diff --git a/pkgs/applications/misc/opencpn/default.nix b/pkgs/applications/misc/opencpn/default.nix
index 9240b5d8910e4..aee162a6464e6 100644
--- a/pkgs/applications/misc/opencpn/default.nix
+++ b/pkgs/applications/misc/opencpn/default.nix
@@ -1,4 +1,4 @@
-{ stdenv, fetchFromGitHub, pkgconfig, cmake, gtk2, wxGTK30, libpulseaudio, curl,
+{ stdenv, fetchFromGitHub, pkgconfig, cmake, wxGTK30, libpulseaudio, curl,
   gettext, glib, portaudio }:
 
 stdenv.mkDerivation rec {
@@ -13,14 +13,9 @@ stdenv.mkDerivation rec {
   };
 
   nativeBuildInputs = [ pkgconfig ];
-  buildInputs = [ cmake gtk2 wxGTK30 libpulseaudio curl gettext
+  buildInputs = [ cmake wxGTK30 wxGTK30.gtk libpulseaudio curl gettext
                   glib portaudio ];
 
-  cmakeFlags = [
-    "-DGTK2_GDKCONFIG_INCLUDE_DIR=${gtk2.out}/lib/gtk-2.0/include"
-    "-DGTK2_GLIBCONFIG_INCLUDE_DIR=${glib.out}/lib/glib-2.0/include"
-  ];
-
   enableParallelBuilding = true;
 
   meta = {
diff --git a/pkgs/applications/misc/prusa-slicer/default.nix b/pkgs/applications/misc/prusa-slicer/default.nix
index f3cd6fdb0f628..16dc39bc1fdf4 100644
--- a/pkgs/applications/misc/prusa-slicer/default.nix
+++ b/pkgs/applications/misc/prusa-slicer/default.nix
@@ -1,6 +1,6 @@
-{ stdenv, lib, fetchFromGitHub, makeWrapper, cmake, pkgconfig
+{ stdenv, lib, fetchFromGitHub, makeWrapper, cmake, pkgconfig, wrapGAppsHook
 , boost, cereal, curl, eigen, expat, glew, libpng, tbb, wxGTK30
-, gtest, nlopt, xorg, makeDesktopItem
+, gtest, nlopt, xorg, makeDesktopItem, gnome3
 }:
 let
   nloptVersion = if lib.hasAttr "version" nlopt
@@ -17,6 +17,7 @@ stdenv.mkDerivation rec {
     cmake
     makeWrapper
     pkgconfig
+    wrapGAppsHook
   ];
 
   buildInputs = [
@@ -30,10 +31,12 @@ stdenv.mkDerivation rec {
     tbb
     wxGTK30
     xorg.libX11
-  ] ++ checkInputs;
+  ];
 
   checkInputs = [ gtest ];
 
+  doCheck = true;
+
   # The build system uses custom logic - defined in
   # xs/src/libnest2d/cmake_modules/FindNLopt.cmake in the package source -
   # for finding the nlopt library, which doesn't pick up the package in the nix store.
@@ -66,6 +69,7 @@ stdenv.mkDerivation rec {
   cmakeFlags = [
     "-DSLIC3R_FHS=1"
     "-DSLIC3R_WX_STABLE=1"  # necessary when compiling against wxGTK 3.0
+    "-DSLIC3R_GTK=3"
   ];
 
   postInstall = ''
diff --git a/pkgs/applications/misc/slade/default.nix b/pkgs/applications/misc/slade/default.nix
index d2d5e9548a0c3..79eb0dc5d2052 100644
--- a/pkgs/applications/misc/slade/default.nix
+++ b/pkgs/applications/misc/slade/default.nix
@@ -1,24 +1,26 @@
-{ stdenv, fetchFromGitHub, cmake, pkgconfig, wxGTK, gtk2, sfml, fluidsynth, curl, freeimage, ftgl, glew, zip }:
+{ stdenv, fetchFromGitHub, cmake, pkgconfig, zip, which, wrapGAppsHook
+, wxGTK, sfml, fluidsynth, curl, freeimage, ftgl, glew
+}:
 
