diff --git a/nixos/lib/make-ext4-fs.nix b/nixos/lib/make-ext4-fs.nix
index f06649e1991a5..21c69ed560a32 100644
--- a/nixos/lib/make-ext4-fs.nix
+++ b/nixos/lib/make-ext4-fs.nix
@@ -10,7 +10,7 @@
 pkgs.stdenv.mkDerivation {
   name = "ext4-fs.img";
 
-  buildInputs = with pkgs; [e2fsprogs libfaketime perl];
+  nativeBuildInputs = with pkgs; [e2fsprogs libfaketime perl];
 
   # For obtaining the closure of `storePaths'.
   exportReferencesGraph =
diff --git a/nixos/lib/make-squashfs.nix b/nixos/lib/make-squashfs.nix
index e66c0ae8f6615..9d47a3222cc27 100644
--- a/nixos/lib/make-squashfs.nix
+++ b/nixos/lib/make-squashfs.nix
@@ -8,7 +8,7 @@
 stdenv.mkDerivation {
   name = "squashfs.img";
 
-  buildInputs = [perl squashfsTools];
+  nativeBuildInputs = [perl squashfsTools];
 
   # For obtaining the closure of `storeContents'.
   exportReferencesGraph =
diff --git a/nixos/modules/security/wrappers/default.nix b/nixos/modules/security/wrappers/default.nix
index 1f64213accd46..77e4b2a616d8e 100644
--- a/nixos/modules/security/wrappers/default.nix
+++ b/nixos/modules/security/wrappers/default.nix
@@ -17,7 +17,7 @@ let
     hardeningEnable = [ "pie" ];
     installPhase = ''
       mkdir -p $out/bin
-      gcc -Wall -O2 -DWRAPPER_DIR=\"${parentWrapperDir}\" \
+      $CC -Wall -O2 -DWRAPPER_DIR=\"${parentWrapperDir}\" \
           -lcap-ng -lcap ${./wrapper.c} -o $out/bin/security-wrapper
     '';
   };
@@ -79,7 +79,7 @@ let
                  ({ owner = "root";
                     group = "root";
                   } // s)
-          else if 
+          else if
              (s ? "setuid" && s.setuid) ||
              (s ? "setgid" && s.setgid) ||
              (s ? "permissions")
diff --git a/pkgs/applications/networking/browsers/w3m/default.nix b/pkgs/applications/networking/browsers/w3m/default.nix
index f65e2fe1851b3..626b3b2195de8 100644
--- a/pkgs/applications/networking/browsers/w3m/default.nix
+++ b/pkgs/applications/networking/browsers/w3m/default.nix
@@ -53,8 +53,12 @@ stdenv.mkDerivation rec {
 
   hardeningDisable = [ "format" ];
 
-  configureFlags = "--with-ssl=${openssl.dev} --with-gc=${boehmgc.dev}"
-    + optionalString graphicsSupport " --enable-image=${optionalString x11Support "x11,"}fb";
+  configureFlags =
+    [ "--with-ssl=${openssl.dev}" "--with-gc=${boehmgc.dev}" ]
+    ++ optionals (stdenv.buildPlatform != stdenv.hostPlatform) [
+      "ac_cv_func_setpgrp_void=yes"
+    ]
+    ++ optional graphicsSupport "--enable-image=${optionalString x11Support "x11,"}fb";
 
   preConfigure = ''
     substituteInPlace ./configure --replace "/lib /usr/lib /usr/local/lib /usr/ucblib /usr/ccslib /usr/ccs/lib /lib64 /usr/lib64" /no-such-path
diff --git a/pkgs/development/libraries/glibc/common.nix b/pkgs/development/libraries/glibc/common.nix
index cfec3209b98aa..d317a5701f19d 100644
--- a/pkgs/development/libraries/glibc/common.nix
+++ b/pkgs/development/libraries/glibc/common.nix
@@ -228,6 +228,6 @@ stdenv.mkDerivation ({
 
