diff --git a/.github/workflows/cron-other.yml b/.github/workflows/cron-other.yml
index d839a2cc4..d0d0c1e47 100644
--- a/.github/workflows/cron-other.yml
+++ b/.github/workflows/cron-other.yml
@@ -20,7 +20,7 @@ jobs:
     runs-on: ${{ matrix.os }}
     strategy:
       matrix:
-        python-version: [3.6, 3.7, 3.8, 3.9]
+        python-version: [3.7, 3.8, 3.9]
         os: ["windows-latest", "ubuntu-latest"]
     env:
       QISKIT_IBM_API_TOKEN: ${{ secrets.QISKIT_IBM_API_TOKEN }}
@@ -49,7 +49,7 @@ jobs:
     runs-on: ${{ matrix.os }}
     strategy:
       matrix:
-        python-version: [3.6, 3.7, 3.8, 3.9]
+        python-version: [3.7, 3.8, 3.9]
         os: ["windows-latest", "ubuntu-latest"]
     env:
       QISKIT_IBM_API_TOKEN: ${{ secrets.QISKIT_IBM_API_TOKEN }}
@@ -77,7 +77,7 @@ jobs:
     runs-on: ${{ matrix.os }}
     strategy:
       matrix:
-        python-version: [3.6, 3.7, 3.8, 3.9]
+        python-version: [3.7, 3.8, 3.9]
         os: ["windows-latest", "ubuntu-latest"]
     env:
       QISKIT_IBM_API_TOKEN: ${{ secrets.QISKIT_IBM_API_TOKEN }}
diff --git a/.github/workflows/cron-slow.yml b/.github/workflows/cron-slow.yml
index de81e5853..174406410 100644
--- a/.github/workflows/cron-slow.yml
+++ b/.github/workflows/cron-slow.yml
@@ -29,10 +29,10 @@ jobs:
       QISKIT_IN_PARALLEL: True
     steps:
       - uses: actions/checkout@v2
-      - name: Set up Python 3.6
+      - name: Set up Python 3.7
         uses: actions/setup-python@v2
         with:
-          python-version: 3.6
+          python-version: 3.7
       - name: Install Deps
         run: |
           python -m pip install --upgrade pip
diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index 7d38fd304..784bc4234 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -61,7 +61,7 @@ jobs:
     runs-on: macOS-latest
     strategy:
       matrix:
-        python-version: [3.6, 3.7, 3.8, 3.9]
+        python-version: [3.7, 3.8, 3.9]
     env:
       QISKIT_IBM_API_TOKEN: ${{ secrets.QISKIT_IBM_API_TOKEN }}
       QISKIT_IBM_API_URL: ${{ secrets.QISKIT_IBM_API_URL }}
diff --git a/.github/workflows/pr.yml b/.github/workflows/pr.yml
index 4b0725d7b..45a148535 100644
--- a/.github/workflows/pr.yml
+++ b/.github/workflows/pr.yml
@@ -18,7 +18,7 @@ jobs:
     runs-on: ${{ matrix.os }}
     strategy:
       matrix:
-        python-version: [3.6, 3.7, 3.8, 3.9]
+        python-version: [3.7, 3.8, 3.9]
         os: ["macOS-latest", "ubuntu-latest", "windows-latest"]
     env:
       QISKIT_IBM_API_TOKEN: ${{ secrets.QISKIT_IBM_API_TOKEN }}
diff --git a/releasenotes/notes/remove-python-3.6-b350d50670076123.yaml b/releasenotes/notes/remove-python-3.6-b350d50670076123.yaml
new file mode 100644
index 000000000..966b6cd14
--- /dev/null
+++ b/releasenotes/notes/remove-python-3.6-b350d50670076123.yaml
@@ -0,0 +1,4 @@
+---
+upgrade:
+  - |
+    Python 3.6 support has been dropped since it is reaching end of life in Dec 2021.
diff --git a/requirements-dev.txt b/requirements-dev.txt
index db75504d6..751e72dec 100644
--- a/requirements-dev.txt
+++ b/requirements-dev.txt
@@ -5,7 +5,7 @@ vcrpy
 pproxy==2.1.8
 Sphinx>=1.8.3
 sphinx-rtd-theme>=0.4.0
-sphinx-tabs>=1.1.11 
+sphinx-tabs>=1.1.11
 sphinx-automodapi
 sphinx-autodoc-typehints
 matplotlib>=2.1
@@ -25,4 +25,4 @@ qiskit_rng
 qiskit-aer
 websockets>=8
 scikit-quant;platform_system != 'Windows'
-qiskit-experiments; python_version > '3.6'
+qiskit-experiments;
diff --git a/setup.py b/setup.py
index 870c62e67..b91377239 100644
--- a/setup.py
+++ b/setup.py
@@ -61,7 +61,6 @@
         "Operating System :: MacOS",
         "Operating System :: POSIX :: Linux",
         "Programming Language :: Python :: 3 :: Only",
-        "Programming Language :: Python :: 3.6",
         "Programming Language :: Python :: 3.7",
         "Programming Language :: Python :: 3.8",
         "Programming Language :: Python :: 3.9",
@@ -71,7 +70,7 @@
     packages=setuptools.find_packages(exclude=['test*']),
     install_requires=REQUIREMENTS,
     include_package_data=True,
-    python_requires=">=3.6",
+    python_requires=">=3.7",
     zip_safe=False,
     extras_require={'visualization': ['matplotlib>=2.1', 'ipywidgets>=7.3.0',
                                       "seaborn>=0.9.0", "plotly>=4.4",
diff --git a/test/ibm/test_registration.py b/test/ibm/test_registration.py
index 737a9d9a2..2c512a458 100644
--- a/test/ibm/test_registration.py
+++ b/test/ibm/test_registration.py
@@ -18,7 +18,6 @@
 from unittest import skipIf
 from typing import Dict, Any
 import copy
-import sys
 
 from requests_ntlm import HttpNtlmAuth
 from qiskit_ibm import IBMProvider
@@ -60,12 +59,6 @@ def test_load_account_no_credentials(self) -> None:
         self.assertIn('No IBM Quantum credentials found',
                       str(context_manager.exception))
 
-    # Test not supported in Python 3.6 since patching a classmethod
-    # (in mock_ibm_provider) incorrectly throws
-    # TypeError: 'NonCallableMagicMock' object is not callable
-    # which was fixed in later versions
-    @skipIf(sys.version_info.major == 3 and sys.version_info.minor == 6,
-            'Test not supported on Python 3.6')
     def test_store_credentials_overwrite(self) -> None:
         """Test overwriting qiskitrc credentials."""
         credentials = Credentials('QISKITRC_TOKEN', url=QISKIT_IBM_API_URL)
diff --git a/tox.ini b/tox.ini
index a7141e1f7..2edcdeccd 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,6 +1,6 @@
 [tox]
 minversion = 2.1
-envlist = py36, py37, py38, py39, lint, docs
+envlist = py37, py38, py39, lint, docs
 skipsdist = True
 
 [testenv]