 stdenv.mkDerivation rec {
   pname = "slade";
-  version = "3.1.1.5";
+  version = "3.1.7";
 
   src = fetchFromGitHub {
     owner = "sirjuddington";
     repo = "SLADE";
     rev = version;
-    sha256 = "0mdn59jm6ab4cdh99bgvadif3wdlqmk5mq635gg7krq35njgw6f6";
+    sha256 = "1yfq7ghg9whys7a07xfcza8rwyfhnrcz6qi5bay1ilj3ml4m12zy";
   };
 
-  nativeBuildInputs = [ cmake pkgconfig zip ];
-  buildInputs = [ wxGTK gtk2 sfml fluidsynth curl freeimage ftgl glew ];
+  nativeBuildInputs = [ cmake pkgconfig zip which wrapGAppsHook ];
+  buildInputs = [ wxGTK wxGTK.gtk sfml fluidsynth curl freeimage ftgl glew ];
 
   enableParallelBuilding = true;
 
   meta = with stdenv.lib; {
     description = "Doom editor";
-    homepage = http://slade.mancubus.net/;
+    homepage = "http://slade.mancubus.net/";
     license = licenses.gpl2;
     platforms = [ "x86_64-linux" "i686-linux" ];
     maintainers = with maintainers; [ abbradar ];
diff --git a/pkgs/applications/misc/slade/git.nix b/pkgs/applications/misc/slade/git.nix
deleted file mode 100644
index 9ee30d347b0a8..0000000000000
--- a/pkgs/applications/misc/slade/git.nix
+++ /dev/null
@@ -1,26 +0,0 @@
-{ stdenv, fetchFromGitHub, cmake, pkgconfig, wxGTK, gtk2, sfml, fluidsynth, curl, freeimage, ftgl, glew, zip }:
-
-stdenv.mkDerivation {
-  name = "slade-git-3.1.2.2018.01.29";
-
-  src = fetchFromGitHub {
-    owner = "sirjuddington";
-    repo = "SLADE";
-    rev = "f7409c504b40c4962f419038db934c32688ddd2e";
-    sha256 = "14icxiy0r9rlcc10skqs1ylnxm1f0f3irhzfmx4sazq0pjv5ivld";
-  };
-
-  cmakeFlags = ["-DNO_WEBVIEW=1"];
-  nativeBuildInputs = [ cmake pkgconfig zip ];
-  buildInputs = [ wxGTK gtk2 sfml fluidsynth curl freeimage ftgl glew ];
-
-  enableParallelBuilding = true;
-
-  meta = with stdenv.lib; {
-    description = "Doom editor";
-    homepage = http://slade.mancubus.net/;
-    license = licenses.gpl2Plus;
-    platforms = [ "x86_64-linux" "i686-linux" ];
-    maintainers = with maintainers; [ ertes ];
-  };
-}
diff --git a/pkgs/applications/misc/xchm/default.nix b/pkgs/applications/misc/xchm/default.nix
index 6a5e62f54e1e5..ce6cc86c2b6ed 100644
--- a/pkgs/applications/misc/xchm/default.nix
+++ b/pkgs/applications/misc/xchm/default.nix
@@ -17,7 +17,7 @@ stdenv.mkDerivation rec {
   configureFlags = [ "--with-wx-prefix=${wxGTK30}" ];
 
   preConfigure = ''
-    export LDFLAGS="$LDFLAGS $(${wxGTK30}/bin/wx-config --libs | sed -e s@-pthread@@) -lwx_gtk2u_aui-3.0"
+    export LDFLAGS="$LDFLAGS $(${wxGTK30}/bin/wx-config --libs | sed -e s@-pthread@@) -lwx_gtk3u_aui-3.0"
   '';
 
