diff --git a/build_tools/github_actions/configure_ci_labels.py b/build_tools/github_actions/configure_ci_labels.py
index bf1fb6f77ef..e25dc2e6957 100755
--- a/build_tools/github_actions/configure_ci_labels.py
+++ b/build_tools/github_actions/configure_ci_labels.py
@@ -64,6 +64,7 @@ class Label:
     Label("ci:asan", COLOR_CI_GENERAL, "Opt-in to building ASAN"),
     Label("ci:host-asan", COLOR_CI_GENERAL, "Opt-in to running multi-arch host-asan CI on a pull request"),
     Label("ci:run-multi-gpu", COLOR_CI_GENERAL, "Opt-in to running multi-GPU tests"),
+    Label("ci:cpu-test-only", COLOR_CI_GENERAL, "Run only CPU tests (skip GPU tests)"),
     # ci:platform: labels (platform selection)
     Label("ci:platform:linux", COLOR_CI_PLATFORM, "Run CI only on Linux (skip Windows builds/tests)"),
     Label("ci:platform:windows", COLOR_CI_PLATFORM, "Run CI only on Windows (skip Linux builds/tests)"),
diff --git a/build_tools/github_actions/configure_multi_arch_ci.py b/build_tools/github_actions/configure_multi_arch_ci.py
index 395f205cad7..1963242475f 100755
--- a/build_tools/github_actions/configure_multi_arch_ci.py
+++ b/build_tools/github_actions/configure_multi_arch_ci.py
@@ -1601,6 +1601,13 @@ def _expand_build_config_for_platform(
                     f"(global={jobs.test_rocm.test_type})"
                 )
 
+        # ci:cpu-test-only label: disable GPU tests, only run CPU-only tests.
+        # This is useful for changes that don't require GPU testing (e.g., docs,
+        # build scripts, CPU-only components).
+        if "ci:cpu-test-only" in ci_inputs.pr_labels and test_runs_on:
+            test_runs_on = ""
+            print(f"  {family_name}: GPU tests disabled by 'ci:cpu-test-only' label")
+
         # CPU test runner for components that don't need GPU access (e.g.,
         # components with linux_cpu_runner: True). This allows CPU-only tests
         # to run even when GPU testing is gated (e.g., trigger_test_label_only).
diff --git a/build_tools/github_actions/tests/configure_multi_arch_ci_test.py b/build_tools/github_actions/tests/configure_multi_arch_ci_test.py
index d43e2ec0cda..c832c2a8701 100644
--- a/build_tools/github_actions/tests/configure_multi_arch_ci_test.py
+++ b/build_tools/github_actions/tests/configure_multi_arch_ci_test.py
@@ -3046,5 +3046,55 @@ def test_families_without_multi_label_use_primary_only(self):
                 self.assertEqual(gfx103x_info["test-runs-on"], "linux-gfx1030-gpu-rocm")
 
 
+# ---------------------------------------------------------------------------
+class TestCpuTestOnlyLabel(unittest.TestCase):
+    """ci:cpu-test-only label: disable GPU tests, keep CPU-only tests."""
+
+    def _expand(self, pr_labels=None, platform="linux", family="gfx94x"):
+        ci_inputs = cm.CIInputs(
+            run_id="1",
+            event_name="pull_request",
+            commit_ref="feature",
+            base_ref="HEAD^1",
+            build_variant="release",
+            pr_labels=pr_labels or [],
+        )
+        result = cm.expand_build_configs(
+            ci_inputs=ci_inputs,
+            git_context=cm.GitContext(),
+            targets=cm.TargetSelection(**{f"{platform}_families": [family]}),
+            jobs=_jobs(),
+        )
+        return getattr(result, platform).per_family_info[0]
+
+    def test_label_disables_gpu_keeps_cpu(self):
+        """Label disables GPU tests but keeps CPU runner and tests_enabled."""
+        entry = self._expand(pr_labels=["ci:cpu-test-only"])
+        self.assertEqual(entry["test-runs-on"], "")
+        self.assertNotEqual(entry["test-runs-on-cpu"], "")
+        self.assertTrue(entry["tests_enabled"])
+
+    def test_without_label_gpu_tests_run(self):
+        """Without label, GPU tests run normally."""
+        self.assertNotEqual(self._expand()["test-runs-on"], "")
+
+    def test_works_on_windows(self):
+        """Label works on Windows."""
+        entry = self._expand(["ci:cpu-test-only"], platform="windows", family="gfx110x")
+        self.assertEqual(entry["test-runs-on"], "")
+
+    def test_label_disables_multi_gpu(self):
+        """Label also disables multi-GPU tests."""
+        entry = self._expand(pr_labels=["ci:cpu-test-only"])
+        self.assertNotIn("test-runs-on-multi-gpu", entry)
+        self.assertNotIn("test-runs-on-multi-gpu-labels", entry)
+
+    def test_without_label_multi_gpu_present(self):
+        """Without label, multi-GPU info is present (when platform supports it)."""
+        entry = self._expand()
+        # gfx94x has multi-GPU support
+        self.assertIn("test-runs-on-multi-gpu-labels", entry)
+
+
 if __name__ == "__main__":
     unittest.main()
diff --git a/docs/development/ci_behavior_manipulation.md b/docs/development/ci_behavior_manipulation.md
index 99631af1dc5..4b528f659f0 100644
--- a/docs/development/ci_behavior_manipulation.md
+++ b/docs/development/ci_behavior_manipulation.md
@@ -26,6 +26,7 @@ The following labels may be added to a pull request to modify CI behavior:
 | `ci:asan`                  | Enable ASAN CI builds and tests. ASAN CI is skipped by default on PRs unless this label is present.                                                                                               |
 | `ci:host-asan`             | Alias for `ci:asan`. Enable ASAN CI builds and tests.                                                                                                                                             |
 | `ci:run-multi-gpu`         | Opt-in to running multi-GPU tests.                                                                                                                                                                |
+| `ci:cpu-test-only`         | Run only CPU tests (skip GPU tests). Useful for changes that don't require GPU testing.                                                                                                           |
 | `ci:platform:linux`        | Run CI only on Linux (skip Windows builds/tests)                                                                                                                                                  |
 | `ci:platform:windows`      | Run CI only on Windows (skip Linux builds/tests)                                                                                                                                                  |
 | `ci:gfx...`                | Opt-in to building and testing the specified gfx family (e.g. `ci:gfx120X-all`, `ci:gfx950-dcgpu`)                                                                                                |