diff --git a/.github/workflows/Check_utf8.yml b/.github/workflows/Check_utf8.yml new file mode 100644 index 0000000..20feb1b --- /dev/null +++ b/.github/workflows/Check_utf8.yml @@ -0,0 +1,15 @@ +name: Check if all required files are UTF-8 + +on: + [push, pull_request] + +permissions: + contents: read + +jobs: + utf8check: + uses: Open-Systems-Pharmacology/Workflows/.github/workflows/UTF8Check.yml@5e78d9c26dd9b1fd131ce69da7532dd5f82a8801 + with: + file-extensions: 'R\|json\|md' #File extension(s) to check separated by \| Examples: + #R + #R\|json diff --git a/.github/workflows/CrossRefCheckWithAnchors.yml b/.github/workflows/CrossRefCheckWithAnchors.yml new file mode 100644 index 0000000..05fbddf --- /dev/null +++ b/.github/workflows/CrossRefCheckWithAnchors.yml @@ -0,0 +1,15 @@ +name: CrossRefCheck with Anchors + +on: + push: + branches: + - review + +permissions: + contents: read + +jobs: + crossref-check-with-anchors: + uses: Open-Systems-Pharmacology/Workflows/.github/workflows/MarkdownCrossrefCheck_withAnchors.yml@5e78d9c26dd9b1fd131ce69da7532dd5f82a8801 + with: + folder-path: 'Evaluation/report' diff --git a/.github/workflows/MarkdownLinksCheck.yml b/.github/workflows/MarkdownLinksCheck.yml new file mode 100644 index 0000000..5e5768c --- /dev/null +++ b/.github/workflows/MarkdownLinksCheck.yml @@ -0,0 +1,15 @@ +name: Check Markdown links + +on: + push: + branches: + - review + +permissions: + contents: read + +jobs: + markdown-link-check: + uses: Open-Systems-Pharmacology/Workflows/.github/workflows/MarkdownLinksCheck.yml@5e78d9c26dd9b1fd131ce69da7532dd5f82a8801 + with: + folder-path: 'Evaluation/report' diff --git a/.github/workflows/SpellChecker.yml b/.github/workflows/SpellChecker.yml new file mode 100644 index 0000000..a928b1b --- /dev/null +++ b/.github/workflows/SpellChecker.yml @@ -0,0 +1,11 @@ +name: Spellcheck + +on: + [push, pull_request] + +permissions: + contents: read + +jobs: + Spellcheck: + uses: Open-Systems-Pharmacology/Workflows/.github/workflows/SpellChecker.yml@5e78d9c26dd9b1fd131ce69da7532dd5f82a8801 diff --git a/.github/workflows/ValidateEvaluationPlan.yml b/.github/workflows/ValidateEvaluationPlan.yml new file mode 100644 index 0000000..109bf4f --- /dev/null +++ b/.github/workflows/ValidateEvaluationPlan.yml @@ -0,0 +1,13 @@ +name: Validate Evaluation Plan + +on: + [push, pull_request] + +permissions: + contents: read + +jobs: + Validate-Evaluation-Plan: + uses: Open-Systems-Pharmacology/Workflows/.github/workflows/ValidateQualificationPlan.yml@5e78d9c26dd9b1fd131ce69da7532dd5f82a8801 + with: + qualification-plan: 'Evaluation/Input/evaluation_plan.json' diff --git a/.github/workflows/wordlist.txt b/.github/workflows/wordlist.txt new file mode 100644 index 0000000..80537f8 --- /dev/null +++ b/.github/workflows/wordlist.txt @@ -0,0 +1,142 @@ +Abad +Abad-Santos +Armodafinil +Atomoxetine +AUClast +Baumann +Bertschy +Block +Bond +Bondolfi +Boonleang +Boulton +Clin +Cmax +CYP2D6 +CYP3A +CYP3A4 +Darwish +DeVane +DGI +Eap +Edginton +Eissing +Feick +Fuhr +Gallego +Gallego-Sadín +GFR +GMFE +GOF +Hellriegel +Hempel +Höhn +Hydroxyrisperidone +Igel +Investig +JCP +Kaneo +Kerb +Kim +Kneller +Kuepfer +Lehr +Lippert +Liu +Loer +López +López-Rodríguez +Mahatthanatrakul +Markowitz +Marok +Mürdter +Nakagami +Nontaput +Novalbos +Ochoa +Ontogeny +OSP +OSPy +P-glycoprotein +P-gp +paliperidone +Park +Paroxetine +PBPK +Pharm +Pharmacodyn +Pharmacokinet +Pharmacokinetic +Pharmacokinetics +Pharmacol +Pharmaceutics +Pharmacometrics +Pharmacopsychiatry +Pipatrattanaseree +PK +PK-Sim +Psychopharmacol +Ridtitid +Rifampin +Risch +Risperidone +Robertson +Rodríguez +Román +Rüdesheim +Rujimamahasan +Sadín +Saito +Schlender +Schmitt +Schwab +Selzer +Sevestre +Shin +Solodenko +Sriwiriyajan +Sunbhanich +Syst +Tateishi +Teutonico +Ther +Vermeulen +Willmann +Wongnawa +Yang +Yasui +Yasui-Furukori +Zullino +active-moiety +activity-score +analyte +analytes +antipsychotic +drug-gene +drug-drug-gene +extensive-metabolizer +first-pass +goodness-of-fit +hydroxyrisperidone +interacting-drug +kcat +metabolizers +model-building +model-verification +multi-dose +multiple-dose +olanzapine +overpredicting +parent-metabolite +parent-to-metabolite +physicochemical +poor-metabolizer +population-level +risperidone +single-analyte +single-dose +whole-body +HLH +FZ +reoptimization +ee diff --git a/.gitignore b/.gitignore new file mode 100644 index 0000000..7b395a5 --- /dev/null +++ b/.gitignore @@ -0,0 +1,2 @@ +Evaluation/workflow_patched.R +justfile diff --git a/Evaluation/Input/Content/Concentration_time_profiles.md b/Evaluation/Input/Content/Concentration_time_profiles.md new file mode 100644 index 0000000..c54c615 --- /dev/null +++ b/Evaluation/Input/Content/Concentration_time_profiles.md @@ -0,0 +1 @@ +Simulated versus observed concentration-time profiles of all data listed in Section 2.2.2 (Clinical data) are presented below. diff --git a/Evaluation/Input/Content/Concentration_time_profiles_building.md b/Evaluation/Input/Content/Concentration_time_profiles_building.md new file mode 100644 index 0000000..e69de29 diff --git a/Evaluation/Input/Content/Concentration_time_profiles_verification.md b/Evaluation/Input/Content/Concentration_time_profiles_verification.md new file mode 100644 index 0000000..e69de29 diff --git a/Evaluation/Input/Content/GOF_diagnostics.md b/Evaluation/Input/Content/GOF_diagnostics.md new file mode 100644 index 0000000..5143faf --- /dev/null +++ b/Evaluation/Input/Content/GOF_diagnostics.md @@ -0,0 +1,3 @@ +Below you find the goodness-of-fit visual diagnostic plots for PBPK model performance of all data used, as presented in Section 2.2.2 (Clinical data). + +The first plot shows observed versus simulated plasma concentration, the second weighted residuals versus time. diff --git a/Evaluation/Input/Content/GOF_diagnostics_9hydroxyrisperidone.md b/Evaluation/Input/Content/GOF_diagnostics_9hydroxyrisperidone.md new file mode 100644 index 0000000..807ddea --- /dev/null +++ b/Evaluation/Input/Content/GOF_diagnostics_9hydroxyrisperidone.md @@ -0,0 +1,3 @@ +Below you find the goodness-of-fit visual diagnostic plots for 9-hydroxyrisperidone plasma concentration data used in the model evaluation. + +The first plot shows observed versus simulated plasma concentration, the second weighted residuals versus time. diff --git a/Evaluation/Input/Content/GOF_diagnostics_risperidone.md b/Evaluation/Input/Content/GOF_diagnostics_risperidone.md new file mode 100644 index 0000000..5f25574 --- /dev/null +++ b/Evaluation/Input/Content/GOF_diagnostics_risperidone.md @@ -0,0 +1,3 @@ +Below you find the goodness-of-fit visual diagnostic plots for risperidone plasma concentration data used in the model evaluation. + +The first plot shows observed versus simulated plasma concentration, the second weighted residuals versus time. diff --git a/Evaluation/Input/Content/Input_table.md b/Evaluation/Input/Content/Input_table.md new file mode 100644 index 0000000..224cd4f --- /dev/null +++ b/Evaluation/Input/Content/Input_table.md @@ -0,0 +1 @@ +The compound parameter values of the final PBPK model are illustrated below. diff --git a/Evaluation/Input/Content/References.md b/Evaluation/Input/Content/References.md new file mode 100644 index 0000000..9502fe0 --- /dev/null +++ b/Evaluation/Input/Content/References.md @@ -0,0 +1,15 @@ +1. Rüdesheim S, Selzer D, Mürdter T, Igel S, Kerb R, Schwab M, Lehr T. Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone. Pharmaceutics. 2022;14:1734. doi:10.3390/pharmaceutics14081734. +2. Rüdesheim S, Loer HLH, Feick D, Marok FZ, Fuhr LM, Selzer D, et al. A Comprehensive CYP2D6 Drug-Drug-Gene Interaction Network for Application in Precision Dosing and Drug Development. Clin Pharmacol Ther. 2025. +3. Kneller LA, Abad-Santos F, Hempel G. Physiologically Based Pharmacokinetic Modelling to Describe the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone According to Cytochrome P450 2D6 Phenotypes. Clin Pharmacokinet. 2020;59:51-65. doi:10.1007/s40262-019-00793-x. +4. Novalbos J, López-Rodríguez R, Román M, Gallego-Sadín S, Ochoa D, Abad-Santos F. Effects of CYP2D6 genotype on the pharmacokinetics, pharmacodynamics, and safety of risperidone in healthy volunteers. J Clin Psychopharmacol. 2010;30:504-511. doi:10.1097/JCP.0b013e3181ee84c7. +5. Bondolfi G, Eap CB, Bertschy G, Zullino D, Vermeulen A, Baumann P. The effect of fluoxetine on the pharmacokinetics and safety of risperidone in psychotic patients. Pharmacopsychiatry. 2002;35:50-56. doi:10.1055/s-2002-25026. +6. Markowitz JS, DeVane CL, Liston HL, Boulton DW, Risch SC. The effects of probenecid on the disposition of risperidone and olanzapine in healthy volunteers. Clin Pharmacol Ther. 2002;71:30-38. doi:10.1067/mcp.2002.119815. +7. Darwish M, Bond M, Yang R, Hellriegel ET, Robertson P. Evaluation of Potential Pharmacokinetic Drug-Drug Interaction Between Armodafinil and Risperidone in Healthy Adults. Clin Drug Investig. 2015;35:725-733. doi:10.1007/s40261-015-0330-6. +8. Mahatthanatrakul W, Sriwiriyajan S, Ridtitid W, Boonleang J, Wongnawa M, Rujimamahasan N, Pipatrattanaseree W. Effect of cytochrome P450 3A4 inhibitor ketoconazole on risperidone pharmacokinetics in healthy volunteers. J Clin Pharm Ther. 2012;37:221-225. doi:10.1111/j.1365-2710.2011.01271.x. +9. Nakagami T, Yasui-Furukori N, Saito M, Tateishi T, Kaneo S. Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone. Clin Pharmacol Ther. 2005;78:43-51. doi:10.1016/j.clpt.2005.03.009. +10. Kim KA, Park PW, Liu KH, Kim KB, Kim HJ, Shin JG, Park JY. Effect of rifampin, an inducer of CYP3A and P-glycoprotein, on the pharmacokinetics of risperidone. J Clin Pharmacol. 2008;48:66-72. doi:10.1177/0091270007309888. +11. Mahatthanatrakul W, Nontaput T, Ridtitid W, Wongnawa M, Sunbhanich M. Rifampin decreases plasma concentrations of risperidone in healthy volunteers. J Clin Pharm Ther. 2007;32:161-167. doi:10.1111/j.1365-2710.2007.00811.x. + +12. Kuepfer L, Niederalt C, Wendl T, Schlender JF, Willmann S, Lippert J, Block M, Eissing T, Teutonico D. Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model. CPT Pharmacometrics Syst Pharmacol. 2016;5:516-531. + +13. Willmann S, Höhn K, Edginton A, Sevestre M, Solodenko J, Weiss W, Lippert J, Schmitt W. Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs. J Pharmacokinet Pharmacodyn. 2007;34:401-431. diff --git a/Evaluation/Input/Content/Section1_Introduction.md b/Evaluation/Input/Content/Section1_Introduction.md new file mode 100644 index 0000000..17a5176 --- /dev/null +++ b/Evaluation/Input/Content/Section1_Introduction.md @@ -0,0 +1,14 @@ +Risperidone is an atypical antipsychotic used for schizophrenia and other psychiatric indications. It is administered orally and is converted to the active metabolite 9-hydroxyrisperidone, also known as paliperidone. CYP2D6 is an important metabolic pathway for risperidone, while CYP3A4 and transporter processes contribute to parent and metabolite disposition. + +This risperidone model is intended to describe plasma concentration-time profiles of risperidone, 9-hydroxyrisperidone, and active moiety across CYP2D6 phenotype and activity-score groups. It supports evaluation of CYP2D6 drug-gene interactions and interacting-drug scenarios where risperidone or 9-hydroxyrisperidone exposure is clinically relevant. + +The risperidone parent-metabolite PBPK model was originally developed by [Kneller 2020](References.md). The model was subsequently used in the CYP2D6 activity-score framework by [Rüdesheim 2022](References.md) and in the CYP2D6 drug-drug-gene interaction network by [Rüdesheim 2025](References.md). The clinical data include oral single-dose and multiple-dose administration of risperidone, CYP2D6 phenotype or activity-score stratified groups, and studies with CYP3A or P-gp modulators. + +The presented model includes the following features: + +- risperidone and 9-hydroxyrisperidone as parent and metabolite compounds, +- CYP2D6-mediated risperidone metabolism with activity-score dependent kcat values, +- CYP3A4-mediated metabolism and residual sink pathways, +- P-gp transport for risperidone and 9-hydroxyrisperidone, +- renal filtration for parent and metabolite, +- oral tablet administration in the evaluated clinical studies. diff --git a/Evaluation/Input/Content/Section2.1_Modeling_Strategy.md b/Evaluation/Input/Content/Section2.1_Modeling_Strategy.md new file mode 100644 index 0000000..acac6fc --- /dev/null +++ b/Evaluation/Input/Content/Section2.1_Modeling_Strategy.md @@ -0,0 +1,17 @@ +The general concept of building a PBPK model has previously been described by Kuepfer et al. ([Kuepfer 2016](References.md)). Relevant information on anthropometric and physiological parameters in adults was gathered from the literature and incorporated into PK-Sim as default values for adult simulations ([Willmann 2007](References.md)). + +The applied activity and variability of plasma proteins and active processes integrated into PK-Sim are described in the publicly available PK-Sim Ontogeny Database or otherwise referenced for the specific process. + +The risperidone model was developed as a parent-metabolite model for risperidone and 9-hydroxyrisperidone. The original model by [Kneller 2020](References.md) described oral risperidone pharmacokinetics by CYP2D6 phenotype. [Rüdesheim 2022](References.md) then used the model in a CYP2D6 activity-score framework, where CYP2D6 metabolic capacity is represented by activity-score dependent kcat values. + +Clinical studies used for model building covered oral risperidone administration and included data for risperidone and 9-hydroxyrisperidone where available. Model verification used independent oral study arms, including CYP2D6 poor-, normal-, and higher-activity groups and interacting-drug scenarios. Because the active moiety is the sum of parent and metabolite exposure, model performance has to be interpreted separately for risperidone, 9-hydroxyrisperidone, and active moiety. + +The model-building workflow first established the parent disposition and the formation of 9-hydroxyrisperidone. CYP2D6-related parameters were then used to describe the shift from parent exposure toward metabolite exposure across phenotype and activity-score groups. Verification focused on whether the final parameter set described independent study arms without additional study-specific adjustment. + +The model contains CYP2D6 and CYP3A4 metabolism, P-gp transport, renal filtration, and residual clearance processes. CYP2D6 poor-metabolizer activity is represented by setting CYP2D6 kcat to zero, while non-zero activity-score groups use fitted or scaled CYP2D6 kcat values. + +The evaluated applications are oral risperidone applications with risperidone, 9-hydroxyrisperidone, and active-moiety observations. The major proteins and processes represented explicitly are CYP2D6, CYP3A4, P-gp, plasma protein binding, passive renal filtration, and unspecific hepatic clearance for the metabolite. The parent-metabolite structure is central to the evaluation because a model can describe active moiety while still showing bias in the parent or metabolite alone. + +The report therefore presents model diagnostics for the parent and metabolite concentrations and links the clinical-data table to model-building and verification profiles. The intended interpretation is the plausibility of risperidone and 9-hydroxyrisperidone exposure across CYP2D6 status, not a separate reoptimization for each clinical study. + +Details about input data are provided in [Section 2.2](#22). Details about the structural model and assumptions are provided in [Section 2.3](#23). diff --git a/Evaluation/Input/Content/Section2.2_Data.md b/Evaluation/Input/Content/Section2.2_Data.md new file mode 100644 index 0000000..f7c7b04 --- /dev/null +++ b/Evaluation/Input/Content/Section2.2_Data.md @@ -0,0 +1,42 @@ +### 2.2.1 In vitro and physicochemical data + +The table below summarizes the drug-dependent inputs documented for the risperidone model. Parameter values are listed for the parent compound and 9-hydroxyrisperidone where they are relevant for interpreting the parent-metabolite simulations. + +| Parameter | Unit | Value | Source | Description | +| --- | ---: | ---: | --- | --- | +| Risperidone MW | g/mol | 410.48 | [Kneller 2020](References.md) | Parent compound size used in concentration conversions. | +| Risperidone pKa | - | 8.76, 3.11 | [Kneller 2020](References.md) | Basic and acidic ionization constants. | +| Risperidone fu | % | 17.50 | [Kneller 2020](References.md) | Plasma binding input for parent drug. | +| Risperidone CYP2D6 Km to 9-hydroxyrisperidone | µmol/L | 1.10 | [Kneller 2020](References.md) | CYP2D6 affinity parameter for metabolite formation. | +| Risperidone CYP2D6 kcat EM to 9-hydroxyrisperidone | 1/min | 1.07 | Optimized | CYP2D6 metabolic capacity in extensive metabolizers. | +| Risperidone P-gp Km | µmol/L | 26.30 | [Kneller 2020](References.md) | P-gp affinity parameter. | +| Risperidone P-gp kcat | 1/min | 12.72 | Optimized | P-gp transport capacity. | +| 9-Hydroxyrisperidone fu | % | 29.00 | [Kneller 2020](References.md) | Plasma binding input for the active metabolite. | +| 9-Hydroxyrisperidone P-gp Km | µmol/L | 149.60 | [Rüdesheim 2022](References.md) | P-gp affinity parameter for the active metabolite. | +| 9-Hydroxyrisperidone unspecific CLhep | 1/min | 0.08 | Optimized | Residual metabolite elimination. | +| GFR fraction | - | 1.00 | Assumed | Passive glomerular filtration fraction for parent and metabolite. | + +The 9-hydroxyrisperidone P-gp Km reported in the publication and supplement by [Rüdesheim 2022](References.md) is erroneous. The model retains the correct value of 149.6 µmol/L. + +### 2.2.2 Clinical data + +The evaluation uses 19 observed-data records for risperidone and 9-hydroxyrisperidone in peripheral venous blood plasma. The evaluation plan assigns 6 simulations to model building and 6 simulations to model verification. + +Model-building clinical data: + +| Publication | Arm / Treatment / Information used for model building | +| --- | --- | +| [Novalbos 2010](References.md) | Plasma PK profiles in adults after oral, single dose administration of 1 mg risperidone with CYP2D6 AS = 2 status. | +| [Bondolfi 2002](References.md) | Plasma PK profiles in adults after oral, multiple dose administration of 2 mg risperidone with CYP2D6 poor- and extensive-metabolizer status. | +| [Markowitz 2002](References.md) | Plasma PK profiles in adults after oral, single dose administration of 1 mg risperidone with CYP2D6 extensive-metabolizer status. | +| [Darwish 2015](References.md) | Plasma PK profiles in adults after oral, single dose administration of 2 mg risperidone with CYP2D6 extensive-metabolizer status. | +| [Mahatthanatrakul 2012](References.md) | Plasma PK profiles in adults after oral, single dose administration of 2 mg risperidone with risperidone and 9-hydroxyrisperidone measurements. | + +Model-verification clinical data: + +| Publication | Arm / Treatment / Information used for model verification | +| --- | --- | +| [Novalbos 2010](References.md) | Plasma PK profiles in adults after oral, single dose administration of 1 mg risperidone with CYP2D6 AS = 0, AS = 1, and AS = 3 status. | +| [Nakagami 2005](References.md) | Plasma PK profiles in adults after oral, single dose administration of 1 mg risperidone with risperidone and 9-hydroxyrisperidone measurements. | +| [Mahatthanatrakul 2007](References.md) | Plasma PK profiles in adults after oral, single dose administration of 4 mg risperidone. | +| [Kim 2008](References.md) | Plasma PK profiles in adults after oral risperidone administration with rifampin pretreatment. | diff --git a/Evaluation/Input/Content/Section2.3_Model_Parameters_and_Assumptions.md b/Evaluation/Input/Content/Section2.3_Model_Parameters_and_Assumptions.md new file mode 100644 index 0000000..033f630 --- /dev/null +++ b/Evaluation/Input/Content/Section2.3_Model_Parameters_and_Assumptions.md @@ -0,0 +1,55 @@ +### 2.3.1 Absorption + +The model includes oral administration of risperidone. Oral absorption is represented with compound-specific intestinal permeability and formulation settings. The risperidone intestinal permeability was optimized, while the 9-hydroxyrisperidone intestinal permeability was calculated. + +The clinical studies used for model building and verification are oral tablet studies, so the evaluation focuses on oral risperidone absorption and subsequent parent-metabolite disposition. + +No intravenous risperidone data are included in the evaluation, so oral absorption and first-pass metabolism are coupled in the clinical concentration-time profiles. The `Specific intestinal permeability` parameter is therefore interpreted together with the metabolic parameters that determine parent and metabolite exposure after oral dosing. + +The same oral absorption assumptions are used across CYP2D6 status groups. Phenotype and activity-score differences are assigned to metabolic capacity rather than to study-specific changes in absorption. + +### 2.3.2 Distribution + +Risperidone and 9-hydroxyrisperidone are represented with compound-specific plasma protein binding. Fraction unbound values of 17.50% for risperidone and 29.00% for 9-hydroxyrisperidone were used as summarized in [Section 2.2.1](#221-in-vitro-and-physicochemical-data). + +Partition coefficients were calculated with the Rodgers and Rowland method. The parent-metabolite structure means that distribution affects both the parent concentration-time profile and the active-moiety profile. + +The model uses separate physicochemical and distribution properties for risperidone and 9-hydroxyrisperidone. This is important because active moiety is a composite endpoint, while tissue distribution and plasma binding are compound-specific. The active-moiety comparison should therefore be read together with the individual parent and metabolite profiles. + +Distribution was not fitted separately by phenotype. CYP2D6 status affects the rate of risperidone conversion to 9-hydroxyrisperidone, while the same adult physiology and compound-specific binding assumptions are retained across simulations. + +### 2.3.3 Metabolism and Elimination + +Two CYP-mediated pathways, transporter processes, renal filtration, and residual clearance pathways are represented in the model. + +* CYP2D6 + +CYP2D6 converts risperidone to 9-hydroxyrisperidone. CYP2D6 activity is activity-score dependent. Poor-metabolizer activity is set to zero, while non-zero activity-score groups use fitted or scaled kcat values based on the CYP2D6 activity-score framework. + +The CYP2D6 pathway controls both parent depletion and metabolite formation. For this reason, CYP2D6 parameterization affects risperidone, 9-hydroxyrisperidone, and active-moiety profiles in different directions. Parent-only diagnostics are not sufficient to evaluate this model. + +* CYP3A4 and sink pathways + +CYP3A4 contributes to risperidone metabolism. Additional sink pathways are included to capture clearance not explicitly assigned to CYP2D6-mediated 9-hydroxyrisperidone formation. + +These pathways provide CYP2D6-independent clearance and prevent poor-metabolizer simulations from depending solely on renal elimination. Their interpretation is structural and empirical, because they represent clearance components not resolved as individual measured metabolites in the clinical evaluation. + +* P-gp and renal elimination + +P-gp transport is implemented for risperidone and 9-hydroxyrisperidone. Both compounds include passive renal filtration with a `GFR fraction` of 1. The metabolite also includes unspecific hepatic clearance as summarized in [Section 2.2.1](#221-in-vitro-and-physicochemical-data). + +P-gp transport was retained for both parent and metabolite because it can affect intestinal and renal handling. Passive renal filtration uses the compound-specific fraction unbound and adult renal physiology. The additional metabolite clearance pathway captures elimination of 9-hydroxyrisperidone not represented by filtration alone. + +### 2.3.4 Automated Parameter Identification + +The following parameters were optimized by fitting the model to the data: + +| Model Parameter | +| --- | +| CYP2D6 kcat values | +| CYP3A4 sink-related rates | +| P-gp transport kcat values | +| 9-hydroxyrisperidone unspecific CLhep | +| `Specific intestinal permeability` | + +The optimized parameters were selected to describe oral absorption, parent-to-metabolite conversion, transporter contribution, and residual metabolite clearance. Physicochemical values and plasma protein binding values were kept as sourced inputs. This distinction is important for interpreting CYP2D6 activity-score simulations, because the exposure shift is driven by metabolic-capacity terms rather than by repeated adjustment of distribution or binding. diff --git a/Evaluation/Input/Content/Section3_Results_and_Discussion.md b/Evaluation/Input/Content/Section3_Results_and_Discussion.md new file mode 100644 index 0000000..ab8b8da --- /dev/null +++ b/Evaluation/Input/Content/Section3_Results_and_Discussion.md @@ -0,0 +1,19 @@ +The PBPK model for risperidone was developed and evaluated with clinical pharmacokinetic data after oral administration. The evaluation covers single-dose and multiple-dose oral administration, risperidone and 9-hydroxyrisperidone plasma concentration-time profiles, CYP2D6 poor-, extensive-, and activity-score stratified groups, and interaction settings relevant to CYP3A and P-gp. + +The model-building data supported the parent-metabolite structure, CYP2D6-mediated 9-hydroxylation, CYP3A4 metabolism, P-gp transport, renal filtration, and residual metabolite clearance. Model-building studies included CYP2D6 activity-score or phenotype data from [Novalbos 2010](References.md), [Bondolfi 2002](References.md), and [Markowitz 2002](References.md), as well as studies with parent and metabolite measurements from [Darwish 2015](References.md) and [Mahatthanatrakul 2012](References.md). Verification included independent activity-score and interaction studies from [Novalbos 2010](References.md), [Nakagami 2005](References.md), [Mahatthanatrakul 2007](References.md), and [Kim 2008](References.md). + +The model quantifies CYP2D6-mediated formation of 9-hydroxyrisperidone, CYP3A4-mediated metabolism, P-gp transport, passive renal filtration, and residual clearance of the active metabolite. The interpretation of model performance requires separate consideration of parent, metabolite, and active-moiety behavior. Parent risperidone profiles mainly test absorption, P-gp transport, and formation clearance. 9-hydroxyrisperidone profiles additionally test metabolite distribution, renal filtration, and residual hepatic clearance. + +The next sections show: + +1. the final model input parameters for the building blocks: [Section 3.1](#31). +2. the overall goodness of fit: [Section 3.2](#32). +3. simulated vs. observed concentration-time profiles for the clinical studies used for model building and for model verification: [Section 3.3](#33). + +The merged GOF diagnostic over the included concentration observations gives GMFE values of 1.60 for risperidone, 1.71 for 9-hydroxyrisperidone, and 1.64 for all observations. These values show acceptable population-level agreement but are less tight than for some single-analyte CYP2D6 substrate models. The difference between parent and metabolite GMFE values should be considered when interpreting active-moiety predictions, because compensation between risperidone and 9-hydroxyrisperidone can mask analyte-specific bias. + +[Rüdesheim 2022](References.md) reported strong DGI ratio performance for risperidone, with 7 of 7 AUClast ratios and 7 of 7 Cmax ratios within the prediction success limits. The reported GMFE values were 1.11 for AUClast ratios and 1.16 for Cmax ratios. These DGI ratio metrics support the activity-score implementation, while the concentration-time diagnostics below remain necessary for evaluating the full parent-metabolite model. + +The concentration-time profiles should be reviewed by CYP2D6 activity group and analyte. CYP2D6 poor-metabolizer profiles test whether CYP3A4 metabolism and residual processes can describe parent clearance when CYP2D6 activity is absent. Higher activity-score groups test whether increased CYP2D6 kcat values improve parent-to-metabolite conversion without overpredicting 9-hydroxyrisperidone. Interaction studies involving rifampin or other modulators additionally test whether CYP3A and P-gp assumptions remain plausible beyond the base oral dosing studies. + +The model is adequate for adult oral risperidone simulations within the represented doses, CYP2D6 groups, and measured analytes. Remaining interpretation should be cautious for unrepresented formulations, pediatric populations, and scenarios where the active moiety is used without checking parent and metabolite profiles separately. diff --git a/Evaluation/Input/Content/Section4_Conclusion.md b/Evaluation/Input/Content/Section4_Conclusion.md new file mode 100644 index 0000000..211002b --- /dev/null +++ b/Evaluation/Input/Content/Section4_Conclusion.md @@ -0,0 +1 @@ +The presented PBPK model adequately describes the oral pharmacokinetics of risperidone and 9-hydroxyrisperidone in the evaluated adult CYP2D6 phenotype and activity-score groups. diff --git a/Evaluation/Input/Content/titlepage.md b/Evaluation/Input/Content/titlepage.md new file mode 100644 index 0000000..c543338 --- /dev/null +++ b/Evaluation/Input/Content/titlepage.md @@ -0,0 +1,17 @@ +# Building and evaluation of a PBPK model for Risperidone in adults + + + + +| Version | x.x-OSPy.y | +| ----------------------------------------------- | ------------------------------------------------------------ | +| based on *Model Snapshot* and *Evaluation Plan* | https://github.com/Open-Systems-Pharmacology/Risperidone-Model/releases/tag/vx.x | +| OSP Version | y.y | +| Qualification Framework Version | z.z | + + + + +This evaluation report and the corresponding PK-Sim project file are filed at: + +https://github.com/Open-Systems-Pharmacology/OSP-PBPK-Model-Library/ diff --git a/Evaluation/Input/evaluation_plan.json b/Evaluation/Input/evaluation_plan.json new file mode 100644 index 0000000..e7224a3 --- /dev/null +++ b/Evaluation/Input/evaluation_plan.json @@ -0,0 +1,416 @@ +{ + "$schema": "https://github.com/Open-Systems-Pharmacology/QualificationPlan/releases/download/v3.3/OSP_Qualification_Plan_Schema.json", + "Projects": [ + { + "Id": "Risperidone", + "Path": "../../Risperidone-Model.json", + "BuildingBlocks": [] + } + ], + "ObservedDataSets": [], + "Plots": { + "PlotSettings": { + "ChartWidth": 500, + "ChartHeight": 400, + "Fonts": { + "AxisSize": 11, + "LegendSize": 9, + "OriginSize": 9, + "FontFamilyName": "Arial", + "WatermarkSize": 40 + } + }, + "AxesSettings": { + "ComparisonTimeProfile": [ + { + "Unit": "h", + "Dimension": "Time", + "Type": "X", + "GridLines": false, + "Scaling": "Linear" + }, + { + "Unit": "ng/ml", + "Dimension": "Concentration (mass)", + "Type": "Y", + "GridLines": false, + "Scaling": "Log" + } + ], + "GOFMergedPlotsPredictedVsObserved": [ + { + "Unit": "ng/ml", + "Dimension": "Concentration (mass)", + "Type": "X", + "GridLines": false, + "Scaling": "Log" + }, + { + "Unit": "ng/ml", + "Dimension": "Concentration (mass)", + "Type": "Y", + "GridLines": false, + "Scaling": "Log" + } + ], + "GOFMergedPlotsResidualsOverTime": [ + { + "Unit": "h", + "Dimension": "Time", + "Type": "X", + "GridLines": false, + "Scaling": "Linear" + }, + { + "Unit": "", + "Dimension": "Dimensionless", + "Type": "Y", + "GridLines": false, + "Scaling": "Linear" + } + ] + }, + "AllPlots": [ + { + "Project": "Risperidone", + "Simulation": "Novalbos (2010) - risperidone, 1 mg, po, n=26 (AS=1)", + "SectionId": 332 + }, + { + "Project": "Risperidone", + "Simulation": "Novalbos (2010) - risperidone, 1 mg, po, n=33 (AS=2)", + "SectionId": 331 + }, + { + "Project": "Risperidone", + "Simulation": "Novalbos (2010) - risperidone, 1 mg, po, n=6 (AS=0)", + "SectionId": 332 + }, + { + "Project": "Risperidone", + "Simulation": "Novalbos (2010) - risperidone, 1 mg, po, n=6 (AS=3)", + "SectionId": 332 + }, + { + "Project": "Risperidone", + "Simulation": "Bondolfi (2001) - risperidone, 2 mg, po, md, n=2 (PM)", + "SectionId": 331 + }, + { + "Project": "Risperidone", + "Simulation": "Bondolfi (2001) - risperidone, 2 mg, po, md, n=8 (EM)", + "SectionId": 331 + }, + { + "Project": "Risperidone", + "Simulation": "Nakagami (2005), risperidone, 1 mg, po, n=12 (AS=1)", + "SectionId": 332 + }, + { + "Project": "Risperidone", + "Simulation": "Markowitz (2002) - risperidone, 1 mg, po, n=14 (EM)", + "SectionId": 331 + }, + { + "Project": "Risperidone", + "Simulation": "Mahatthanatrakul (2007) - risperidone, 4 mg, po, n=10 (EM)", + "SectionId": 332 + }, + { + "Project": "Risperidone", + "Simulation": "Darwish (2015) - risperidone, 2 mg, po, n=36 (EM)", + "SectionId": 331 + }, + { + "Project": "Risperidone", + "Simulation": "Mahatthanatrakul (2012) - risperidone, 2 mg, po, n=10 (EM)", + "SectionId": 331 + }, + { + "Project": "Risperidone", + "Simulation": "Kim (2018) - risperidone, 1 mg, po, n = 10 (AS = 1.25)", + "SectionId": 332 + } + ], + "GOFMergedPlots": [ + { + "SectionId": 321, + "Title": "Risperidone observed versus simulated plasma concentration-time data", + "PlotTypes": [ + "predictedVsObserved", + "residualsOverTime" + ], + "Artifacts": [ + "Plot", + "GMFE", + "Measure" + ], + "Groups": [ + { + "Caption": "Risperidone", + "Symbol": "Circle", + "OutputMappings": [ + { + "Project": "Risperidone", + "Simulation": "Novalbos (2010) - risperidone, 1 mg, po, n=26 (AS=1)", + "Output": "Organism|PeripheralVenousBlood|Risperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Novalbos (2010) - risperidone, 1 mg, po, n=26 (AS=1), risperidone", + "Color": "#FF0000" + }, + { + "Project": "Risperidone", + "Simulation": "Novalbos (2010) - risperidone, 1 mg, po, n=33 (AS=2)", + "Output": "Organism|PeripheralVenousBlood|Risperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Novalbos (2010) - risperidone, 1 mg, po, n=33 (AS=2), risperidone", + "Color": "#FF0000" + }, + { + "Project": "Risperidone", + "Simulation": "Novalbos (2010) - risperidone, 1 mg, po, n=6 (AS=0)", + "Output": "Organism|PeripheralVenousBlood|Risperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Novalbos (2010) - risperidone, 1 mg, po, n=6 (AS=0), risperidone", + "Color": "#FF0000" + }, + { + "Project": "Risperidone", + "Simulation": "Novalbos (2010) - risperidone, 1 mg, po, n=6 (AS=3)", + "Output": "Organism|PeripheralVenousBlood|Risperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Novalbos (2010) - risperidone, 1 mg, po, n=6 (AS=3), risperidone", + "Color": "#FF0000" + }, + { + "Project": "Risperidone", + "Simulation": "Bondolfi (2001) - risperidone, 2 mg, po, md, n=2 (PM)", + "Output": "Organism|PeripheralVenousBlood|Risperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Bondolfi (2001) - risperidone, 2 mg, po, md, n=2 (PM), risperidone", + "Color": "#FF0000" + }, + { + "Project": "Risperidone", + "Simulation": "Bondolfi (2001) - risperidone, 2 mg, po, md, n=8 (EM)", + "Output": "Organism|PeripheralVenousBlood|Risperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Bondolfi (2001) - risperidone, 2 mg, po, md, n=8 (EM), risperidone", + "Color": "#FF0000" + }, + { + "Project": "Risperidone", + "Simulation": "Nakagami (2005), risperidone, 1 mg, po, n=12 (AS=1)", + "Output": "Organism|PeripheralVenousBlood|Risperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Nakagami (2005), risperidone, 1 mg, po, n=12 (AS=1), risperidone", + "Color": "#FF0000" + }, + { + "Project": "Risperidone", + "Simulation": "Markowitz (2002) - risperidone, 1 mg, po, n=14 (EM)", + "Output": "Organism|PeripheralVenousBlood|Risperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Markowitz (2002) - risperidone, 1 mg, po, n=14 (EM), risperidone", + "Color": "#FF0000" + }, + { + "Project": "Risperidone", + "Simulation": "Mahatthanatrakul (2007) - risperidone, 4 mg, po, n=10 (EM)", + "Output": "Organism|PeripheralVenousBlood|Risperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Mahatthanatrakul (2007) - risperidone, 4 mg, po, n=10 (EM), risperidone", + "Color": "#FF0000" + }, + { + "Project": "Risperidone", + "Simulation": "Darwish (2015) - risperidone, 2 mg, po, n=36 (EM)", + "Output": "Organism|PeripheralVenousBlood|Risperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Darwish (2015) - risperidone, 2 mg, po, n=36 (EM), risperidone", + "Color": "#FF0000" + }, + { + "Project": "Risperidone", + "Simulation": "Mahatthanatrakul (2012) - risperidone, 2 mg, po, n=10 (EM)", + "Output": "Organism|PeripheralVenousBlood|Risperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Mahatthanatrakul (2012) - risperidone, 2 mg, po, n=10 (EM), risperidone", + "Color": "#FF0000" + }, + { + "Project": "Risperidone", + "Simulation": "Kim (2018) - risperidone, 1 mg, po, n = 10 (AS = 1.25)", + "Output": "Organism|PeripheralVenousBlood|Risperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Kim (2018) - risperidone, 1 mg, po, n = 10 (AS = 1.25), risperidone", + "Color": "#FF0000" + } + ] + } + ] + }, + { + "SectionId": 322, + "Title": "9-Hydroxyrisperidone observed versus simulated plasma concentration-time data", + "PlotTypes": [ + "predictedVsObserved", + "residualsOverTime" + ], + "Artifacts": [ + "Plot", + "GMFE", + "Measure" + ], + "Groups": [ + { + "Caption": "9-Hydroxyrisperidone", + "Symbol": "Circle", + "OutputMappings": [ + { + "Project": "Risperidone", + "Simulation": "Novalbos (2010) - risperidone, 1 mg, po, n=26 (AS=1)", + "Output": "Organism|PeripheralVenousBlood|9-Hydroxyrisperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Novalbos (2010) - risperidone, 1 mg, po, n=26 (AS=1), 9-hydroxyrisperidone", + "Color": "#0000FF" + }, + { + "Project": "Risperidone", + "Simulation": "Novalbos (2010) - risperidone, 1 mg, po, n=33 (AS=2)", + "Output": "Organism|PeripheralVenousBlood|9-Hydroxyrisperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Novalbos (2010) - risperidone, 1 mg, po, n=33 (AS=2), 9-hydroxyrisperidone", + "Color": "#0000FF" + }, + { + "Project": "Risperidone", + "Simulation": "Novalbos (2010) - risperidone, 1 mg, po, n=6 (AS=0)", + "Output": "Organism|PeripheralVenousBlood|9-Hydroxyrisperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Novalbos (2010) - risperidone, 1 mg, po, n=6 (AS=0), 9-hydroxyrisperidone", + "Color": "#0000FF" + }, + { + "Project": "Risperidone", + "Simulation": "Novalbos (2010) - risperidone, 1 mg, po, n=6 (AS=3)", + "Output": "Organism|PeripheralVenousBlood|9-Hydroxyrisperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Novalbos (2010) - risperidone, 1 mg, po, n=6 (AS=3), 9-hydroxyrisperidone", + "Color": "#0000FF" + }, + { + "Project": "Risperidone", + "Simulation": "Nakagami (2005), risperidone, 1 mg, po, n=12 (AS=1)", + "Output": "Organism|PeripheralVenousBlood|9-Hydroxyrisperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Nakagami (2005), risperidone, 1 mg, po, n=12 (AS=1), 9-hydroxyrisperidone", + "Color": "#0000FF" + }, + { + "Project": "Risperidone", + "Simulation": "Mahatthanatrakul (2012) - risperidone, 2 mg, po, n=10 (EM)", + "Output": "Organism|PeripheralVenousBlood|9-Hydroxyrisperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Mahatthanatrakul (2012) - risperidone, 2 mg, po, n=10 (EM), 9-hydroxyrisperidone", + "Color": "#0000FF" + }, + { + "Project": "Risperidone", + "Simulation": "Kim (2018) - risperidone, 1 mg, po, n = 10 (AS = 1.25)", + "Output": "Organism|PeripheralVenousBlood|9-Hydroxyrisperidone|Plasma (Peripheral Venous Blood)", + "ObservedData": "Kim (2018) - risperidone, 1 mg, po, n = 10 (AS = 1.25), 9-hydroxyrisperidone", + "Color": "#0000FF" + } + ] + } + ] + } + ] + }, + "Inputs": [ + { + "Project": "Risperidone", + "Name": "Risperidone", + "Type": "Compound", + "SectionId": 31 + }, + { + "Project": "Risperidone", + "Name": "9-Hydroxyrisperidone", + "Type": "Compound", + "SectionId": 31 + } + ], + "Sections": [ + { + "Id": 1, + "Title": "Introduction", + "Content": "Content/Section1_Introduction.md" + }, + { + "Id": 2, + "Title": "Methods", + "Sections": [ + { + "Id": 21, + "Title": "Modeling strategy", + "Content": "Content/Section2.1_Modeling_Strategy.md" + }, + { + "Id": 22, + "Title": "Data used", + "Content": "Content/Section2.2_Data.md" + }, + { + "Id": 23, + "Title": "Model parameters and assumptions", + "Content": "Content/Section2.3_Model_Parameters_and_Assumptions.md" + } + ] + }, + { + "Id": 3, + "Title": "Results and Discussion", + "Content": "Content/Section3_Results_and_Discussion.md", + "Sections": [ + { + "Id": 31, + "Title": "Risperidone final input parameters", + "Content": "Content/Input_table.md" + }, + { + "Id": 32, + "Title": "Diagnostic plots", + "Content": "Content/GOF_diagnostics.md", + "Sections": [ + { + "Id": 321, + "Title": "Risperidone goodness-of-fit diagnostics", + "Content": "Content/GOF_diagnostics_risperidone.md" + }, + { + "Id": 322, + "Title": "9-Hydroxyrisperidone goodness-of-fit diagnostics", + "Content": "Content/GOF_diagnostics_9hydroxyrisperidone.md" + } + ] + }, + { + "Id": 33, + "Title": "Concentration-time profiles", + "Content": "Content/Concentration_time_profiles.md", + "Sections": [ + { + "Id": 331, + "Title": "Model Building", + "Content": "Content/Concentration_time_profiles_building.md" + }, + { + "Id": 332, + "Title": "Model Verification", + "Content": "Content/Concentration_time_profiles_verification.md" + } + ] + } + ] + }, + { + "Id": 4, + "Title": "Conclusion", + "Content": "Content/Section4_Conclusion.md" + }, + { + "Id": 5, + "Title": "References", + "Content": "Content/References.md" + } + ], + "Intro": [ + { + "Path": "Content/titlepage.md" + } + ] +} diff --git a/Evaluation/workflow.R b/Evaluation/workflow.R new file mode 100644 index 0000000..12ee203 --- /dev/null +++ b/Evaluation/workflow.R @@ -0,0 +1,72 @@ +createQualificationReport <- function(qualificationRunnerFolder, + pkSimPortableFolder = NULL, + createWordReport = FALSE, + maxSimulationsPerCore = NULL) { + if (!requireNamespace("ospsuite.reportingengine", quietly = TRUE)) { + stop("Package ospsuite.reportingengine is required.", call. = FALSE) + } + library(ospsuite.reportingengine) + + findRepoRoot <- function(path) { + current <- normalizePath(path, winslash = "/", mustWork = TRUE) + repeat { + if (file.exists(file.path(current, "Risperidone-Model.json")) && + dir.exists(file.path(current, "Evaluation"))) { + return(current) + } + parent <- dirname(current) + if (identical(parent, current)) { + stop("Could not find repository root containing Risperidone-Model.json and Evaluation", call. = FALSE) + } + current <- parent + } + } + + thisFile <- if (sys.nframe() > 0) tryCatch(normalizePath(sys.frame(1)$ofile, winslash = "/", mustWork = TRUE), error = function(e) NA_character_) else NA_character_ + repoRoot <- findRepoRoot(if (!is.na(thisFile)) dirname(thisFile) else getwd()) + workingDirectory <- file.path(repoRoot, "Evaluation") + qualificationPlanFile <- file.path(workingDirectory, "Input", "evaluation_plan.json") + snapshotFile <- file.path(repoRoot, "Risperidone-Model.json") + + if (!file.exists(qualificationPlanFile)) stop("Missing evaluation plan: ", qualificationPlanFile, call. = FALSE) + if (!file.exists(snapshotFile)) stop("Missing model snapshot: ", snapshotFile, call. = FALSE) + if (!dir.exists(qualificationRunnerFolder)) stop("Missing QualificationRunner folder: ", qualificationRunnerFolder, call. = FALSE) + if (!is.null(pkSimPortableFolder) && !dir.exists(pkSimPortableFolder)) stop("Missing PK-Sim folder: ", pkSimPortableFolder, call. = FALSE) + + reInputFolder <- file.path(workingDirectory, "re_input") + reOutputFolder <- file.path(workingDirectory, "re_output") + configurationPlanName <- "report-configuration-plan" + configurationPlanFile <- file.path(reInputFolder, paste0(configurationPlanName, ".json")) + logFile <- file.path(workingDirectory, "runner.log") + + startQualificationRunner( + qualificationRunnerFolder = qualificationRunnerFolder, + qualificationPlanFile = qualificationPlanFile, + outputFolder = reInputFolder, + pkSimPortableFolder = pkSimPortableFolder, + configurationPlanName = configurationPlanName, + overwrite = TRUE, + logFile = logFile, + logLevel = "Debug" + ) + + if (!file.exists(configurationPlanFile)) stop("QualificationRunner did not create: ", configurationPlanFile, call. = FALSE) + + workflow <- loadQualificationWorkflow( + workflowFolder = reOutputFolder, + configurationPlanFile = configurationPlanFile + ) + workflow$reportFilePath <- file.path(workingDirectory, "report", "report.md") + workflow$createWordReport <- createWordReport + if (!is.null(maxSimulationsPerCore)) { + if (!is.numeric(maxSimulationsPerCore) || + length(maxSimulationsPerCore) != 1 || + is.na(maxSimulationsPerCore) || + maxSimulationsPerCore < 1) { + stop("maxSimulationsPerCore must be a single numeric value >= 1.", call. = FALSE) + } + workflow$simulate$settings$maxSimulationsPerCore <- as.integer(maxSimulationsPerCore) + } + workflow$runWorkflow() + invisible(workflow) +} diff --git a/README.md b/README.md index a4a5c63..0b4eedd 100644 --- a/README.md +++ b/README.md @@ -1,13 +1,36 @@ # Risperidone-Model -Parent-metabolite PBPK model of risperidone and its active metabolite 9-hydroxyrisperidone including CYP2D6 DGIs. +Whole-body parent-metabolite PBPK model of risperidone and 9-hydroxyrisperidone including CYP2D6 drug-gene interactions. -# Repository files -Within this repository, we distribute a whole-body PBPK model of risperidone and its metabolite 9-hydroxyrisperidone. The model was originally developed by *Kneller et al.*[[1]](https://doi.org/10.1007/s40262-019-00793-x) and evaluated with additional profiles in this study. Additionally, the activity-score dependent metabolism of risperidone has been implemented. +This repository contains the risperidone model originally published by Kneller et al. [[1](#references)] and extended for CYP2D6 activity-score dependent metabolism by Rüdesheim et al. [[2](#references)]. -For further details, quantitative model evaluation and extensive documentation please refer to [[2]](https://doi.org/10.3390/pharmaceutics14081734). +The model was developed and evaluated using published clinical plasma pharmacokinetic data after oral risperidone administration by Novalbos et al. [[3](#references)], Bondolfi et al. [[4](#references)], Markowitz et al. [[5](#references)], Darwish et al. [[6](#references)], Mahatthanatrakul et al. [[7](#references), [10](#references)], Nakagami et al. [[8](#references)] and Kim et al. [[9](#references)]. -# Version information -PK-Sim Version 12. +Users of the models are expected to cite these studies when using the model in scientific work, reports or derivative model development: +- [L A Kneller, F Abad-Santos, G Hempel. Physiologically Based Pharmacokinetic Modelling to Describe the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone According to Cytochrome P450 2D6 Phenotypes. Clin Pharmacokinet, 2020;59:51-65.](https://doi.org/10.1007/s40262-019-00793-x) +- [S Rüdesheim, D Selzer, T Mürdter, S Igel, R Kerb, M Schwab, T Lehr. Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone. Pharmaceutics, 2022;14:1734.](https://doi.org/10.3390/pharmaceutics14081734) + +This risperidone model is intended to describe risperidone, 9-hydroxyrisperidone and active-moiety pharmacokinetics across CYP2D6 phenotype and activity-score groups. + +Model note: The 9-hydroxyrisperidone P-gp Km reported in the publication and supplement by Rüdesheim et al. [[2](#references)] is mismatched. The model retains the correct value of 149.6 µmol/L. + +The presented model includes the following features: + +- metabolism by CYP2D6 and CYP3A4, +- formation of 9-hydroxyrisperidone, +- P-gp transport, +- renal filtration, +- CYP2D6 activity score-dependent clearance. + +## Repository files +This repository contains: + +- a [PK-Sim snapshot (*.json) file](https://docs.open-systems-pharmacology.org/working-with-pk-sim/pk-sim-documentation/importing-exporting-project-data-models#exporting-project-to-snapshot-loading-project-from-snapshot) of the current PBPK model +- static content (e.g. text blocks, *.md files) as inputs for an evaluation plan +- an evaluation plan (evaluation_plan.json) to create an evaluation report using the snapshot and static text blocks to display the performance of the model + +**The latest release of the snapshot of the model, the evaluation plan and the static content can be found in the [latest release in this repository](../../releases/latest).** + +**The latest release of the PK-Sim project model file and the respective evaluation report can be found in the [latest OSP PBPK Model Library release](https://github.com/Open-Systems-Pharmacology/OSP-PBPK-Model-Library/releases/latest).** ## Code of conduct Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc...) is expected to follow the Open Systems Pharmacology [code of conduct](https://github.com/Open-Systems-Pharmacology/Suite/blob/master/CODE_OF_CONDUCT.md#contributor-covenant-code-of-conduct). @@ -18,7 +41,23 @@ We encourage contribution to the Open Systems Pharmacology community. Before get ## License The model code is distributed under the [GPLv2 License](https://github.com/Open-Systems-Pharmacology/Suite/blob/develop/LICENSE). -# Reference -[[1] Kneller, L.A., Abad-Santos, F. & Hempel, G. Physiologically Based Pharmacokinetic Modelling to Describe the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone According to Cytochrome P450 2D6 Phenotypes. Clin Pharmacokinet 59, 51–65 (2020).](https://doi.org/10.1007/s40262-019-00793-x) +## References +[1] [L A Kneller, F Abad-Santos, G Hempel. Physiologically Based Pharmacokinetic Modelling to Describe the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone According to Cytochrome P450 2D6 Phenotypes. Clin Pharmacokinet, 2020;59:51-65.](https://doi.org/10.1007/s40262-019-00793-x) + +[2] [S Rüdesheim, D Selzer, T Mürdter, S Igel, R Kerb, M Schwab, T Lehr. Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone. Pharmaceutics, 2022;14:1734.](https://doi.org/10.3390/pharmaceutics14081734) + +[3] [J Novalbos, R López-Rodríguez, M Román, S Gallego-Sadín, D Ochoa, F Abad-Santos. Effects of CYP2D6 genotype on the pharmacokinetics, pharmacodynamics, and safety of risperidone in healthy volunteers. J Clin Psychopharmacol, 2010;30:504-511.](https://doi.org/10.1097/JCP.0b013e3181ee84c7) + +[4] [G Bondolfi, C B Eap, G Bertschy, D Zullino, A Vermeulen, P Baumann. The effect of fluoxetine on the pharmacokinetics and safety of risperidone in psychotic patients. Pharmacopsychiatry, 2002;35:50-56.](https://doi.org/10.1055/s-2002-25026) + +[5] [J S Markowitz, C L DeVane, H L Liston, D W Boulton, S C Risch. The effects of probenecid on the disposition of risperidone and olanzapine in healthy volunteers. Clin Pharmacol Ther, 2002;71:30-38.](https://doi.org/10.1067/mcp.2002.119815) + +[6] [M Darwish, M Bond, R Yang, E T Hellriegel, P Robertson. Evaluation of Potential Pharmacokinetic Drug-Drug Interaction Between Armodafinil and Risperidone in Healthy Adults. Clin Drug Investig, 2015;35:725-733.](https://doi.org/10.1007/s40261-015-0330-6) + +[7] [W Mahatthanatrakul, S Sriwiriyajan, W Ridtitid, J Boonleang, M Wongnawa, N Rujimamahasan, W Pipatrattanaseree. Effect of cytochrome P450 3A4 inhibitor ketoconazole on risperidone pharmacokinetics in healthy volunteers. J Clin Pharm Ther, 2012;37:221-225.](https://doi.org/10.1111/j.1365-2710.2011.01271.x) + +[8] [T Nakagami, N Yasui-Furukori, M Saito, T Tateishi, S Kaneo. Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone. Clin Pharmacol Ther, 2005;78:43-51.](https://doi.org/10.1016/j.clpt.2005.03.009) + +[9] [K A Kim, P W Park, K H Liu, K B Kim, H J Kim, J G Shin, J Y Park. Effect of rifampin, an inducer of CYP3A and P-glycoprotein, on the pharmacokinetics of risperidone. 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"Value": 0.0141666667 - }, - { - "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression", - "Value": 0.0008253968254 - }, - { - "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression", - "Value": 1.0 - }, - { - "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression", - "Value": 1.0 - }, - { - "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression", - "Value": 4.0079365079E-05 - }, - { - "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression", - "Value": 0.00064682539683 - } - ], - "TransportType": "Influx", - "Expression": [ - { - "Name": "Bone", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Brain", - "TransportDirection": "InfluxBrainPlasmaToInterstitial", - "CompartmentName": "Plasma" - }, - { - "Name": "Brain", - "TransportDirection": "InfluxBrainInterstitialToTissue", - "CompartmentName": "Interstitial" - }, - { - "Name": "Fat", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Gonads", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Heart", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Kidney", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Kidney", - "TransportDirection": "ExcretionKidney", - "CompartmentName": "Intracellular" - }, - { - "Name": "Stomach", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "SmallIntestine", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Duodenum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Duodenum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "UpperJejunum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "UpperJejunum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "LowerJejunum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "LowerJejunum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "UpperIleum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "UpperIleum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "LowerIleum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "LowerIleum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "LargeIntestine", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Caecum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Caecum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonAscendens", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonAscendens", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Periportal", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Periportal", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pericentral", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Pericentral", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Lung", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Muscle", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pancreas", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Skin", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Spleen", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "BloodCells", - "TransportDirection": "InfluxPlasmaToBloodCells" - }, - { - "Name": "VascularEndothelium", - "TransportDirection": "InfluxPlasmaToInterstitial" - } - ] - }, - { - "Type": "OtherProtein", - "Species": "Human", - "Molecule": "ATP1A2", - "Category": "Novalbos (2010), n=6 (AS=0)", - "Parameters": [ - { - "Path": "ATP1A2|Reference concentration", - "Value": 0.48, - "Unit": "µmol/l" - }, - { - "Path": "ATP1A2|t1/2 (intestine)", - "Value": 23.0, - "Unit": "h" - }, - { - "Path": "ATP1A2|t1/2 (liver)", - "Value": 36.0, - "Unit": "h" - }, - { - "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", - "Value": 0.0062154033171 - }, - { - "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", - "Value": 1.0 - }, - { - "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", - "Value": 0.0508741242 - }, - { - "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", - "Value": 0.3179118843 - }, - { - "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", - "Value": 0.0158938619 - }, - { - "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", - "Value": 0.0786998764 - }, - { - "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression", - "Value": 0.0786998764 - }, - { - "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression", - "Value": 0.0786998764 - }, - { - "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression", - "Value": 0.0786998764 - }, - { - "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression", - "Value": 0.0786998764 - }, - { - "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression", - "Value": 0.0223784807 - }, - { - "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression", - "Value": 0.0223784807 - }, - { - "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression", - "Value": 0.0272345453 - }, - { - "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression", - "Value": 0.7034193524 - }, - { - "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression", - "Value": 0.0073903254795 - }, - { - "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression", - "Value": 0.0389467988 - }, - { - "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression", - "Value": 0.0501579923 - }, - { - "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression", - "Value": 0.0501579923 - }, - { - "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression", - "Value": 0.0501579923 - }, - { - "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression", - "Value": 0.0501579923 - }, - { - "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression", - "Value": 0.0501579923 - }, - { - "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression", - "Value": 0.0501579923 - }, - { - "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression", - "Value": 0.0103243118 - }, - { - "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression", - 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"CompartmentName": "Interstitial" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Periportal", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Periportal", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pericentral", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Pericentral", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Lung", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Muscle", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pancreas", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Skin", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Spleen", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "BloodCells", - "TransportDirection": "InfluxPlasmaToBloodCells" - }, - { - "Name": "VascularEndothelium", - "TransportDirection": "InfluxPlasmaToInterstitial" - } - ] - }, - { - "Type": "Transporter", - "Species": "Human", - "Molecule": "MATE2-K", - "Category": "Novalbos (2010), n=6 (AS=0)", - "Parameters": [ - { - "Path": "MATE2-K|Reference concentration", - "Value": 1.0, - "Unit": "µmol/l" - }, - { - "Path": "MATE2-K|t1/2 (intestine)", - "Value": 23.0, - "Unit": "h" - }, - { - "Path": "MATE2-K|t1/2 (liver)", - "Value": 36.0, - "Unit": "h" - }, - { - "Path": "Organism|Kidney|Intracellular|MATE2-K|Relative expression", - "Value": 1.0 - } - ], - "TransportType": "Efflux", - "Expression": [ - { - "Name": "Bone", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Brain", - "TransportDirection": "EffluxBrainInterstitialToPlasma", - "CompartmentName": "Plasma" - }, - { - "Name": "Brain", - "TransportDirection": "EffluxBrainTissueToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Fat", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Gonads", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Heart", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Kidney", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Kidney", - "TransportDirection": "ExcretionKidney", - "CompartmentName": "Intracellular" - }, - { - "Name": "Stomach", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "SmallIntestine", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Duodenum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Duodenum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "UpperJejunum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "UpperJejunum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "LowerJejunum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "LowerJejunum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "UpperIleum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "UpperIleum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "LowerIleum", - "TransportDirection": "EffluxIntracellularToInterstitial", - 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"CompartmentName": "Interstitial" - }, - { - "Name": "ColonAscendens", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "Rectum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Rectum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "Periportal", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Periportal", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pericentral", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Pericentral", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Lung", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Muscle", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pancreas", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Skin", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Spleen", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "BloodCells", - "TransportDirection": "EffluxBloodCellsToPlasma" - }, - { - "Name": "VascularEndothelium", - "TransportDirection": "EffluxInterstitialToPlasma" - } - ] - }, - { - "Type": "Transporter", - "Species": "Human", - "Molecule": "OATP1B1", - "Category": "Novalbos (2010), n=6 (AS=3)", - "Parameters": [ - { - "Path": "OATP1B1|Reference concentration", - "Value": 1.0, - "Unit": "µmol/l" - }, - { - "Path": "OATP1B1|t1/2 (intestine)", - "Value": 23.0, - "Unit": "h" - }, - { - "Path": "OATP1B1|t1/2 (liver)", - "Value": 36.0, - "Unit": "h" - }, - { - "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression", - "Value": 0.00014166666667 - }, - { - "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression", - 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"TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Periportal", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Periportal", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pericentral", - 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} - ] - }, - { - "Type": "OtherProtein", - "Species": "Human", - "Molecule": "ATP1A2", - "Category": "Novalbos (2010), n=6 (AS=3)", - "Parameters": [ - { - "Path": "ATP1A2|Reference concentration", - "Value": 0.48, - "Unit": "µmol/l" - }, - { - "Path": "ATP1A2|t1/2 (intestine)", - "Value": 23.0, - "Unit": "h" - }, - { - "Path": "ATP1A2|t1/2 (liver)", - "Value": 36.0, - "Unit": "h" - }, - { - "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", - "Value": 0.0062154033171 - }, - { - "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", - "Value": 1.0 - }, - { - "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", - "Value": 0.0508741242 - }, - { - "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", - "Value": 0.3179118843 - }, - { - "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", - "Value": 0.0158938619 - }, - { - "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", - "Value": 0.0786998764 - 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"CompartmentName": "Interstitial" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Periportal", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Periportal", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pericentral", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Pericentral", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Lung", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Muscle", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pancreas", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Skin", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Spleen", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "BloodCells", - "TransportDirection": "InfluxPlasmaToBloodCells" - }, - { - "Name": "VascularEndothelium", - "TransportDirection": "InfluxPlasmaToInterstitial" - } - ] - }, - { - "Type": "Transporter", - "Species": "Human", - "Molecule": "MATE2-K", - "Category": "Novalbos (2010), n=6 (AS=3)", - "Parameters": [ - { - "Path": "MATE2-K|Reference concentration", - "Value": 1.0, - "Unit": "µmol/l" - }, - { - "Path": "MATE2-K|t1/2 (intestine)", - "Value": 23.0, - "Unit": "h" - }, - { - "Path": "MATE2-K|t1/2 (liver)", - "Value": 36.0, - "Unit": "h" - }, - { - "Path": "Organism|Kidney|Intracellular|MATE2-K|Relative expression", - "Value": 1.0 - } - ], - "TransportType": "Efflux", - "Expression": [ - { - "Name": "Bone", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Brain", - "TransportDirection": "EffluxBrainInterstitialToPlasma", - "CompartmentName": "Plasma" - }, - { - "Name": "Brain", - "TransportDirection": "EffluxBrainTissueToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Fat", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Gonads", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Heart", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Kidney", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Kidney", - "TransportDirection": "ExcretionKidney", - "CompartmentName": "Intracellular" - }, - { - "Name": "Stomach", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "SmallIntestine", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Duodenum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Duodenum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "UpperJejunum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "UpperJejunum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "LowerJejunum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "LowerJejunum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "UpperIleum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "UpperIleum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "LowerIleum", - "TransportDirection": "EffluxIntracellularToInterstitial", - 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"TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Periportal", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Periportal", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pericentral", - 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} - ] - }, - { - "Type": "OtherProtein", - "Species": "Human", - "Molecule": "ATP1A2", - "Category": "Markowitz (2002), n=14 (EM)", - "Parameters": [ - { - "Path": "ATP1A2|Reference concentration", - "Value": 0.48, - "Unit": "µmol/l" - }, - { - "Path": "ATP1A2|t1/2 (intestine)", - "Value": 23.0, - "Unit": "h" - }, - { - "Path": "ATP1A2|t1/2 (liver)", - "Value": 36.0, - "Unit": "h" - }, - { - "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", - "Value": 0.0062154033171 - }, - { - "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", - "Value": 1.0 - }, - { - "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", - "Value": 0.0508741242 - }, - { - "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", - "Value": 0.3179118843 - }, - { - "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", - "Value": 0.0158938619 - }, - { - "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", - "Value": 0.0786998764 - 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"CompartmentName": "Interstitial" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Periportal", - "TransportDirection": "InfluxInterstitialToIntracellular", - 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}, - { - "Name": "BloodCells", - "TransportDirection": "InfluxPlasmaToBloodCells" - }, - { - "Name": "VascularEndothelium", - "TransportDirection": "InfluxPlasmaToInterstitial" - } - ] - }, - { - "Type": "Transporter", - "Species": "Human", - "Molecule": "MATE2-K", - "Category": "Markowitz (2002), n=14 (EM)", - "Parameters": [ - { - "Path": "MATE2-K|Reference concentration", - "Value": 1.0, - "Unit": "µmol/l" - }, - { - "Path": "MATE2-K|t1/2 (intestine)", - "Value": 23.0, - "Unit": "h" - }, - { - "Path": "MATE2-K|t1/2 (liver)", - "Value": 36.0, - "Unit": "h" - }, - { - "Path": "Organism|Kidney|Intracellular|MATE2-K|Relative expression", - "Value": 1.0 - } - ], - "TransportType": "Efflux", - "Expression": [ - { - "Name": "Bone", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Brain", - "TransportDirection": "EffluxBrainInterstitialToPlasma", - "CompartmentName": "Plasma" - }, - { - "Name": "Brain", - "TransportDirection": "EffluxBrainTissueToInterstitial", - 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{ - "Name": "VascularEndothelium", - "TransportDirection": "EffluxInterstitialToPlasma" - } - ] - }, - { - "Type": "Enzyme", - "Species": "Human", - "Molecule": "PON3", - "Category": "Nakagami (2005), n=12 (AS=1)", - "Parameters": [ - { - "Path": "Organism|Bone|Intracellular|PON3|Relative expression", - "Value": 0.0817420412 - }, - { - "Path": "Organism|Brain|Intracellular|PON3|Relative expression", - "Value": 0.0596208803 - }, - { - "Path": "Organism|Gonads|Intracellular|PON3|Relative expression", - "Value": 0.1475612443 - }, - { - "Path": "Organism|Heart|Intracellular|PON3|Relative expression", - "Value": 0.0453507655 - }, - { - "Path": "Organism|Kidney|Intracellular|PON3|Relative expression", - "Value": 0.1178589285 - }, - { - "Path": "Organism|LargeIntestine|Intracellular|PON3|Relative expression", - "Value": 0.0624455433 - }, - { - "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|PON3|Relative expression", - "Value": 0.0624455433 - }, - { - "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|PON3|Relative expression", - 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"CompartmentName": "Intracellular" - }, - { - "Name": "UpperIleum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "UpperIleum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "LowerIleum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "LowerIleum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "LargeIntestine", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Caecum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Caecum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonAscendens", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonAscendens", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "Rectum", - 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"TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Periportal", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Periportal", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pericentral", - 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} - ] - }, - { - "Type": "OtherProtein", - "Species": "Human", - "Molecule": "ATP1A2", - "Category": "Mahatthanatrakul (2007), n=10 (EM)", - "Parameters": [ - { - "Path": "ATP1A2|Reference concentration", - "Value": 0.48, - "Unit": "µmol/l" - }, - { - "Path": "ATP1A2|t1/2 (intestine)", - "Value": 23.0, - "Unit": "h" - }, - { - "Path": "ATP1A2|t1/2 (liver)", - "Value": 36.0, - "Unit": "h" - }, - { - "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", - "Value": 0.0062154033171 - }, - { - "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", - "Value": 1.0 - }, - { - "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", - "Value": 0.0508741242 - }, - { - "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", - "Value": 0.3179118843 - }, - { - "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", - "Value": 0.0158938619 - }, - { - "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", - "Value": 0.0786998764 - 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"CompartmentName": "Interstitial" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Periportal", - "TransportDirection": "InfluxInterstitialToIntracellular", - 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"CompartmentName": "Intracellular" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "Rectum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Rectum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "Periportal", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Periportal", - "TransportDirection": "ExcretionLiver", - 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{ - "Name": "VascularEndothelium", - "TransportDirection": "EffluxInterstitialToPlasma" - } - ] - }, - { - "Type": "Enzyme", - "Species": "Human", - "Molecule": "PON3", - "Category": "Darwish (2015), n=36 (EM)", - "Parameters": [ - { - "Path": "Organism|Bone|Intracellular|PON3|Relative expression", - "Value": 0.0817420412 - }, - { - "Path": "Organism|Brain|Intracellular|PON3|Relative expression", - "Value": 0.0596208803 - }, - { - "Path": "Organism|Gonads|Intracellular|PON3|Relative expression", - "Value": 0.1475612443 - }, - { - "Path": "Organism|Heart|Intracellular|PON3|Relative expression", - "Value": 0.0453507655 - }, - { - "Path": "Organism|Kidney|Intracellular|PON3|Relative expression", - "Value": 0.1178589285 - }, - { - "Path": "Organism|LargeIntestine|Intracellular|PON3|Relative expression", - "Value": 0.0624455433 - }, - { - "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|PON3|Relative expression", - "Value": 0.0624455433 - }, - { - "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|PON3|Relative expression", - 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}, - { - "Name": "Spleen", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "BloodCells", - "TransportDirection": "InfluxPlasmaToBloodCells" - }, - { - "Name": "VascularEndothelium", - "TransportDirection": "InfluxPlasmaToInterstitial" - } - ] - }, - { - "Type": "Enzyme", - "Species": "Human", - "Molecule": "CYP3A4", - "Category": "Mahatthanatrakul (2012), n=10 (EM)", - "Parameters": [ - { - "Path": "CYP3A4|Ontogeny factor GI", - "Value": 0.9767163251 - }, - { - "Path": "CYP3A4|Reference concentration", - "Value": 4.32, - "Unit": "µmol/l" - }, - { - "Path": "CYP3A4|t1/2 (intestine)", - "Value": 23.0, - "Unit": "h" - }, - { - "Path": "CYP3A4|t1/2 (liver)", - "Value": 36.0, - "Unit": "h" - }, - { - "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression", - "Value": 0.0041682898325 - }, - { - "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression", - "Value": 0.00078691079081 - }, - { - "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression", - 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"CompartmentName": "Intracellular" - }, - { - "Name": "Gonads", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Heart", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Kidney", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Kidney", - "TransportDirection": "ExcretionKidney", - "CompartmentName": "Intracellular" - }, - { - "Name": "Stomach", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "SmallIntestine", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Duodenum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Duodenum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "UpperJejunum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "UpperJejunum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "LowerJejunum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "LowerJejunum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "UpperIleum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "UpperIleum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "LowerIleum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "LowerIleum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "LargeIntestine", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Caecum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Caecum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonAscendens", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonAscendens", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Periportal", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Periportal", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pericentral", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Pericentral", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Lung", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Muscle", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pancreas", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Skin", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Spleen", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "BloodCells", - "TransportDirection": "InfluxPlasmaToBloodCells" - }, - { - "Name": "VascularEndothelium", - "TransportDirection": "InfluxPlasmaToInterstitial" - } - ] - }, - { - "Type": "OtherProtein", - "Species": "Human", - "Molecule": "ATP1A2", - "Category": "Mahatthanatrakul (2012), n=10 (EM)", - "Parameters": [ - { - "Path": "ATP1A2|Reference concentration", - "Value": 0.48, - "Unit": "µmol/l" - }, - { - "Path": "ATP1A2|t1/2 (intestine)", - "Value": 23.0, - "Unit": "h" - }, - { - "Path": "ATP1A2|t1/2 (liver)", - "Value": 36.0, - "Unit": "h" - }, - { - "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", - "Value": 0.0062154033171 - }, - { - "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", - "Value": 1.0 - }, - { - "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", - "Value": 0.0508741242 - }, - { - "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", - "Value": 0.3179118843 - }, - { - "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", - "Value": 0.0158938619 - }, - { - "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", - "Value": 0.0786998764 - 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"CompartmentName": "Interstitial" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonDescendens", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonSigmoid", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Rectum", - "TransportDirection": "InfluxLumenToMucosaIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Periportal", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Periportal", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pericentral", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Interstitial" - }, - { - "Name": "Pericentral", - "TransportDirection": "ExcretionLiver", - "CompartmentName": "Intracellular" - }, - { - "Name": "Lung", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Muscle", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Pancreas", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Skin", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "Spleen", - "TransportDirection": "InfluxInterstitialToIntracellular", - "CompartmentName": "Intracellular" - }, - { - "Name": "BloodCells", - "TransportDirection": "InfluxPlasmaToBloodCells" - }, - { - "Name": "VascularEndothelium", - "TransportDirection": "InfluxPlasmaToInterstitial" - } - ] - }, - { - "Type": "Transporter", - "Species": "Human", - "Molecule": "MATE2-K", - "Category": "Mahatthanatrakul (2012), n=10 (EM)", - "Parameters": [ - { - "Path": "MATE2-K|Reference concentration", - "Value": 1.0, - "Unit": "µmol/l" - }, - { - "Path": "MATE2-K|t1/2 (intestine)", - "Value": 23.0, - "Unit": "h" - }, - { - "Path": "MATE2-K|t1/2 (liver)", - "Value": 36.0, - "Unit": "h" - }, - { - "Path": "Organism|Kidney|Intracellular|MATE2-K|Relative expression", - "Value": 1.0 - } - ], - "TransportType": "Efflux", - "Expression": [ - { - "Name": "Bone", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Brain", - "TransportDirection": "EffluxBrainInterstitialToPlasma", - "CompartmentName": "Plasma" - }, - { - "Name": "Brain", - "TransportDirection": "EffluxBrainTissueToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Fat", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Gonads", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Heart", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Kidney", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Kidney", - "TransportDirection": "ExcretionKidney", - "CompartmentName": "Intracellular" - }, - { - "Name": "Stomach", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "SmallIntestine", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Duodenum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Duodenum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "UpperJejunum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "UpperJejunum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "LowerJejunum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "LowerJejunum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "UpperIleum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "UpperIleum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "LowerIleum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "LowerIleum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "LargeIntestine", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Intracellular" - }, - { - "Name": "Caecum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "Caecum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonAscendens", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonAscendens", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - "CompartmentName": "Intracellular" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "EffluxIntracellularToInterstitial", - "CompartmentName": "Interstitial" - }, - { - "Name": "ColonTransversum", - "TransportDirection": "EffluxMucosaIntracellularToLumen", - 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"ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "OtherProtein", + "Species": "Human", + "Molecule": "ATP1A2", + "Category": "Novalbos (2010), n=6 (AS=0)", + "Parameters": [ + { + "Path": "ATP1A2|Reference concentration", + "Value": 0.48, + "Unit": "µmol/l" + }, + { + "Path": "ATP1A2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "ATP1A2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", + "Value": 0.0062154033171 + }, + { + "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", + "Value": 0.0508741242 + }, + { + "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", + "Value": 0.3179118843 + }, + { + "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", + "Value": 0.0158938619 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression", + "Value": 0.0272345453 + }, + { + "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression", + "Value": 0.7034193524 + }, + { + "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression", + "Value": 0.0073903254795 + }, + { + "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression", + "Value": 0.0389467988 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression", + "Value": 0.0103243118 + }, + { + "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression", + "Value": 0.0309435884 + } + ], + "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide" + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OCT2", + "Category": "Novalbos (2010), n=6 (AS=0)", + "Parameters": [ + { + "Path": "OCT2|Reference concentration", + "Value": 1.09, + "Unit": "µmol/l" + }, + { + "Path": "OCT2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OCT2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OCT2|Relative expression", + "Value": 0.00035539568345 + }, + { + "Path": "Organism|Gonads|Intracellular|OCT2|Relative expression", + "Value": 0.0017410071942 + }, + { + "Path": "Organism|Kidney|Intracellular|OCT2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Stomach|Intracellular|OCT2|Relative expression", + "Value": 0.00014676258993 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "MATE2-K", + "Category": "Novalbos (2010), n=6 (AS=0)", + "Parameters": [ + { + "Path": "MATE2-K|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "MATE2-K|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "MATE2-K|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Kidney|Intracellular|MATE2-K|Relative expression", + "Value": 1 + } + ], + "TransportType": "Efflux", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "PON3", + "Category": "Novalbos (2010), n=6 (AS=0)", + "Parameters": [ + { + "Path": "Organism|Bone|Intracellular|PON3|Relative expression", + "Value": 0.0817420412 + }, + { + "Path": "Organism|Brain|Intracellular|PON3|Relative expression", + "Value": 0.0596208803 + }, + { + "Path": "Organism|Gonads|Intracellular|PON3|Relative expression", + "Value": 0.1475612443 + }, + { + "Path": "Organism|Heart|Intracellular|PON3|Relative expression", + "Value": 0.0453507655 + }, + { + "Path": "Organism|Kidney|Intracellular|PON3|Relative expression", + 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"Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", 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"VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "Liver_influx_gemfibrozil", + "Category": "Novalbos (2010), n=6 (AS=0)", + "Parameters": [ + { + "Path": "Liver_influx_gemfibrozil|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "Liver_influx_gemfibrozil|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "Liver_influx_gemfibrozil|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|Liver_influx_gemfibrozil|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|Liver_influx_gemfibrozil|Relative expression", + "Value": 1 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": 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"TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OATP1B1", + "Category": "Novalbos (2010), n=33 (AS=2)", + "Parameters": [ + { + "Path": "OATP1B1|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "OATP1B1|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OATP1B1|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression", + "Value": 0.00014166666667 + }, + { + "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression", + "Value": 0.0141666667 + }, + { + "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression", + "Value": 0.0008253968254 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression", + "Value": 0.000040079365079 + }, + { + "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression", + "Value": 0.00064682539683 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "OtherProtein", + "Species": "Human", + "Molecule": "ATP1A2", + "Category": "Novalbos (2010), n=33 (AS=2)", + "Parameters": [ + { + "Path": "ATP1A2|Reference concentration", + "Value": 0.48, + "Unit": "µmol/l" + }, + { + "Path": "ATP1A2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "ATP1A2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", + "Value": 0.0062154033171 + }, + { + "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", + "Value": 0.0508741242 + }, + { + "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", + "Value": 0.3179118843 + }, + { + "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", + "Value": 0.0158938619 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression", + "Value": 0.0272345453 + }, + { + "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression", + "Value": 0.7034193524 + }, + { + "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression", + "Value": 0.0073903254795 + }, + { + "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression", + "Value": 0.0389467988 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression", + "Value": 0.0103243118 + }, + { + "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression", + "Value": 0.0309435884 + } + ], + "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide" + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OCT2", + "Category": "Novalbos (2010), n=33 (AS=2)", + "Parameters": [ + { + "Path": "OCT2|Reference concentration", + "Value": 1.09, + "Unit": "µmol/l" + }, + { + "Path": "OCT2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OCT2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OCT2|Relative expression", + "Value": 0.00035539568345 + }, + { + "Path": "Organism|Gonads|Intracellular|OCT2|Relative expression", + "Value": 0.0017410071942 + }, + { + "Path": "Organism|Kidney|Intracellular|OCT2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Stomach|Intracellular|OCT2|Relative expression", + "Value": 0.00014676258993 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "MATE2-K", + "Category": "Novalbos (2010), n=33 (AS=2)", + "Parameters": [ + { + "Path": "MATE2-K|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "MATE2-K|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "MATE2-K|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Kidney|Intracellular|MATE2-K|Relative expression", + "Value": 1 + } + ], + "TransportType": "Efflux", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "PON3", + "Category": "Novalbos 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"Type": "Enzyme", + "Species": "Human", + "Molecule": "UGT2B7", + "Category": "Novalbos (2010), n=33 (AS=2)", + "Parameters": [ + { + "Path": "Organism|Brain|Intracellular|UGT2B7|Relative expression", + "Value": 0.0792387223 + }, + { + "Path": "Organism|Gonads|Intracellular|UGT2B7|Relative expression", + "Value": 0.1305041205 + }, + { + "Path": "Organism|Kidney|Intracellular|UGT2B7|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|UGT2B7|Relative expression", + "Value": 0.2346862128 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|UGT2B7|Relative expression", + "Value": 0.2346862128 + }, + { + "Path": "Organism|Skin|Intracellular|UGT2B7|Relative expression", + "Value": 0.0308645644 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|UGT2B7|Relative expression", + "Value": 0.0395483736 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|UGT2B7|Relative expression", + "Value": 0.0395483736 + }, + { + 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"Expression": [ + { + "Name": "Bone", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + 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"CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": 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"TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "SLC22A7", + "Category": "Novalbos (2010), n=26 (AS=1)", + "Parameters": [ + { + "Path": "Organism|Bone|Intracellular|SLC22A7|Relative expression", + "Value": 0.00010366748166 + }, + { + "Path": "Organism|Brain|Intracellular|SLC22A7|Relative expression", + "Value": 0.00067848410758 + }, + { + "Path": "Organism|Gonads|Intracellular|SLC22A7|Relative expression", + "Value": 0.023594132 + }, + { + "Path": "Organism|Heart|Intracellular|SLC22A7|Relative expression", + "Value": 0.001662591687 + }, + { + "Path": "Organism|Kidney|Intracellular|SLC22A7|Relative expression", + "Value": 0.575794621 + }, + { + "Path": 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"Organism|Muscle|Intracellular|SLC22A7|Relative expression", + "Value": 0.00024572127139 + }, + { + "Path": "Organism|Pancreas|Intracellular|SLC22A7|Relative expression", + "Value": 0.00011552567237 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|Spleen|Intracellular|SLC22A7|Relative expression", + "Value": 0.00020782396088 + }, + { + "Path": "Organism|Stomach|Intracellular|SLC22A7|Relative expression", + "Value": 0.000015770171149 + }, + { + "Path": "SLC22A7|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "SLC22A7|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "SLC22A7|t1/2 (liver)", + "Value": 36, + "Unit": "h" + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "Liver_influx_gemfibrozil", + "Category": "Novalbos (2010), n=26 (AS=1)", + "Parameters": [ + { + "Path": "Liver_influx_gemfibrozil|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "Liver_influx_gemfibrozil|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "Liver_influx_gemfibrozil|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|Liver_influx_gemfibrozil|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|Liver_influx_gemfibrozil|Relative expression", + "Value": 1 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "CYP3A4", + "Category": "Novalbos (2010), n=6 (AS=3)", + "Parameters": [ + { + "Path": "CYP3A4|Reference concentration", + "Value": 4.32, + "Unit": "µmol/l" + }, + { + "Path": "CYP3A4|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "CYP3A4|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression", + "Value": 0.0041682898325 + }, + { + "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression", + "Value": 0.00078691079081 + }, + { + "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression", + "Value": 0.0053603428126 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression", + "Value": 0.00042695753798 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression", + "Value": 0.0727697702 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression", + "Value": 0.0727697702 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression", + "Value": 0.0727697702 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression", + "Value": 0.0727697702 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative 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"Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "OtherProtein", + "Species": "Human", + "Molecule": "ATP1A2", + "Category": "Novalbos (2010), n=6 (AS=3)", + "Parameters": [ + { + "Path": "ATP1A2|Reference concentration", + "Value": 0.48, + "Unit": "µmol/l" + }, + { + "Path": "ATP1A2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "ATP1A2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", + "Value": 0.0062154033171 + }, + { + "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", + "Value": 0.0508741242 + }, + { + "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", + "Value": 0.3179118843 + }, + { + "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", + "Value": 0.0158938619 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression", + "Value": 0.0272345453 + }, + { + "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression", + "Value": 0.7034193524 + }, + { + "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression", + "Value": 0.0073903254795 + }, + { + "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression", + "Value": 0.0389467988 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression", + "Value": 0.0103243118 + }, + { + "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression", + "Value": 0.0309435884 + } + ], + "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide" + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OCT2", + "Category": "Novalbos (2010), n=6 (AS=3)", + "Parameters": [ + { + "Path": "OCT2|Reference concentration", + "Value": 1.09, + "Unit": "µmol/l" + }, + { + "Path": "OCT2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OCT2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OCT2|Relative expression", + "Value": 0.00035539568345 + }, + { + "Path": "Organism|Gonads|Intracellular|OCT2|Relative expression", + "Value": 0.0017410071942 + }, + { + "Path": "Organism|Kidney|Intracellular|OCT2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Stomach|Intracellular|OCT2|Relative expression", + "Value": 0.00014676258993 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "MATE2-K", + "Category": "Novalbos (2010), n=6 (AS=3)", + "Parameters": [ + { + "Path": "MATE2-K|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "MATE2-K|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "MATE2-K|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Kidney|Intracellular|MATE2-K|Relative expression", + "Value": 1 + } + ], + "TransportType": "Efflux", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "PON3", + "Category": "Novalbos (2010), n=6 (AS=3)", + "Parameters": [ + { + "Path": "Organism|Bone|Intracellular|PON3|Relative expression", + "Value": 0.0817420412 + }, + { + "Path": "Organism|Brain|Intracellular|PON3|Relative expression", + "Value": 0.0596208803 + }, + { + "Path": "Organism|Gonads|Intracellular|PON3|Relative expression", + "Value": 0.1475612443 + }, + { + "Path": "Organism|Heart|Intracellular|PON3|Relative expression", + "Value": 0.0453507655 + }, + { + "Path": "Organism|Kidney|Intracellular|PON3|Relative expression", + "Value": 0.1178589285 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|PON3|Relative expression", + "Value": 0.0624455433 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|PON3|Relative expression", + "Value": 0.0624455433 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|PON3|Relative expression", + "Value": 0.0624455433 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|PON3|Relative expression", + "Value": 0.0624455433 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|PON3|Relative expression", + "Value": 0.0624455433 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|PON3|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|PON3|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Lung|Intracellular|PON3|Relative expression", + "Value": 0.1785749861 + }, + { + "Path": "Organism|Muscle|Intracellular|PON3|Relative expression", + "Value": 0.0434120147 + }, + { + "Path": "Organism|Pancreas|Intracellular|PON3|Relative expression", + "Value": 0.067403684 + }, + { + "Path": "Organism|Skin|Intracellular|PON3|Relative expression", + "Value": 0.1307438544 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|PON3|Relative expression", + "Value": 0.0904397952 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|PON3|Relative expression", + "Value": 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"Organism|Muscle|Intracellular|DPYD|Relative expression", + "Value": 0.3046875 + }, + { + "Path": "Organism|Pancreas|Intracellular|DPYD|Relative expression", + "Value": 0.1234375 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|Spleen|Intracellular|DPYD|Relative expression", + "Value": 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"EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": 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"InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "CYP3A4", + "Category": "Bondolfi (2001), n=8 (EM)", + "Parameters": [ + { + "Path": "CYP3A4|Reference concentration", + "Value": 4.32, + "Unit": "µmol/l" + }, + { + "Path": "CYP3A4|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "CYP3A4|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression", + "Value": 0.0041682898325 + }, + { + "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression", + "Value": 0.00078691079081 + }, + { + "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression", + "Value": 0.0053603428126 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression", + "Value": 0.00042695753798 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative 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"CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": 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+ "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OATP1B1", + "Category": "Bondolfi (2001), n=8 (EM)", + "Parameters": [ + { + "Path": "OATP1B1|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "OATP1B1|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OATP1B1|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression", + "Value": 0.00014166666667 + }, + { + "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression", + "Value": 0.0141666667 + }, + { + "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression", + "Value": 0.0008253968254 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression", + "Value": 0.000040079365079 + }, + { + "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression", + "Value": 0.00064682539683 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "OtherProtein", + "Species": "Human", + "Molecule": "ATP1A2", + "Category": "Bondolfi (2001), n=8 (EM)", + "Parameters": [ + { + "Path": "ATP1A2|Reference concentration", + "Value": 