   meta = with stdenv.lib; {
diff --git a/pkgs/applications/networking/ftp/filezilla/default.nix b/pkgs/applications/networking/ftp/filezilla/default.nix
index f12fdefc781b2..0c4bccd435058 100644
--- a/pkgs/applications/networking/ftp/filezilla/default.nix
+++ b/pkgs/applications/networking/ftp/filezilla/default.nix
@@ -4,7 +4,6 @@
 , dbus
 , gettext
 , gnutls
-, gtk2
 , libfilezilla
 , libidn
 , nettle
@@ -35,7 +34,6 @@ stdenv.mkDerivation rec {
     dbus
     gettext
     gnutls
-    gtk2
     libfilezilla
     libidn
     nettle
@@ -43,6 +41,7 @@ stdenv.mkDerivation rec {
     sqlite
     tinyxml
     wxGTK30
+    wxGTK30.gtk
     xdg_utils
   ];
 
diff --git a/pkgs/applications/science/misc/boinc/default.nix b/pkgs/applications/science/misc/boinc/default.nix
index c806b558da0ec..1d059b409f51d 100644
--- a/pkgs/applications/science/misc/boinc/default.nix
+++ b/pkgs/applications/science/misc/boinc/default.nix
@@ -1,6 +1,6 @@
 { fetchFromGitHub, stdenv, autoconf, automake, pkgconfig, m4, curl,
 libGLU_combined, libXmu, libXi, freeglut, libjpeg, libtool, wxGTK30, xcbutil,
-sqlite, gtk2, patchelf, libXScrnSaver, libnotify, libX11, libxcb }:
+sqlite, patchelf, libXScrnSaver, libnotify, libX11, libxcb }:
 
 let
   majorVersion = "7.14";
@@ -22,7 +22,7 @@ stdenv.mkDerivation rec {
   nativeBuildInputs = [ libtool automake autoconf m4 pkgconfig ];
 
   buildInputs = [
-    curl libGLU_combined libXmu libXi freeglut libjpeg wxGTK30 sqlite gtk2 libXScrnSaver
+    curl libGLU_combined libXmu libXi freeglut libjpeg wxGTK30 wxGTK30.gtk sqlite libXScrnSaver
     libnotify patchelf libX11 libxcb xcbutil
   ];
 
diff --git a/pkgs/applications/science/misc/fityk/default.nix b/pkgs/applications/science/misc/fityk/default.nix
index 8d0336f582827..f8b81be07c9b0 100644
--- a/pkgs/applications/science/misc/fityk/default.nix
+++ b/pkgs/applications/science/misc/fityk/default.nix
@@ -1,5 +1,5 @@
-{ stdenv, fetchFromGitHub, autoreconfHook, wxGTK30, boost, lua, zlib, bzip2
-, xylib, readline, gnuplot, swig3 }:
+{ stdenv, fetchFromGitHub, fetchpatch, autoreconfHook, wxGTK30, boost, lua, zlib
+, bzip2, xylib, readline, gnuplot, swig3 }:
 
 let
   name    = "fityk";
@@ -15,6 +15,14 @@ stdenv.mkDerivation {
     sha256 = "0kmrjjjwrh6xgw590awcd52b86kksmv6rfgih75zvpiavr1ygwsi";
   };
 
