diff --git a/pkgs/build-support/cc-wrapper/default.nix b/pkgs/build-support/cc-wrapper/default.nix
index 001123fe3d857..6caf5103325a0 100644
--- a/pkgs/build-support/cc-wrapper/default.nix
+++ b/pkgs/build-support/cc-wrapper/default.nix
@@ -629,6 +629,20 @@ stdenvNoCC.mkDerivation {
       echo " -L${libcxx_solib}" >> $out/nix-support/cc-ldflags
     ''
 
+    ## Prevent clang from seeing /usr/include. There is a desire to achieve this
+    ## through alternate means because it breaks -sysroot and related functionality.
+    #
+    # This flag prevents global system header directories from
+    # leaking through on non‐NixOS Linux. However, on macOS, the
+    # SDK path is used as the sysroot, and forcing `-nostdlibinc`
+    # breaks `-isysroot` with an unwrapped compiler. As macOS has
+    # no `/usr/include`, there’s essentially no risk to dropping
+    # the flag there. See discussion in NixOS/nixpkgs#191152.
+    #
+    + optionalString ((cc.isClang or false) && !targetPlatform.isDarwin) ''
+      echo " -nostdlibinc" >> $out/nix-support/cc-cflags
+    ''
+
     ##
     ## Man page and info support
     ##
diff --git a/pkgs/development/compilers/llvm/common/clang/add-nostdlibinc-flag.patch b/pkgs/development/compilers/llvm/common/clang/add-nostdlibinc-flag.patch
deleted file mode 100644
index 80c2eb3623832..0000000000000
--- a/pkgs/development/compilers/llvm/common/clang/add-nostdlibinc-flag.patch
+++ /dev/null
@@ -1,18 +0,0 @@
-diff --git a/lib/Driver/Driver.cpp b/lib/Driver/Driver.cpp
-index 3f29afd35971..223d2769cdfc 100644
---- a/lib/Driver/Driver.cpp
-+++ b/lib/Driver/Driver.cpp
-@@ -491,6 +491,13 @@ DerivedArgList *Driver::TranslateInputArgs(const InputArgList &Args) const {
-   }
- #endif
- 
-+  {
-+    Arg *A = DAL->MakeFlagArg(/*BaseArg=*/nullptr,
-+                              Opts.getOption(options::OPT_nostdlibinc));
-+    A->claim();
-+    DAL->append(A);
-+  }
-+
-   return DAL;
- }
- 
diff --git a/pkgs/development/compilers/llvm/common/default.nix b/pkgs/development/compilers/llvm/common/default.nix
index 707bb91b875de..f0a3b054d7001 100644
--- a/pkgs/development/compilers/llvm/common/default.nix
+++ b/pkgs/development/compilers/llvm/common/default.nix
@@ -529,23 +529,6 @@ let
             # mis-compilation in firefox.
             # See: https://bugzilla.mozilla.org/show_bug.cgi?id=1741454
             (metadata.getVersionFile "clang/revert-malloc-alignment-assumption.patch")
-          # This patch prevents global system header directories from
-          # leaking through on non‐NixOS Linux. However, on macOS, the
-          # SDK path is used as the sysroot, and forcing `-nostdlibinc`
-          # breaks `-isysroot` with an unwrapped compiler. As macOS has
-          # no `/usr/include`, there’s essentially no risk to skipping
-          # the patch there. It’s possible that Homebrew headers in
-          # `/usr/local/include` might leak through to unwrapped
-          # compilers being used without an SDK set or something, but
-          # it hopefully shouldn’t matter.
-          #
-          # TODO: Figure out a better solution to this whole problem so
-          # that we won’t have to choose between breaking unwrapped
-          # compilers breaking libclang when we can do Linux‐to‐Darwin
-          # cross‐compilation again.
-          ++ lib.optional (
-            !args.stdenv.hostPlatform.isDarwin || !args.stdenv.targetPlatform.isDarwin
-          ) ./clang/add-nostdlibinc-flag.patch
           ++ [
             (substituteAll {
               src =