diff --git a/qiskit_ibm_runtime/qiskit/primitives/base_sampler.py b/qiskit_ibm_runtime/qiskit/primitives/base_sampler.py
index bb09e240da..ccf9b80ced 100644
--- a/qiskit_ibm_runtime/qiskit/primitives/base_sampler.py
+++ b/qiskit_ibm_runtime/qiskit/primitives/base_sampler.py
@@ -359,6 +359,14 @@ def run(
                     f"the number of parameters ({circuit.num_parameters}) for the {i}-th circuit."
                 )
 
+        for i, circuit in enumerate(circuits):
+            if circuit.num_clbits == 0:
+                raise QiskitError(
+                    f"The {i}-th circuit does not have any classical bit. "
+                    "Sampler requires classical bits, plus measurements "
+                    "on the desired qubits."
+                )
+
         return self._run(circuits, parameter_values, parameter_views, **run_options)
 
     @abstractmethod
diff --git a/releasenotes/notes/add-sampler-error-check-20e5672c7ff17004.yaml b/releasenotes/notes/add-sampler-error-check-20e5672c7ff17004.yaml
new file mode 100644
index 0000000000..881012228b
--- /dev/null
+++ b/releasenotes/notes/add-sampler-error-check-20e5672c7ff17004.yaml
@@ -0,0 +1,7 @@
+
+---
+upgrade:
+  - |
+    Added a validation check to :meth:`~qiskit_ibm_runtime.Sampler.run`.
+    It raises an error if there is no classical bit.
+