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<!DOCTYPE html><html lang="en" itemscope itemtype="http://schema.org/Article"><head><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width,initial-scale=1"><meta name="description" content="RTXI, the Real-Time eXperiment Interface, is a hard real-time data acquisition and control application for biological research. At its core is a Real-Time Operating System (RTOS), which uses a modi..."><meta itemprop="name" content="Home"><meta itemprop="description" content="RTXI, the Real-Time eXperiment Interface, is a hard real-time data acquisition and control application for biological research. At its core is a Real-Time Operating System (RTOS), which uses a modi..."><meta itemprop="image" content="http://rtxi.org/assets/img/rtxi-logo-square.png"><meta name="twitter:card" content="summary"><meta name="twitter:title" content="Home"><meta name="twitter:description" content="RTXI, the Real-Time eXperiment Interface, is a hard real-time data acquisition and control application for biological research. At its core is a Real-Time Operating System (RTOS), which uses a modi..."><meta name="twitter:image:src" content="http://rtxi.org/assets/img/rtxi-logo-square.png"><meta property="og:title" content="Home"><meta property="og:type" content="article"><meta property="og:url" content="http://rtxi.org/"><meta property="og:image" content="http://rtxi.org/assets/img/rtxi-logo-square.png"><meta property="og:description" content="RTXI, the Real-Time eXperiment Interface, is a hard real-time data acquisition and control application for biological research. At its core is a Real-Time Operating System (RTOS), which uses a modi..."><meta property="og:site_name" content="RTXI | The Real-time eXperiment Interface"><meta property="article:section" content=""><meta property="article:tag" content=""><title>Home | The Real-time eXperiment Interface</title><link href="/assets/css/default.min.css" rel="stylesheet"><link rel="apple-touch-icon" href="/assets/img/apple-touch-icon.png"><link rel="icon" href="/assets/img/favicon.ico"></head><body><nav class="navbar navbar-inverse navbar-fixed-top" role="navigation"><div class="container"><div class="navbar-header"><button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false" aria-controls="navbar"><span class="sr-only">Toggle navigation</span> <span class="icon-bar"></span> <span class="icon-bar"></span> <span class="icon-bar"></span></button> <a class="navbar-brand" rel="home" href="/"><b>RTXI</b></a></div><div class="row"><div id="navbar" class="navbar-collapse collapse navbar-right" style="text-align:center;"><ul class="nav navbar-nav"><li><a href="/install/">Install</a></li><li><a href="/modules/">Modules</a></li><li><a href="/papers/">Papers</a></li><li><a href="/docs/">Docs</a></li><li><a href="/stats/">Stats</a></li><li><a href="/community/">Community</a></li><li><a href="/contact/">Contact</a></li><li><a href="/feed.xml"><i class="glyphicons glyphicon-rss"></i></a></li></ul></div></div></div></nav><div style="padding-top:30px"><link href="/assets/css/carousel.css" rel="stylesheet"><div id="myCarousel" class="carousel slide" data-interval="false" data-ride="" data-pause="hover"><ol class="carousel-indicators"><li data-target="#myCarousel" data-slide-to="0" class="active"></li><li data-target="#myCarousel" data-slide-to="1"></li></ol><div class="carousel-inner" role="listbox"><div class="item active"><div class="container"><img src="/assets/img/rtxi-banner-white.svg" class="hidden-xs img-responsive center-block" style="margin-top:75px;"> <img src="/assets/img/rtxi-banner-white-vertical.svg" class="visible-xs img-responsive center-block" style="margin-top:75px;"><div class="carousel-caption"><p class="lead"></p></div></div></div></div><a class="left carousel-control" href="#myCarousel" role="button" data-slide="prev"><span class="glyphicon glyphicon-chevron-left"></span> <span class="sr-only">Previous</span> </a><a class="right carousel-control" href="#myCarousel" role="button" data-slide="next"><span class="glyphicon glyphicon-chevron-right"></span> <span class="sr-only">Next</span></a></div><div class="container"><div class="col-lg-9"><div class="row"><div class="panel panel-default"><div class="panel-heading"><h2 class="" style="text-align:center">Introducing RTXI</h2></div><div class="panel-body"><div class="row"><div class="col-xs-12"><p><strong>RTXI</strong>, the <strong>Real-Time eXperiment Interface</strong>, is a <strong>hard real-time</strong> data acquisition and control application for biological research. At its core is a Real-Time Operating System (RTOS), which uses a modified Linux kernel to provide <strong>deterministic</strong> control in a variety of experimental settings. RTXI is a <strong>fast</strong>, <strong>free</strong>, and <strong>open-source</strong> system currently used in labs all over the world to probe diverse, technologically challenging problems, such as dynamic probing of ion-channel function, control of cardiac arrhythmia dynamics, and control of deep-brain stimulation patterns.</p></div></div><div class="row"><div class="col-sm-6"><h3 class="page-header" style="text-align:center">Why real-time?</h3><p>Experimentalists' ability to perturb biological systems has traditionally been limited to rigid pre-programmed protocols or more flexible, albeit reflex-constrained, operator-controlled protocols. In contrast, real-time control allows dynamic probing of biological systems by parameter perturbations calculated from instantaneous system measurements. With it, researchers can address diverse unanswered questions that are not amenable to traditional approaches.</p></div><div class="col-sm-6"><h3 class="page-header" style="text-align:center">Why RTXI?</h3><p>Unfortunately, real-time control is not possible with standard operating systems and software. Furthermore, commercial real-time systems are costly and often designed for industrial applications, and the proprietary software licenses and drivers that come with them constrain their flexibility in experimental settings. To get away from that, we developed RTXI. It's fast, free, and flexible, and it's compatible with a wide range of experimentation hardware.