diff --git a/app/src/assets/localization/en/labware_position_check.json b/app/src/assets/localization/en/labware_position_check.json
index b466fd7f3442..822963459ce3 100644
--- a/app/src/assets/localization/en/labware_position_check.json
+++ b/app/src/assets/localization/en/labware_position_check.json
@@ -52,6 +52,7 @@
   "ensure_nozzle_position_desktop": "<block>Ensure that the {{tip_type}} is centered above and level with {{item_location}}. If it isn't, use the controls below or your keyboard to jog the pipette until it is properly aligned.</block>",
   "ensure_nozzle_position_odd": "<block>Ensure that the {{tip_type}} is centered above and level with {{item_location}}. If it isn't, tap <bold>Move pipette</bold> and then jog the pipette until it is properly aligned.</block>",
   "ensure_probe_attached": "Ensure it is properly attached before proceeding.",
+  "ensure_tip_rack_accurately_placed": "Ensure the tip rack is accurately placed in the slot as outlined above to prevent damage to your labware.",
   "exit": "Exit",
   "exit_screen_confirm_exit": "Exit and discard all labware offsets",
   "exit_screen_go_back": "Go back to labware position check",
diff --git a/app/src/organisms/LabwarePositionCheck/steps/HandleLabware/EditOffset/PrepareLabware/PlaceItemInstruction.tsx b/app/src/organisms/LabwarePositionCheck/steps/HandleLabware/EditOffset/PrepareLabware/PlaceItemInstruction.tsx
index 9033ca4bff1f..e1dd952299bf 100644
--- a/app/src/organisms/LabwarePositionCheck/steps/HandleLabware/EditOffset/PrepareLabware/PlaceItemInstruction.tsx
+++ b/app/src/organisms/LabwarePositionCheck/steps/HandleLabware/EditOffset/PrepareLabware/PlaceItemInstruction.tsx
@@ -1,7 +1,15 @@
 import { Trans, useTranslation } from 'react-i18next'
 import { useSelector } from 'react-redux'
+import { css } from 'styled-components'
 
-import { TYPOGRAPHY, LegacyStyledText } from '@opentrons/components'
+import {
+  TYPOGRAPHY,
+  LegacyStyledText,
+  Flex,
+  DIRECTION_COLUMN,
+  SPACING,
+  RESPONSIVENESS,
+} from '@opentrons/components'
 
 import {
   selectIsSelectedLwTipRack,
@@ -9,6 +17,7 @@ import {
   OFFSET_KIND_DEFAULT,
   selectLwDisplayName,
   getFlexSlotNameOnly,
+  selectActivePipetteChannelCount,
 } from '/app/redux/protocol-runs'
 import { UnorderedList } from '/app/molecules/UnorderedList'
 import { DescriptionContent } from '/app/molecules/InterventionModal'
@@ -23,6 +32,7 @@ import type {
 import type { State } from '/app/redux/types'
 import type { LPCWizardContentProps } from '/app/organisms/LabwarePositionCheck/types'
 import type { EditOffsetContentProps } from '/app/organisms/LabwarePositionCheck/steps/HandleLabware/EditOffset'
+import { InlineNotification } from '/app/atoms/InlineNotification'
 
 export function PlaceItemInstruction(
   props: EditOffsetContentProps
@@ -33,11 +43,14 @@ export function PlaceItemInstruction(
   const { protocolData } = useSelector(
     (state: State) => state.protocolRuns[runId]?.lpc as LPCWizardState
   )
+  const isActivePipette96ch =
+    useSelector(selectActivePipetteChannelCount(runId)) === 96
   const isLwTiprack = useSelector(selectIsSelectedLwTipRack(runId))
   const selectedLwInfo = useSelector(
     selectSelectedLwOverview(runId)
   ) as SelectedLwOverview
   const offsetLocationDetails = selectedLwInfo.offsetLocationDetails as OffsetLocationDetails
+  const isDefaultOffset = offsetLocationDetails.kind === OFFSET_KIND_DEFAULT
 
   const buildHeader = (): string =>
     t('prepare_item_in_location', {
@@ -57,35 +70,52 @@ export function PlaceItemInstruction(
   ) as LabwareStackupDetail[]
 
