diff --git a/qiskit/circuit/quantumcircuit.py b/qiskit/circuit/quantumcircuit.py
index ccf9ff724abb..ac5079cb3e11 100644
--- a/qiskit/circuit/quantumcircuit.py
+++ b/qiskit/circuit/quantumcircuit.py
@@ -441,21 +441,26 @@ def calibrations(self, calibrations: dict):
         """
         self._calibrations = defaultdict(dict, calibrations)
 
-    def has_calibration_for(self, instruction: CircuitInstruction):
+    def has_calibration_for(self, instruction: CircuitInstruction | tuple):
         """Return True if the circuit has a calibration defined for the instruction context. In this
         case, the operation does not need to be translated to the device basis.
         """
-        if not self.calibrations or instruction.operation.name not in self.calibrations:
+        if isinstance(instruction, CircuitInstruction):
+            operation = instruction.operation
+            qubits = instruction.qubits
+        else:
+            operation, qubits, _ = instruction
+        if not self.calibrations or operation.name not in self.calibrations:
             return False
-        qubits = tuple(self.qubits.index(qubit) for qubit in instruction.qubits)
+        qubits = tuple(self.qubits.index(qubit) for qubit in qubits)
         params = []
-        for p in instruction.operation.params:
+        for p in operation.params:
             if isinstance(p, ParameterExpression) and not p.parameters:
                 params.append(float(p))
             else:
                 params.append(p)
         params = tuple(params)
-        return (qubits, params) in self.calibrations[instruction.operation.name]
+        return (qubits, params) in self.calibrations[operation.name]
 
     @property
     def metadata(self) -> dict:
diff --git a/test/python/circuit/test_circuit_properties.py b/test/python/circuit/test_circuit_properties.py
index 67c6cca5518b..806b771ea469 100644
--- a/test/python/circuit/test_circuit_properties.py
+++ b/test/python/circuit/test_circuit_properties.py
@@ -1255,6 +1255,43 @@ def test_calibrations_no_params(self):
         self.assertEqual(set(circ.calibrations["h"].keys()), {((0,), ())})
         self.assertEqual(circ.calibrations["h"][((0,), ())].instructions, q0_x180.instructions)
 
+    def test_has_calibration_for(self):
+        """Test that `has_calibration_for` returns a correct answer."""
+        qc = QuantumCircuit(3)
+
+        with pulse.build() as q0_x180:
+            pulse.play(pulse.library.Gaussian(20, 1.0, 3.0), pulse.DriveChannel(0))
+        qc.add_calibration("h", [0], q0_x180)
+
+        qc.h(0)
+        qc.h(1)
+
+        self.assertTrue(qc.has_calibration_for(qc.data[0]))
+        self.assertFalse(qc.has_calibration_for(qc.data[1]))
+
+    def test_has_calibration_for_legacy(self):
+        """Test that `has_calibration_for` returns a correct answer when presented with a legacy 3
+        tuple."""
+        qc = QuantumCircuit(3)
+
+        with pulse.build() as q0_x180:
+            pulse.play(pulse.library.Gaussian(20, 1.0, 3.0), pulse.DriveChannel(0))
+        qc.add_calibration("h", [0], q0_x180)
+
+        qc.h(0)
+        qc.h(1)
+
+        self.assertTrue(
+            qc.has_calibration_for(
+                (qc.data[0].operation, list(qc.data[0].qubits), list(qc.data[0].clbits))
+            )
+        )
+        self.assertFalse(
+            qc.has_calibration_for(
+                (qc.data[1].operation, list(qc.data[1].qubits), list(qc.data[1].clbits))
+            )
+        )
+
     def test_metadata_copy_does_not_share_state(self):
         """Verify mutating the metadata of a circuit copy does not impact original."""
         # ref: https://github.com/Qiskit/qiskit-terra/issues/6057