</p></div></div><img class="img-responsive" style="margin: 0 auto; padding-top:20px" src="/assets/img/dclamp.png"></div><div class="panel-footer"><a href="/docs"><button type="button" class="pull-right btn btn-primary btn-lg">Read the Docs</button></a><div class="clearfix"></div></div></div><div class="panel panel-info"><div class="panel-heading"><h3 class="" style="text-align:center">Latest Publications</h3></div><div class="panel-body"><div class="row"><div class="col-sm-12 col-md-6"><div class="row"><div class="col-xs-12"><a href="/papers/2017/01/05/kilohertz-frequency-nerve-block-enhances-anti-inflammatory-effects-of-vagus-nerve-stimulation/" style="color:inherit;"><div class="panel"><div class="panel-heading"><h4 class="panel-title">Kilohertz frequency nerve block enhances anti-inflammatory effects of vagus nerve stimulation</h4></div><div class="panel-body hidden-xs"><p>Efferent activation of the cervical vagus nerve (cVN) dampens systemic inflammatory processes, potentially modulating a wide-range of inflammatory pathological conditions. In contrast, afferent cVN activation amplifies systemic inflammatory processes, leading to activation of the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system through the greater splanchnic nerve (GSN), and elevation of pro-inflammatory cytokines. Ideally, to clinically implement anti-inflammatory...</p></div></div></a></div></div><div class="row"><div class="col-xs-12"><a href="/papers/2016/08/23/illuminating-myocyte-fibroblast-homotypic-and-heterotypic-gap-junction-dynamics-using-dynamic-clamp/" style="color:inherit;"><div class="panel"><div class="panel-heading"><h4 class="panel-title">Illuminating Myocyte-Fibroblast Homotypic and Heterotypic Gap Junction Dynamics Using Dynamic Clamp</h4></div><div class="panel-body hidden-xs"><p>Fibroblasts play a significant role in the development of electrical and mechanical dysfunction of the heart; however, the underlying mechanisms are only partially understood. One widely studied mechanism suggests that fibroblasts produce excess extracellular matrix, resulting in collagenous septa that slow propagation, cause zig-zag conduction paths, and decouple cardiomyocytes, resulting in a substrate for cardiac arrhythmia. An emerging mechanism suggests that fibroblasts promote arrhyt...</p></div></div></a></div></div></div><div class="col-sm-12 col-md-6"><div class="row"><div class="col-xs-12"><a href="http://www.sciencedirect.com/science/article/pii/S0079610715002539" style="color:inherit;"><div class="panel"><div class="panel-heading"><h4 class="panel-title">Cell-specific Dynamic Clamp analysis of the role of funny I f current in cardiac pacemaking</h4></div><div class="panel-body hidden-xs"><p>We used the Dynamic Clamp technique for i) comparative validation of conflicting computational models of the hyperpolarization-activated funny current, If, and ii) quantification of the role of If in mediating autonomic modulation of heart rate. Experimental protocols based on the injection of a real-time recalculated synthetic If current in sinoatrial rabbit cells were developed.</p></div></div></a></div></div><div class="row"><div class="col-xs-12"><a href="http://circep.ahajournals.org/content/early/2015/06/22/CIRCEP.114.002572.short" style="color:inherit;"><div class="panel"><div class="panel-heading"><h4 class="panel-title">IKr Impact on Repolarization and Its Variability Assessed by Dynamic-Clamp</h4></div><div class="panel-body hidden-xs"><p>Repolarization and its stability are exquisitely sensitive to IKr features. Information on the relative importance of specific IKr abnormalities is missing and would assist in the evaluation of arrhythmogenic risk.</p></div></div></a></div></div></div></div></div><div class="panel-footer"><a href="/papers/"><button type="button" class="pull-right btn btn-primary btn-lg">All Publications</button></a><div class="clearfix"></div></div></div></div></div><div class="row"><div class="col-lg-3"><div class="panel panel-success"><div class="panel-heading" style="text-align:center"><h3>News <a href="/feed.xml" style="color:inherit"><i class="pull-right glyphicons glyphicon-rss"></i></a></h3></div><div class="panel-body"><div class="media"><div class="media-body"><h4 class="media-heading"><a href="/news/2023/11/30/rtxi-300-released/">RTXI 3.0.0 Released!</a></h4><div class="text-muted"> 30 Nov 2023</div><div><p>RTXI v3.0.0 is now available</p></div></div></div><div class="media"><div class="media-body"><h4 class="media-heading"><a href="/news/2021/07/22/rtxi-v23-release/">RTXI 2.3 Release</a></h4><div class="text-muted"> 22 Jul 2021</div><div><p>A new version of RTXI is now available!</p><p>New features include:</p></div></div></div><div class="media"><div class="media-body"><h4 class="media-heading"><a href="/news/2018/01/09/rtxi-v22-released/">RTXI 2.2 Released</a></h4><div class="text-muted"> 09 Jan 2018</div><div><p>New version with long-term support and a new real-time kernel!</p></div></div></div><div class="media"><div class="media-body"><h4 class="media-heading"><a href="/news/2017/06/01/paper-published/">Technical overview of RTXI</a></h4><div class="text-muted"> 01 Jun 2017</div><div><p>Ever been curious about how RTXI works? Check out the new paper recently published in PLOS Computational Biology:</p></div></div></div><div class="media"><div class="media-body"><h4 class="media-heading"><a href="/news/2015/10/09/fall-newsletter/">RTXI Fall Newsletter</a></h4><div class="text-muted"> 09 Oct 2015</div><div><p>There have been lots of new developments in RTXI over the past few months. Look forward to the upcoming release of RTXI 2.1, and we encourage those of you attending SfN 2015 to check out our poster!</p></div></div></div></div></div></div></div></div></div></body><style>html {
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