   # To avoid a dependency on the build system 'bash'.
   preFixup = ''
-    rm $bin/bin/{ldd,tzselect,catchsegv,xtrace}
+    rm -f $bin/bin/{ldd,tzselect,catchsegv,xtrace}
   '';
 })
diff --git a/pkgs/development/libraries/glibc/locales.nix b/pkgs/development/libraries/glibc/locales.nix
index debd7b39c86a0..7090c5ceceeca 100644
--- a/pkgs/development/libraries/glibc/locales.nix
+++ b/pkgs/development/libraries/glibc/locales.nix
@@ -6,7 +6,7 @@
    https://sourceware.org/git/?p=glibc.git;a=blob;f=localedata/SUPPORTED
 */
 
-{ stdenv, callPackage, writeText
+{ stdenv, buildPackages, callPackage, writeText
 , allLocales ? true, locales ? [ "en_US.UTF-8/UTF-8" ]
 }:
 
@@ -26,7 +26,7 @@ callPackage ./common.nix { inherit stdenv; } {
   # $TMPDIR/nix/store/...-glibc-.../lib/locale/locale-archive.
   buildPhase =
     ''
-      mkdir -p $TMPDIR/"${stdenv.cc.libc.out}/lib/locale"
+      mkdir -p $TMPDIR/"${buildPackages.stdenv.cc.libc.out}/lib/locale"
 
       # Hack to allow building of the locales (needed since glibc-2.12)
       sed -i -e 's,^$(rtld-prefix) $(common-objpfx)locale/localedef,localedef --prefix='$TMPDIR',' ../glibc-2*/localedata/Makefile
diff --git a/pkgs/development/libraries/libomxil-bellagio/default.nix b/pkgs/development/libraries/libomxil-bellagio/default.nix
index 5140402eacb9a..28c8a915c6357 100644
--- a/pkgs/development/libraries/libomxil-bellagio/default.nix
+++ b/pkgs/development/libraries/libomxil-bellagio/default.nix
@@ -8,7 +8,10 @@ stdenv.mkDerivation rec {
     url = "mirror://sourceforge/omxil/omxil/Bellagio%20${version}/${name}.tar.gz";
     sha256 = "0k6p6h4npn8p1qlgq6z3jbfld6n1bqswzvxzndki937gr0lhfg2r";
   };
-  
+
+  configureFlags =
+    stdenv.lib.optionals (stdenv.hostPlatform != stdenv.buildPlatform) [ "ac_cv_func_malloc_0_nonnull=yes" ];
+
   patches = [ ./fedora-fixes.patch ];
 
   meta = with stdenv.lib; {
diff --git a/pkgs/development/libraries/pixman/default.nix b/pkgs/development/libraries/pixman/default.nix
index dc378711d36ba..3980af97a597c 100644
--- a/pkgs/development/libraries/pixman/default.nix
+++ b/pkgs/development/libraries/pixman/default.nix
@@ -15,7 +15,7 @@ stdenv.mkDerivation rec {
 
   configureFlags = stdenv.lib.optional stdenv.isArm "--disable-arm-iwmmxt";
 
-  doCheck = true;
+  doCheck = stdenv.hostPlatform == stdenv.buildPlatform;
 
   postInstall = glib.flattenInclude;
 
diff --git a/pkgs/development/libraries/uthash/default.nix b/pkgs/development/libraries/uthash/default.nix
index 9c252004656c1..6337edf68caf2 100644
--- a/pkgs/development/libraries/uthash/default.nix
+++ b/pkgs/development/libraries/uthash/default.nix
@@ -15,7 +15,7 @@ stdenv.mkDerivation rec {
 
   buildInputs = stdenv.lib.optional doCheck perl;
 
-  doCheck = true;
+  doCheck = stdenv.buildPlatform == stdenv.hostPlatform;
   checkTarget = "-C tests/";
 
   installPhase = ''
diff --git a/pkgs/development/perl-modules/generic/default.nix b/pkgs/development/perl-modules/generic/default.nix
index 9e21a141c728d..833f3094011c3 100644
--- a/pkgs/development/perl-modules/generic/default.nix
+++ b/pkgs/development/perl-modules/generic/default.nix
@@ -2,11 +2,12 @@ perl:
 
