diff --git a/pkgs/development/python-modules/makefun/default.nix b/pkgs/development/python-modules/makefun/default.nix
index ab3428b502e6a..ece4f85008c67 100644
--- a/pkgs/development/python-modules/makefun/default.nix
+++ b/pkgs/development/python-modules/makefun/default.nix
@@ -2,6 +2,7 @@
   lib,
   fetchPypi,
   buildPythonPackage,
+  pythonAtLeast,
 
   # build-system
   setuptools,
@@ -33,6 +34,11 @@ buildPythonPackage rec {
 
   nativeCheckInputs = [ pytestCheckHook ];
 
+  disabledTests = lib.optionals (pythonAtLeast "3.12") [
+    # https://github.com/smarie/python-makefun/issues/102
+    "test_args_order_and_kind"
+  ];
+
   pythonImportsCheck = [ "makefun" ];
 
   meta = with lib; {
diff --git a/pkgs/development/python-modules/twisted/default.nix b/pkgs/development/python-modules/twisted/default.nix
index 8492807e71d21..8449cc2a6f125 100644
--- a/pkgs/development/python-modules/twisted/default.nix
+++ b/pkgs/development/python-modules/twisted/default.nix
@@ -130,6 +130,10 @@ buildPythonPackage rec {
       echo 'WorkerReporterTests.test_addSkipPyunit.skip = "'WorkerReporter' object has no attribute '_testStarted'"' >> src/twisted/trial/_dist/test/test_workerreporter.py
       echo 'LocalWorkerAMPTests.test_runSkip.skip = "twisted.protocols.amp.UnknownRemoteError: Code<UNKNOWN>: Unknown Error"' >> src/twisted/trial/_dist/test/test_worker.py
 
+      # https://github.com/twisted/twisted/issues/12194
+      echo 'FlattenerErrorTests.test_asynchronousFlattenError.skip = "builtins.KeyError: 'root'"' >> src/twisted/web/test/test_flatten.py
+      echo 'FlattenerErrorTests.test_cancel.skip = "builtins.KeyError: 'root'"' >> src/twisted/web/test/test_flatten.py
+
       # not packaged
       substituteInPlace src/twisted/test/test_failure.py \
         --replace "from cython_test_exception_raiser import raiser  # type: ignore[import]" "raiser = None"