diff --git a/pkgs/development/web/nodejs/v22.nix b/pkgs/development/web/nodejs/v22.nix
index 462766a97d272..f850d04d575d5 100644
--- a/pkgs/development/web/nodejs/v22.nix
+++ b/pkgs/development/web/nodejs/v22.nix
@@ -58,5 +58,15 @@ buildNodejs {
         hash = "sha256-k3h8mPgvaIYGAkGmaL+ix7kUnyLw4/PF7wXMAWrPMXo=";
         revert = true;
       })
+      # Fixes builds with Nix sandbox on Darwin for gyp.
+      # See https://github.com/NixOS/nixpkgs/issues/261820
+      # and https://github.com/nodejs/gyp-next/pull/216
+      (fetchpatch2 {
+        name = "gyp-darwin-sandbox.patch";
+        url = "https://github.com/nodejs/gyp-next/commit/706d04aba5bd18f311dc56f84720e99f64c73466.patch?full_index=1";
+        hash = "sha256-1iyeeAprmWpmLafvOOXW45iZ4jWFSloWJxQ0reAKBOo=";
+        stripLen = 1;
+        extraPrefix = "deps/npm/node_modules/node-gyp/gyp/";
+      })
     ];
 }