diff --git a/pkgs/development/python-modules/twisted/default.nix b/pkgs/development/python-modules/twisted/default.nix
index fae5ef8cf1039..86e009d55c408 100644
--- a/pkgs/development/python-modules/twisted/default.nix
+++ b/pkgs/development/python-modules/twisted/default.nix
@@ -16,6 +16,7 @@
 , glibcLocales
 , h2
 , hyperlink
+, hypothesis
 , idna
 , incremental
 , priority
@@ -45,7 +46,7 @@
 
 buildPythonPackage rec {
   pname = "twisted";
-  version = "22.8.0";
+  version = "22.10.0";
   format = "setuptools";
 
   disabled = pythonOlder "3.6";
@@ -54,17 +55,9 @@ buildPythonPackage rec {
     pname = "Twisted";
     inherit version;
     extension = "tar.gz";
-    hash = "sha256-5bYN458tHaFT++GHTYhf4/y9sh/MRG+nWaU+j8NRO+0=";
+    hash = "sha256-Mqy9QKlPX0bntCwQm/riswIlCUVWF4Oot6BZBI8tTTE=";
   };
 
-  patches = [
-    (fetchpatch {
-      name = "fix-test_openFileDescriptors.patch";
-      url = "https://github.com/twisted/twisted/commit/47f47634940141466177261b20bb43c300531e38.patch";
-      hash = "sha256-wacnF166PnZHXJEqTlPZUdDILJIVHOcnC2a34SQumvs=";
-    })
-  ];
-
   __darwinAllowLocalNetworking = true;
 
   propagatedBuildInputs = [
@@ -116,6 +109,11 @@ buildPythonPackage rec {
   '' + lib.optionalString (stdenv.isAarch64 && stdenv.isDarwin) ''
     echo 'AbortConnectionTests_AsyncioSelectorReactorTests.test_fullWriteBufferAfterByteExchange.skip = "Timeout after 120 seconds"' >> src/twisted/internet/test/test_tcp.py
     echo 'AbortConnectionTests_AsyncioSelectorReactorTests.test_resumeProducingAbort.skip = "Timeout after 120 seconds"' >> src/twisted/internet/test/test_tcp.py
+
+    echo 'PosixReactorBaseTests.test_removeAllSkipsInternalReaders.skip = "Fails due to unclosed event loop"' >> src/twisted/internet/test/test_posixbase.py
+    echo 'PosixReactorBaseTests.test_wakerIsInternalReader.skip = "Fails due to unclosed event loop"' >> src/twisted/internet/test/test_posixbase.py
+
+    echo 'TCPPortTests.test_connectionLostFailed.skip = "Fails due to unclosed event loop"' >> src/twisted/internet/test/test_posixbase.py
   '';
 
   # Generate Twisted's plug-in cache. Twisted users must do it as well. See
@@ -128,6 +126,7 @@ buildPythonPackage rec {
   checkInputs = [
     git
     glibcLocales
+    hypothesis
     pyhamcrest
   ]
   ++ passthru.optional-dependencies.conch
@@ -169,11 +168,7 @@ buildPythonPackage rec {
 
   meta = with lib; {
     homepage = "https://github.com/twisted/twisted";
-    description = "Twisted, an event-driven networking engine written in Python";
-    longDescription = ''
-      Twisted is an event-driven networking engine written in Python
-      and licensed under the MIT license.
-    '';
+    description = "Asynchronous networking framework written in Python";
     license = licenses.mit;
     maintainers = with maintainers; [ SuperSandro2000 ];
   };