diff --git a/pkgs/by-name/ja/jasper/package.nix b/pkgs/by-name/ja/jasper/package.nix
index 29fd8fd5a9e62..b3f59aa816a0f 100644
--- a/pkgs/by-name/ja/jasper/package.nix
+++ b/pkgs/by-name/ja/jasper/package.nix
@@ -5,6 +5,7 @@
 , libGL
 , libheif
 , libjpeg
+, darwin
 , pkg-config
 , stdenv
 , enableHEIFCodec ? true
@@ -35,10 +36,16 @@ stdenv.mkDerivation (finalAttrs: {
     libheif
   ] ++ lib.optionals enableJPGCodec [
     libjpeg
-  ] ++ lib.optionals enableOpenGL [
-    freeglut
-    libGL
-  ];
+  ] ++ lib.optionals enableOpenGL (
+    if stdenv.hostPlatform.isDarwin then [
+      darwin.apple_sdk.frameworks.OpenGL
+      darwin.apple_sdk.frameworks.GLUT
+      darwin.apple_sdk.frameworks.Cocoa
+    ] else [
+      libGL
+      freeglut
+    ]
+  );
 
   # Since "build" already exists and is populated, cmake tries to use it,
   # throwing uncomprehensible error messages...
diff --git a/pkgs/development/libraries/fox/default.nix b/pkgs/development/libraries/fox/default.nix
index 2715e2c80ca43..746526d8ba127 100644
--- a/pkgs/development/libraries/fox/default.nix
+++ b/pkgs/development/libraries/fox/default.nix
@@ -6,7 +6,6 @@
 , libtiff
 , zlib
 , bzip2
-, libGL
 , libGLU
 , libXcursor
 , libXext
@@ -24,7 +23,7 @@ stdenv.mkDerivation rec {
     sha256 = "sha256-bu+IEqNkv9OAf96dPYre3CP759pjalVIbYyc3QSQW2w=";
   };
 
-  buildInputs = [ libpng libjpeg libtiff zlib bzip2 libGL libGLU libXcursor libXext libXrandr libXft ]
+  buildInputs = [ libpng libjpeg libtiff zlib bzip2 libGLU libXcursor libXext libXrandr libXft ]
     ++ lib.optional stdenv.isDarwin CoreServices;
 
   doCheck = true;
diff --git a/pkgs/development/libraries/freeglut/default.nix b/pkgs/development/libraries/freeglut/default.nix
index 69c3b65e4a51c..d70a065582587 100644
--- a/pkgs/development/libraries/freeglut/default.nix
+++ b/pkgs/development/libraries/freeglut/default.nix
@@ -1,4 +1,4 @@
-{ lib, stdenv, fetchurl, libICE, libXext, libXi, libXrandr, libXxf86vm, libGL, libGLU, cmake
+{ lib, stdenv, fetchurl, libICE, libXext, libXi, libXrandr, libXxf86vm, libGLX, libGLU, cmake, darwin
 , testers
 }:
 
@@ -14,11 +14,12 @@ stdenv.mkDerivation (finalAttrs: {
   outputs = [ "out" "dev" ];
 
   nativeBuildInputs = [ cmake ];
-  buildInputs = [ libICE libXext libXi libXrandr libXxf86vm libGL libGLU ];
+  buildInputs = [ libICE libXext libXi libXrandr libXxf86vm libGLU ]
+    ++ lib.optional stdenv.isDarwin [ darwin.apple_sdk.frameworks.OpenGL ];
 
   cmakeFlags = lib.optionals stdenv.isDarwin [
-                 "-DOPENGL_INCLUDE_DIR=${libGL}/include"
-                 "-DOPENGL_gl_LIBRARY:FILEPATH=${libGL}/lib/libGL.dylib"
+                 "-DOPENGL_INCLUDE_DIR=${libGLX.dev}/include"
+                 "-DOPENGL_gl_LIBRARY:FILEPATH=${libGLX}/lib/libGL.dylib"
                  "-DOPENGL_glu_LIBRARY:FILEPATH=${libGLU}/lib/libGLU.dylib"
                  "-DFREEGLUT_BUILD_DEMOS:BOOL=OFF"
                  "-DFREEGLUT_BUILD_STATIC:BOOL=OFF"
diff --git a/pkgs/development/libraries/mesa-glu/default.nix b/pkgs/development/libraries/mesa-glu/default.nix
index bcff20f1847cd..e5f7de185d956 100644
--- a/pkgs/development/libraries/mesa-glu/default.nix
+++ b/pkgs/development/libraries/mesa-glu/default.nix
@@ -1,6 +1,6 @@
 { lib, stdenv, fetchurl
 , meson, ninja
-, pkg-config, libGL, ApplicationServices
+, pkg-config, mesa, ApplicationServices
 , testers
 , gitUpdater
 }:
@@ -17,7 +17,7 @@ stdenv.mkDerivation (finalAttrs: {
   };
 
   nativeBuildInputs = [ meson ninja pkg-config ];
-  propagatedBuildInputs = [ libGL ]
+  propagatedBuildInputs = [ mesa ]
     ++ lib.optional stdenv.isDarwin ApplicationServices;
 
   outputs = [ "out" "dev" ];
diff --git a/pkgs/development/libraries/mesa/stubs.nix b/pkgs/development/libraries/mesa/stubs.nix
index f9c462e9b3267..4f7d39d9b3e74 100644
--- a/pkgs/development/libraries/mesa/stubs.nix
+++ b/pkgs/development/libraries/mesa/stubs.nix
@@ -1,50 +1,37 @@
 { stdenv
+, lib
 , libglvnd
-, mesa
 , OpenGL
 , testers
 }:
 
 stdenv.mkDerivation (finalAttrs: {
   pname = "libGL";
-  inherit (if stdenv.hostPlatform.isDarwin then mesa else libglvnd) version;
+  version = if stdenv.hostPlatform.isDarwin then "4.1" else libglvnd.version;
   outputs = [ "out" "dev" ];
 
-  # On macOS, libglvnd is not supported, so we just use what mesa
-  # build. We need to also include OpenGL.framework, and some
-  # extra tricks to go along with. We add mesa’s libGLX to support
-  # the X extensions to OpenGL.
-  buildCommand = if stdenv.hostPlatform.isDarwin then ''
-    mkdir -p $out/nix-support $dev
-    echo ${OpenGL} >> $out/nix-support/propagated-build-inputs
-    ln -s ${mesa.out}/lib $out/lib
+  propagatedBuildInputs = lib.optionals stdenv.isDarwin [ OpenGL ];
 
+  # On macOS, provide the OpenGL framework as well as a pkg-config file for OpenGL.framework.
+  # Packages that still need GL_X_ specifically can pull in libGLX instead, which will be
+  # Mesa, as libglvnd does not work on macOS.
+  buildCommand = if stdenv.hostPlatform.isDarwin then ''
     mkdir -p $dev/lib/pkgconfig $dev/nix-support
+
     echo "$out" > $dev/nix-support/propagated-build-inputs
-    ln -s ${mesa.dev}/include $dev/include
+
+    mkdir -p $out/lib
+    ln -s ${OpenGL}/Library/Frameworks/OpenGL.framework/Libraries/libGL.tbd $out/lib/libGL.tbd
+
+    mkdir -p $dev/include
+    ln -s ${OpenGL}/Library/Frameworks/OpenGL.framework/Headers $dev/include/GL
 
     cat <<EOF >$dev/lib/pkgconfig/gl.pc
   Name: gl
   Description: gl library
-  Version: ${mesa.version}
-  Libs: -L${mesa.out}/lib -lGL
-  Cflags: -I${mesa.dev}/include
-  EOF
-
-    cat <<EOF >$dev/lib/pkgconfig/glesv1_cm.pc
-  Name: glesv1_cm
-  Description: glesv1_cm library
-  Version: ${mesa.version}
-  Libs: -L${mesa.out}/lib -lGLESv1_CM
-  Cflags: -I${mesa.dev}/include
-  EOF
-
-    cat <<EOF >$dev/lib/pkgconfig/glesv2.pc
-  Name: glesv2
-  Description: glesv2 library
-  Version: ${mesa.version}
-  Libs: -L${mesa.out}/lib -lGLESv2
-  Cflags: -I${mesa.dev}/include
+  Version: 4.1
+  Libs: -F${OpenGL} -framework OpenGL
+  Cflags: -F${OpenGL}
   EOF
   ''
 
