diff --git a/pkgs/development/interpreters/python/hooks/default.nix b/pkgs/development/interpreters/python/hooks/default.nix
index 001e477b9185b..144cc9bb1853d 100644
--- a/pkgs/development/interpreters/python/hooks/default.nix
+++ b/pkgs/development/interpreters/python/hooks/default.nix
@@ -160,6 +160,20 @@ in {
       };
     } ./setuptools-check-hook.sh) {};
 
+    setuptoolsRustBuildHook = callPackage ({ makePythonHook, setuptools-rust, rust }:
+      makePythonHook {
+        name = "setuptools-rust-setup-hook";
+        propagatedBuildInputs = [ setuptools-rust ];
+        substitutions = {
+          pyLibDir = "${python}/lib/${python.libPrefix}";
+          cargoBuildTarget = rust.toRustTargetSpec stdenv.hostPlatform;
+          cargoLinkerVar = lib.toUpper (
+              builtins.replaceStrings ["-"] ["_"] (
+                rust.toRustTarget stdenv.hostPlatform));
+          targetLinker = "${stdenv.cc}/bin/${stdenv.cc.targetPrefix}cc";
+        };
+      } ./setuptools-rust-hook.sh) {};
+
   unittestCheckHook = callPackage ({ makePythonHook }:
     makePythonHook {
       name = "unittest-check-hook";
diff --git a/pkgs/development/interpreters/python/hooks/setuptools-rust-hook.sh b/pkgs/development/interpreters/python/hooks/setuptools-rust-hook.sh
new file mode 100644
index 0000000000000..917c19ef9b31b
--- /dev/null
+++ b/pkgs/development/interpreters/python/hooks/setuptools-rust-hook.sh
@@ -0,0 +1,18 @@
+echo "Sourcing setuptools-rust-hook"
+
+setuptoolsRustSetup() {
+    # This can work only if rustPlatform.cargoSetupHook is also included
+    if ! command -v cargoSetupPostPatchHook >/dev/null; then
+        echo "ERROR: setuptools-rust has to be used alongside with rustPlatform.cargoSetupHook!"
+        exit 1
+    fi
+
+    export PYO3_CROSS_LIB_DIR="@pyLibDir@"
+    export CARGO_BUILD_TARGET=@cargoBuildTarget@
+    # TODO theoretically setting linker should not be required because it is
+    # already set in pkgs/build-support/rust/hooks/default.nix but build fails
+    # on missing linker without this.
+    export CARGO_TARGET_@cargoLinkerVar@_LINKER=@targetLinker@
+}
+
+preConfigureHooks+=(setuptoolsRustSetup)
diff --git a/pkgs/development/python-modules/cryptography/default.nix b/pkgs/development/python-modules/cryptography/default.nix
index 2ebcb9efffe2a..8346b4f4418d1 100644
--- a/pkgs/development/python-modules/cryptography/default.nix
+++ b/pkgs/development/python-modules/cryptography/default.nix
@@ -6,7 +6,7 @@
 , rustPlatform
 , cargo
 , rustc
-, setuptools-rust
+, setuptoolsRustBuildHook
 , openssl
 , Security
 , isPyPy
@@ -54,7 +54,7 @@ buildPythonPackage rec {
 
   nativeBuildInputs = [
     rustPlatform.cargoSetupHook
-    setuptools-rust
+    setuptoolsRustBuildHook
     cargo
     rustc
     pkg-config