 { buildInputs ? [], name, ... } @ attrs:
 
-perl.stdenv.mkDerivation (
+with perl.stdenv;
+mkDerivation (
   {
     outputs = [ "out" "devdoc" ];
 
-    doCheck = true;
+    doCheck = hostPlatform == buildPlatform;
 
     checkTarget = "test";
 
diff --git a/pkgs/os-specific/linux/cpupower/default.nix b/pkgs/os-specific/linux/cpupower/default.nix
index d6d529627e244..c148b6cb5045e 100644
--- a/pkgs/os-specific/linux/cpupower/default.nix
+++ b/pkgs/os-specific/linux/cpupower/default.nix
@@ -5,6 +5,7 @@ stdenv.mkDerivation {
 
   src = kernel.src;
 
+  nativeBuildInputs = [ gettext ];
   buildInputs = [ coreutils pciutils gettext ];
 
   configurePhase = ''
@@ -15,7 +16,7 @@ stdenv.mkDerivation {
   '';
 
   buildPhase = ''
-    make
+    make CROSS=${stdenv.cc.targetPrefix}
   '';
 
   installPhase = ''
diff --git a/pkgs/os-specific/linux/mdadm/default.nix b/pkgs/os-specific/linux/mdadm/default.nix
index 1e2c1dafb2db6..31dd0cbf18d84 100644
--- a/pkgs/os-specific/linux/mdadm/default.nix
+++ b/pkgs/os-specific/linux/mdadm/default.nix
@@ -15,7 +15,7 @@ stdenv.mkDerivation rec {
 
   # This is to avoid self-references, which causes the initrd to explode
   # in size and in turn prevents mdraid systems from booting.
-  allowedReferences = [ stdenv.glibc.out ];
+  allowedReferences = [ stdenv.cc.libc.out ];
 
   patches = [ ./no-self-references.patch ];
 
diff --git a/pkgs/tools/misc/ms-sys/default.nix b/pkgs/tools/misc/ms-sys/default.nix
index 744e5d99ef5e9..3b7f3019998c4 100644
--- a/pkgs/tools/misc/ms-sys/default.nix
+++ b/pkgs/tools/misc/ms-sys/default.nix
@@ -3,13 +3,13 @@
 stdenv.mkDerivation rec {
   name = "ms-sys-${version}";
   version = "2.5.3";
- 
+
   src = fetchurl {
     url = "mirror://sourceforge/ms-sys/${name}.tar.gz";
     sha256 = "0mijf82cbji4laip6hiy3l5ka5mzq5sivjvyv7wxnc2fd3v7hgp0";
   };
 
-  buildInputs = [ gettext ];
+  nativeBuildInputs = [ gettext ];
 
   enableParallelBuilding = true;
 
diff --git a/pkgs/tools/misc/parted/default.nix b/pkgs/tools/misc/parted/default.nix
index 68240210e7466..2670367475345 100644
--- a/pkgs/tools/misc/parted/default.nix
+++ b/pkgs/tools/misc/parted/default.nix
@@ -31,7 +31,7 @@ stdenv.mkDerivation rec {
 
   # Tests were previously failing due to Hydra running builds as uid 0.
   # That should hopefully be fixed now.
-  doCheck = true;
+  doCheck = stdenv.buildPlatform == stdenv.hostPlatform;
 
   preCheck =
     stdenv.lib.optionalString doCheck
diff --git a/pkgs/tools/system/ddrescue/default.nix b/pkgs/tools/system/ddrescue/default.nix
index 5f439ccdb530d..bf2ff5a620670 100644
--- a/pkgs/tools/system/ddrescue/default.nix
+++ b/pkgs/tools/system/ddrescue/default.nix
@@ -16,6 +16,7 @@ stdenv.mkDerivation rec {
   nativeBuildInputs = [ lzip ];
 
   doCheck = hostPlatform == buildPlatform;
+  configureFlags = [ "CXX=${stdenv.cc.targetPrefix}c++" ];
 
   meta = with stdenv.lib; {
     description = "GNU ddrescue, a data recovery tool";