+  patches = [
+    # Allow building with GTK 3
+    (fetchpatch {
+      url = "https://salsa.debian.org/science-team/fityk/raw/67b995963dba56914d25ab3bbcd420fcba24861d/debian/patches/permit-gtk3.patch";
+      sha256 = "12by8w0gd0n8qkljn7lhlz9lhdswpkygkpszm77anrqz54hd3gqr";
+    })
+  ];
+
   nativeBuildInputs = [ autoreconfHook ];
   buildInputs = [ wxGTK30 boost lua zlib bzip2 xylib readline
     gnuplot swig3 ];
diff --git a/pkgs/applications/science/misc/golly/beta.nix b/pkgs/applications/science/misc/golly/beta.nix
deleted file mode 100644
index 99159fba5b435..0000000000000
--- a/pkgs/applications/science/misc/golly/beta.nix
+++ /dev/null
@@ -1,51 +0,0 @@
-{stdenv, fetchgit
-, wxGTK, perl, python2, zlib, libGLU_combined, libX11
-, automake, autoconf
-}:
-
-stdenv.mkDerivation rec {
-  pname = "golly";
-  version = "2.8.99.2.20161122";
-  #src = fetchurl {
-  #  url="mirror://sourceforge/project/golly/golly/golly-2.8/golly-2.8-src.tar.gz";
-  #  sha256="0a4vn2hm7h4b47v2iwip1z3n9y8isf79v08aipl2iqms2m3p5204";
-  #};
-  src = fetchgit {
-    url = "git://git.code.sf.net/p/golly/code";
-    rev = "93495edf3c9639332c6eb43ca7149c69629ee5d8";
-    sha256 = "1j308s9zlqkr3wnl1l32s5zk7r3g4ijwawkkysl8j5ik9sibi2gk";
-  };
-
-  setSourceRoot = ''
-    export sourceRoot="$(echo */gui-wx/configure)"
-  '';
-
-  nativeBuildInputs = [autoconf automake];
-
-  buildInputs = [
-    wxGTK perl python2 zlib libGLU_combined libX11
-  ];
-
-  # Link against Python explicitly as it is needed for scripts
-  makeFlags=[
-    "AM_LDFLAGS="
-  ];
-  NIX_LDFLAGS="-l${python2.libPrefix} -lperl -ldl -lGL";
-  preConfigure=''
-    export NIX_LDFLAGS="$NIX_LDFLAGS -L$(dirname "$(find ${perl} -name libperl.so)")"
-    export NIX_CFLAGS_COMPILE="$NIX_CFLAGS_COMPILE
-      -DPYTHON_SHLIB=$(basename "$(
-        readlink -f ${python2}/lib/libpython*.so)")"
-
-    sh autogen.sh
-  '';
-
-  meta = {
-    inherit version;
-    description = "Cellular automata simulation program";
-    license = stdenv.lib.licenses.gpl2;
-    maintainers = [stdenv.lib.maintainers.raskin];
-    platforms = stdenv.lib.platforms.linux;
-    downloadPage = "https://sourceforge.net/projects/golly/files/golly";
-  };
-}
diff --git a/pkgs/development/libraries/wxsqliteplus/default.nix b/pkgs/development/libraries/wxsqliteplus/default.nix
index 9ca15d4977b91..c3d76da9709e4 100644
--- a/pkgs/development/libraries/wxsqliteplus/default.nix
+++ b/pkgs/development/libraries/wxsqliteplus/default.nix
@@ -1,4 +1,4 @@
-{ stdenv, fetchFromGitHub, wxGTK, wxsqlite3, sqlite }:
+{ stdenv, fetchFromGitHub, wrapGAppsHook, wxGTK, wxsqlite3, sqlite, glib }:
 
 stdenv.mkDerivation rec {
   pname = "wxsqliteplus";
@@ -8,10 +8,12 @@ stdenv.mkDerivation rec {
     owner = "guanlisheng";
     repo = "wxsqliteplus";
     rev = "v${version}";
-    sha1 = "yr9ysviv4hbrxn900z1wz8j32frimvx1";
+    sha256 = "0mgfq813pli56mar7pdxlhwjf5k10j196rs3jd0nc8b6dkzkzlnf";
   };
 
-  buildInputs = [ wxGTK wxsqlite3 sqlite ];
+  nativeBuildInputs = [ wrapGAppsHook ];
+
+  buildInputs = [ wxGTK wxsqlite3 sqlite glib ];
 