   return (
-    <DescriptionContent
-      headline={buildHeader()}
-      message={
-        <UnorderedList
-          items={[
-            <ClearDeckCopy
-              {...props}
-              key="clear_deck"
-              slotOnlyDisplayLocation={slotOnlyDisplayLocation}
-              labwareInfo={selectedLwInfo}
-            />,
-            ...lwOnlyLocSeq.map((component, index) => (
-              <PlaceItemInstructionContent
-                key={`${slotOnlyDisplayLocation}-${index}`}
-                isLwTiprack={isLwTiprack}
+    <Flex css={CONATINER_STYLE}>
+      <DescriptionContent
+        headline={buildHeader()}
+        message={
+          <UnorderedList
+            items={[
+              <ClearDeckCopy
+                {...props}
+                key="clear_deck"
                 slotOnlyDisplayLocation={slotOnlyDisplayLocation}
                 labwareInfo={selectedLwInfo}
-                lwComponent={component}
-                isFirstItemInStackup={index === 0}
-                {...props}
-              />
-            )),
-          ]}
+              />,
+              ...lwOnlyLocSeq.map((component, index) => (
+                <PlaceItemInstructionContent
+                  key={`${slotOnlyDisplayLocation}-${index}`}
+                  isLwTiprack={isLwTiprack}
+                  slotOnlyDisplayLocation={slotOnlyDisplayLocation}
+                  labwareInfo={selectedLwInfo}
+                  lwComponent={component}
+                  isFirstItemInStackup={index === 0}
+                  {...props}
+                />
+              )),
+            ]}
+          />
+        }
+      />
+      {isActivePipette96ch && isDefaultOffset && (
+        <InlineNotification
+          type="alert"
+          heading={t('ensure_tip_rack_accurately_placed')}
         />
-      }
-    />
+      )}
+    </Flex>
   )
 }
 
