diff --git a/pkgs/development/tools/analysis/valgrind/default.nix b/pkgs/development/tools/analysis/valgrind/default.nix
index c8046b68cd96d..82f064a2d4510 100644
--- a/pkgs/development/tools/analysis/valgrind/default.nix
+++ b/pkgs/development/tools/analysis/valgrind/default.nix
@@ -17,8 +17,8 @@ stdenv.mkDerivation rec {
     # Fix build on ELFv2 powerpc64
     # https://bugs.kde.org/show_bug.cgi?id=398883
     (fetchurl {
-      url = "https://github.com/void-linux/void-packages/raw/3e16b4606235885463fc9ab45b4c120f1a51aa28/srcpkgs/valgrind/patches/elfv2-ppc64-be.patch";
-      sha256 = "NV/F+5aqFZz7+OF5oN5MUTpThv4H5PEY9sBgnnWohQY=";
+      url = "https://git.adelielinux.org/adelie/packages/-/raw/f9558def812134e8c40d4d71d5c1cb7f998a4c48/user/valgrind/0001-Ensure-ELFv2-is-supported-on-PPC64.patch";
+      hash = "sha256-ESjJWnjLXcu75y1TYpDK022CFc8lcdt4ISvxu8wXlxM=";
     })
     # Fix checks on Musl.
     # https://bugs.kde.org/show_bug.cgi?id=453929
@@ -87,7 +87,8 @@ stdenv.mkDerivation rec {
     lib.optional stdenv.hostPlatform.isx86_64 "--enable-only64bit"
     ++ lib.optional stdenv.hostPlatform.isDarwin "--with-xcodedir=${xnu}/include";
 
-  doCheck = true;
+  # PPC64 ELFv2 patch does not fix tests
+  doCheck = !(with stdenv.hostPlatform; isPower64 && isAbiElfv2);
 
   postInstall = ''
     for i in $out/libexec/valgrind/*.supp; do
@@ -131,7 +132,15 @@ stdenv.mkDerivation rec {
     platforms = with lib.platforms; lib.intersectLists
       (x86 ++ power ++ s390x ++ armv7 ++ aarch64 ++ mips)
       (darwin ++ freebsd ++ illumos ++ linux);
-    badPlatforms = [ lib.systems.inspect.platformPatterns.isStatic ];
+    badPlatforms = with lib.systems.inspect; [
+      platformPatterns.isStatic
+    ]
+    # We can build for PPC64 ELFv2, but analysing any PPC64 ELFv2 binary produced by Nixpkgs causes many issues: https://github.com/NixOS/nixpkgs/pull/295906
+    # Effectively unusable with Nixpkgs binaries
+    ++ (map
+      (variant: lib.recursiveUpdate (lib.recursiveUpdate patterns.isPower64 patterns.isBigEndian) variant)
+      patterns.isAbiElfv2
+    );
     broken = stdenv.isDarwin; # https://hydra.nixos.org/build/128521440/nixlog/2
   };
 }