diff --git a/pkgs/applications/blockchains/bitcoin-knots/default.nix b/pkgs/applications/blockchains/bitcoin-knots/default.nix
index 49e97d731593e..03c8c8ba1f82c 100644
--- a/pkgs/applications/blockchains/bitcoin-knots/default.nix
+++ b/pkgs/applications/blockchains/bitcoin-knots/default.nix
@@ -134,7 +134,7 @@ stdenv.mkDerivation (finalAttrs: {
 
   nativeCheckInputs = [ python3 ];
 
-  doCheck = true;
+  doCheck = stdenv.buildPlatform.canExecute stdenv.hostPlatform;
 
   checkFlags = [
     "LC_ALL=en_US.UTF-8"
diff --git a/pkgs/applications/blockchains/bitcoin/default.nix b/pkgs/applications/blockchains/bitcoin/default.nix
index 1c63e4293929b..c78489205a76d 100644
--- a/pkgs/applications/blockchains/bitcoin/default.nix
+++ b/pkgs/applications/blockchains/bitcoin/default.nix
@@ -172,7 +172,7 @@ stdenv.mkDerivation (finalAttrs: {
 
   nativeCheckInputs = [ python3 ];
 
-  doCheck = true;
+  doCheck = stdenv.buildPlatform.canExecute stdenv.hostPlatform;
 
   checkFlags = [
     "LC_ALL=en_US.UTF-8"
diff --git a/pkgs/build-support/go/module.nix b/pkgs/build-support/go/module.nix
index 5c9b7a84f8a3f..9b19d5a25a433 100644
--- a/pkgs/build-support/go/module.nix
+++ b/pkgs/build-support/go/module.nix
@@ -359,7 +359,7 @@ lib.extendMkDerivation {
           ''
         );
 
-      doCheck = args.doCheck or true;
+      doCheck = args.doCheck or (stdenv.buildPlatform.canExecute stdenv.hostPlatform);
       checkPhase =
         args.checkPhase or ''
           runHook preCheck
diff --git a/pkgs/by-name/fe/feedbackd-device-themes/package.nix b/pkgs/by-name/fe/feedbackd-device-themes/package.nix
index 6b38b57950226..5542333dad934 100644
--- a/pkgs/by-name/fe/feedbackd-device-themes/package.nix
+++ b/pkgs/by-name/fe/feedbackd-device-themes/package.nix
@@ -35,7 +35,7 @@ stdenv.mkDerivation (finalAttrs: {
     (lib.mesonOption "validate" (if finalAttrs.doCheck then "enabled" else "disabled"))
   ];
 
-  doCheck = true;
+  doCheck = stdenv.buildPlatform.canExecute stdenv.hostPlatform;
 
   passthru = {
     updateScript = nix-update-script { };
diff --git a/pkgs/by-name/gs/gsl-lite/package.nix b/pkgs/by-name/gs/gsl-lite/package.nix
index 8a916de95881d..3445d79d17b5d 100644
--- a/pkgs/by-name/gs/gsl-lite/package.nix
+++ b/pkgs/by-name/gs/gsl-lite/package.nix
@@ -26,7 +26,7 @@ stdenv.mkDerivation (finalAttrs: {
   ];
 
   # Building tests is broken on Darwin.
-  doCheck = !stdenv.hostPlatform.isDarwin;
+  doCheck = stdenv.buildPlatform.canExecute stdenv.hostPlatform && !stdenv.hostPlatform.isDarwin;
 
   meta = {
     description = "Single-file header-only version of ISO C++ GSL";
diff --git a/pkgs/by-name/gz/gz-cmake/package.nix b/pkgs/by-name/gz/gz-cmake/package.nix
index c5995dae8250e..09afbf0851bbc 100644
--- a/pkgs/by-name/gz/gz-cmake/package.nix
+++ b/pkgs/by-name/gz/gz-cmake/package.nix
@@ -43,7 +43,7 @@ stdenv.mkDerivation (finalAttrs: {
 
   nativeCheckInputs = [ python3 ];
 
-  doCheck = true;
+  doCheck = stdenv.buildPlatform.canExecute stdenv.hostPlatform;
 
   # Extract the version by matching the tag's prefix.
   passthru.updateScript = nix-update-script {
diff --git a/pkgs/by-name/in/iniparser/package.nix b/pkgs/by-name/in/iniparser/package.nix
index d467ca2834487..53e24461b300c 100644
--- a/pkgs/by-name/in/iniparser/package.nix
+++ b/pkgs/by-name/in/iniparser/package.nix
@@ -44,7 +44,7 @@ stdenv.mkDerivation (finalAttrs: {
   cmakeFlags = [
     (lib.cmakeBool "BUILD_TESTING" finalAttrs.doCheck)
   ];
-  doCheck = true;
+  doCheck = stdenv.buildPlatform.canExecute stdenv.hostPlatform;
   nativeCheckInputs = [
     ruby
     ctestCheckHook
diff --git a/pkgs/by-name/li/libvncserver/package.nix b/pkgs/by-name/li/libvncserver/package.nix
index 85e83d0b04606..f518c3731e0e2 100644
--- a/pkgs/by-name/li/libvncserver/package.nix
+++ b/pkgs/by-name/li/libvncserver/package.nix
@@ -69,7 +69,7 @@ stdenv.mkDerivation (finalAttrs: {
     zlib
   ];
 
