diff --git a/agent/anthropic_adapter.py b/agent/anthropic_adapter.py
index ea09c11ea4ff..b612437029d6 100644
--- a/agent/anthropic_adapter.py
+++ b/agent/anthropic_adapter.py
@@ -915,10 +915,18 @@ def normalize_model_name(model: str, preserve_dots: bool = False) -> str:
     - Converts dots to hyphens in version numbers (OpenRouter uses dots,
       Anthropic uses hyphens: claude-opus-4.6 → claude-opus-4-6), unless
       preserve_dots is True (e.g. for Alibaba/DashScope: qwen3.5-plus).
+    - Bedrock cross-region inference profile IDs (us.*, eu.*, ap.*, global.*)
+      use dots as namespace separators — never mangle those.
     """
     lower = model.lower()
     if lower.startswith("anthropic/"):
         model = model[len("anthropic/"):]
+        lower = model.lower()
+    # Bedrock inference profile IDs start with a region prefix followed by a dot
+    # (e.g. us.anthropic.claude-haiku-4-5-20251001-v1:0). Preserve as-is.
+    _BEDROCK_PREFIXES = ("us.", "eu.", "ap.", "global.")
+    if any(lower.startswith(p) for p in _BEDROCK_PREFIXES):
+        return model
     if not preserve_dots:
         # OpenRouter uses dots for version separators (claude-opus-4.6),
         # Anthropic uses hyphens (claude-opus-4-6). Convert dots to hyphens.
diff --git a/agent/auxiliary_client.py b/agent/auxiliary_client.py
index 5735648f13fd..f874766d11af 100644
--- a/agent/auxiliary_client.py
+++ b/agent/auxiliary_client.py
@@ -1885,6 +1885,24 @@ def _wrap_if_needed(client_obj, final_model_str: str, base_url_str: str = ""):
                        "directly supported, try 'auto'", provider)
         return None, None
 
+    elif pconfig.auth_type == "aws_sdk":
+        # Bedrock provider — wrap AnthropicBedrock in AnthropicAuxiliaryClient
+        try:
+            from agent.bedrock_adapter import has_aws_credentials, resolve_bedrock_region
+            from agent.anthropic_adapter import build_anthropic_bedrock_client
+        except ImportError as exc:
+            logger.warning("resolve_provider_client: bedrock imports failed: %s", exc)
+            return None, None
+        if not has_aws_credentials():
+            logger.warning("resolve_provider_client: bedrock requested but no AWS credentials found")
+            return None, None
+        region = resolve_bedrock_region()
+        real_client = build_anthropic_bedrock_client(region)
+        final_model = _normalize_resolved_model(model or _read_main_model(), provider)
+        client = AnthropicAuxiliaryClient(real_client, final_model, "aws-sdk", f"https://bedrock-runtime.{region}.amazonaws.com")
+        logger.info("resolve_provider_client: bedrock (%s, region=%s)", final_model, region)
+        return (_to_async_client(client, final_model) if async_mode else (client, final_model))
+
     logger.warning("resolve_provider_client: unhandled auth_type %s for %s",
                    pconfig.auth_type, provider)
     return None, None
diff --git a/run_agent.py b/run_agent.py
index 855b67a8471c..25d9a6061bd9 100644
--- a/run_agent.py
+++ b/run_agent.py
@@ -5220,6 +5220,26 @@ def _anthropic_messages_create(self, api_kwargs: dict):
             self._try_refresh_anthropic_client_credentials()
         return self._anthropic_client.messages.create(**api_kwargs)
 
+    def _rebuild_anthropic_client(self) -> None:
+        """Rebuild the Anthropic client after an interrupt or stale call.
+
+        Handles both direct Anthropic and Bedrock-hosted Anthropic models
+        correctly — rebuilding with the Bedrock SDK when provider is bedrock,
+        rather than always falling back to build_anthropic_client() which
+        requires a direct Anthropic API key.
+        """
+        if getattr(self, "provider", None) == "bedrock":
+            from agent.anthropic_adapter import build_anthropic_bedrock_client
+            region = getattr(self, "_bedrock_region", "us-east-1") or "us-east-1"
+            self._anthropic_client = build_anthropic_bedrock_client(region)
+        else:
+            from agent.anthropic_adapter import build_anthropic_client
+            self._anthropic_client = build_anthropic_client(
+                self._anthropic_api_key,
+                getattr(self, "_anthropic_base_url", None),
+                timeout=get_provider_request_timeout(self.provider, self.model),
+            )
+
     def _interruptible_api_call(self, api_kwargs: dict):
         """
         Run the API call in a background thread so the main conversation loop
@@ -5318,14 +5338,8 @@ def _call():
                 )
                 try:
                     if self.api_mode == "anthropic_messages":
-                        from agent.anthropic_adapter import build_anthropic_client
-
                         self._anthropic_client.close()
-                        self._anthropic_client = build_anthropic_client(
-                            self._anthropic_api_key,
-                            getattr(self, "_anthropic_base_url", None),
-                            timeout=get_provider_request_timeout(self.provider, self.model),
-                        )
+                        self._rebuild_anthropic_client()
                     else:
                         rc = request_client_holder.get("client")
                         if rc is not None:
@@ -5350,14 +5364,8 @@ def _call():
                 # seed future retries.
                 try:
                     if self.api_mode == "anthropic_messages":
-                        from agent.anthropic_adapter import build_anthropic_client
-
                         self._anthropic_client.close()
-                        self._anthropic_client = build_anthropic_client(
-                            self._anthropic_api_key,
-                            getattr(self, "_anthropic_base_url", None),
-                            timeout=get_provider_request_timeout(self.provider, self.model),
-                        )
+                        self._rebuild_anthropic_client()
                     else:
                         request_client = request_client_holder.get("client")
                         if request_client is not None:
@@ -6198,14 +6206,8 @@ def _call():
             if self._interrupt_requested:
                 try:
                     if self.api_mode == "anthropic_messages":
-                        from agent.anthropic_adapter import build_anthropic_client
-
                         self._anthropic_client.close()
-                        self._anthropic_client = build_anthropic_client(
-                            self._anthropic_api_key,
-                            getattr(self, "_anthropic_base_url", None),
-                            timeout=get_provider_request_timeout(self.provider, self.model),
-                        )
+                        self._rebuild_anthropic_client()
                     else:
                         request_client = request_client_holder.get("client")
                         if request_client is not None: