diff --git a/pkgs/by-name/ng/nghttp2/package.nix b/pkgs/by-name/ng/nghttp2/package.nix
index ff4d4bfa88c68..86a223f5cbef9 100644
--- a/pkgs/by-name/ng/nghttp2/package.nix
+++ b/pkgs/by-name/ng/nghttp2/package.nix
@@ -88,14 +88,6 @@ stdenv.mkDerivation rec {
     (lib.enableFeature enableHttp3 "http3")
   ];
 
-  env.NIX_CFLAGS_COMPILE = toString (
-    lib.optionals
-      (stdenv.hostPlatform.isDarwin && lib.versionOlder stdenv.hostPlatform.darwinMinVersion "10.13")
-      [
-        "-faligned-allocation"
-      ]
-  );
-
   # Unit tests require CUnit and setting TZDIR environment variable
   doCheck = enableTests;
   nativeCheckInputs = lib.optionals (enableTests) [
diff --git a/pkgs/development/libraries/qt-6/modules/qtquick3dphysics.nix b/pkgs/development/libraries/qt-6/modules/qtquick3dphysics.nix
index 6c74677b337ca..b49c286f9df07 100644
--- a/pkgs/development/libraries/qt-6/modules/qtquick3dphysics.nix
+++ b/pkgs/development/libraries/qt-6/modules/qtquick3dphysics.nix
@@ -12,8 +12,5 @@ qtModule {
     qtbase
     qtquick3d
   ];
-  env.NIX_CFLAGS_COMPILE = lib.optionalString (
-    stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isx86_64
-  ) "-faligned-allocation";
   meta.mainProgram = "cooker";
 }
diff --git a/pkgs/development/python-modules/pybind11/default.nix b/pkgs/development/python-modules/pybind11/default.nix
index d5cbf75a5c69f..1c1933537a00c 100644
--- a/pkgs/development/python-modules/pybind11/default.nix
+++ b/pkgs/development/python-modules/pybind11/default.nix
@@ -26,27 +26,6 @@ let
       pythonSitePackages = "${python}/${python.sitePackages}";
     };
   } ./setup-hook.sh;
-
-  # clang 16 defaults to C++17, which results in the use of aligned allocations by pybind11.
-  # libc++ supports aligned allocations via `posix_memalign`, which is available since 10.6,
-  # but clang has a check hard-coded requiring 10.13 because that’s when Apple first shipped a
-  # support for C++17 aligned allocations on macOS.
-  # Tell clang we’re targeting 10.13 on x86_64-darwin while continuing to use the default SDK.
-  stdenv' =
-    if stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isx86_64 then
-      python.stdenv.override (oldStdenv: {
-        buildPlatform = oldStdenv.buildPlatform // {
-          darwinMinVersion = "10.13";
-        };
-        targetPlatform = oldStdenv.targetPlatform // {
-          darwinMinVersion = "10.13";
-        };
-        hostPlatform = oldStdenv.hostPlatform // {
-          darwinMinVersion = "10.13";
-        };
-      })
-    else
-      python.stdenv;
 in
 buildPythonPackage rec {
   pname = "pybind11";
@@ -69,8 +48,6 @@ buildPythonPackage rec {
   buildInputs = lib.optionals (pythonOlder "3.9") [ libxcrypt ];
   propagatedNativeBuildInputs = [ setupHook ];
 
-  stdenv = stdenv';
-
   dontUseCmakeBuildDir = true;
 
   # Don't build tests if not needed, read the doInstallCheck value at runtime
diff --git a/pkgs/development/web/nodejs/nodejs.nix b/pkgs/development/web/nodejs/nodejs.nix
index 2c4f996aa2a64..fece685a4fa43 100644
--- a/pkgs/development/web/nodejs/nodejs.nix
+++ b/pkgs/development/web/nodejs/nodejs.nix
@@ -148,10 +148,6 @@ let
       # Note: do not set TERM=dumb environment variable globally, it is used in
       # test-ci-js test suite to skip tests that otherwise run fine.
       NINJA = "TERM=dumb ninja";
-    } // lib.optionalAttrs (stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isx86_64) {
-      # Make sure libc++ uses `posix_memalign` instead of `aligned_alloc` on x86_64-darwin.
-      # Otherwise, nodejs would require the 11.0 SDK and macOS 10.15+.
-      NIX_CFLAGS_COMPILE = "-D__ENVIRONMENT_MAC_OS_X_VERSION_MIN_REQUIRED__=101300 -Wno-macro-redefined";
     };
 
     # NB: technically, we do not need bash in build inputs since all scripts are