   makeFlags = [
     "LDFLAGS=-L${wxsqlite3}/lib"
@@ -20,7 +22,7 @@ stdenv.mkDerivation rec {
   preBuild = ''
     sed -ie 's|all: $(LIBPREFIX)wxsqlite$(LIBEXT)|all: |g' Makefile
     sed -ie 's|wxsqliteplus$(EXEEXT): $(WXSQLITEPLUS_OBJECTS) $(LIBPREFIX)wxsqlite$(LIBEXT)|wxsqliteplus$(EXEEXT):  $(WXSQLITEPLUS_OBJECTS) |g' Makefile
-    sed -ie 's|-lwxsqlite |-lwxcode_gtk2u_wxsqlite3-3.0 |g' Makefile
+    sed -ie 's|-lwxsqlite |-lwxcode_gtk3u_wxsqlite3-3.0 |g' Makefile
   '';
 
   installPhase = ''
diff --git a/pkgs/development/libraries/wxwidgets/3.0/default.nix b/pkgs/development/libraries/wxwidgets/3.0/default.nix
index a12447562b81b..4f2653b191ec1 100644
--- a/pkgs/development/libraries/wxwidgets/3.0/default.nix
+++ b/pkgs/development/libraries/wxwidgets/3.0/default.nix
@@ -5,7 +5,7 @@
 , withMesa ? stdenv.lib.elem stdenv.hostPlatform.system stdenv.lib.platforms.mesaPlatforms
 , libGLU ? null, libGL ? null
 , compat24 ? false, compat26 ? true, unicode ? true
-, withGtk2 ? true
+, withGtk2 ? false
 , withWebKit ? false, webkitgtk24x-gtk2 ? null, webkitgtk ? null
 , AGL ? null, Carbon ? null, Cocoa ? null, Kernel ? null, QTKit ? null
 }:
diff --git a/pkgs/development/libraries/wxwidgets/3.1/default.nix b/pkgs/development/libraries/wxwidgets/3.1/default.nix
index 8fe75153de6d6..90ca0ab248f47 100644
--- a/pkgs/development/libraries/wxwidgets/3.1/default.nix
+++ b/pkgs/development/libraries/wxwidgets/3.1/default.nix
@@ -4,7 +4,7 @@
 , libGLSupported ? stdenv.lib.elem stdenv.hostPlatform.system stdenv.lib.platforms.mesaPlatforms
 , withMesa ? libGLSupported, libGLU ? null, libGL ? null
 , compat28 ? false, compat30 ? true, unicode ? true
-, withGtk2 ? true
+, withGtk2 ? false
 , withWebKit ? false, webkitgtk24x-gtk2 ? null, webkitgtk ? null
 , AGL ? null, Carbon ? null, Cocoa ? null, Kernel ? null, QTKit ? null
 }:
diff --git a/pkgs/development/python-modules/wxPython/3.0.nix b/pkgs/development/python-modules/wxPython/3.0.nix
index 98461dfb40442..aa5937947d8d5 100644
--- a/pkgs/development/python-modules/wxPython/3.0.nix
+++ b/pkgs/development/python-modules/wxPython/3.0.nix
@@ -56,10 +56,9 @@ buildPythonPackage rec {
       --replace "return wxPyTestDisplayAvailable();" "return true;"
   '' + lib.optionalString (!stdenv.isDarwin) ''
     substituteInPlace wx/lib/wxcairo.py \
-      --replace 'cairoLib = None' 'cairoLib = ctypes.CDLL("${cairo}/lib/libcairo.so")'
-    substituteInPlace wx/lib/wxcairo.py \
+      --replace 'cairoLib = None' 'cairoLib = ctypes.CDLL("${cairo}/lib/libcairo.so")' \
       --replace '_dlls = dict()' '_dlls = {k: ctypes.CDLL(v) for k, v in [
-        ("gdk",        "${wxGTK.gtk}/lib/libgtk-x11-2.0.so"),
+        ("gdk",        "${wxGTK.gtk}/lib/libgdk-3.so"),
         ("pangocairo", "${pango.out}/lib/libpangocairo-1.0.so"),
         ("appsvc",     None)
       ]}'
@@ -68,7 +67,7 @@ buildPythonPackage rec {
   buildPhase = "";
 