-  doCheck = enableShared;
+  doCheck = stdenv.buildPlatform.canExecute stdenv.hostPlatform && enableShared;
 
   meta = with lib; {
     description = "VNC server library";
diff --git a/pkgs/by-name/nl/nlopt/package.nix b/pkgs/by-name/nl/nlopt/package.nix
index 5a78662322e86..8962187b46c64 100644
--- a/pkgs/by-name/nl/nlopt/package.nix
+++ b/pkgs/by-name/nl/nlopt/package.nix
@@ -130,7 +130,7 @@ clangStdenv.mkDerivation (finalAttrs: {
       --no-directory-urls
   '';
 
-  doCheck = true;
+  doCheck = stdenv.buildPlatform.canExecute stdenv.hostPlatform;
 
   postFixup = ''
     substituteInPlace $out/lib/cmake/nlopt/NLoptLibraryDepends.cmake --replace-fail \
diff --git a/pkgs/by-name/so/sobjectizer/package.nix b/pkgs/by-name/so/sobjectizer/package.nix
index e46c47baafabf..4bc4817b2fb92 100644
--- a/pkgs/by-name/so/sobjectizer/package.nix
+++ b/pkgs/by-name/so/sobjectizer/package.nix
@@ -44,7 +44,7 @@ stdenv.mkDerivation (finalAttrs: {
   ];
 
   # The tests require the shared library thanks to the patch.
-  doCheck = withShared;
+  doCheck = stdenv.buildPlatform.canExecute stdenv.hostPlatform && withShared;
 
   # Receive semi-automated updates.
   passthru.updateScript = pkgs.nix-update-script { };
diff --git a/pkgs/by-name/tp/tpm2-pkcs11/package.nix b/pkgs/by-name/tp/tpm2-pkcs11/package.nix
index 233f578d6596e..d2b8cd2ad0774 100644
--- a/pkgs/by-name/tp/tpm2-pkcs11/package.nix
+++ b/pkgs/by-name/tp/tpm2-pkcs11/package.nix
@@ -158,7 +158,7 @@ chosenStdenv.mkDerivation (finalAttrs: {
     "dev"
   ];
 
-  doCheck = true;
+  doCheck = stdenv.buildPlatform.canExecute stdenv.hostPlatform;
   dontStrip = true;
   dontPatchELF = true;
 
diff --git a/pkgs/by-name/z3/z3/package.nix b/pkgs/by-name/z3/z3/package.nix
index 8dca36473acea..8f8649591b852 100644
--- a/pkgs/by-name/z3/z3/package.nix
+++ b/pkgs/by-name/z3/z3/package.nix
@@ -103,7 +103,7 @@ stdenv.mkDerivation (finalAttrs: {
     (lib.cmakeFeature "Z3_JAVA_JAR_INSTALLDIR" "${placeholder "java"}/share/java")
   ];
 
-  doCheck = true;
+  doCheck = stdenv.buildPlatform.canExecute stdenv.hostPlatform;
   checkPhase = ''
     runHook preCheck
 
diff --git a/pkgs/development/cuda-modules/packages/cudnn-frontend/package.nix b/pkgs/development/cuda-modules/packages/cudnn-frontend/package.nix
index b9e622b9f31e1..42478dc98ebc8 100644
--- a/pkgs/development/cuda-modules/packages/cudnn-frontend/package.nix
+++ b/pkgs/development/cuda-modules/packages/cudnn-frontend/package.nix
@@ -99,7 +99,7 @@ stdenv.mkDerivation (finalAttrs: {
     nlohmann_json
   ];
 
-  doCheck = true;
+  doCheck = stdenv.buildPlatform.canExecute stdenv.hostPlatform;
 
   postInstall = optionalString finalAttrs.doCheck ''
     moveToOutput "bin/legacy_samples" "$legacy_samples"
diff --git a/pkgs/tools/system/nvtop/build-nvtop.nix b/pkgs/tools/system/nvtop/build-nvtop.nix
index 79721da656b43..81d5ce47cf932 100644
--- a/pkgs/tools/system/nvtop/build-nvtop.nix
+++ b/pkgs/tools/system/nvtop/build-nvtop.nix
@@ -90,7 +90,7 @@ stdenv.mkDerivation (finalAttrs: {
     + (lib.optionalString nvidia "addDriverRunpath $out/bin/nvtop");
 
   # https://github.com/Syllo/nvtop/commit/33ec008e26a00227a666ccb11321e9971a50daf8
-  doCheck = !stdenv.hostPlatform.isDarwin;
+  doCheck = stdenv.buildPlatform.canExecute stdenv.hostPlatform && !stdenv.hostPlatform.isDarwin;
 
   passthru = {
     tests.version = testers.testVersion {