diff --git a/pkgs/by-name/uv/uv/package.nix b/pkgs/by-name/uv/uv/package.nix
index c068002c920ce..9c57f911f3566 100644
--- a/pkgs/by-name/uv/uv/package.nix
+++ b/pkgs/by-name/uv/uv/package.nix
@@ -8,9 +8,7 @@
   rust-jemalloc-sys,
 
   # nativeBuildInputs
-  cmake,
   installShellFiles,
-  pkg-config,
 
   buildPackages,
   versionCheckHook,
@@ -36,13 +34,7 @@ rustPlatform.buildRustPackage (finalAttrs: {
     rust-jemalloc-sys
   ];
 
-  nativeBuildInputs = [
-    cmake
-    installShellFiles
-    pkg-config
-  ];
-
-  dontUseCmakeConfigure = true;
+  nativeBuildInputs = [ installShellFiles ];
 
   cargoBuildFlags = [
     "--package"
@@ -64,9 +56,7 @@ rustPlatform.buildRustPackage (finalAttrs: {
     ''
   );
 
-  nativeInstallCheckInputs = [
-    versionCheckHook
-  ];
+  nativeInstallCheckInputs = [ versionCheckHook ];
   versionCheckProgramArg = "--version";
   doInstallCheck = true;
 
diff --git a/pkgs/development/python-modules/uv/default.nix b/pkgs/development/python-modules/uv/default.nix
index 57f9bd8238df7..2ab81cf60602c 100644
--- a/pkgs/development/python-modules/uv/default.nix
+++ b/pkgs/development/python-modules/uv/default.nix
@@ -1,37 +1,45 @@
 {
   buildPythonPackage,
-  installShellFiles,
-  pkg-config,
-  rustPlatform,
-  pkgs,
+  hatchling,
+  lib,
+  uv,
 }:
 
 buildPythonPackage {
-  inherit (pkgs.uv)
+  inherit (uv)
     pname
     version
     src
-    cargoDeps
-    dontUseCmakeConfigure
     meta
-    cargoBuildFlags
-    postInstall
-    versionCheckProgramArg
     ;
+  pyproject = true;
 
-  postPatch = ''
-    substituteInPlace python/uv/_find_uv.py \
-      --replace-fail '"""Return the uv binary path."""' "return '$out/bin/uv'"
-  '';
+  build-system = [ hatchling ];
 
-  nativeBuildInputs = [
-    pkgs.cmake
-    installShellFiles
-    pkg-config
-    rustPlatform.cargoSetupHook
-    rustPlatform.maturinBuildHook
-  ];
+  postPatch =
+    # Do not rely on path lookup at runtime to find the uv binary.
+    # Use the propagated binary instead.
+    ''
+      substituteInPlace python/uv/_find_uv.py \
+        --replace-fail '"""Return the uv binary path."""' "return '${lib.getExe uv}'"
+    ''
+    # Sidestep the maturin build system in favour of reusing the binary already built by nixpkgs,
+    # to avoid rebuilding the uv binary for every active python package set.
+    + ''
+      substituteInPlace pyproject.toml \
+        --replace-fail 'requires = ["maturin>=1.0,<2.0"]' 'requires = ["hatchling"]' \
+        --replace-fail 'build-backend = "maturin"' 'build-backend = "hatchling.build"'
+
+      cat >> pyproject.toml <<EOF
+      [tool.hatch.build]
+      packages = ['python/uv']
+
+      EOF
+    '';
+
+  postInstall = ''
+    mkdir -p $out/bin && ln -s ${lib.getExe uv} $out/bin/uv
+  '';
 
-  pyproject = true;
   pythonImportsCheck = [ "uv" ];
 }
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index cf29590efc11d..bd0e58573d026 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -18613,7 +18613,7 @@ self: super: with self; {
 
   uuid6 = callPackage ../development/python-modules/uuid6 { };
 
-  uv = callPackage ../development/python-modules/uv { };
+  uv = callPackage ../development/python-modules/uv { inherit (pkgs) uv; };
 
   uv-build = callPackage ../development/python-modules/uv-build { };