   installPhase = ''
-    ${python.interpreter} setup.py install WXPORT=${if stdenv.isDarwin then "osx_cocoa" else "gtk2"} NO_HEADERS=0 BUILD_GLCANVAS=${if openglSupport then "1" else "0"} UNICODE=1 --prefix=$out
+    ${python.interpreter} setup.py install WXPORT=${if stdenv.isDarwin then "osx_cocoa" else "gtk3"} NO_HEADERS=0 BUILD_GLCANVAS=${if openglSupport then "1" else "0"} UNICODE=1 --prefix=$out
     wrapPythonPrograms
   '';
 
diff --git a/pkgs/games/rigsofrods/default.nix b/pkgs/games/rigsofrods/default.nix
index 09550339f83db..21fde7b8be987 100644
--- a/pkgs/games/rigsofrods/default.nix
+++ b/pkgs/games/rigsofrods/default.nix
@@ -1,5 +1,5 @@
 { fetchFromGitHub, stdenv, wxGTK30, freeimage, cmake, zziplib, libGLU_combined, boost,
-  pkgconfig, libuuid, openal, ogre, ois, curl, gtk2, mygui, unzip,
+  pkgconfig, libuuid, openal, ogre, ois, curl, mygui, unzip,
   angelscript, ogrepaged, mysocketw, libxcb
   }:
 
@@ -27,7 +27,7 @@ stdenv.mkDerivation rec {
 
   nativeBuildInputs = [ pkgconfig ];
   buildInputs = [ wxGTK30 freeimage cmake zziplib libGLU_combined boost
-    libuuid openal ogre ois curl gtk2 mygui unzip angelscript
+    libuuid openal ogre ois curl wxGTK30.gtk mygui unzip angelscript
     ogrepaged mysocketw libxcb ];
 
   meta = {
diff --git a/pkgs/tools/text/poedit/default.nix b/pkgs/tools/text/poedit/default.nix
index 4d29c380483d5..5fb858594f166 100644
--- a/pkgs/tools/text/poedit/default.nix
+++ b/pkgs/tools/text/poedit/default.nix
@@ -1,5 +1,5 @@
 { stdenv, fetchurl, autoconf, automake, libtool, gettext, pkgconfig, wxGTK30,
-  boost, icu, lucenepp, asciidoc, libxslt, xmlto, gtk2, gtkspell2, pugixml,
+  boost, icu, lucenepp, asciidoc, libxslt, xmlto, gtkspell3, pugixml,
   nlohmann_json, hicolor-icon-theme, wrapGAppsHook }:
 
 stdenv.mkDerivation rec {
@@ -14,7 +14,7 @@ stdenv.mkDerivation rec {
   nativeBuildInputs = [ autoconf automake asciidoc wrapGAppsHook 
     libxslt xmlto boost libtool pkgconfig ];
 
-  buildInputs = [ lucenepp nlohmann_json wxGTK30 icu pugixml gtk2 gtkspell2 hicolor-icon-theme ];
+  buildInputs = [ lucenepp nlohmann_json wxGTK30 icu pugixml wxGTK30.gtk gtkspell3 hicolor-icon-theme ];
 
   propagatedBuildInputs = [ gettext ];
   
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 7c227bbb198b9..f849ea9f64cdc 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -2786,7 +2786,9 @@ in
 
   dotnetfx40 = callPackage ../development/libraries/dotnetfx40 { };
 
-  dolphinEmu = callPackage ../misc/emulators/dolphin-emu { };
+  dolphinEmu = callPackage ../misc/emulators/dolphin-emu {
+    wxGTK30 = wxGTK30.override { withGtk2 = true; };
+  };
   dolphinEmuMaster = qt5.callPackage ../misc/emulators/dolphin-emu/master.nix {
     inherit (darwin.apple_sdk.frameworks) CoreBluetooth ForceFeedback IOKit OpenGL;
   };
@@ -2796,11 +2798,7 @@ in
   doom-bcc = callPackage ../games/zdoom/bcc-git.nix { };
 
