diff --git a/src/general/EndosymbiosisData.cs b/src/general/EndosymbiosisData.cs
index 2b948068d1..b67094d294 100644
--- a/src/general/EndosymbiosisData.cs
+++ b/src/general/EndosymbiosisData.cs
@@ -113,6 +113,15 @@ public bool CancelEndosymbiosisTarget(int targetSpeciesId)
         return true;
     }
 
+    public bool CancelAllEndosymbiosisTargets()
+    {
+        if (StartedEndosymbiosis == null)
+            return false;
+
+        StartedEndosymbiosis = null;
+        return true;
+    }
+
     public InProgressEndosymbiosis MarkEndosymbiosisDone(InProgressEndosymbiosis endosymbiosisToComplete)
     {
         if (StartedEndosymbiosis == null)
diff --git a/src/microbe_stage/MicrobeStage.cs b/src/microbe_stage/MicrobeStage.cs
index 6771e16217..688395558a 100644
--- a/src/microbe_stage/MicrobeStage.cs
+++ b/src/microbe_stage/MicrobeStage.cs
@@ -586,6 +586,8 @@ public void MoveToMulticellular()
             throw new Exception("failed to keep the current scene root");
         }
 
+        GameWorld.PlayerSpecies.Endosymbiosis.CancelAllEndosymbiosisTargets();
+
         // TODO: The multicellular stage needs to be able to track statistics and not break organelle unlocks
         GameWorld.UnlockProgress.UnlockAll = true;