+const CONATINER_STYLE = css`
+  flex-direction: ${DIRECTION_COLUMN};
+  gap: ${SPACING.spacing12};
+
+  @media ${RESPONSIVENESS.touchscreenMediaQuerySpecs} {
+    gap: ${SPACING.spacing24};
+  }
+`
+
 interface PlaceItemInstructionContentProps extends LPCWizardContentProps {
   isLwTiprack: boolean
   slotOnlyDisplayLocation: string
diff --git a/app/src/organisms/LabwarePositionCheck/steps/HandleLabware/EditOffset/PrepareLabware/__tests__/PlaceItemInstruction.test.tsx b/app/src/organisms/LabwarePositionCheck/steps/HandleLabware/EditOffset/PrepareLabware/__tests__/PlaceItemInstruction.test.tsx
new file mode 100644
index 000000000000..0626a724ad1d
--- /dev/null
+++ b/app/src/organisms/LabwarePositionCheck/steps/HandleLabware/EditOffset/PrepareLabware/__tests__/PlaceItemInstruction.test.tsx
@@ -0,0 +1,232 @@
+import { describe, expect, it, beforeEach, vi } from 'vitest'
+import { screen } from '@testing-library/react'
+import { useSelector } from 'react-redux'
+
+import { renderWithProviders } from '/app/__testing-utils__'
+import { i18n } from '/app/i18n'
+import {
+  selectIsSelectedLwTipRack,
+  selectSelectedLwOverview,
+  OFFSET_KIND_DEFAULT,
+  selectLwDisplayName,
+  getFlexSlotNameOnly,
+  selectActivePipetteChannelCount,
+  OFFSET_KIND_LOCATION_SPECIFIC,
+} from '/app/redux/protocol-runs'
+import { PlaceItemInstruction } from '../PlaceItemInstruction'
+
+vi.mock('react-redux', async () => {
+  const actual = await vi.importActual('react-redux')
+  return {
+    ...actual,
+    useSelector: vi.fn(),
+  }
+})
+vi.mock('/app/redux/protocol-runs')
+
+describe('PlaceItemInstruction', () => {
+  const mockRunId = 'mock_run_id'
+  const mockProps = {
+    runId: mockRunId,
+  }
+  const mockSlotLocation = 'Slot C2'
+  const mockLwDisplayName = 'Mock Labware'
+  const mockTipRackDisplayName = 'Mock Tip Rack'
+  const mockLpcState = {
+    protocolData: {},
+  }
+
+  const mockTipRackStackup = {
+    offsetLocationDetails: {
+      kind: OFFSET_KIND_DEFAULT,
+      closestBeneathModuleModel: null,
+      lwModOnlyStackupDetails: [{ kind: 'labware', labwareUri: 'tiprack-uri' }],
+    },
+  }
+
+  const mockLabwareStackup = {
+    offsetLocationDetails: {
+      kind: OFFSET_KIND_DEFAULT,
+      closestBeneathModuleModel: null,
+      lwModOnlyStackupDetails: [{ kind: 'labware', labwareUri: 'labware-uri' }],
+    },
+  }
+
+  const mockLabwareWithModuleStackup = {
+    offsetLocationDetails: {
+      kind: OFFSET_KIND_LOCATION_SPECIFIC,
+      closestBeneathModuleModel: 'temperatureModule',
+      lwModOnlyStackupDetails: [
+        { kind: 'module', moduleModel: 'temperatureModule' },
+        { kind: 'labware', labwareUri: 'labware-uri' },
+      ],
+    },
+  }
+
+  const render = () => {
+    // @ts-expect-error Not all props necessary for testing.
+    return renderWithProviders(<PlaceItemInstruction {...mockProps} />, {
+      i18nInstance: i18n,
+    })[0]
+  }
+
+  beforeEach(() => {
+    vi.clearAllMocks()
+
+    vi.mocked(getFlexSlotNameOnly).mockReturnValue(mockSlotLocation)
+    vi.mocked(selectLwDisplayName).mockReturnValue(() => mockLwDisplayName)
+
+    vi.mocked(selectIsSelectedLwTipRack).mockImplementation(() => () => false)
+    vi.mocked(selectSelectedLwOverview).mockImplementation(() => () =>
+      mockLabwareStackup as any
+    )
+    vi.mocked(selectActivePipetteChannelCount).mockImplementation(() => () => 8)
+
+    vi.mocked(useSelector).mockImplementation(selector => {
+      return selector({
+        protocolRuns: {
+          [mockRunId]: {
+            lpc: mockLpcState,
+          },
+        },
+      })
+    })
+  })
+
+  it('should render prepare labware instruction in slot location', () => {
+    render()
+
+    screen.getByText(`Prepare labware in ${mockSlotLocation}`)
+  })
+
+  it('should render prepare tip rack instruction in slot location', () => {
+    vi.mocked(selectIsSelectedLwTipRack).mockImplementation(() => () => true)
+    vi.mocked(selectSelectedLwOverview).mockImplementation(() => () =>
+      mockTipRackStackup as any
+    )
+
+    render()
+
+    screen.getByText(`Prepare tip rack in ${mockSlotLocation}`)
+  })
+
+  it('should show clear deck instruction for default offsets', () => {
+    render()
+
+    screen.getByText(
+      /Clear all deck slots of labware and remove any modules from/
+    )
+  })
+
+  it('should show clear deck but modules instruction for non-default offset with a module', () => {
+    vi.mocked(selectSelectedLwOverview).mockImplementation(() => () =>
+      mockLabwareWithModuleStackup as any
+    )
+
+    render()
+
+    screen.getByText(
+      'Clear all deck slots of labware, leaving modules in place'
+    )
+  })
+
+  it('should show a place labware instruction', () => {
+    render()
+
+    const listItems = screen.getAllByRole('listitem')
+    const labwareItem = listItems.find(
+      li =>
+        li.textContent?.includes('Place a') &&
+        li.textContent.includes(mockLwDisplayName) &&
+        li.textContent.includes(mockSlotLocation)
+    )
+
+    expect(labwareItem).toBeTruthy()
+  })
+
+  it('should show a place tip rack instruction', () => {
+    vi.mocked(selectIsSelectedLwTipRack).mockImplementation(() => () => true)
+    vi.mocked(selectSelectedLwOverview).mockImplementation(() => () =>
+      mockTipRackStackup as any
+    )
+    vi.mocked(selectLwDisplayName).mockReturnValue(() => mockTipRackDisplayName)
+
+    render()
+
+    const listItems = screen.getAllByRole('listitem')
+    const tipRackItem = listItems.find(
+      li =>
+        li.textContent?.includes('Place') &&
+        li.textContent.includes('full') &&
+        li.textContent.includes(mockTipRackDisplayName) &&
+        li.textContent.includes(mockSlotLocation)
+    )
+    expect(tipRackItem).toBeTruthy()
+  })
+
+  it('should show inline notification for 96-channel pipette when calibrating a default offset', () => {
+    vi.mocked(selectIsSelectedLwTipRack).mockImplementation(() => () => true)
+    vi.mocked(selectSelectedLwOverview).mockImplementation(() => () =>
+      mockTipRackStackup as any
+    )
+    vi.mocked(selectActivePipetteChannelCount).mockImplementation(() => () =>
+      96
+    )
+
+    render()
+
+    screen.getByText(
+      'Ensure the tip rack is accurately placed in the slot as outlined above to prevent damage to your labware.'
+    )
+  })
+
+  it('should not show inline notification for other pipettes when calibrating a default offset', () => {
+    render()
+
+    expect(
+      screen.queryByText(
+        'Ensure the tip rack is accurately placed in the slot as outlined above to prevent damage to your labware.'
+      )
+    ).not.toBeInTheDocument()
+  })
+
+  it('should show next place labware instruction for the second item in a stackup', () => {
+    const multiItemStackup = {
+      offsetLocationDetails: {
+        kind: OFFSET_KIND_DEFAULT,
+        closestBeneathModuleModel: null,
+        lwModOnlyStackupDetails: [
+          { kind: 'labware', labwareUri: 'labware-uri-1' },
+          { kind: 'labware', labwareUri: 'labware-uri-2' },
+        ],
+      },
+    } as any
+
+    vi.mocked(selectSelectedLwOverview).mockImplementation(() => () =>
+      multiItemStackup
+    )
+    vi.mocked(selectLwDisplayName).mockImplementation((runId, uri) => {
+      return () =>
+        uri === 'labware-uri-1' ? 'First Labware' : 'Second Labware'
+    })
+
+    render()
+
+    const listItems = screen.getAllByRole('listitem')
+
+    const firstLabwareItem = listItems.find(
+      li =>
+        li.textContent?.includes('Place a') &&
+        li.textContent?.includes('First Labware')
+    )
+
+    const secondLabwareItem = listItems.find(
+      li =>
+        li.textContent?.includes('Next, place a') &&
+        li.textContent?.includes('Second Labware')
+    )
+
+    expect(firstLabwareItem).toBeTruthy()
+    expect(secondLabwareItem).toBeTruthy()
+  })
+})