   slade = callPackage ../applications/misc/slade {
-    wxGTK = wxGTK30;
-  };
-
-  sladeUnstable = callPackage ../applications/misc/slade/git.nix {
-    wxGTK = wxGTK30;
+    wxGTK = wxGTK30.override { withWebKit = true; };
   };
 
   drive = callPackage ../applications/networking/drive { };
@@ -22927,6 +22925,7 @@ in
     mygui = mygui.override {
       withOgre = true;
     };
+    wxGTK30 = wxGTK30.override { withGtk2 = true; };
   };
 
   riko4 = callPackage ../games/riko4 { };
@@ -24161,7 +24160,6 @@ in
   gravit = callPackage ../applications/science/astronomy/gravit { };
 
   golly = callPackage ../applications/science/misc/golly { wxGTK = wxGTK30; };
-  golly-beta = callPackage ../applications/science/misc/golly/beta.nix { wxGTK = wxGTK30; };
 
   megam = callPackage ../applications/science/misc/megam { };
 
diff --git a/pkgs/top-level/perl-packages.nix b/pkgs/top-level/perl-packages.nix
index 9b9eb3ff230ae..be8c469ddc5a5 100644
--- a/pkgs/top-level/perl-packages.nix
+++ b/pkgs/top-level/perl-packages.nix
@@ -250,8 +250,11 @@ let
       url = mirror://cpan/authors/id/M/MD/MDOOTSON/Alien-wxWidgets-0.69.tar.gz;
       sha256 = "0jg2dmkzhj03f6b0vmv597yryfw9cclsdn9ynvvlrzzgpd5lw8jk";
     };
-    propagatedBuildInputs = [ pkgs.pkgconfig pkgs.gtk2 pkgs.wxGTK30 ModulePluggable ];
-    buildInputs = [ LWPProtocolHttps ];
+    # Don't try to find GTK2
+    AUTOMATED_TESTING = false;
+    nativeBuildInputs = [ pkgs.pkgconfig ];
+    propagatedBuildInputs = [ ModulePluggable ];
+    buildInputs = [ pkgs.wxGTK30 LWPProtocolHttps ];
   };
 
   AnyEvent = buildPerlPackage {
@@ -20080,6 +20083,10 @@ let
       url = mirror://cpan/authors/id/M/MD/MDOOTSON/Wx-0.9932.tar.gz;
       sha256 = "0w0vcpk8bmklh16c0z1vxgipnmvdw7cckcmay7k7cihgb99vdz8w";
     };
+    patches = [ (fetchpatch {
+      url = "https://src.fedoraproject.org/rpms/perl-Wx/raw/aad232e010f3aff77966442dae55b9266e876617/f/gtk3.patch";
+      sha256 = "0gpc3ncf1q78y2hrzdw7965yy8q88h7jplzq6w6625nk613jd28a";
+    }) ];
     propagatedBuildInputs = [ AlienWxWidgets ];
     # Testing requires an X server:
     #   Error: Unable to initialize GTK, is DISPLAY set properly?"
@@ -20094,7 +20101,8 @@ let
       url = mirror://cpan/authors/id/M/MB/MBARBON/Wx-GLCanvas-0.09.tar.gz;
       sha256 = "1q4gvj4gdx4l8k4mkgiix24p9mdfy1miv7abidf0my3gy2gw5lka";
     };
-    propagatedBuildInputs = [ pkgs.libGLU Wx ];
+    buildInputs = [ pkgs.xorg.libX11 pkgs.libGLU ];
+    propagatedBuildInputs = [ Wx ];
     doCheck = false;
   };
 
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 061033f941966..2ec9deaaaccfc 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -5281,7 +5281,7 @@ in {
 
   wxPython_4_0 = callPackage ../development/python-modules/wxPython/4.0.nix {
     inherit (pkgs) pkgconfig;
-    wxGTK = pkgs.wxGTK30.override { withGtk2 = false; withWebKit = true; };
+    wxGTK = pkgs.wxGTK30.override { withWebKit = true; };
   };
 
   xml2rfc = callPackage ../development/python-modules/xml2rfc { };