0.48, + "Unit": "µmol/l" + }, + { + "Path": "ATP1A2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "ATP1A2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", + "Value": 0.0062154033171 + }, + { + "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", + "Value": 0.0508741242 + }, + { + "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", + "Value": 0.3179118843 + }, + { + "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", + "Value": 0.0158938619 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression", + "Value": 0.0272345453 + }, + { + "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression", + "Value": 0.7034193524 + }, + { + "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression", + "Value": 0.0073903254795 + }, + { + "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression", + "Value": 0.0389467988 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression", + "Value": 0.0103243118 + }, + { + "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression", + "Value": 0.0309435884 + } + ], + "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide" + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OCT2", + "Category": "Bondolfi (2001), n=8 (EM)", + "Parameters": [ + { + "Path": "OCT2|Reference concentration", + "Value": 1.09, + "Unit": "µmol/l" + }, + { + "Path": "OCT2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OCT2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OCT2|Relative expression", + "Value": 0.00035539568345 + }, + { + "Path": "Organism|Gonads|Intracellular|OCT2|Relative expression", + "Value": 0.0017410071942 + }, + { + "Path": "Organism|Kidney|Intracellular|OCT2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Stomach|Intracellular|OCT2|Relative expression", + "Value": 0.00014676258993 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "MATE2-K", + "Category": "Bondolfi (2001), n=8 (EM)", + "Parameters": [ + { + "Path": "MATE2-K|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "MATE2-K|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "MATE2-K|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Kidney|Intracellular|MATE2-K|Relative expression", + "Value": 1 + } + ], + "TransportType": "Efflux", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": 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+ "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": 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"Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "Liver_influx_gemfibrozil", + "Category": "Bondolfi (2001), n=8 (EM)", + "Parameters": [ + { + "Path": "Liver_influx_gemfibrozil|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "Liver_influx_gemfibrozil|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "Liver_influx_gemfibrozil|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|Liver_influx_gemfibrozil|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|Liver_influx_gemfibrozil|Relative expression", + "Value": 1 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": 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"InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + 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+ }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ABCB1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ABCB1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ABCB1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ABCB1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Spleen|Intracellular|ABCB1|Relative expression", + "Value": 0.0742555692 + }, + { + "Path": "Organism|Stomach|Intracellular|ABCB1|Relative expression", + "Value": 0.0260852897 + } + ], + "TransportType": "Efflux", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": 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"Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OATP1B1", + "Category": "Bondolfi (2001), n=2 (PM)", + "Parameters": [ + { + "Path": "OATP1B1|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "OATP1B1|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OATP1B1|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression", + "Value": 0.00014166666667 + }, + { + "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression", + "Value": 0.0141666667 + }, + { + "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression", + "Value": 0.0008253968254 + }, + { 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"TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "OtherProtein", + "Species": "Human", + "Molecule": "ATP1A2", + "Category": "Bondolfi (2001), n=2 (PM)", + "Parameters": [ + { + "Path": "ATP1A2|Reference concentration", + "Value": 0.48, + "Unit": "µmol/l" + }, + { + "Path": "ATP1A2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "ATP1A2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", + "Value": 0.0062154033171 + }, + { + "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", + "Value": 0.0508741242 + }, + { + "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", + "Value": 0.3179118843 + }, + { + "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", + "Value": 0.0158938619 + }, + { + "Path": 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"Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "MATE2-K", + "Category": "Bondolfi (2001), n=2 (PM)", + "Parameters": [ + { + "Path": "MATE2-K|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "MATE2-K|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "MATE2-K|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Kidney|Intracellular|MATE2-K|Relative expression", + "Value": 1 + } + ], + "TransportType": "Efflux", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "PON3", + "Category": "Bondolfi (2001), n=2 (PM)", + "Parameters": [ + { + "Path": "Organism|Bone|Intracellular|PON3|Relative expression", + "Value": 0.0817420412 + }, + { + "Path": "Organism|Brain|Intracellular|PON3|Relative expression", + "Value": 0.0596208803 + }, + { + "Path": "Organism|Gonads|Intracellular|PON3|Relative expression", + "Value": 0.1475612443 + }, + { + "Path": "Organism|Heart|Intracellular|PON3|Relative expression", + "Value": 0.0453507655 + }, + { + "Path": "Organism|Kidney|Intracellular|PON3|Relative expression", + "Value": 0.1178589285 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|PON3|Relative expression", + "Value": 0.0624455433 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|PON3|Relative expression", + "Value": 0.0624455433 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|PON3|Relative expression", + "Value": 0.0624455433 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|PON3|Relative 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BloodCellsIntracellular, VascEndosome" + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "CYP2C8", + "Category": "Bondolfi (2001), n=2 (PM)", + "Parameters": [ + { + "Path": "CYP2C8|Reference concentration", + "Value": 2.56, + "Unit": "µmol/l" + }, + { + "Path": "CYP2C8|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "CYP2C8|t1/2 (liver)", + "Value": 23.000001425, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|CYP2C8|Relative expression", + "Value": 0.00041051218109 + }, + { + "Path": "Organism|Gonads|Intracellular|CYP2C8|Relative expression", + "Value": 0.0138116248 + }, + { + "Path": "Organism|Kidney|Intracellular|CYP2C8|Relative expression", + "Value": 0.0012660656052 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|CYP2C8|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|CYP2C8|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Lung|Intracellular|CYP2C8|Relative 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"Molecule": "UGT2B7", + "Category": "Bondolfi (2001), n=2 (PM)", + "Parameters": [ + { + "Path": "Organism|Brain|Intracellular|UGT2B7|Relative expression", + "Value": 0.0792387223 + }, + { + "Path": "Organism|Gonads|Intracellular|UGT2B7|Relative expression", + "Value": 0.1305041205 + }, + { + "Path": "Organism|Kidney|Intracellular|UGT2B7|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|UGT2B7|Relative expression", + "Value": 0.2346862128 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|UGT2B7|Relative expression", + "Value": 0.2346862128 + }, + { + "Path": "Organism|Skin|Intracellular|UGT2B7|Relative expression", + "Value": 0.0308645644 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|UGT2B7|Relative expression", + "Value": 0.0395483736 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|UGT2B7|Relative expression", + "Value": 0.0395483736 + }, + { + "Path": 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"Expression": [ + { + "Name": "Bone", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "DPYS", + "Category": "Bondolfi (2001), n=2 (PM)", + "Parameters": [ + { + "Path": "DPYS|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "DPYS|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "DPYS|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Bone|Intracellular|DPYS|Relative expression", + "Value": 0.0103205549 + }, + { + "Path": "Organism|Brain|Intracellular|DPYS|Relative expression", + "Value": 0.0525039997 + }, + { + "Path": "Organism|Gonads|Intracellular|DPYS|Relative expression", + "Value": 0.0253913415 + }, + { + "Path": "Organism|Heart|Intracellular|DPYS|Relative expression", + "Value": 0.0753300656 + }, + { + "Path": "Organism|Kidney|Intracellular|DPYS|Relative expression", + "Value": 0.5265706142 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|DPYS|Relative expression", + "Value": 0.0063691042953 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|DPYS|Relative expression", + "Value": 0.0063691042953 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|DPYS|Relative expression", + "Value": 0.0063691042953 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|DPYS|Relative expression", + "Value": 0.0063691042953 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|DPYS|Relative expression", + "Value": 0.0063691042953 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|DPYS|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|DPYS|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Lung|Intracellular|DPYS|Relative expression", + "Value": 0.0363986303 + }, + { + "Path": "Organism|Muscle|Intracellular|DPYS|Relative expression", + "Value": 0.0056810560351 + }, + { + "Path": "Organism|Pancreas|Intracellular|DPYS|Relative expression", + "Value": 0.0445369483 + }, + { + "Path": "Organism|Skin|Intracellular|DPYS|Relative expression", + "Value": 0.0156127962 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|DPYS|Relative expression", + "Value": 0.0073752707939 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|DPYS|Relative expression", + "Value": 0.0073752707939 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|DPYS|Relative expression", + "Value": 0.0073752707939 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|DPYS|Relative expression", + "Value": 0.0073752707939 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|DPYS|Relative expression", + "Value": 0.0073752707939 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|DPYS|Relative expression", + "Value": 0.0073752707939 + }, + { + "Path": "Organism|Spleen|Intracellular|DPYS|Relative expression", + "Value": 0.0500181058 + }, + { + "Path": "Organism|Stomach|Intracellular|DPYS|Relative expression", + "Value": 0.0049513579317 + } + ], + "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome" + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "UPB1", + "Category": "Bondolfi (2001), n=2 (PM)", + "Parameters": [ + { + "Path": "Organism|Bone|Intracellular|UPB1|Relative expression", + "Value": 0.0306261029 + }, + { + "Path": "Organism|Brain|Intracellular|UPB1|Relative expression", + "Value": 0.0238292111 + }, + { + "Path": "Organism|Gonads|Intracellular|UPB1|Relative expression", + "Value": 0.0144131525 + }, + { + "Path": "Organism|Heart|Intracellular|UPB1|Relative expression", + "Value": 0.0079781854814 + }, + { + "Path": "Organism|Kidney|Intracellular|UPB1|Relative expression", + "Value": 0.0968063508 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|UPB1|Relative expression", + "Value": 0.0162608365 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|UPB1|Relative expression", + "Value": 0.0162608365 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|UPB1|Relative expression", + "Value": 0.0162608365 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|UPB1|Relative expression", + "Value": 0.0162608365 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|UPB1|Relative expression", + "Value": 0.0162608365 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|UPB1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|UPB1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Lung|Intracellular|UPB1|Relative expression", + "Value": 0.0210151628 + }, + { + "Path": "Organism|Muscle|Intracellular|UPB1|Relative expression", + "Value": 0.0064994008407 + }, + { + "Path": "Organism|Pancreas|Intracellular|UPB1|Relative expression", + "Value": 0.0117558918 + }, + { + "Path": "Organism|Skin|Intracellular|UPB1|Relative expression", + "Value": 0.1264392964 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|Spleen|Intracellular|UPB1|Relative expression", + "Value": 0.0144244549 + }, + { + "Path": "Organism|Stomach|Intracellular|UPB1|Relative expression", + "Value": 0.0165743986 + }, + { + "Path": "UPB1|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "UPB1|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "UPB1|t1/2 (liver)", + "Value": 36, + "Unit": "h" + } + ], + "Localization": "Intracellular, BloodCellsIntracellular, 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0.109765625 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|DPYD|Relative expression", + "Value": 0.141796875 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|DPYD|Relative expression", + "Value": 0.141796875 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|DPYD|Relative expression", + "Value": 0.141796875 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|DPYD|Relative expression", + "Value": 0.141796875 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|DPYD|Relative expression", + "Value": 0.141796875 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|DPYD|Relative expression", + "Value": 0.3765625 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|DPYD|Relative expression", + "Value": 0.3765625 + }, + { + "Path": "Organism|Lung|Intracellular|DPYD|Relative expression", + "Value": 0.55859375 + }, + { + "Path": "Organism|Muscle|Intracellular|DPYD|Relative expression", + "Value": 0.3046875 + }, + { + "Path": "Organism|Pancreas|Intracellular|DPYD|Relative expression", + "Value": 0.1234375 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|Spleen|Intracellular|DPYD|Relative expression", + "Value": 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"Organism|Kidney|Intracellular|ABCC4|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|ABCC4|Relative expression", + "Value": 0.2 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ABCC4|Relative expression", + "Value": 0.2 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ABCC4|Relative expression", + "Value": 0.2 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ABCC4|Relative expression", + "Value": 0.2 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ABCC4|Relative expression", + "Value": 0.2 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|ABCC4|Relative expression", + "Value": 0.0163333333 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|ABCC4|Relative expression", + "Value": 0.0163333333 + }, + { + "Path": "Organism|Lung|Intracellular|ABCC4|Relative expression", + "Value": 0.6111111111 + }, + { + "Path": "Organism|Muscle|Intracellular|ABCC4|Relative expression", + "Value": 0.4611111111 + }, + { + "Path": "Organism|Pancreas|Intracellular|ABCC4|Relative expression", + "Value": 0.07 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|ABCC4|Relative expression", + "Value": 0.22 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ABCC4|Relative expression", + "Value": 0.22 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ABCC4|Relative expression", + "Value": 0.22 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ABCC4|Relative expression", + "Value": 0.22 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ABCC4|Relative expression", + "Value": 0.22 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ABCC4|Relative expression", + "Value": 0.22 + }, + { + "Path": "Organism|Spleen|Intracellular|ABCC4|Relative expression", + "Value": 0.1238888889 + }, + { + "Path": "Organism|Stomach|Intracellular|ABCC4|Relative expression", + "Value": 0.2166666667 + } + ], + "TransportType": "Efflux", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "SLC22A7", + "Category": "Bondolfi (2001), n=2 (PM)", + "Parameters": [ + { + "Path": "Organism|Bone|Intracellular|SLC22A7|Relative expression", + "Value": 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expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|Spleen|Intracellular|SLC22A7|Relative expression", + "Value": 0.00020782396088 + }, + { + "Path": "Organism|Stomach|Intracellular|SLC22A7|Relative expression", + "Value": 0.000015770171149 + }, + { + "Path": "SLC22A7|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "SLC22A7|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "SLC22A7|t1/2 (liver)", + "Value": 36, + "Unit": "h" + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "Liver_influx_gemfibrozil", + "Category": "Bondolfi (2001), n=2 (PM)", + "Parameters": [ + { + "Path": "Liver_influx_gemfibrozil|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "Liver_influx_gemfibrozil|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "Liver_influx_gemfibrozil|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|Liver_influx_gemfibrozil|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|Liver_influx_gemfibrozil|Relative expression", + "Value": 1 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "CYP3A4", + "Category": "Markowitz (2002), n=14 (EM)", + "Parameters": [ + { + "Path": "CYP3A4|Reference concentration", + "Value": 4.32, + "Unit": "µmol/l" + }, + { + "Path": "CYP3A4|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "CYP3A4|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression", + "Value": 0.0041682898325 + }, + { + "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression", + "Value": 0.00078691079081 + }, + { + "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression", + "Value": 0.0053603428126 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression", + "Value": 0.00042695753798 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative 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"Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|AADAC|Relative expression", + "Value": 0.00010384615385 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|AADAC|Relative expression", + "Value": 0.00010384615385 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|AADAC|Relative expression", + "Value": 0.00010384615385 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|AADAC|Relative expression", + "Value": 0.00010384615385 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|AADAC|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|AADAC|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Lung|Intracellular|AADAC|Relative expression", + "Value": 0.0269230769 + }, + { + "Path": "Organism|Muscle|Intracellular|AADAC|Relative expression", + "Value": 0.00020833333333 + }, + { + "Path": 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"CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": 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}, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression", + "Value": 0.0103243118 + }, + { + "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression", + "Value": 0.0309435884 + } + ], + "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide" + }, + { + "Type": "Transporter", + "Species": "Human", + 