@@ -79,10 +66,9 @@ stdenv.mkDerivation (finalAttrs: {
   passthru.tests.pkg-config = testers.testMetaPkgConfig finalAttrs.finalPackage;
 
   meta = {
-    description = "Stub bindings using " + (if stdenv.hostPlatform.isDarwin then "mesa" else "libglvnd");
-    pkgConfigModules = [ "gl" "egl" "glesv1_cm" "glesv2" ];
-  } // {
-    inherit (if stdenv.hostPlatform.isDarwin then mesa.meta else libglvnd.meta)
-      homepage license platforms badPlatforms;
-  };
+    description = "Stub bindings using " + (if stdenv.hostPlatform.isDarwin then "OpenGL.framework" else "libglvnd");
+    pkgConfigModules = [ "gl" ] ++ lib.optionals (!stdenv.hostPlatform.isDarwin) [ "egl" "glesv1_cm" "glesv2" ];
+  } // (if stdenv.hostPlatform.isDarwin
+    then { inherit (OpenGL.meta) platforms; }
+    else { inherit (libglvnd.meta) homepage license platforms badPlatforms; });
 })
diff --git a/pkgs/development/libraries/physics/geant4/default.nix b/pkgs/development/libraries/physics/geant4/default.nix
index 3b67b6a3756ed..c9e6b83d6c082 100644
--- a/pkgs/development/libraries/physics/geant4/default.nix
+++ b/pkgs/development/libraries/physics/geant4/default.nix
@@ -3,8 +3,8 @@
 , enableQT             ? false # deprecated name
 , enableQt             ? enableQT
 , enableXM             ? false
-, mesa
-, enableOpenGLX11      ? !mesa.meta.broken
+, libGLX
+, enableOpenGLX11      ? !libGLX.meta.broken
 , enablePython         ? false
 , enableRaytracerX11   ? false
 
@@ -32,6 +32,7 @@
 , libGLU, libGL
 , libXext
 , libXmu
+, darwin
 
 # For enablePython
 , boost
@@ -77,8 +78,8 @@ stdenv.mkDerivation rec {
     "-DGEANT4_USE_SYSTEM_ZLIB=ON"
     "-DGEANT4_BUILD_MULTITHREADED=${if enableMultiThreading then "ON" else "OFF"}"
   ] ++ lib.optionals (enableOpenGLX11 && stdenv.isDarwin) [
-    "-DXQuartzGL_INCLUDE_DIR=${libGL.dev}/include"
-    "-DXQuartzGL_gl_LIBRARY=${libGL}/lib/libGL.dylib"
+    "-DXQuartzGL_INCLUDE_DIR=${libGLX.dev}/include"
+    "-DXQuartzGL_gl_LIBRARY=${libGLX}/lib/libGL.dylib"
   ] ++ lib.optionals (enableMultiThreading && enablePython) [
     "-DGEANT4_BUILD_TLS_MODEL=global-dynamic"
   ] ++ lib.optionals enableInventor [
@@ -98,7 +99,8 @@ stdenv.mkDerivation rec {
   buildInputs =
     lib.optionals enableOpenGLX11 [ libGLU libXext libXmu ]
     ++ lib.optionals enableInventor [ libXpm coin3d soxt motif ]
-    ++ lib.optionals enablePython [ boost_python python3 ];
+    ++ lib.optionals enablePython [ boost_python python3 ]
+    ++ lib.optionals stdenv.isDarwin [ darwin.apple_sdk.frameworks.OpenGL ];
 
   propagatedBuildInputs = [ clhep expat xercesc zlib ]
     ++ lib.optionals enableOpenGLX11 [ libGL ]
diff --git a/pkgs/development/libraries/recastnavigation/default.nix b/pkgs/development/libraries/recastnavigation/default.nix
index b4119f1133f5f..a789239708a31 100644
--- a/pkgs/development/libraries/recastnavigation/default.nix
+++ b/pkgs/development/libraries/recastnavigation/default.nix
@@ -1,4 +1,4 @@
-{ stdenv, lib, fetchFromGitHub, cmake, libGL, SDL2, libGLU, catch }:
+{ stdenv, lib, fetchFromGitHub, cmake, libGL, SDL2, libGLU, catch, darwin }:
 
 stdenv.mkDerivation rec {
   pname = "recastai";
@@ -31,7 +31,8 @@ stdenv.mkDerivation rec {
 
   nativeBuildInputs = [ cmake ];
 
