diff --git a/pkgs/development/interpreters/python/catch_conflicts/catch_conflicts_py2.py b/pkgs/development/interpreters/python/catch_conflicts/catch_conflicts_py2.py
new file mode 100644
index 0000000000000..bb82900c65a92
--- /dev/null
+++ b/pkgs/development/interpreters/python/catch_conflicts/catch_conflicts_py2.py
@@ -0,0 +1,30 @@
+import pkg_resources
+import collections
+import sys
+
+do_abort = False
+packages = collections.defaultdict(list)
+
+for f in sys.path:
+    for req in pkg_resources.find_distributions(f):
+        if req not in packages[req.project_name]:
+            # some exceptions inside buildPythonPackage
+            if req.project_name in ['setuptools', 'pip', 'wheel']:
+                continue
+            packages[req.project_name].append(req)
+
+
+for name, duplicates in packages.items():
+    if len(duplicates) > 1:
+        do_abort = True
+        print("Found duplicated packages in closure for dependency '{}': ".format(name))
+        for dup in duplicates:
+            print("  " + repr(dup))
+
+if do_abort:
+    print("")
+    print(
+        'Package duplicates found in closure, see above. Usually this '
+        'happens if two packages depend on different version '
+        'of the same dependency.')
+    sys.exit(1)
diff --git a/pkgs/development/interpreters/python/hooks/default.nix b/pkgs/development/interpreters/python/hooks/default.nix
index f7cc10274ae36..0a4600b9d6c39 100644
--- a/pkgs/development/interpreters/python/hooks/default.nix
+++ b/pkgs/development/interpreters/python/hooks/default.nix
@@ -106,9 +106,16 @@ in {
   pythonCatchConflictsHook = callPackage ({ makePythonHook, setuptools }:
     makePythonHook {
       name = "python-catch-conflicts-hook";
-      substitutions = {
+      substitutions = let
+        useLegacyHook = lib.versionOlder python.version "3.10";
+      in {
         inherit pythonInterpreter pythonSitePackages;
-        catchConflicts=../catch_conflicts/catch_conflicts.py;
+        catchConflicts = if useLegacyHook then
+          ../catch_conflicts/catch_conflicts_py2.py
+        else
+          ../catch_conflicts/catch_conflicts.py;
+      } // lib.optionalAttrs useLegacyHook {
+        inherit setuptools;
       };
     } ./python-catch-conflicts-hook.sh) {};
 
diff --git a/pkgs/development/interpreters/python/python2/mk-python-derivation.nix b/pkgs/development/interpreters/python/python2/mk-python-derivation.nix
index 6d51b51b215d4..1a6f9c784cf67 100644
--- a/pkgs/development/interpreters/python/python2/mk-python-derivation.nix
+++ b/pkgs/development/interpreters/python/python2/mk-python-derivation.nix
@@ -57,8 +57,7 @@
 # Raise an error if two packages are installed with the same name
 # TODO: For cross we probably need a different PYTHONPATH, or not
 # add the runtime deps until after buildPhase.
-# FIXME: disabled for Python 2 because broken
-, catchConflicts ? false
+, catchConflicts ? (python.stdenv.hostPlatform == python.stdenv.buildPlatform)
 
 # Additional arguments to pass to the makeWrapper function, which wraps
 # generated binaries.