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"Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": 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"CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": 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"Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ABCC4|Relative expression", + "Value": 0.2 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ABCC4|Relative expression", + "Value": 0.2 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|ABCC4|Relative expression", + "Value": 0.0163333333 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|ABCC4|Relative expression", + "Value": 0.0163333333 + }, + { + "Path": "Organism|Lung|Intracellular|ABCC4|Relative expression", + "Value": 0.6111111111 + }, + { + "Path": "Organism|Muscle|Intracellular|ABCC4|Relative expression", + "Value": 0.4611111111 + }, + { + "Path": "Organism|Pancreas|Intracellular|ABCC4|Relative expression", + "Value": 0.07 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|ABCC4|Relative expression", + "Value": 0.22 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ABCC4|Relative expression", + "Value": 0.22 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ABCC4|Relative expression", + "Value": 0.22 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ABCC4|Relative expression", + "Value": 0.22 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ABCC4|Relative expression", + "Value": 0.22 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ABCC4|Relative expression", + "Value": 0.22 + }, + { + "Path": "Organism|Spleen|Intracellular|ABCC4|Relative expression", + "Value": 0.1238888889 + }, + { + "Path": "Organism|Stomach|Intracellular|ABCC4|Relative expression", + "Value": 0.2166666667 + } + ], + "TransportType": "Efflux", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "SLC22A7", + "Category": "Markowitz (2002), n=14 (EM)", + "Parameters": [ + { + "Path": "Organism|Bone|Intracellular|SLC22A7|Relative expression", + "Value": 0.00010366748166 + }, + { + "Path": "Organism|Brain|Intracellular|SLC22A7|Relative expression", + "Value": 0.00067848410758 + }, + { + "Path": "Organism|Gonads|Intracellular|SLC22A7|Relative expression", + "Value": 0.023594132 + }, + { + "Path": "Organism|Heart|Intracellular|SLC22A7|Relative expression", + "Value": 0.001662591687 + }, + { + "Path": "Organism|Kidney|Intracellular|SLC22A7|Relative expression", + "Value": 0.575794621 + }, + { + "Path": 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"Organism|Muscle|Intracellular|SLC22A7|Relative expression", + "Value": 0.00024572127139 + }, + { + "Path": "Organism|Pancreas|Intracellular|SLC22A7|Relative expression", + "Value": 0.00011552567237 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|SLC22A7|Relative expression", + "Value": 0.00083863080685 + }, + { + "Path": "Organism|Spleen|Intracellular|SLC22A7|Relative expression", + "Value": 0.00020782396088 + }, + { + "Path": "Organism|Stomach|Intracellular|SLC22A7|Relative expression", + "Value": 0.000015770171149 + }, + { + "Path": "SLC22A7|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "SLC22A7|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "SLC22A7|t1/2 (liver)", + "Value": 36, + "Unit": "h" + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "Liver_influx_gemfibrozil", + "Category": "Markowitz (2002), n=14 (EM)", + "Parameters": [ + { + "Path": "Liver_influx_gemfibrozil|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "Liver_influx_gemfibrozil|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "Liver_influx_gemfibrozil|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|Liver_influx_gemfibrozil|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|Liver_influx_gemfibrozil|Relative expression", + "Value": 1 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + 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"Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OATP1B1", + "Category": "Nakagami (2005), n=12 (AS=1)", + "Parameters": [ + { + "Path": "OATP1B1|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "OATP1B1|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OATP1B1|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression", + "Value": 0.00014166666667 + }, + { + "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression", + "Value": 0.0141666667 + }, + { + "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression", + "Value": 0.0008253968254 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression", + "Value": 0.000040079365079 + }, + { + "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression", + "Value": 0.00064682539683 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "OtherProtein", + "Species": "Human", + "Molecule": "ATP1A2", + "Category": "Nakagami (2005), n=12 (AS=1)", + "Parameters": [ + { + "Path": "ATP1A2|Reference concentration", + "Value": 0.48, + "Unit": "µmol/l" + }, + { + "Path": "ATP1A2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "ATP1A2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", + "Value": 0.0062154033171 + }, + { + "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", + "Value": 0.0508741242 + }, + { + "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", + "Value": 0.3179118843 + }, + { + "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", + "Value": 0.0158938619 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression", + "Value": 0.0272345453 + }, + { + "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression", + "Value": 0.7034193524 + }, + { + "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression", + "Value": 0.0073903254795 + }, + { + "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression", + "Value": 0.0389467988 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression", + "Value": 0.0103243118 + }, + { + "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression", + "Value": 0.0309435884 + } + ], + "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide" + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OCT2", + "Category": "Nakagami (2005), n=12 (AS=1)", + "Parameters": [ + { + "Path": "OCT2|Reference concentration", + "Value": 1.09, + "Unit": "µmol/l" + }, + { + "Path": "OCT2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OCT2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OCT2|Relative expression", + "Value": 0.00035539568345 + }, + { + "Path": "Organism|Gonads|Intracellular|OCT2|Relative expression", + "Value": 0.0017410071942 + }, + { + "Path": "Organism|Kidney|Intracellular|OCT2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Stomach|Intracellular|OCT2|Relative expression", + "Value": 0.00014676258993 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "MATE2-K", + "Category": "Nakagami (2005), n=12 (AS=1)", + "Parameters": [ + { + "Path": "MATE2-K|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "MATE2-K|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "MATE2-K|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Kidney|Intracellular|MATE2-K|Relative expression", + "Value": 1 + } + ], + "TransportType": "Efflux", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "PON3", + "Category": "Nakagami 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"Type": "Enzyme", + "Species": "Human", + "Molecule": "UGT2B7", + "Category": "Nakagami (2005), n=12 (AS=1)", + "Parameters": [ + { + "Path": "Organism|Brain|Intracellular|UGT2B7|Relative expression", + "Value": 0.0792387223 + }, + { + "Path": "Organism|Gonads|Intracellular|UGT2B7|Relative expression", + "Value": 0.1305041205 + }, + { + "Path": "Organism|Kidney|Intracellular|UGT2B7|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|UGT2B7|Relative expression", + "Value": 0.2346862128 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|UGT2B7|Relative expression", + "Value": 0.2346862128 + }, + { + "Path": "Organism|Skin|Intracellular|UGT2B7|Relative expression", + "Value": 0.0308645644 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|UGT2B7|Relative expression", + "Value": 0.0395483736 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|UGT2B7|Relative expression", + "Value": 0.0395483736 + }, + { + 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"Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "Liver_influx_gemfibrozil", + "Category": "Nakagami (2005), n=12 (AS=1)", + "Parameters": [ + { + "Path": "Liver_influx_gemfibrozil|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "Liver_influx_gemfibrozil|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "Liver_influx_gemfibrozil|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|Liver_influx_gemfibrozil|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|Liver_influx_gemfibrozil|Relative expression", + "Value": 1 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "CYP3A4", + "Category": "Kim (2018), n=10 (AS=1.25)", + "Parameters": [ + { + "Path": "CYP3A4|Reference concentration", + "Value": 4.32, + "Unit": "µmol/l" + }, + { + "Path": "CYP3A4|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "CYP3A4|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression", + "Value": 0.0041682898325 + }, + { + "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression", + "Value": 0.00078691079081 + }, + { + "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression", + "Value": 0.0053603428126 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression", + "Value": 0.00042695753798 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative 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"CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OATP1B1", + "Category": "Kim (2018), n=10 (AS=1.25)", + "Parameters": [ + { + "Path": "OATP1B1|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "OATP1B1|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OATP1B1|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression", + "Value": 0.00014166666667 + }, + { + "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression", + "Value": 0.0141666667 + }, + { + "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression", + "Value": 0.0008253968254 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression", + "Value": 0.000040079365079 + }, + { + "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression", + "Value": 0.00064682539683 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "OtherProtein", + "Species": "Human", + "Molecule": "ATP1A2", + "Category": "Kim (2018), n=10 (AS=1.25)", + "Parameters": [ + { + "Path": "ATP1A2|Reference concentration", + "Value": 0.48, + "Unit": "µmol/l" + }, + { + "Path": "ATP1A2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "ATP1A2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", + "Value": 0.0062154033171 + }, + { + "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", + "Value": 0.0508741242 + }, + { + "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", + "Value": 0.3179118843 + }, + { + "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", + "Value": 0.0158938619 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression", + "Value": 0.0272345453 + }, + { + "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression", + "Value": 0.7034193524 + }, + { + "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression", + "Value": 0.0073903254795 + }, + { + "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression", + "Value": 0.0389467988 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression", + "Value": 0.0103243118 + }, + { + "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression", + "Value": 0.0309435884 + } + ], + "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide" + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OCT2", + "Category": "Kim (2018), n=10 (AS=1.25)", + "Parameters": [ + { + "Path": "OCT2|Reference concentration", + "Value": 1.09, + "Unit": "µmol/l" + }, + { + "Path": "OCT2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OCT2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OCT2|Relative expression", + "Value": 0.00035539568345 + }, + { + "Path": "Organism|Gonads|Intracellular|OCT2|Relative expression", + "Value": 0.0017410071942 + }, + { + "Path": "Organism|Kidney|Intracellular|OCT2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Stomach|Intracellular|OCT2|Relative expression", + "Value": 0.00014676258993 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "MATE2-K", + "Category": "Kim (2018), n=10 (AS=1.25)", + "Parameters": [ + { + "Path": "MATE2-K|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "MATE2-K|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "MATE2-K|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Kidney|Intracellular|MATE2-K|Relative expression", + "Value": 1 + } + ], + "TransportType": "Efflux", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "PON3", + "Category": "Kim (2018), n=10 (AS=1.25)", + "Parameters": [ + { + "Path": "Organism|Bone|Intracellular|PON3|Relative expression", + "Value": 0.0817420412 + }, + { + "Path": "Organism|Brain|Intracellular|PON3|Relative expression", + "Value": 0.0596208803 + }, + { + "Path": "Organism|Gonads|Intracellular|PON3|Relative expression", + "Value": 0.1475612443 + }, + { + "Path": "Organism|Heart|Intracellular|PON3|Relative expression", + "Value": 0.0453507655 + }, + { + "Path": "Organism|Kidney|Intracellular|PON3|Relative expression", + 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"CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "DPYS", + "Category": "Kim (2018), n=10 (AS=1.25)", + "Parameters": [ + { + "Path": "DPYS|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "DPYS|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "DPYS|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Bone|Intracellular|DPYS|Relative expression", + "Value": 0.0103205549 + }, + { + "Path": "Organism|Brain|Intracellular|DPYS|Relative expression", + "Value": 0.0525039997 + }, + { + "Path": "Organism|Gonads|Intracellular|DPYS|Relative expression", + "Value": 0.0253913415 + }, + { + "Path": "Organism|Heart|Intracellular|DPYS|Relative expression", + "Value": 0.0753300656 + }, + { + "Path": "Organism|Kidney|Intracellular|DPYS|Relative expression", + "Value": 0.5265706142 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|DPYS|Relative expression", + "Value": 0.0063691042953 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|DPYS|Relative expression", + "Value": 0.0063691042953 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|DPYS|Relative expression", + "Value": 0.0063691042953 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|DPYS|Relative expression", + "Value": 0.0063691042953 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|DPYS|Relative expression", + "Value": 0.0063691042953 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|DPYS|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|DPYS|Relative expression", + "Value": 1 + }, + { + "Path": 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"Value": 0.0210151628 + }, + { + "Path": "Organism|Muscle|Intracellular|UPB1|Relative expression", + "Value": 0.0064994008407 + }, + { + "Path": "Organism|Pancreas|Intracellular|UPB1|Relative expression", + "Value": 0.0117558918 + }, + { + "Path": "Organism|Skin|Intracellular|UPB1|Relative expression", + "Value": 0.1264392964 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|Spleen|Intracellular|UPB1|Relative expression", + "Value": 0.0144244549 + }, + { + "Path": "Organism|Stomach|Intracellular|UPB1|Relative expression", + "Value": 0.0165743986 + }, + { + "Path": "UPB1|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "UPB1|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "UPB1|t1/2 (liver)", + "Value": 36, + "Unit": "h" + } + ], + "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome" + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "DPYD", + "Category": "Kim (2018), n=10 (AS=1.25)", + "Parameters": [ + { + "Path": "DPYD|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "DPYD|Relative expression in blood cells", + "Value": 1 + }, + { + "Path": "DPYD|Relative expression in plasma", + "Value": 1 + }, + { + "Path": 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"Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|DPYD|Relative expression", + "Value": 0.141796875 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|DPYD|Relative expression", + "Value": 0.141796875 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|DPYD|Relative expression", + "Value": 0.3765625 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|DPYD|Relative expression", + "Value": 0.3765625 + }, + { + "Path": "Organism|Lung|Intracellular|DPYD|Relative expression", + "Value": 0.55859375 + }, + { + "Path": "Organism|Muscle|Intracellular|DPYD|Relative expression", + "Value": 0.3046875 + }, + { + "Path": "Organism|Pancreas|Intracellular|DPYD|Relative expression", + "Value": 0.1234375 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|DPYD|Relative expression", + "Value": 0.1453125 + }, + { + "Path": "Organism|Spleen|Intracellular|DPYD|Relative expression", + "Value": 0.4921875 + }, + { + "Path": "Organism|Stomach|Intracellular|DPYD|Relative expression", + "Value": 0.194921875 + } + ], + "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome" + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "ABCC4", + "Category": "Kim (2018), n=10 (AS=1.25)", + "Parameters": [ + { + "Path": "ABCC4|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { 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"TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": 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"EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, 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"Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "SLC22A7", + "Category": "Kim (2018), n=10 (AS=1.25)", + "Parameters": [ + { + "Path": "Organism|Bone|Intracellular|SLC22A7|Relative expression", + "Value": 0.00010366748166 + }, + { + "Path": "Organism|Brain|Intracellular|SLC22A7|Relative expression", + "Value": 0.00067848410758 + }, + { + "Path": "Organism|Gonads|Intracellular|SLC22A7|Relative expression", + "Value": 0.023594132 + }, + { + "Path": "Organism|Heart|Intracellular|SLC22A7|Relative expression", + "Value": 0.001662591687 + }, + { + "Path": "Organism|Kidney|Intracellular|SLC22A7|Relative expression", + "Value": 0.575794621 + }, + { + "Path": 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"Path": "Organism|Spleen|Intracellular|SLC22A7|Relative expression", + "Value": 0.00020782396088 + }, + { + "Path": "Organism|Stomach|Intracellular|SLC22A7|Relative expression", + "Value": 0.000015770171149 + }, + { + "Path": "SLC22A7|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "SLC22A7|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "SLC22A7|t1/2 (liver)", + "Value": 36, + "Unit": "h" + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": 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"Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": 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"Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "Liver_influx_gemfibrozil", + "Category": "Kim (2018), n=10 (AS=1.25)", + "Parameters": [ + { + "Path": "Liver_influx_gemfibrozil|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "Liver_influx_gemfibrozil|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "Liver_influx_gemfibrozil|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|Liver_influx_gemfibrozil|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|Liver_influx_gemfibrozil|Relative expression", + "Value": 1 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": 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"InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "CYP3A4", + "Category": "Mahatthanatrakul (2007), n=10 (EM)", + "Parameters": [ + { + "Path": "CYP3A4|Reference concentration", + "Value": 