserPublicAndPrivateKeysParamsPOST';
 export * from './v1/e2e/e2eUpdateGroupKeyParamsPOST';
 export * from './v1/e2e';
diff --git a/packages/rest-typings/src/v1/e2e.ts b/packages/rest-typings/src/v1/e2e.ts
index b065ac10386eb..7c7bd8a1d1a66 100644
--- a/packages/rest-typings/src/v1/e2e.ts
+++ b/packages/rest-typings/src/v1/e2e.ts
@@ -67,27 +67,6 @@ const E2eUpdateGroupKeySchema = {
 
 export const isE2eUpdateGroupKeyProps = ajv.compile<E2eUpdateGroupKeyProps>(E2eUpdateGroupKeySchema);
 
-type E2eSetRoomKeyIdProps = {
-	rid: string;
-	keyID: string;
-};
-
-const E2eSetRoomKeyIdSchema = {
-	type: 'object',
-	properties: {
-		rid: {
-			type: 'string',
-		},
-		keyID: {
-			type: 'string',
-		},
-	},
-	required: ['rid', 'keyID'],
-	additionalProperties: false,
-};
-
-export const isE2eSetRoomKeyIdProps = ajv.compile<E2eSetRoomKeyIdProps>(E2eSetRoomKeyIdSchema);
-
 type E2EProvideUsersGroupKeyProps = {
 	usersSuggestedGroupKeys: Record<IRoom['_id'], { _id: IUser['_id']; key: string; oldKeys: ISubscription['suggestedOldRoomKeys'] }[]>;
 };
@@ -187,9 +166,6 @@ export type E2eEndpoints = {
 	'/v1/e2e.rejectSuggestedGroupKey': {
 		POST: (params: E2eGetUsersOfRoomWithoutKeyProps) => void;
 	};
-	'/v1/e2e.setRoomKeyID': {
-		POST: (params: E2eSetRoomKeyIdProps) => void;
-	};
 	'/v1/e2e.fetchMyKeys': {
 		GET: () => { public_key: string; private_key: string };
 	};
diff --git a/packages/rest-typings/src/v1/e2e/e2eSetRoomKeyIDParamsPOST.ts b/packages/rest-typings/src/v1/e2e/e2eSetRoomKeyIDParamsPOST.ts
deleted file mode 100644
index 8977d8c96b6dc..0000000000000
--- a/packages/rest-typings/src/v1/e2e/e2eSetRoomKeyIDParamsPOST.ts
+++ /dev/null
@@ -1,26 +0,0 @@
-import Ajv from 'ajv';
-
-const ajv = new Ajv({
-	coerceTypes: true,
-});
-
-export type e2eSetRoomKeyIDParamsPOST = {
-	rid: string;
-	keyID: string;
-};
-
-const e2eSetRoomKeyIDParamsPOSTSchema = {
-	type: 'object',
-	properties: {
-		rid: {
-			type: 'string',
-		},
-		keyID: {
-			type: 'string',
-		},
-	},
-	additionalProperties: false,
-	required: ['rid', 'keyID'],
-};
-
-export const ise2eSetRoomKeyIDParamsPOST = ajv.compile<e2eSetRoomKeyIDParamsPOST>(e2eSetRoomKeyIDParamsPOSTSchema);