diff --git a/pkgs/development/libraries/webkitgtk/default.nix b/pkgs/development/libraries/webkitgtk/default.nix
index 5ad079e133ca6..ee4af8214a379 100644
--- a/pkgs/development/libraries/webkitgtk/default.nix
+++ b/pkgs/development/libraries/webkitgtk/default.nix
@@ -29,11 +29,14 @@
 , libepoxy
 , libjxl
 , at-spi2-core
+, cairo
 , libxml2
 , libsoup
 , libsecret
 , libxslt
 , harfbuzz
+, hyphen
+, libsysprof-capture
 , libpthreadstubs
 , nettle
 , libtasn1
@@ -50,6 +53,8 @@
 , libmanette
 , geoclue2
 , flite
+, fontconfig
+, freetype
 , openssl
 , sqlite
 , gst-plugins-base
@@ -73,7 +78,7 @@
 
 stdenv.mkDerivation (finalAttrs: {
   pname = "webkitgtk";
-  version = "2.44.3";
+  version = "2.46.0";
   name = "${finalAttrs.pname}-${finalAttrs.version}+abi=${if lib.versionAtLeast gtk3.version "4.0" then "6.0" else "4.${if lib.versions.major libsoup.version == "2" then "0" else "1"}"}";
 
   outputs = [ "out" "dev" "devdoc" ];
@@ -84,7 +89,7 @@ stdenv.mkDerivation (finalAttrs: {
 
   src = fetchurl {
     url = "https://webkitgtk.org/releases/webkitgtk-${finalAttrs.version}.tar.xz";
-    hash = "sha256-3ILQQuysqYGkhSNXwG5SNXQzGc8QqUzTatQbl4g6C1Q=";
+    hash = "sha256-1NQzBA8ZAVFWDFC96ECFAIn4e61P76nr20quhWo99Do=";
   };
 
   patches = lib.optionals stdenv.hostPlatform.isLinux [
@@ -124,6 +129,7 @@ stdenv.mkDerivation (finalAttrs: {
 
   buildInputs = [
     at-spi2-core
+    cairo # required even when using skia
     enchant2
     libavif
     libepoxy
@@ -132,6 +138,7 @@ stdenv.mkDerivation (finalAttrs: {
     gst-plugins-bad
     gst-plugins-base
     harfbuzz
+    hyphen
     libGL
     libGLU
     mesa # for libEGL headers
@@ -141,6 +148,7 @@ stdenv.mkDerivation (finalAttrs: {
     libintl
     lcms2
     libpthreadstubs
+    libsysprof-capture
     libtasn1
     libwebp
     libxkbcommon
@@ -151,6 +159,10 @@ stdenv.mkDerivation (finalAttrs: {
     p11-kit
     sqlite
     woff2
+  ] ++ lib.optionals stdenv.hostPlatform.isBigEndian [
+    # https://bugs.webkit.org/show_bug.cgi?id=274032
+    fontconfig
+    freetype
   ] ++ lib.optionals stdenv.hostPlatform.isDarwin [
     libedit
     readline
@@ -196,7 +208,6 @@ stdenv.mkDerivation (finalAttrs: {
     [
       "-DENABLE_INTROSPECTION=ON"
       "-DPORT=GTK"
-      "-DUSE_LIBHYPHEN=OFF"
       "-DUSE_SOUP2=${cmakeBool (lib.versions.major libsoup.version == "2")}"
       "-DUSE_LIBSECRET=${cmakeBool withLibsecret}"
       "-DENABLE_EXPERIMENTAL_FEATURES=${cmakeBool enableExperimental}"