4.32, + "Unit": "µmol/l" + }, + { + "Path": "CYP3A4|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "CYP3A4|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression", + "Value": 0.0041682898325 + }, + { + "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression", + "Value": 0.00078691079081 + 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"Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|MAOA|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|MAOA|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|MAOA|Relative expression", + "Value": 0.4779005525 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|MAOA|Relative expression", + "Value": 0.4779005525 + }, + { + "Path": "Organism|Lung|Intracellular|MAOA|Relative expression", + "Value": 0.638121547 + }, + { + "Path": "Organism|Muscle|Intracellular|MAOA|Relative expression", + "Value": 0.2582872928 + }, + { + "Path": "Organism|Pancreas|Intracellular|MAOA|Relative expression", + "Value": 0.4019337017 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|MAOA|Relative expression", + "Value": 0.9930939227 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|MAOA|Relative expression", + "Value": 0.9930939227 + }, + { + "Path": 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"Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OATP1B1", + "Category": "Mahatthanatrakul (2007), n=10 (EM)", + "Parameters": [ + { + "Path": "OATP1B1|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "OATP1B1|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OATP1B1|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression", + "Value": 0.00014166666667 + }, + { + "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression", + "Value": 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"TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": 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"CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": 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"TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + 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"Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": 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{ + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": 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"TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": 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"TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + 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"TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "CYP3A4", + "Category": "Darwish (2015), n=36 (EM)", + "Parameters": [ + { + "Path": "CYP3A4|Reference concentration", + "Value": 4.32, + "Unit": "µmol/l" + }, + { + "Path": "CYP3A4|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "CYP3A4|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression", + "Value": 0.0041682898325 + }, + { + "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression", + "Value": 0.00078691079081 + }, + { + "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression", + "Value": 0.0053603428126 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression", + "Value": 1 + }, + { + "Path": 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"Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "OtherProtein", + "Species": "Human", + "Molecule": "ATP1A2", + "Category": "Darwish (2015), n=36 (EM)", + "Parameters": [ + { + "Path": "ATP1A2|Reference concentration", + "Value": 0.48, + "Unit": "µmol/l" + }, + { + "Path": "ATP1A2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "ATP1A2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", + "Value": 0.0062154033171 + }, + { + "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", + "Value": 0.0508741242 + }, + { + "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", + "Value": 0.3179118843 + }, + { + "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", + "Value": 0.0158938619 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression", + "Value": 0.0272345453 + }, + { + "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression", + "Value": 0.7034193524 + }, + { + "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression", + "Value": 0.0073903254795 + }, + { + "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression", + "Value": 0.0389467988 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression", + "Value": 0.0103243118 + }, + { + "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression", + "Value": 0.0309435884 + } + ], + "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide" + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OCT2", + "Category": "Darwish (2015), n=36 (EM)", + "Parameters": [ + { + "Path": "OCT2|Reference concentration", + "Value": 1.09, + "Unit": "µmol/l" + }, + { + "Path": "OCT2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OCT2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OCT2|Relative expression", + "Value": 0.00035539568345 + }, + { + "Path": "Organism|Gonads|Intracellular|OCT2|Relative expression", + "Value": 0.0017410071942 + }, + { + "Path": "Organism|Kidney|Intracellular|OCT2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Stomach|Intracellular|OCT2|Relative expression", + "Value": 0.00014676258993 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "MATE2-K", + "Category": "Darwish (2015), n=36 (EM)", + "Parameters": [ + { + "Path": "MATE2-K|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "MATE2-K|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "MATE2-K|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Kidney|Intracellular|MATE2-K|Relative expression", + "Value": 1 + } + ], + "TransportType": "Efflux", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "PON3", + "Category": "Darwish (2015), n=36 (EM)", + "Parameters": [ + { + "Path": "Organism|Bone|Intracellular|PON3|Relative expression", + "Value": 0.0817420412 + }, + { + "Path": "Organism|Brain|Intracellular|PON3|Relative expression", + "Value": 0.0596208803 + }, + { + "Path": "Organism|Gonads|Intracellular|PON3|Relative expression", + "Value": 0.1475612443 + }, + { + "Path": 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"Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", 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"Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + 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"EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OATP1B1", + "Category": "Mahatthanatrakul (2012), n=10 (EM)", + "Parameters": [ + { + "Path": "OATP1B1|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "OATP1B1|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OATP1B1|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression", + "Value": 0.00014166666667 + }, + { + "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression", + "Value": 0.0141666667 + }, + { + "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression", + "Value": 0.0008253968254 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression", + "Value": 0.000040079365079 + }, + { + "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression", + "Value": 0.00064682539683 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "OtherProtein", + "Species": "Human", + "Molecule": "ATP1A2", + "Category": "Mahatthanatrakul (2012), n=10 (EM)", + "Parameters": [ + { + "Path": "ATP1A2|Reference concentration", + "Value": 0.48, + "Unit": "µmol/l" + }, + { + "Path": "ATP1A2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "ATP1A2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Bone|Intracellular|ATP1A2|Relative expression", + "Value": 0.0062154033171 + }, + { + "Path": "Organism|Brain|Intracellular|ATP1A2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Gonads|Intracellular|ATP1A2|Relative expression", + "Value": 0.0508741242 + }, + { + "Path": "Organism|Heart|Intracellular|ATP1A2|Relative expression", + "Value": 0.3179118843 + }, + { + "Path": "Organism|Kidney|Intracellular|ATP1A2|Relative expression", + "Value": 0.0158938619 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0786998764 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|ATP1A2|Relative expression", + "Value": 0.0223784807 + }, + { + "Path": "Organism|Lung|Intracellular|ATP1A2|Relative expression", + "Value": 0.0272345453 + }, + { + "Path": "Organism|Muscle|Intracellular|ATP1A2|Relative expression", + "Value": 0.7034193524 + }, + { + "Path": "Organism|Pancreas|Intracellular|ATP1A2|Relative expression", + "Value": 0.0073903254795 + }, + { + "Path": "Organism|Skin|Intracellular|ATP1A2|Relative expression", + "Value": 0.0389467988 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ATP1A2|Relative expression", + "Value": 0.0501579923 + }, + { + "Path": "Organism|Spleen|Intracellular|ATP1A2|Relative expression", + "Value": 0.0103243118 + }, + { + "Path": "Organism|Stomach|Intracellular|ATP1A2|Relative expression", + "Value": 0.0309435884 + } + ], + "Localization": "Interstitial, BloodCellsMembrane, VascMembranePlasmaSide" + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "OCT2", + "Category": "Mahatthanatrakul (2012), n=10 (EM)", + "Parameters": [ + { + "Path": "OCT2|Reference concentration", + "Value": 1.09, + "Unit": "µmol/l" + }, + { + "Path": "OCT2|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "OCT2|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|OCT2|Relative expression", + "Value": 0.00035539568345 + }, + { + "Path": "Organism|Gonads|Intracellular|OCT2|Relative expression", + "Value": 0.0017410071942 + }, + { + "Path": "Organism|Kidney|Intracellular|OCT2|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|OCT2|Relative expression", + "Value": 0.00014446043165 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|OCT2|Relative expression", + "Value": 0.00045827338129 + }, + { + "Path": "Organism|Stomach|Intracellular|OCT2|Relative expression", + "Value": 0.00014676258993 + } + ], + "TransportType": "Influx", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainPlasmaToInterstitial", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "InfluxBrainInterstitialToTissue", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "InfluxLumenToMucosaIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "InfluxInterstitialToIntracellular", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "InfluxPlasmaToBloodCells" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "InfluxPlasmaToInterstitial" + } + ] + }, + { + "Type": "Transporter", + "Species": "Human", + "Molecule": "MATE2-K", + "Category": "Mahatthanatrakul (2012), n=10 (EM)", + "Parameters": [ + { + "Path": "MATE2-K|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "MATE2-K|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "MATE2-K|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Kidney|Intracellular|MATE2-K|Relative expression", + "Value": 1 + } + ], + "TransportType": "Efflux", + "Expression": [ + { + "Name": "Bone", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainInterstitialToPlasma", + "CompartmentName": "Plasma" + }, + { + "Name": "Brain", + "TransportDirection": "EffluxBrainTissueToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Fat", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Gonads", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Heart", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "PON3", + "Category": "Mahatthanatrakul (2012), n=10 (EM)", + "Parameters": [ + { + "Path": "Organism|Bone|Intracellular|PON3|Relative expression", + "Value": 0.0817420412 + }, + { + "Path": "Organism|Brain|Intracellular|PON3|Relative expression", + "Value": 0.0596208803 + }, + { + "Path": "Organism|Gonads|Intracellular|PON3|Relative expression", + "Value": 0.1475612443 + }, + { + "Path": "Organism|Heart|Intracellular|PON3|Relative expression", + "Value": 0.0453507655 + }, + { + "Path": "Organism|Kidney|Intracellular|PON3|Relative expression", + "Value": 0.1178589285 + }, + { + "Path": "Organism|LargeIntestine|Intracellular|PON3|Relative expression", + "Value": 0.0624455433 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|PON3|Relative expression", + "Value": 0.0624455433 + }, + { + "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|PON3|Relative expression", + "Value": 0.0624455433 + }, + { + "Path": 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"Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|PON3|Relative expression", + "Value": 0.0904397952 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|PON3|Relative expression", + "Value": 0.0904397952 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|PON3|Relative expression", + "Value": 0.0904397952 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|PON3|Relative expression", + "Value": 0.0904397952 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|PON3|Relative expression", + "Value": 0.0904397952 + }, + { + "Path": "Organism|Spleen|Intracellular|PON3|Relative expression", + "Value": 0.0599732583 + }, + { + "Path": "Organism|Stomach|Intracellular|PON3|Relative expression", + "Value": 0.0863065596 + }, + { + "Path": "PON3|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "PON3|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "PON3|t1/2 (liver)", + "Value": 36, + "Unit": "h" + } + ], + "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome" + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "CYP2C8", + "Category": "Mahatthanatrakul (2012), n=10 (EM)", + "Parameters": [ + { + "Path": "CYP2C8|Reference concentration", + "Value": 2.56, + "Unit": "µmol/l" + }, + { + "Path": "CYP2C8|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "CYP2C8|t1/2 (liver)", + "Value": 23.000001425, + "Unit": "h" + }, + { + "Path": "Organism|Brain|Intracellular|CYP2C8|Relative expression", + "Value": 0.00041051218109 + }, + { + "Path": "Organism|Gonads|Intracellular|CYP2C8|Relative expression", + "Value": 0.0138116248 + }, + { + "Path": "Organism|Kidney|Intracellular|CYP2C8|Relative expression", + "Value": 0.0012660656052 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|CYP2C8|Relative expression", + "Value": 1 + }, + { + "Path": 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"Intracellular, BloodCellsIntracellular, VascEndosome", + "Ontogeny": { + "Name": "CYP2C8" + } + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "UGT2B7", + "Category": "Mahatthanatrakul (2012), n=10 (EM)", + "Parameters": [ + { + "Path": "Organism|Brain|Intracellular|UGT2B7|Relative expression", + "Value": 0.0792387223 + }, + { + "Path": "Organism|Gonads|Intracellular|UGT2B7|Relative expression", + "Value": 0.1305041205 + }, + { + "Path": "Organism|Kidney|Intracellular|UGT2B7|Relative expression", + "Value": 1 + }, + { + "Path": "Organism|Liver|Pericentral|Intracellular|UGT2B7|Relative expression", + "Value": 0.2346862128 + }, + { + "Path": "Organism|Liver|Periportal|Intracellular|UGT2B7|Relative expression", + "Value": 0.2346862128 + }, + { + "Path": "Organism|Skin|Intracellular|UGT2B7|Relative expression", + "Value": 0.0308645644 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|UGT2B7|Relative expression", + "Value": 0.0395483736 + }, + { + "Path": 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{ + "Path": "Organism|Pancreas|Intracellular|ABCC3|Relative expression", + "Value": 0.3563380282 + }, + { + "Path": "Organism|SmallIntestine|Intracellular|ABCC3|Relative expression", + "Value": 0.3612676056 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|ABCC3|Relative expression", + "Value": 0.3612676056 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|ABCC3|Relative expression", + "Value": 0.3612676056 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|ABCC3|Relative expression", + "Value": 0.3612676056 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|ABCC3|Relative expression", + "Value": 0.3612676056 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|ABCC3|Relative expression", + "Value": 0.3612676056 + }, + { + "Path": "Organism|Spleen|Intracellular|ABCC3|Relative expression", + "Value": 0.1563380282 + }, + { + "Path": 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"Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "LowerIleum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "LargeIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Caecum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonAscendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonTransversum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonDescendens", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "ColonSigmoid", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Rectum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "Periportal", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Periportal", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pericentral", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Pericentral", + "TransportDirection": "ExcretionLiver", + "CompartmentName": "Intracellular" + }, + { + "Name": "Lung", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Muscle", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Pancreas", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Skin", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Spleen", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "BloodCells", + "TransportDirection": "EffluxBloodCellsToPlasma" + }, + { + "Name": "VascularEndothelium", + "TransportDirection": "EffluxInterstitialToPlasma" + } + ] + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "DPYS", + "Category": "Mahatthanatrakul (2012), n=10 (EM)", + "Parameters": [ + { + "Path": "DPYS|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { 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"Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|UPB1|Relative expression", + "Value": 0.1181563322 + }, + { + "Path": "Organism|Spleen|Intracellular|UPB1|Relative expression", + "Value": 0.0144244549 + }, + { + "Path": "Organism|Stomach|Intracellular|UPB1|Relative expression", + "Value": 0.0165743986 + }, + { + "Path": "UPB1|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "UPB1|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "UPB1|t1/2 (liver)", + "Value": 36, + "Unit": "h" + } + ], + "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome" + }, + { + "Type": "Enzyme", + "Species": "Human", + "Molecule": "DPYD", + "Category": "Mahatthanatrakul (2012), n=10 (EM)", + "Parameters": [ + { + "Path": "DPYD|Reference concentration", + "Value": 1, + "Unit": "µmol/l" + }, + { + "Path": "DPYD|Relative expression in blood cells", + "Value": 1 + }, + { + "Path": "DPYD|Relative expression in plasma", + "Value": 1 + }, + { + "Path": "DPYD|t1/2 (intestine)", + "Value": 23, + "Unit": "h" + }, + { + "Path": "DPYD|t1/2 (liver)", + "Value": 36, + "Unit": "h" + }, + { + "Path": "Organism|Bone|Intracellular|DPYD|Relative expression", + "Value": 0.78515625 + }, + { + "Path": "Organism|Brain|Intracellular|DPYD|Relative expression", + "Value": 0.058203125 + }, + { + "Path": "Organism|Gonads|Intracellular|DPYD|Relative expression", + "Value": 0.091796875 + }, + { + "Path": "Organism|Heart|Intracellular|DPYD|Relative 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"Name": "Kidney", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Kidney", + "TransportDirection": "ExcretionKidney", + "CompartmentName": "Intracellular" + }, + { + "Name": "Stomach", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "SmallIntestine", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Intracellular" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "Duodenum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": "Intracellular" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxIntracellularToInterstitial", + "CompartmentName": "Interstitial" + }, + { + "Name": "UpperJejunum", + "TransportDirection": "EffluxMucosaIntracellularToLumen", + "CompartmentName": 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