-  buildInputs = [ libGL SDL2 libGLU ];
+  buildInputs = [ libGL SDL2 libGLU ]
+    ++ lib.optionals stdenv.isDarwin [ darwin.apple_sdk.frameworks.OpenGL ];
 
   meta = with lib; {
     homepage = "https://github.com/recastnavigation/recastnavigation";
diff --git a/pkgs/development/python-modules/vispy/default.nix b/pkgs/development/python-modules/vispy/default.nix
index 36833c75ff48b..e5bac31c47ade 100644
--- a/pkgs/development/python-modules/vispy/default.nix
+++ b/pkgs/development/python-modules/vispy/default.nix
@@ -35,7 +35,9 @@ buildPythonPackage rec {
     (substituteAll {
       src = ./library-paths.patch;
       fontconfig = "${fontconfig.lib}/lib/libfontconfig${stdenv.hostPlatform.extensions.sharedLibrary}";
-      gl = "${libGL.out}/lib/libGL${stdenv.hostPlatform.extensions.sharedLibrary}";
+      gl = if stdenv.isDarwin
+        then "/System/Library/Frameworks/OpenGL.framework/Versions/Current/OpenGL"
+        else "${libGL.out}/lib/libGL${stdenv.hostPlatform.extensions.sharedLibrary}";
     })
   ];
 
diff --git a/pkgs/development/tools/misc/unixbench/default.nix b/pkgs/development/tools/misc/unixbench/default.nix
index 4edd464a763d2..d5f060af82cf5 100644
--- a/pkgs/development/tools/misc/unixbench/default.nix
+++ b/pkgs/development/tools/misc/unixbench/default.nix
@@ -6,7 +6,7 @@
 , installShellFiles
 , perl
 , xorg
-, libGL
+, libGLX
 , coreutils
 , unixtools
 , targetPackages
@@ -49,7 +49,7 @@ stdenv.mkDerivation rec {
   buildInputs = [ perl ] ++ lib.optionals withGL [
     xorg.libX11
     xorg.libXext
-    libGL
+    libGLX
   ];
 
   runtimeDependencies = [
diff --git a/pkgs/games/ddnet/default.nix b/pkgs/games/ddnet/default.nix
index 84ecbf4e91cf2..ce83238aa1844 100644
--- a/pkgs/games/ddnet/default.nix
+++ b/pkgs/games/ddnet/default.nix
@@ -101,7 +101,8 @@ stdenv.mkDerivation rec {
     "-DCLIENT=${if buildClient then "ON" else "OFF"}"
   ];
 
-  doCheck = true;
+  # Tests loop forever on Darwin for some reason
+  doCheck = !stdenv.isDarwin;
   checkTarget = "run_tests";
 
   postInstall = lib.optionalString (!buildClient) ''
diff --git a/pkgs/games/mar1d/default.nix b/pkgs/games/mar1d/default.nix
index b069e3fecc46a..0722654b48682 100644
--- a/pkgs/games/mar1d/default.nix
+++ b/pkgs/games/mar1d/default.nix
@@ -8,6 +8,7 @@
 , ninja
 , pkg-config
 , fetchFromGitHub
+, darwin
 }:
 
 stdenv.mkDerivation rec {
@@ -28,6 +29,8 @@ stdenv.mkDerivation rec {
     SDL2_mixer
     libconfig
     libGLU
+  ] ++ lib.optionals stdenv.isDarwin [
+    darwin.apple_sdk.frameworks.OpenGL
   ];
 
   meta = with lib; {
diff --git a/pkgs/servers/x11/xorg/overrides.nix b/pkgs/servers/x11/xorg/overrides.nix
index cd7e116c17d59..7bf46d945251d 100644
--- a/pkgs/servers/x11/xorg/overrides.nix
+++ b/pkgs/servers/x11/xorg/overrides.nix
@@ -835,6 +835,7 @@ self: super:
         buildInputs = commonBuildInputs ++ [
           bootstrap_cmds automake autoconf
           Xplugin Carbon Cocoa
+          mesa
         ];
         propagatedBuildInputs = commonPropagatedBuildInputs ++ [
           libAppleWM xorgproto
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index cdca4c0bd7d3d..8b9769d51a16e 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -23231,6 +23231,8 @@ with pkgs;
   # Default libGLU
   libGLU = mesa_glu;
 
+  libGLX = if stdenv.isDarwin then mesa else libglvnd;
+
   mesa = if stdenv.isDarwin
     then darwin.apple_sdk_11_0.callPackage ../development/libraries/mesa/darwin.nix {
       inherit (darwin.apple_sdk_11_0.libs) Xplugin;